Kappa-opioid receptor signaling in the striatum as a potential modulator of dopamine transmission in cocaine dependence

Frontiers in Psychiatry

Volumn 4, Issue JUN, 2013, Pages

  Trifilieff, Pierre ^a,b   Martinez, Diana ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b NutriNeuro Bordeaux University   (France)

Author keywords

Cocaine dependence; Dopamine; Dopamine receptor; Imaging; Kappa opioid receptor; Striatum

Indexed keywords

5' GUANIDINONALTRINDOLE; ARYLACETIC ACID DERIVATIVE; DOPAMINE; DOPAMINE 2 RECEPTOR; DYNORPHIN; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR ANTAGONIST; NORBINALTORPHIMINE; RACLOPRIDE; SALVINORIN A; UNCLASSIFIED DRUG;

COCAINE DEPENDENCE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CORPUS STRIATUM; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; DRUG SEEKING BEHAVIOR; DRUG SELF ADMINISTRATION; HUMAN; IMAGING SYSTEM; NEUROCHEMISTRY; NEUROMODULATION; NONHUMAN; PRESYNAPTIC POTENTIAL; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; UPREGULATION;

EID: 84884554332     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2013.00044     Document Type: Review

References (182)

1. Abi-Dargham, A., Simpson, N., Kegeles, L., Parsey, R., Hwang, D. R., Anjilvel, S., et al. (1999). PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756. Synapse 32, 93-109. doi:10.1002/(SICI)1098-2396(199905)32:2<93::AIDSYN3>3.0.CO;2-C
2. Ackerman, J. M., and White, F. J. (1992). Decreased activity of rat A10 dopamine neurons following withdrawal from repeated cocaine. Eur. J. Pharmacol. 218, 171-173. doi:10.1016/0014-2999(92)90161-V
3. Acri, J. B., Thompson, A. C., and Shippenberg, T. (2001). Modulation of pre- and post-synaptic dopamine D2 receptor function by the selective kappa-opioid receptor agonist U69593. Synapse 39, 343-350. doi:10.1002/1098-2396(20010315)39:4<343::AIDSYN1018>3.0.CO;2-Q
4. Amato, L., Minozzi, S., Pani, P. P., Solimini, R., Vecchi, S., Zuccaro, P., et al. (2011). Dopamine agonists for the treatment of cocaine dependence. Cochrane Database Syst. Rev. CD003352.
5. Bals-Kubik, R., Ableitner, A., Herz, A., and Shippenberg, T. S. (1993). Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats. J. Pharmacol. Exp. Ther. 264, 489-495.
6. Bateup, H. S., Santini, E., Shen, W., Birnbaum, S., Valjent, E., Surmeier, D. J., et al. (2010). Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proc. Natl. Acad. Sci. U.S.A. 107, 14845-14850. doi:10.1073/pnas.1009874107
7. Beardsley, P. M., Howard, J. L., Shelton, K. L., and Carroll, F. I. (2005). Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs. cocaine primes and its antidepressant-like effects in rats. Psychopharmacology (Berl.) 183, 118-126. doi:10.1007/s00213-005-0167-4
8. Berridge, K. C. (2007). The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl.) 191, 391-431. doi:10.1007/s00213-006-0578-x
9. Bisaga, A., Aharonovich, E., Cheng, W. Y., Levin, F. R., Mariani, J. J., Raby, W. N., et al. (2010). A placebo-controlled trial of memantine for cocaine dependence with high-value voucher incentives during a pre-randomization lead-in period. Drug Alcohol Depend. 111, 97-104. doi:10.1016/j.drugalcdep.2010.04.006
10. Boileau, I., Payer, D., Houle, S., Behzadi, A., Rusjan, P. M., Tong, J., et al. (2012). Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study. J. Neurosci. 32, 1353-1359. doi:10.1523/JNEUROSCI.4371-11.2012
11. Breier, A., Su, T. P., Saunders, R., Carson, R. E., Kolachana, B. S., Debartolomeis, A., et al. (1997). Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc. Natl. Acad. Sci. U.S.A. 94, 2569-2574. doi:10.1073/pnas.94.6.2569
12. Brodie, M. S., and Dunwiddie, T. V. (1990). Cocaine effects in the ventral tegmental area: evidence for an indirect dopaminergic mechanism of action. Naunyn Schmiedebergs Arch. Pharmacol. 342, 660-665. doi:10.1007/BF00175709
13. Bruijnzeel, A. W. (2009). kappa-Opioid receptor signaling and brain reward function. Brain Res. Rev. 62, 127-146. doi:10.1016/j.brainresrev.2009.09.008
14. Busto, U. E., Redden, L., Mayberg, H., Kapur, S., Houle, S., and Zawertailo, L. A. (2009). Dopaminergic activity in depressed smokers: a positron emission tomography study. Synapse 63, 681-689. doi:10.1002/syn.20646
15. Butelman, E. R., Yuferov, V., and Kreek, M. J. (2012). kappa-Opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends Neurosci. 35, 587-596. doi:10.1016/j.tins.2012.05.005
16. Carey, A. N., Borozny, K., Aldrich, J. V., and McLaughlin, J. P. (2007). Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn. Eur. J. Pharmacol. 569, 84-89. doi:10.1016/j.ejphar.2007.05.007
17. Carlezon, W. A. Jr., Beguin, C., Dinieri, J. A., Baumann, M. H., Richards, M. R., Todtenkopf, M. S., et al. (2006). Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. J. Pharmacol. Exp. Ther. 316, 440-447. doi:10.1124/jpet.105.092304
18. Carlezon, W. A. Jr., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., et al. (1998). Regulation of cocaine reward by CREB. Science 282, 2272-2275. doi:10.1126/science.282.5397.2272
19. Carroll, I., Thomas, J. B., Dykstra, L. A., Granger, A. L., Allen, R. M., Howard, J. L., et al. (2004). Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist. Eur. J. Pharmacol. 501, 111-119. doi:10.1016/j.ejphar.2004.08.028
20. Castner, S. A., Al-Tikriti, M. S., Baldwin, R. M., Seibyl, J. P., Innis, R. B., and Goldman-Rakic, P. S. (2000). Behavioral changes and [123I]IBZM equilibrium SPECT measurement of amphetamine-induced dopamine release in rhesus monkeys exposed to subchronic amphetamine. Neuropsychopharmacology 22, 4-13. doi:10.1016/S0893-133X(99)00080-9
21. Chefer, V. I., Czyzyk, T., Bolan, E. A., Moron, J., Pintar, J. E., and Shippenberg, T. S. (2005). Endogenous kappa-opioid receptor systems regulate mesoaccumbal dopamine dynamics and vulnerability to cocaine. J. Neurosci. 25, 5029-5037. doi:10.1523/JNEUROSCI.0854-05.2005
22. Chen, Y., Chen, C., and Liu-Chen, L. Y. (2007). Dynorphin peptides differentially regulate the human kappa opioid receptor. Life Sci. 80, 1439-1448. doi:10.1016/j.lfs.2007.01.018
23. Chou, Y. H., Karlsson, P., Halldin, C., Olsson, H., and Farde, L. (1999). A PET study of D(1)-like dopamine receptor ligand binding during altered endogenous dopamine levels in the primate brain. Psychopharmacology (Berl.) 146, 220-227. doi:10.1007/s002130051110
24. Crain, S. M., and Shen, K. F. (1996). Modulatory effects of Gs-coupled excitatory opioid receptor functions on opioid analgesia, tolerance, and dependence. Neurochem. Res. 21, 1347-1351. doi:10.1007/BF02532375
25. Czoty, P. W., Morgan, D., Shannon, E. E., Gage, H. D., and Nader, M. A. (2004). Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine. Psychopharmacology (Berl.) 174, 381-388. doi:10.1007/s00213-003-1752-z
26. Dalley, J. W., Everitt, B. J., and Robbins, T. W. (2011). Impulsivity, compulsivity, and top-down cognitive control. Neuron 69, 680-694. doi:10.1016/j.neuron.2011.01.020
27. Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S., Theobald, D. E., Laane, K., et al. (2007). Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science 315, 1267-1270. doi:10.1126/science.1137073
28. Daunais, J. B., and McGinty, J. F. (1995). Cocaine binges differentially alter striatal preprodynorphin and zif/268 mRNAs. Brain Res. Mol. Brain Res. 29, 201-210. doi:10.1016/0169-328X(94)00246-B
29. Daunais, J. B., and McGinty, J. F. (1996). The effects of D1 or D2 dopamine receptor blockade on zif/268 and preprodynorphin gene expression in rat forebrain following a short-term cocaine binge. Brain Res. Mol. Brain Res. 35, 237-248. doi:10.1016/0169-328X(95)00226-I
30. Daunais, J. B., Roberts, D. C., and McGinty, J. F. (1993). Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum. Neuroreport 4, 543-546. doi:10.1097/00001756-199305000-00020
31. Daunais, J. B., Roberts, D. C., and McGinty, J. F. (1995). Short-term cocaine self administration alters striatal gene expression. Brain Res. Bull. 37, 523-527. doi:10.1016/0361-9230(95)00049-K
32. De La Garza, R. II, Ashbrook, L. H., Evans, S. E., Jacobsen, C. A., Kalechstein, A. D., and Newton, T. F. (2009). Influence of verbal recall of a recent stress experience on anxiety and desire for cocaine in non-treatment seeking, cocaine-addicted volunteers. Am. J. Addict. 18, 481-487. doi:10.3109/10550490903205876
33. Di Chiara, G., and Imperato, A. (1988). Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J. Pharmacol. Exp. Ther. 244, 1067-1080.
34. Donzanti, B. A., Althaus, J. S., Payson, M. M., and Von Voigtlander, P. F. (1992). Kappa agonist-induced reduction in dopamine release: site of action and tolerance. Res. Commun. Chem. Pathol. Pharmacol. 78, 193-210.
35. Drakenberg, K., Nikoshkov, A., Horvath, M. C., Fagergren, P., Gharibyan, A., Saarelainen, K., et al. (2006). Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers. Proc. Natl. Acad. Sci. U.S.A. 103, 7883-7888. doi:10.1073/pnas.0600871103
36. Drevets, W. C., Gautier, C., Price, J. C., Kupfer, D. J., Kinahan, P. E., Grace, A. A., et al. (2001). Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. Biol. Psychiatry 49, 81-96. doi:10.1016/S0006-3223(00)01038-6
37. Elman, I., and Lukas, S. E. (2005). Effects of cortisol and cocaine on plasma prolactin and growth hormone levels in cocaine-dependent volunteers. Addict. Behav. 30, 859-864. doi:10.1016/j.addbeh.2004.08.019
38. Elman, I., Lukas, S. E., Karlsgodt, K. H., Gasic, G. P., and Breiter, H. C. (2003). Acute cortisol administration triggers craving in individuals with cocaine dependence. Psychopharmacol. Bull. 37, 84-89.
39. Endoh, T., Matsuura, H., Tanaka, C., and Nagase, H. (1992). Nor-binaltorphimine: a potent and selective kappa-opioid receptor antagonist with long-lasting activity in vivo. Arch. Int. Pharmacodyn. Ther. 316, 30-42.
40. Endres, C. J., Kolachana, B. S., Saunders, R. C., Su, T., Weinberger, D., Breier, A., et al. (1997). Kinetic modeling of [C-11]raclopride: combined PET-microdialysis studies. J. Cereb. Blood Flow Metab. 17, 932-942. doi:10.1097/00004647-199709000-00002
41. Everitt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W., and Robbins, T. W. (2008). Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos. Trans. R. Soc. Lond. B Biol. Sci. 363, 3125-3135. doi:10.1098/rstb.2008.0089
42. Fagergren, P., Smith, H. R., Daunais, J. B., Nader, M. A., Porrino, L. J., and Hurd, Y. L. (2003). Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration. Eur. J. Neurosci. 17, 2212-2218. doi:10.1046/j.1460-9568.2003.02636.x
43. Ford, C. P., Mark, G. P., and Williams, J. T. (2006). Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location. J. Neurosci. 26, 2788-2797. doi:10.1523/JNEUROSCI.4331-05.2006
44. Fox, H. C., Garcia, M. Jr., Kemp, K., Milivojevic, V., Kreek, M. J., and Sinha, R. (2006). Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals. Psychopharmacology (Berl.) 185, 348-357. doi:10.1007/s00213-005-0303-1
45. Frankel, P. S., Alburges, M. E., Bush, L., Hanson, G. R., and Kish, S. J. (2007). Brain levels of neuropeptides in human chronic methamphetamine users. Neuropharmacology 53, 447-454. doi:10.1016/j.neuropharm.2007.06.009
46. Frankel, P. S., Alburges, M. E., Bush, L., Hanson, G. R., and Kish, S. J. (2008). Striatal and ventral pallidum dynorphin concentrations are markedly increased in human chronic cocaine users. Neuropharmacology 55, 41-46. doi:10.1016/j.neuropharm.2008.04.019
47. Fuentealba, J. A., Gysling, K., Magendzo, K., and Andres, M. E. (2006). Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases stimulated dopamine extracellular levels in the rat nucleus accumbens. J. Neurosci. Res. 84, 450-459. doi:10.1002/jnr.20890
48. Fusar-Poli, P., and Meyer-Lindenberg, A. (2013). Striatal presynaptic dopamine in schizophrenia, part I: meta-analysis of dopamine active transporter (DAT) density. Schizophr. Bull. 39, 22-32. doi:10.1093/schbul/sbr111
49. Gao, W. Y., Lee, T. H., King, G. R., and Ellinwood, E. H. (1998). Alterations in baseline activity and quinpirole sensitivity in putative dopamine neurons in the substantia nigra and ventral tegmental area after withdrawal from cocaine pretreatment. Neuropsychopharmacology 18, 222-232. doi:10.1016/S0893-133X(97)00132-2
50. Gehrke, B. J., Chefer, V. I., and Shippenberg, T. S. (2008). Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum. Psychopharmacology (Berl.) 197, 509-517. doi:10.1007/s00213-007-1067-6
51. George, S. R., and O'Dowd, B. F. (2007). A novel dopamine receptor signaling unit in brain: heterooligomers of D1 and D2 dopamine receptors. ScientificWorldJournal 7, 58-63. doi:10.1100/tsw.2007.223
52. Gerfen, C. R. (2000). Molecular effects of dopamine on striatal-projection pathways. Trends Neurosci. 23, S64-S70. doi:10.1016/S1471-1931(00)00019-7
53. Gerfen, C. R., and Surmeier, D. J. (2011). Modulation of striatal projection systems by dopamine. Annu. Rev. Neurosci. 34, 441-466. doi:10.1146/annurev-neuro-061010-113641
54. Gerrits, M. A., Petromilli, P., Westenberg, H. G., Di Chiara, G., and Van Ree, J. M. (2002). Decrease in basal dopamine levels in the nucleus accumbens shell during daily drug-seeking behaviour in rats. Brain Res. 924, 141-150. doi:10.1016/S0006-8993(01)03105-5
55. Girault, J. A. (2012). Signaling in striatal neurons: the phosphoproteins of reward, addiction, and dyskinesia. Prog. Mol. Biol. Transl. Sci. 106, 33-62. doi:10.1016/B978-0-12-396456-4.00006-7
56. Gorelick, D. A., Kim, Y. K., Bencherif, B., Boyd, S. J., Nelson, R., Copersino, M. L., et al. (2008). Brain mu-opioid receptor binding: relationship to relapse to cocaine use after monitored abstinence. Psychopharmacology (Berl.) 200, 475-486. doi:10.1007/s00213-008-1225-5
57. Groman, S. M., and Jentsch, J. D. (2012). Cognitive control and the dopamine D(2)-like receptor: a dimensional understanding of addiction. Depress. Anxiety 29, 295-306. doi:10.1002/da.20897
58. Gross, G., and Drescher, K. (2012). "The role of dopamine D(3) receptors in antipsychotic activity and cognitive functions," in Handbook of Experimental Pharmacology, eds M. Geyer and G. Gross (Heidelberg: Springer), 167-210.
59. Gross, R. A., Moises, H. C., Uhler, M. D., and Macdonald, R. L. (1990). Dynorphin A and cAMP-dependent protein kinase independently regulate neuronal calcium currents. Proc. Natl. Acad. Sci. U.S.A. 87, 7025-7029. doi:10.1073/pnas.87.18.7025
60. Grudt, T. J., and Williams, J. T. (1993). kappa-Opioid receptors also increase potassium conductance. Proc. Natl. Acad. Sci. U.S.A. 90, 11429-11432. doi:10.1073/pnas.90.23.11429
61. Haney, M., Collins, E. D., Ward, A. S., Foltin, R. W., and Fischman, M. W. (1999). Effect of a selective dopamine D1 agonist (ABT-431) on smoked cocaine self-administration in humans. Psychopharmacology (Berl.) 143, 102-110. doi:10.1007/s002130050925
62. Haney, M., Ward, A. S., Foltin, R. W., and Fischman, M. W. (2001). Effects of ecopipam, a selective dopamine D1 antagonist, on smoked cocaine self-administration by humans. Psychopharmacology (Berl.) 155, 330-337. doi:10.1007/s002130100725
63. Heijna, M. H., Bakker, J. M., Hogenboom, F., Mulder, A. H., and Schoffelmeer, A. N. (1992). Opioid receptors and inhibition of dopamine-sensitive adenylate cyclase in slices of rat brain regions receiving a dense dopaminergic input. Eur. J. Pharmacol. 229, 197-202. doi:10.1016/0014-2999(92)90555-I
64. Heijna, M. H., Padt, M., Hogenboom, F., Portoghese, P. S., Mulder, A. H., and Schoffelmeer, A. N. (1990). Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex. Eur. J. Pharmacol. 181, 267-278. doi:10.1016/0014-2999(90)90088-N
65. Hurd, Y. L., and Herkenham, M. (1993). Molecular alterations in the neostriatum of human cocaine addicts. Synapse 13, 357-369. doi:10.1002/syn.890130408
66. Hurd, Y. L., and Herkenham, M. (1995). The human neostriatum shows compartmentalization of neuropeptide gene expression in dorsal and ventral regions: an in situ hybridization histochemical analysis. Neuroscience 64, 571-586. doi:10.1016/0306-4522(94)00417-4
67. Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., et al. (2007). Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J. Cereb. Blood Flow Metab. 27, 1533-1539. doi:10.1038/sj.jcbfm.9600493
68. Iremonger, K. J., and Bains, J. S. (2009). Retrograde opioid signaling regulates glutamatergic transmission in the hypothalamus. J. Neurosci. 29, 7349-7358. doi:10.1523/JNEUROSCI.0381-09.2009
69. Izenwasser, S., Acri, J. B., Kunko, P. M., and Shippenberg, T. (1998). Repeated treatment with the selective kappa opioid agonist U-69593 produces a marked depletion of dopamine D2 receptors. Synapse 30, 275-283. doi:10.1002/(SICI)1098-2396(199811)30:3<275::AIDSYN5>3.0.CO;2-8
70. Jackisch, R., Hotz, H., Allgaier, C., and Hertting, G. (1994). Presynaptic opioid receptors on dopaminergic nerves in the rabbit caudate nucleus: coupling to pertussis toxin-sensitive G-proteins and interaction with D2 autoreceptors?. Naunyn Schmiedebergs Arch. Pharmacol. 349, 250-258. doi:10.1007/BF00169291
71. Jenab, S., Festa, E. D., Russo, S. J., Wu, H. B., Inturrisi, C. E., and Quinones-Jenab, V. (2003). MK-801 attenuates cocaine induction of c-fos and preprodynorphin mRNA levels in Fischer rats. Brain Res. Mol. Brain Res. 117, 237-239. doi:10.1016/S0169-328X(03)00319-X
72. Jones, R. M., and Portoghese, P. S. (2000). 5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist. Eur. J. Pharmacol. 396, 49-52. doi:10.1016/S0014-2999(00)00208-9
73. Kirkland Henry, P., Davis, M., and Howell, L. L. (2009). Effects of cocaine self-administration history under limited and extended access conditions on in vivo striatal dopamine neurochemistry and acoustic startle in rhesus monkeys. Psychopharmacology (Berl.) 205, 237-247. doi:10.1007/s00213-009-1534-3
74. Knoll, A. T., Muschamp, J. W., Sillivan, S. E., Ferguson, D., Dietz, D. M., Meloni, E. G., et al. (2011). Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol. Psychiatry 70, 425-433. doi:10.1016/j.biopsych.2011.03.017
75. Koob, G. F. (2013). Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr. Top. Behav. Neurosci. 13, 3-30. doi:10.1007/7854_2011_129
76. Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., et al. (2004). Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci. Biobehav. Rev. 27, 739-749. doi:10.1016/j.neubiorev.2003.11.007
77. Koob, G. F., and Le Moal, M. (2008). Addiction and the brain antireward system. Annu. Rev. Psychol. 59, 29-53. doi:10.1146/annurev.psych.59.103006.093548
78. Kreek, M. J., Levran, O., Reed, B., Schlussman, S. D., Zhou, Y., and Butelman, E. R. (2012). Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics. J. Clin. Invest. 122, 3387-3393. doi:10.1172/JCI60390
79. Lacey, M. G., Mercuri, N. B., and North, R. A. (1990). Actions of cocaine on rat dopaminergic neurones in vitro. Br. J. Pharmacol. 99, 731-735. doi:10.1111/j.1476-5381.1990.tb12998.x
80. Lahti, R. A., Mickelson, M. M., McCall, J. M., and Von Voigtlander, P. F. (1985). [3H]U-69593 a highly selective ligand for the opioid kappa receptor. Eur. J. Pharmacol. 109, 281-284. doi:10.1016/0014-2999(85)90431-5
81. Land, B. B., Bruchas, M. R., Lemos, J. C., Xu, M., Melief, E. J., and Chavkin, C. (2008). The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J. Neurosci. 28, 407-414. doi:10.1523/JNEUROSCI.4458-07.2008
82. Laorden, M. L., Castells, M. T., Martinez, M. D., Martinez, P. J., and Milanes, M. V. (2000). Activation of c-fos expression in hypothalamic nuclei by mu- and kappa-receptor agonists: correlation with catecholaminergic activity in the hypothalamic paraventricular nucleus. Endocrinology 141, 1366-1376. doi:10.1210/en.141.4.1366
83. Laruelle, M. (2000). Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J. Cereb. Blood Flow Metab. 20, 423-451. doi:10.1097/00004647-200003000-00001
84. Laruelle, M., Iyer, R. N., Al-Tikriti, M. S., Zea-Ponce, Y., Malison, R., Zoghbi, S. S., et al. (1997). Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates. Synapse 25, 1-14. doi:10.1002/(SICI)1098-2396(199701)25:1<1::AIDSYN1>3.0.CO;2-H
85. Law, P. Y., Wong, Y. H., and Loh, H. H. (2000). Molecular mechanisms and regulation of opioid receptor signaling. Annu. Rev. Pharmacol. Toxicol. 40, 389-430. doi:10.1146/annurev.pharmtox.40.1.389
86. Lee, T. H., Gao, W. Y., Davidson, C., and Ellinwood, E. H. (1999). Altered activity of midbrain dopamine neurons following 7-day withdrawal from chronic cocaine abuse is normalized by D2 receptor stimulation during the early withdrawal phase. Neuropsychopharmacology 21, 127-136. doi:10.1016/S0893-133X(99)00011-1
87. Li, S. J., Sivam, S. P., McGinty, J. F., Jiang, H. K., Douglass, J., Calavetta, L., et al. (1988). Regulation of the metabolism of striatal dynorphin by the dopaminergic system. J. Pharmacol. Exp. Ther. 246, 403-408.
88. Little, K. Y., Kirkman, J. A., Carroll, F. I., Clark, T. B., and Duncan, G. E. (1993). Cocaine use increases [3H]WIN 35428 binding sites in human striatum. Brain Res. 628, 17-25. doi:10.1016/0006-8993(93)90932-D
89. Little, K. Y., Zhang, L., Desmond, T., Frey, K. A., Dalack, G. W., and Cassin, B. J. (1999). Striatal dopaminergic abnormalities in human cocaine users. Am. J. Psychiatry 156, 238-245.
90. Liu, F. C., and Graybiel, A. M. (1998). Dopamine and calcium signal interactions in the developing striatum: control by kinetics of CREB phosphorylation. Adv. Pharmacol. 42, 682-686. doi:10.1016/S1054-3589(08)60840-6
91. Lobo, M. K., Covington, H. E. III, Chaudhury, D., Friedman, A. K., Sun, H., Damez-Werno, D., et al. (2010). Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330, 385-390. doi:10.1126/science.1188472
92. Maisonneuve, I. M., Archer, S., and Glick, S. D. (1994). U50,488, a kappa agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats. Neurosci. Lett. 181, 57-60. doi:10.1016/0304-3940(94)90559-2
93. Malison, R. T., Best, S. E., Van Dyck, C. H., McCance, E. F., Wallace, E. A., Laruelle, M., et al. (1998). Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT. Am. J. Psychiatry 155, 832-834.
94. Malison, R. T., Mechanic, K. Y., Klummp, H., Baldwin, R. M., Kosten, T. R., Seibyl, J. P., et al. (1999). Reduced amphetamine-stimulated dopamine release in cocaine addicts as measured by [123I]IBZM SPECT. J. Nucl. Med. 40, 110.
95. Margolis, E. B., Hjelmstad, G. O., Bonci, A., and Fields, H. L. (2003). Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. J. Neurosci. 23, 9981-9986.
96. Margolis, E. B., Lock, H., Chefer, V. I., Shippenberg, T. S., Hjelmstad, G. O., and Fields, H. L. (2006). Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proc. Natl. Acad. Sci. U.S.A. 103, 2938-2942. doi:10.1073/pnas.0511159103
97. Marinelli, M., Cooper, D. C., Baker, L. K., and White, F. J. (2003). Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior. Psychopharmacology (Berl.) 168, 84-98. doi:10.1007/s00213-003-1491-1
98. Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D. R., Huang, Y., et al. (2004). Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior. Neuropsychopharmacology 29, 1190-1202. doi:10.1038/sj.npp.1300420
99. Martinez, D., Carpenter, K. M., Liu, F., Slifstein, M., Broft, A., Friedman, A. C., et al. (2011). Imaging dopamine transmission in cocaine dependence: link between neurochemistry and response to treatment. Am. J. Psychiatry 168, 634-641. doi:10.1176/appi.ajp.2010.10050748
100. Martinez, D., Greene, K., Broft, A., Kumar, D., Liu, F., Narendran, R., et al. (2009a). Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion. Am. J. Psychiatry 166, 1170-1177. doi:10.1176/appi.ajp.2009.08121801
101. Martinez, D., Slifstein, M., Narendran, R., Foltin, R. W., Broft, A., Hwang, D. R., et al. (2009b). Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine. Neuropsychopharmacology 34, 1774-1782. doi:10.1038/npp.2008.235
102. Martinez, D., Kim, J. H., Krystal, J., and Abi-Dargham, A. (2007a). Imaging the neurochemistry of alcohol and substance abuse. Neuroimaging Clin. N. Am. 17, 539-555. doi:10.1016/j.nic.2007.07.004
103. Martinez, D., Narendran, R., Foltin, R. W., Slifstein, M., Hwang, D. R., Broft, A., et al. (2007b). Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine. Am. J. Psychiatry 164, 622-629. doi:10.1176/appi.ajp.164.4.622
104. Martinez, D., and Narendran, R. (2010). Imaging neurotransmitter release by drugs of abuse. Curr. Top. Behav. Neurosci. 3, 219-245. doi:10.1007/7854_2009_34
105. Martinez, D., Saccone, P. A., Liu, F., Slifstein, M., Orlowska, D., Grassetti, A., et al. (2012). Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction. Biol. Psychiatry 71, 192-198. doi:10.1016/j.biopsych.2011.08.024
106. Martinez, D., Slifstein, M., Broft, A., Mawlawi, O., Hwang, D. R., Huang, Y., et al. (2003). Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum. J. Cereb. Blood Flow Metab. 23, 285-300. doi:10.1097/00004647-200303000-00004
107. Mash, D. C., and Staley, J. K. (1999). D3 dopamine and kappa opioid receptor alterations in human brain of cocaine-overdose victims. Ann. N. Y. Acad. Sci. 877, 507-522. doi:10.1111/j.1749-6632.1999.tb09286.x
108. Matuskey, D., Gallezot, J., Keunpoong, L., Zheng, M., Lin, S., Carson, R., et al. (2011). Subcortical D3/D2 receptor binding in cocaine dependent humans. J. Nucl. Med. 52, 1284.
109. McClung, C. A., and Nestler, E. J. (2008). Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology 33, 3-17. doi:10.1038/sj.npp.1301544
110. McClung, C. A., Ulery, P. G., Perrotti, L. I., Zachariou, V., Berton, O., and Nestler, E. J. (2004). DeltaFosB: a molecular switch for long-term adaptation in the brain. Brain Res. Mol. Brain Res. 132, 146-154. doi:10.1016/j.molbrainres.2004.05.014
111. McLaughlin, J. P., Land, B. B., Li, S., Pintar, J. E., and Chavkin, C. (2006). Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology 31, 787-794. doi:10.1038/sj.npp.1300860
112. McLaughlin, J. P., Marton-Popovici, M., and Chavkin, C. (2003). Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. J. Neurosci. 23, 5674-5683.
113. Meador-Woodruff, J. H., Little, K. Y., Damask, S. P., Mansour, A., and Watson, S. J. (1993). Effects of cocaine on dopamine receptor gene expression: a study in the postmortem human brain. Biol. Psychiatry 34, 348-355. doi:10.1016/0006-3223(93)90178-G
114. Melis, M., Spiga, S., and Diana, M. (2005). The dopamine hypothesis of drug addiction: hypodopaminergic state. Int. Rev. Neurobiol. 63, 101-154. doi:10.1016/S0074-7742(05)63005-X
115. Morgan, D., Grant, K. A., Gage, H. D., Mach, R. H., Kaplan, J. R., Prioleau, O., et al. (2002). Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat. Neurosci. 5, 169-174. doi:10.1038/nn798
116. Mucha, R. F., and Herz, A. (1985). Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology (Berl.) 86, 274-280. doi:10.1007/BF00432213
117. Munro, C. A., McCaul, M. E., Wong, D. F., Oswald, L. M., Zhou, Y., Brasic, J., et al. (2006). Sex differences in striatal dopamine release in healthy adults. Biol. Psychiatry 59, 966-974. doi:10.1016/j.biopsych.2006.01.008
118. Muschamp, J. W., and Carlezon, W. A. Jr. (2013). Roles of nucleus accumbens CREB and dynorphin in dysregulation of motivation. Cold Spring Harb. Perspect. Med. doi:10.1101/cshperspect.a012005 [Epub ahead of print].
119. Nader, M. A., Morgan, D., Gage, H. D., Nader, S. H., Calhoun, T. L., Buchheimer, N., et al. (2006). PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys. Nat. Neurosci. 9, 1050-1056. doi:10.1038/nn1737
120. Narendran, R., Lopresti, B. J., Martinez, D., Mason, N. S., Himes, M., May, M. A., et al. (2012). In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers. Am. J. Psychiatry 169, 55-63. doi:10.1176/appi.ajp.2011.11010126
121. Nikolarakis, K. E., Almeida, O. F., and Herz, A. (1986). Stimulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (in vitro). Brain Res. 399, 152-155. doi:10.1016/0006-8993(86)90610-4
122. Oliveto, A., Poling, J., Mancino, M. J., Williams, D. K., Thostenson, J., Pruzinsky, R., et al. (2012). Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms. Addiction 107, 131-141. doi:10.1111/j.1360-0443.2011.03552.x
123. Parsons, L. H., Smith, A. D., and Justice, J. B. Jr. (1991). Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine. Synapse 9, 60-65. doi:10.1002/syn.890090109
124. Pascoli, V., Turiault, M., and Luscher, C. (2012). Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour. Nature 481, 71-75. doi:10.1038/nature10709
125. Pfeiffer, A., Brantl, V., Herz, A., and Emrich, H. M. (1986). Psychotomimesis mediated by kappa opiate receptors. Science 233, 774-776. doi:10.1126/science.3016896
126. Redila, V. A., and Chavkin, C. (2008). Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology (Berl.) 200, 59-70. doi:10.1007/s00213-008-1122-y
127. Robertson, M. W., Leslie, C. A., and Bennett, J. P. Jr. (1991). Apparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment. Brain Res. 538, 337-339. doi:10.1016/0006-8993(91)90451-Z
128. Rossetti, Z. L., Melis, F., Carboni, S., and Gessa, G. L. (1992). Dramatic depletion of mesolimbic extracellular dopamine after withdrawal from morphine, alcohol or cocaine: a common neurochemical substrate for drug dependence. Ann. N. Y. Acad. Sci. 654, 513-516. doi:10.1111/j.1749-6632.1992.tb26016.x
129. Roth, B. L., Baner, K., Westkaemper, R., Siebert, D., Rice, K. C., Steinberg, S., et al. (2002). Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proc. Natl. Acad. Sci. U.S.A. 99, 11934-11939. doi:10.1073/pnas.182234399
130. Salamone, J. D., and Correa, M. (2012). The mysterious motivational functions of mesolimbic dopamine. Neuron 76, 470-485. doi:10.1016/j.neuron.2012.10.021
131. Schlussman, S. D., Zhang, Y., Yuferov, V., Laforge, K. S., Ho, A., and Kreek, M. J. (2003). Acute 'binge' cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL/6J but not 129/J mice. Brain Res. 974, 249-253. doi:10.1016/S0006-8993(03)02561-7
132. Schlussman, S. D., Zhou, Y., Bailey, A., Ho, A., and Kreek, M. J. (2005). Steady-dose and escalating-dose "binge" administration of cocaine alter expression of behavioral stereotypy and striatal preprodynorphin mRNA levels in rats. Brain Res. Bull. 67, 169-175. doi:10.1016/j.brainresbull.2005.04.018
133. Schultz, W. (2006). Behavioral theories and the neurophysiology of reward. Annu. Rev. Psychol. 57, 87-115. doi:10.1146/annurev.psych.56.091103.070229
134. Shippenberg, T. S., Zapata, A., and Chefer, V. I. (2007). Dynorphin and the pathophysiology of drug addiction. Pharmacol. Ther. 116, 306-321. doi:10.1016/j.pharmthera.2007.06.011
135. Shirayama, Y., Ishida, H., Iwata, M., Hazama, G. I., Kawahara, R., and Duman, R. S. (2004). Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects. J. Neurochem. 90, 1258-1268. doi:10.1111/j.1471-4159.2004.02589.x
136. Shoptaw, S., Majewska, M. D., Wilkins, J., Twitchell, G., Yang, X., and Ling, W. (2004). Participants receiving dehydroepiandrosterone during treatment for cocaine dependence show high rates of cocaine use in a placebo-controlled pilot study. Exp. Clin. Psychopharmacol. 12, 126-135. doi:10.1037/1064-1297.12.2.126
137. Sinha, R., Catapano, D., and O'Malley, S. (1999). Stress-induced craving and stress response in cocaine dependent individuals. Psychopharmacology (Berl.) 142, 343-351. doi:10.1007/s002130050898
138. Sinha, R., Garcia, M., Paliwal, P., Kreek, M. J., and Rounsaville, B. J. (2006). Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Arch. Gen. Psychiatry 63, 324-331. doi:10.1001/archpsyc.63.3.324
139. Sivam, S. P. (1989). Cocaine selectively increases striatonigral dynorphin levels by a dopaminergic mechanism. J. Pharmacol. Exp. Ther. 250, 818-824.
140. Sivam, S. P. (1996). Dopaminergic regulation of striatonigral tachykinin and dynorphin gene expression: a study with the dopamine uptake inhibitor GBR-12909. Brain Res. Mol. Brain Res. 35, 197-210. doi:10.1016/0169-328X(95)00216-F
141. Smiley, P. L., Johnson, M., Bush, L., Gibb, J. W., and Hanson, G. R. (1990). Effects of cocaine on extrapyramidal and limbic dynorphin systems. J. Pharmacol. Exp. Ther. 253, 938-943.
142. Sokoloff, P., Diaz, J., Le Foll, B., Guillin, O., Leriche, L., Bezard, E., et al. (2006). The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders. CNS Neurol. Disord. Drug Targets 5, 25-43.
143. Song, Z. H., and Takemori, A. E. (1992). Stimulation by corticotropin-releasing factor of the release of immunoreactive dynorphin A from mouse spinal cords in vitro. Eur. J. Pharmacol. 222, 27-32. doi:10.1016/0014-2999(92)90458-G
144. Spanagel, R., Herz, A., and Shippenberg, T. (1992). Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc. Natl. Acad. Sci. U.S.A. 89, 2046-2050. doi:10.1073/pnas.89.6.2046
145. Spanagel, R., Herz, A., and Shippenberg, T. S. (1990). The effects of opioid peptides on dopamine release in the nucleus accumbens: an in vivo microdialysis study. J. Neurochem. 55, 1734-1740. doi:10.1111/j.1471-4159.1990.tb04963.x
146. Spangler, R., Ho, A., Zhou, Y., Maggos, C. E., Yuferov, V., and Kreek, M. J. (1996). Regulation of kappa opioid receptor mRNA in the rat brain by "binge" pattern cocaine administration and correlation with preprodynorphin mRNA. Brain Res. Mol. Brain Res. 38, 71-76. doi:10.1016/0169-328X(95)00319-N
147. Spangler, R., Unterwald, E., and Kreek, M. (1993). Binge cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen. Brain Res. Mol. Brain Res. 19, 323-327. doi:10.1016/0169-328X(93)90133-A
148. Staley, J. K., Rothman, R. B., Rice, K. C., Partilla, J., and Mash, D. C. (1997). Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims. J. Neurosci. 17, 8225-8233.
149. Svingos, A., Chavkin, C., Colago, E., and Pickel, V. (2001). Major coexpression of k-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Synapse 42, 185-192. doi:10.1002/syn.10005
150. Tang, A. H., and Collins, R. J. (1985). Behavioral effects of a novel kappa opioid analgesic, U-50488, in rats and rhesus monkeys. Psychopharmacology (Berl.) 85, 309-314. doi:10.1007/BF00428193
151. Tejeda, H. A., Shippenberg, T. S., and Henriksson, R. (2012). The dynorphin/kappa-opioid receptor system and its role in psychiatric disorders. Cell. Mol. Life Sci. 69, 857-896. doi:10.1007/s00018-011-0844-x
152. Thompson, A., Zapata, A., Justice, J., Vaughan, R., Sharpe, L., and Shippenberg, T. (2000). Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. J. Neurosci. 20, 9333-9340.
153. Ur, E., Wright, D. M., Bouloux, P. M., and Grossman, A. (1997). The effects of spiradoline (U-62066E), a kappa-opioid receptor agonist, on neuroendocrine function in man. Br. J. Pharmacol. 120, 781-784. doi:10.1038/sj.bjp.0700971
154. Valdez, G. R., Platt, D. M., Rowlett, J. K., Ruedi-Bettschen, D., and Spealman, R. D. (2007). Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms. J. Pharmacol. Exp. Ther. 323, 525-533. doi:10.1124/jpet.107.125484
155. Valjent, E., Bertran-Gonzalez, J., Herve, D., Fisone, G., and Girault, J. A. (2009). Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice. Trends Neurosci. 32, 538-547. doi:10.1016/j.tins.2009.06.005
156. Van Bockstaele, E. J., Gracy, K. N., and Pickel, V. M. (1995). Dynorphin-immunoreactive neurons in the rat nucleus accumbens: ultrastructure and synaptic input from terminals containing substance P and/or dynorphin. J. Comp. Neurol. 351, 117-133. doi:10.1002/cne.903510111
157. Volkow, N. D., Fowler, J. S., Wang, G. J., Hitzemann, R., Logan, J., Schlyer, D. J., et al. (1993). Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse 14, 169-177. doi:10.1002/syn.890140210
158. Volkow, N. D., Fowler, J. S., Wolf, A. P., Schlyer, D., Shiue, C. Y., Alpert, R., et al. (1990). Effects of chronic cocaine abuse on postsynaptic dopamine receptors. Am. J. Psychiatry 147, 719-724.
159. Volkow, N. D., Wang, G. J., Fowler, J. S., Hitzemann, R., Angrist, B., Gatley, S. J., et al. (1999). Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. Am. J. Psychiatry 156, 19-26.
160. Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., et al. (1997). Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature 386, 830-833. doi:10.1038/386830a0
161. Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Hitzemann, R., Ding, Y. S., et al. (1996). Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol. Clin. Exp. Res. 20, 1594-1598.
162. Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Schlyer, D., Hitzemann, R., et al. (1994). Imaging endogenous dopamine competition with [11C]raclopride in the human brain. Synapse 16, 255-262. doi:10.1002/syn.890160402
163. Von Voigtlander, P. F., and Lewis, R. A. (1982). U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists. Prog. Neuropsychopharmacol. Biol. Psychiatry 6, 467-470. doi:10.1016/S0278-5846(82)80130-9
164. Wadenberg, M. L. (2003). A review of the properties of spiradoline: a potent and selective kappa-opioid receptor agonist. CNS Drug Rev. 9, 187-198. doi:10.1111/j.1527-3458.2003.tb00248.x
165. Walsh, S. L., Geter-Douglas, B., Strain, E. C., and Bigelow, G. E. (2001). Enadoline and butorphanol: evaluation of kappa-agonists on cocaine pharmacodynamics and cocaine self-administration in humans. J. Pharmacol. Exp. Ther. 299, 147-158.
166. Walters, C. L., and Blendy, J. A. (2001). Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse. J. Neurosci. 21, 9438-9444.
167. Wang, G. J., Smith, L., Volkow, N. D., Telang, F., Logan, J., Tomasi, D., et al. (2012). Decreased dopamine activity predicts relapse in methamphetamine abusers. Mol. Psychiatry 17, 918-925. doi:10.1038/mp.2011.86
168. Wang, G. J., Volkow, N. D., Fowler, J. S., Fischman, M., Foltin, R., Abumrad, N. N., et al. (1997). Cocaine abusers do not show loss of dopamine transporters with age. Life Sci. 61, 1059-1065. doi:10.1016/S0024-3205(97)00614-0
169. Wee, S., and Koob, G. F. (2010). The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology (Berl.) 210, 121-135. doi:10.1007/s00213-010-1825-8
170. Wee, S., Orio, L., Ghirmai, S., Cashman, J. R., and Koob, G. F. (2009). Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology (Berl.) 205, 565-575. doi:10.1007/s00213-009-1563-y
171. Weiss, F., Paulus, M. P., Lorang, M. T., and Koob, G. F. (1992). Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration. J. Neurosci. 12, 4372-4380.
172. Wise, R. A. (2008). Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotox. Res. 14, 169-183. doi:10.1007/BF03033808
173. Wu, J. C., Bell, K., Najafi, A., Widmark, C., Keator, D., Tang, C., et al. (1997). Decreasing striatal 6-FDOPA uptake with increasing duration of cocaine withdrawal. Neuropsychopharmacology 17, 402-409. doi:10.1016/S0893-133X(97)00089-4
174. Xi, Z. X., Fuller, S. A., and Stein, E. A. (1998). Dopamine release in the nucleus accumbens during heroin self-administration is modulated by kappa opioid receptors: an in vivo fast-cyclic voltammetry study. J. Pharmacol. Exp. Ther. 284, 151-161.
175. Yokoo, H., Yamada, S., Yoshida, M., Tanaka, M., and Nishi, S. (1992). Attenuation of the inhibitory effect of dynorphin on dopamine release in the rat nucleus accumbens by repeated treatment with methamphetamine. Eur. J. Pharmacol. 222, 43-47. doi:10.1016/0014-2999(92)90461-C
176. You, Z. B., Herrera-Marschitz, M., and Terenius, L. (1999). Modulation of neurotransmitter release in the basal ganglia of the rat brain by dynorphin peptides. J. Pharmacol. Exp. Ther. 290, 1307-1315.
177. Yuferov, V., Zhou, Y., Laforge, K. S., Spangler, R., Ho, A., and Kreek, M. J. (2001). Elevation of guinea pig brain preprodynorphin mRNA expression and hypothalamic-pituitary-adrenal axis activity by "binge" pattern cocaine administration. Brain Res. Bull. 55, 65-70. doi:10.1016/S0361-9230(01)00496-8
178. Zhang, Y., Butelman, E. R., Schlussman, S. D., Ho, A., and Kreek, M. J. (2004a). Effect of the endogenous kappa opioid agonist dynorphin A(1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology (Berl.) 172, 422-429. doi:10.1007/s00213-003-1688-3
179. Zhang, Y., Butelman, E. R., Schlussman, S. D., Ho, A., and Kreek, M. J. (2004b). Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology (Berl.) 173, 146-152. doi:10.1007/s00213-003-1716-3
180. Zhang, Y., Schlussman, S. D., Rabkin, J., Butelman, E. R., Ho, A., and Kreek, M. J. (2013). Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice. Neuropharmacology 67, 259-266. doi:10.1016/j.neuropharm.2012.10.015
181. Zhou, Y., Spangler, R., Schlussman, S. D., Yuferov, V. P., Sora, I., Ho, A., et al. (2002). Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice. Synapse 45, 220-229. doi:10.1002/syn.10101
182. Zubieta, J. K., Gorelick, D. A., Stauffer, R., Ravert, H. T., Dannals, R. F., and Frost, J. J. (1996). Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving. Nat. Med. 2, 1225-1229. doi:10.1038/nm1196-1225