Effects of ecopipam, a selective dopamine D1 antagonist, on smoked cocaine self-administration by humans

Psychopharmacology

Volumn 155, Issue 4, 2001, Pages 330-337

  Haney, M ^a   Ward, A S ^a   Foltin, R W ^a   Fischman, M W ^a  

^a New York State Psychiatric Institute ^*  (United States)

Author keywords

Cardiovascular effect; Cocaine; Craving; D1 antagonist; Human; SCH 39166; Self administration; Subjective effect

Indexed keywords

COCAINE; DOPAMINE 1 RECEPTOR BLOCKING AGENT; ECOPINAM; ECOPIPAM; PLACEBO; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CLINICAL ARTICLE; CLINICAL TRIAL; COCAINE DEPENDENCE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SELF ADMINISTRATION; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RANDOMIZED CONTROLLED TRIAL; RECEPTOR BLOCKING; SMOKING;

ADMINISTRATION, INHALATION; ADULT; BENZAZEPINES; COCAINE; COCAINE-RELATED DISORDERS; CROSS-OVER STUDIES; DOPAMINE ANTAGONISTS; DOPAMINE UPTAKE INHIBITORS; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; MALE; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, DOPAMINE D1; SELF ADMINISTRATION;

EID: 0035004706     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130100725     Document Type: Article

References (59)

1. Supersensitivity to a D-1 dopamine receptor agonist and subsensitivity to a D-2 receptor agonist following chronic D-1 receptor blockade
2. Effects of stimulation and blockade of dopamine receptor subtypes on the stimulus properties of cocaine discrimination
3. Antagonism of cocaine self-administration by selective dopamine D1 and D2 antagonists
4. Interactions between D1 and D2 dopamine receptor family agonists and antagonists: The effects of chronic exposure on behavior and receptor binding in rats and their clinical implications
5. Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat
6. Discriminative stimulus effects of cocaine: Antagonism by dopamine D1 blockade in the amygdala
7. Effects of dopamine receptor antagonists (D1 and D2) on the demand for smoked cocaine base in rhesus monkeys
8. Pharmacological profile of SCH 39166: A dopamine D1 selective benzonaphthazepine with potential antipsychotic activity
9. Acute extrapyramidal syndrome in Cebus monkeys: Development mediated by dopamine D2 but not D1 receptors
10. Selective D-1 dopamine receptor increase following chronic treatment with SCH 23390
11. Changes in behavioural responses to the combined administration of D1 and D2 dopamine agonists in normosensitive and D1 upersensitives rats
12. Parameters of self-administration of cocaine in rats under a progressive-ratio schedule
13. Chronic administration of SCH 23390 produces sensitization to the discriminative stimulus properties of cocaine
14. Drugs and reinforcement mechanisms: A critical review of the catecholamine theory
15. Ethical and practical issues involved in behavioral pharmacology research that administers drugs of abuse to human volunteers
16. Effects of desipramine maintenance on cocaine self-administration by humans
17. Effects of buprenorphine on the self-administration of cocaine by humans
18. Demonstration of naturalistic methods for cocaine smoking by human volunteers
19. Effects of drugs on food- and cocaine-maintained responding. III. Dopaminergic antagonists
20. Risperidone for the treatment of cocaine dependence: Randomized, double-blind trial
21. Effects of chronic SCH 23390 or acute EEDQ on the discriminative stimulus effects of SKF 38393
22. Effects of pergolide on cocaine self-administration in men and women
23. Effect of a selective dopamine D1 agonist (ABT-431) on smoked cocaine self-administration in humans
24. Effects of chronic SCH 23390 treatment on the biochemical and behavioral properties of D1 and D2 dopamine receptors: Potentiated behavioral responses to a D2 dopamine agonist after selective D1 dopamine receptor up-regulation
25. Characterization of the effects of cocaine and GBR 12909, a dopamine uptake inhibitor, on behavior in the squirrel monkey
26. Effects of selective D1 and D2 dopamine antagonists on cocaine self-administration in the rat
27. In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement
28. Dopamine receptors: Molecular biology, biochemistry and behavioural aspects
29. Acute deleterious effects of cocaine on cardiac conduction, hemodynamics, and ventricular fibrillation threshold: Effects of interaction with a selective dopamine D1 antagonist SCH 39166
30. Multiple receptors for dopamine
31. Effects of continuous infusions of SCH 23390 on cocaine- or food-maintained behavior in rhesus monkeys
32. Blockade of the discriminative stimulus effects of cocaine in rhesus monkeys with the D1 dopamine antagonist SCH 23390
33. Pharmacological characterization of the discriminative stimulus effects of cocaine in rhesus monkeys
34. The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat
35. Enhanced neurobehavioral effects of cocaine with chronic neuroleptic exposure in rats
36. Long-term haloperidol administration enhances and short-term administration attenuates the behavioral effects of cocaine in a place conditioning procedure
37. Failure of odansetron to block the discriminative or reinforcing stimulus effects of cocaine in the rat
38. Discriminative stimulus effects of esteratic local anesthetics in squirrel monkeys
39. Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on intravenous cocaine self-administration under fixed and progressive ratio schedules of reinforcement
40. Preclinical evaluation of pharmacotherapies for treatment of cocaine and opioid abuse using drug selfadministration procedures
41. Cocaine receptors on dopamine transporters are related to self-administration of cocaine
42. Attenuation of the euphoric effects of cocaine by the dopamine D1/D5 antagonist ecopipam (SCH 39166)
43. A review of the effects of dopaminergic agents on humans, animals and drug-seeking behavior, and its implications for medication development
44. Role of dopamine D1 receptors in cocaine lethality
45. Effects of cocaine alone and in combination with haloperidol and SCH 23390 on cardiovascular function in squirrel monkeys
46. 11C-SCH 39166, a selective ligand for visualization of dopamine-D1 receptor binding in the monkey brain using PET
47. Antagonism of behavioral effects of cocaine by selective dopamine receptor blockers
48. Discriminative stimulus effects of cocaine in squirrel monkeys: Involvement of dopamine receptor subtypes
49. Differential modulation of behavioral effects of cocaine by low- and high-efficacy D1 agonists
50. Enhanced stereotyped response to apomorphine after chronic D-1 blockade with SCH 23390
51. Blockade of the discriminative stimulus effects of cocaine in rhesus monkeys with the D1 dopamine antagonists SCH-39166 and A-66359
52. Dopamine receptor antagonists fail to prevent induction of cocaine sensitization
53. Dopamine antagonist effects on behavior maintained by cocaine and alfentanil in rhesus monkeys
54. A psychomotor stimulant theory of addiction
55. Fluctuations in nucleus accumbens dopamine concentrations during intravenous cocaine self-administration in rats
56. Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog
57. Effects of a D1 and a D2 dopamine antagonist on the self-administration of cocaine and piribedil by rhesus monkeys
58. Behavioral and pharmacological aspects of opioid dependence: Mixed agonist-antagonists
59. The effects of a D1 and a D2 dopamine antagonist on behavior maintained by cocaine or food