ΔfosB: A molecular switch for long-term adaptation in the brain

Molecular Brain Research

Volumn 132, Issue 2, 2004, Pages 146-154

  McClung, Colleen A ^a   Ulery, Paula G ^a   Perrotti, Linda I ^a   Zachariou, Venetia ^a   Berton, Olivier ^a   Nestler, Eric J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

FosB; Amino acids; Drugs of abuse: cocaine; Fos family proteins; Neural Basis of behavior

Indexed keywords

PROTEIN FOS; FOSB PROTEIN, RAT; PROTEIN C FOS; TRANSCRIPTION FACTOR;

CELL FUNCTION; COMPLEX FORMATION; CONFERENCE PAPER; GENE REPRESSION; HUMAN; MOLECULAR STABILITY; NERVE CELL PLASTICITY; NEUROBIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ADAPTATION; ANIMAL; BRAIN; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; REVIEW;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BRAIN; GENE EXPRESSION REGULATION; HUMANS; NEURONAL PLASTICITY; PROTO-ONCOGENE PROTEINS C-FOS; TRANSCRIPTION FACTORS;

EID: 9744268957     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.05.014     Document Type: Conference Paper

References (56)

1. Andersson M., Hilbertson A., Cenci M.A. Striatal fosB expression is causally linked with L-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease. Neurobiol. Dis. 6:1999;461-474
2. Andersson M., Konradi C., Cenci M.A. cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum. J. Neurosci. 21:2001;9930-9943
3. Andersson M., Westin J.E., Cenci M.A. Time course of deltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment. Eur. J. Neurosci. 17:2003;661-666
4. Ang E., Chen J.S., Zagouras P., Magna H., Holland J., Schaeffer E., Nestler E.J. Induction of NFκB in nucleus accumbens by chronic cocaine administration. J. Neurochem. 79:2001;221-224
5. Asanuma M., Cadet J.L. Methamphetamine-induced increase in striatal NF-kappaB DNA-binding activity is attenuated in superoxide dismutase transgenic mice. Mol. Brain Res. 60:1998;305-309
6. Atkins J., Carlezon W.A., Chlan J., Nye H.E., Nestler E.J. Region-specific induction of ΔFosB by repeated administration of typical versus atypical antipsychotic drugs. Synapse. 33:1999;118-128
7. Barrot M., Olivier J.D.A., Perrotti L.I., Impey S., Storm D.R., Neve R.L., Zachariou V., Nestler E.J. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc. Natl. Acad. Sci. U. S. A. 99:2002;11435-11440
8. Berton O., Sears R., Carle T., Ulery P., Dileone R., Barrot M., Nestler E.J. ΔFosB in the dorsal raphe mediates stress-induced transcriptional changes in substance P neurons, and modulates behavioral profiles in the learned helplessness model of depression. Abstr.-Soc. Neurosci. 29:2003;521.8
9. Bibb J.A., Chen J.S., Taylor J.R., Svenningsson P., Nishi A., Snyder G.L., Yan Z., Sagawa Z.K., Ouimet C.C., Nairn A.C., Nestler E.J., Greengard P. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature. 410:2001;376-380
10. Bing G., Wang W., Qu Q., Feng Z., Hudson P., Jin L., Zhang W., Bing R., Hong J.S. Long-term expression of Fos-related antigen and transient expression of delta FosB associated with seizures in the rat hippocampus and striatum. J. Neurochem. 68:1997;272-279
11. Brown J.R., Ye H., Bronson R.T., Dikkes P., Greenberg M.E. A defect in nurturing in mice lacking the immediate early gene fosB. Cell. 86:1996;297-309
12. Carle T., Ulery P.G., Nestler E.J. Absence of conserved Fos family C-terminal domain in ΔFosB may contribute to its unique stability. Abstr.-Soc. Neurosci. 29:2003;856.12
13. Carlezon W.A. Jr., Thome J., Olson V.G., Lane-Ladd S.B., Brodkin E.S., Hiroi N., Duman R.S., Neve R.L., Nestler E.J. Regulation of cocaine reward by CREB. Science. 282:1998;2272-2275
14. Cenci M.A. Transcription factors involved in the pathogenesis of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease. Amino Acids. 23:2002;105-109
15. Chen J.S., Nye H.E., Kelz M.B., Hiroi N., Nakabeppu Y., Hope B.T., Nestler E.J. Regulation of ΔFosB and FosB-like proteins by electroconvulsive seizure (ECS) and cocaine treatments. Mol. Pharmacol. 48:1995;880-889
16. Chen J., Kelz M.B., Hope B.T., Nakabeppu Y., Nestler E.J. Chronic FRAs: stable variants of ΔFosB induced in brain by chronic treatments. J. Neurosci. 17:1997;4933-4941
17. Chen J.S., Kelz M.B., Zeng G.Q., Sakai N., Steffen C., Shockett P.E., Picciotto M., Duman R.S., Nestler E.J. Transgenic animals with inducible, targeted gene expression in brain. Mol. Pharmacol. 54:1998;495-503
18. Chen J.S., Zhang Y.J., Kelz M.B., Steffen C., Ang E.S., Zeng L., Nestler E.J. Induction of cyclin-dependent kinase 5 in hippocampus by chronic electroconvulsive seizures: role of ΔFosB. J. Neurosci. 20:2000;8965-8971
19. Chen J., Newton S.S., Zeng L., Adams D.H., Dow A.L., Madsen T.M., Nestler E.J., Duman R.S. Downregulation of the CCAAT-enhancer binding protein beta in deltaFosB transgenic mice and by electroconvulsive seizures. Neuropharmacology. 29:2003;23-31
20. Colby C.R., Whisler K., Steffen C., Nestler E.J., Self D.W. ΔFosB enhances incentive for cocaine. J. Neurosci. 23:2003;2488-2493
21. Dobrazanski P., Noguchi T., Kovary K., Rizzo C.A., Lazo P.S., Bravo R. Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts. Mol. Cell. Biol. 11:1991;5470-5478
22. Doucet J.-P., Nakabeppu Y., Bedard P.J., Hope B.T., Nestler E.J., Jasmin B., Chen J.S., Iadarola M.J., St-Jean M., Wigle N., Blanchet P., Grondin R., Robertson G.S. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of striatal ΔFosB expression. Eur. J. Neurosci. 8:1996;365-381
23. Ehrlich M.E., Sommer J., Canas E., Unterwald E.M. Periadolescent mice show enhanced deltaFosB upregulation in response to cocaine and amphetamine. J. Neurosci. 22:2002;9155-9159
24. Hiroi N., Graybiel A.M. Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum. J. Comp. Neurol. 374:1996;70-83
25. Hiroi N., Brown J., Haile C., Ye H., Greenberg M.E., Nestler E.J. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Proc. Natl. Acad. Sci. U. S. A. 94:1997;10397-10402
26. Hiroi N., Brown J., Ye H., Saudou F., Vaidya V.A., Duman R.S., Greenberg M.E., Nestler E.J. Essential role of the fosB gene in molecular, cellular, and behavioral actions of electroconvulsive seizures. J. Neurosci. 18:1998;6952-6962
27. Hiroi N., Feinberg A., Haile C., Greengard P., Nestler E.J. Involvement of DARPP-32 in induction of ΔFosB variants and development of behavioral sensitization to cocaine. Eur. J. Neurosci. 11:1999;1114-1118
28. Hope B., Kosofsky B., Hyman S.E., Nestler E.J. Regulation of IEG expression and AP-1 binding by chronic cocaine in the rat nucleus accumbens. Proc. Natl. Acad. Sci. U. S. A. 89:1992;5764-5768
29. Hope B.T., Kelz M.B., Duman R.S., Nestler E.J. Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics. J. Neurosci. 14:1994;4318-4328
30. Hope B.T., Nye H.E., Kelz M.B., Self D.W., Iadarola M.J., Nakabeppu Y., Duman R.S., Nestler E.J. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron. 13:1994;1235-1244
31. Kelz M.B., Nestler E.J. ΔFosB: a molecular switch underlying long-term neural plasticity. Curr. Opin. Neurol. 13:2000;715-720
32. Kelz M.B., Chen J.S., Carlezon W.A., Whisler K., Gilden L., Beckmann A.M., Steffen C., Zhang Y.-J., Marotti L., Self D.W., Tkatch R., Baranauskas G., Surmeier D.J., Neve R.L., Duman R.S., Picciotto M.R., Nestler E.J. Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature. 401:1999;272-276
33. Mandelzys A., Gruda M.A., Bravo R., Morgan J.I. Absence of a persistently elevated 37 kDa fos-related antigen and AP-1-like DNA-binding activity in the brains of kainic acid-treated fosB null mice. J. Neurosci. 17:1997;5407-5415
34. McClung C.A., Nestler E.J. Regulation of gene expression and cocaine reward by CREB and ΔFosB. Nat. Neurosci. 6:2003;1208-1215
35. Moratalla R., Elibol B., Vallejo M., Graybiel A.M. Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal. Neuron. 17:1996;147-156
36. Morgan J.I., Curran T. Immediate-early genes: ten years on. Trends Neurosci. 18:1995;66-77
37. Nakabeppu Y., Nathans D. A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity. Cell. 64:19911;751-759
38. Nestler E.J., Barrot M., Self D.W. ΔFosB: a molecular switch for addiction. Proc. Natl. Acad. Sci. U. S. A. 98:2001;11042-11046
39. Norrholm S.D., Bibb J.A., Nestler E.J., Ouimet C.C., Taylor J.R., Greengard P. Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of the neuronal kinase Cdk5. Neuroscience. 116:2003;19-22
40. Nye H.E., Nestler E.J. Induction of chronic Fras (Fos-related antigens) in rat brain by chronic morphine administration. Mol. Pharmacol. 49:1996;636-645
41. Nye H., Hope B.T., Kelz M., Iadarola M., Nestler E.J. Pharmacological studies of the regulation by cocaine of chronic Fra (Fos-related antigen) induction in the striatum and nucleus accumbens. J. Pharmacol. Exp. Ther. 275:1995;1671-1680
42. Olausson P., Jentsch J.D., Nestler E.J., Taylor J.R. Enhanced incentive motivation for food in ΔFosB overexpressing mice. Abstr.-Soc. Neurosci. 28:2002;502.14
43. Peakman M.C., Colby C., Perrotti L.I., Tekumalla P., Carle T., Ulery P., Chao J., Duman C., Steffen C., Monteggia L., Allen M.R., Stock J.L., Duman R.S., McNeish J.D., Barrot M., Self D.W., Nestler E.J., Schaeffer E. Inducible, brain region specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Res. 970:2003;73-86
44. Perez-Otano I., Mandelzys A., Morgan J.I. MPTP-Parkinsonism is accompanied by persistent expression of a delta-FosB-like protein in dopaminergic pathways. Brain Res. 53:1998;41-52
45. Perrotti L.I., Hadeishi Y., Barrot M., Duman R.S., Nestler E.J. Induction of ΔFosB in reward-related brain structures after chronic stress. Abstr.-Soc. Neurosci. 29:2003;112.15
46. Pich E.M., Pagliusi S.R., Tessari M., Talabot-Ayer D., hooft van Huijsduijnen R., Chiamulera C. Common neural substrates for the addictive properties of nicotine and cocaine. Science. 275:1997;83-86
47. Robinson T.E., Kolb B. Persistent structural modifications in nucleus accumbens and prefrontal neurons produced by previous experience with amphetamine. J. Neurosci. 17:1997;8491-8497
48. Schwartz W.J., Carpino J.R.A., De La Iglesia H.O., Baler R., Klein D.C., Nakabeppu Y., Aronin N. Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus. Neuroscience. 98:2000;535-547
49. Shaw T.Z., Gilden L., Kelz M., Chen J., Nestler E.J. Regulation of neuropeptide expression by DfFosB in striatum. Abstr.-Soc. Neurosci. 26:2000;525
50. Tekumalla P.K., Calon F., Rahman Z., Birdi S., Rajput A.H., Hornykiewicz O., Di Paolo T., Bedard P.J., Nestler E.J. Elevated levels of ΔFosB and RGS9 in striatum in Parkinson's disease. Biol. Psychiatry. 50:2001;813-816
51. Thomas M.J., Beurrier C., Bonci A., Malenka R.C. Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. Nat. Neurosci. 4:2001;1217-1223
52. Ulery P.G., Carle T., Nestler E.J. Role of phosphorylation of ΔFosB protein stability. Abstr.-Soc. Neurosci. 29:2003;777.3
53. Werme M., Messer C., Olson L., Gilden L., Thorén P., Nestler E.J., Brené S. ΔFosB regulates wheel running. J. Neurosci. 22:2002;8133-8138
54. White F.J., Hu X.T., Zhang X.-F., Wolf M.E. Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system. J. Pharmacol. Exp. Ther. 273:1995;445-454
55. Yen J., Wisdom R.M., Tratner I., Verma I.M. An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins. Proc. Natl. Acad. Sci. U. S. A. 88:1991;5077-5081
56. Zachariou V., Berton O., Perrotti L.I., Nestler E.J. ΔFosB in the nucleus accumbens modulates morphine reward, tolerance, and dependence. Abstr.-Soc. Neurosci. 29:2003;112.16