Sibutramine decreases body weight gain and increases energy expenditure in obese Zucker rats without changes in NPY and orexins

Nutritional Neuroscience

Volumn 6, Issue 2, 2003, Pages 102-111

  Casado, A ^a   Rodriguez V M ^a   Portillo, M P ^a   Macarulla, M T ^a   Abecia, L C ^a   Echevarria E ^a   Casis, L ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Body composition; Food intake; NPY; Obese Zucker rat; Orexins; Sibutramine

Indexed keywords

NEUROPEPTIDE Y; OREXIN; OREXIN A; OREXIN B; SIBUTRAMINE; SODIUM CHLORIDE; ANOREXIGENIC AGENT; CARRIER PROTEIN; CYCLOBUTANE DERIVATIVE; NEUROPEPTIDE; OREXINS; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BLOOD LEVEL; CARCASS; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENERGY EXPENDITURE; FOOD INTAKE; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMUNOHISTOCHEMISTRY; LATERAL HYPOTHALAMUS; MALE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; RAT STRAIN; WEIGHT GAIN; ADIPOSE TISSUE; ANIMAL; BODY COMPOSITION; CHEMISTRY; DRINKING; EATING; ENERGY METABOLISM; HISTOLOGY; HYPOTHALAMUS; ORGAN SIZE; PATHOPHYSIOLOGY; ZUCKER RAT;

ANIMALIA;

ADIPOSE TISSUE; ANIMALS; APPETITE DEPRESSANTS; BODY COMPOSITION; CARRIER PROTEINS; CYCLOBUTANES; DRINKING; EATING; ENERGY METABOLISM; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEUROPEPTIDE Y; NEUROPEPTIDES; OBESITY; ORGAN SIZE; OXYGEN CONSUMPTION; RATS; RATS, ZUCKER; WEIGHT GAIN;

EID: 0037388354     PISSN: 1028415X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1028415031000094264     Document Type: Article

References (49)

1. Acebes, I., Saracíbar, G., Echevarría, E., Casado, A., Valiente, F.J., Pascual, J. and Casis, L. (2002) "Selective serotonin reuptake inhibitors alter NPY immunostaining in the rat hypothalamus", Neuroscience Research Communications 30, 185-196.
2. AOAC International (1997) In: Cunniff, P., ed, Official Methods of Analysis of AOAC International, 16th Ed. (AOAC International, Gaithersburg).
3. Beck, B., Burlet, A., Nicolas, J.P. and Burlett, C. (1990) "Hypothalamic neuropeptide Y (NPY) in obese Zucker rats: implications in feeding and sexual behaviours", Physiology and Behaviour 47, 449-453.
4. Beck, B., Burlet, A., Bazin, R., Nicolas, J.P. and Burlet, C. (1993) "Elevated neuropeptide Y in the arcuate nucleus of young obese Zucker rats may contribute to the development of their overeating", Journal of Nutrition 123, 1168-1172.
5. Beck, B., Richy, S., Dimitrov, T. and Stricker-Krongrad, A. (2001) "Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker rats", Biochemical and Biophysical Research Communications 286, 518-523.
6. Bray, G.A. (1977) "The Zucker-fatty rat: a review", Federation Proceedings 36, 148-153.
7. Brown, M., Bing, C., King, P., Pickavance, L., Heal, D. and Wilding, J. (2001) "Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wistar rats independently of hypothalamic neuropeptide Y", British Journal of Pharmacology 132, 1898-1904.
8. Buckett, W.R., Thomas, P.C. and Luscombe, G.P. (1988) "The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation", Progress on Neuropsychopharmacology and Biological Psychiatry 12, 575-584.
9. Chronwall, B.M., Di Maggio, D.A., Massari, V.J., Pickel, V.M., Ruggiero, D.A. and O'Donohue, T.L. (1985) "The anatomy of the neuropeptide Y containing neurons in the rat brain", Journal of Neuroscience 15, 1159-1181.
10. Connoley, I.P., Yong-Ling, L., Frost, I., Reckless, I.P., Heal, D.J. and Stock, M. (1999) "Thermogenic effects of sibutramine and its metabolites", British Journal of Pharmacology 126, 1487-1495.
11. Cusin, I., Rohner-Jeanrenaud, F., Stricker-Kongrad, A. and Jeanrenaud, B. (1996) "The weight-reducing effects of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats", Diabetes 45, 1446-1450.
12. De Fanti, B.A., Hamilton, J.S. and Horwitz, B.A. (2001) "Meal-induced changes in extracellular 5-HT in medial hypothalamus of lean (Fa/Fa) and obese (fa/fa) Zucker rats", Brain Research 902, 164-170.
13. Dryden, S., Pickavance, L., Frankish, H.M. and Williams, G. (1995) "Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rat", Brain Research 690, 185-188.
14. Dryden, S., Frankish, H.M., Wang, Q., Pickavance, L. and Williams, G. (1996) "The serotoninergic agent fluoxetine reduces neuropeptide Y levels and neuropeptide Y secretion in the hypothalamus of lean and obese rats", Neuroscience 72, 557-566.
15. Dube, M.G., Horvath, T.L., Kalra, P.S. and Kalra, S.P. (2000) "Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in satiated rats", Peptides 21, 1557-1560.
16. Fabris, R., Granzotto-Pagano, C., Lombardi, A.M., Ferretti, E., Marzolo, M., Seagnol, I., Federspil, G. and Vettor, R. (2000) "Effect of sibutramine on glucose metabolism in genetically obese (fa/fa) rats", International Journal of Obesity 24(Suppl. 2), S124-S126.
17. Grignaschi, G., Fanelli, E., Scagnol, I. and Samanin, R. (1999) "Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats", British Journal of Pharmacology 127, 1190-1194.
18. Gutiérrez, A., Saracíbar, G., Casis, L., Echevarría, E., Rodríguez, V.M., Macarulla, M.T., Abecia, L.C. and Portillo, M.P. (2002) "Effects of fluoxetine administration on NPY and orexins in obese Zucker rat hypothalamus", Obesity Research 10, 532-540.
19. Guy, J., Pelletier, G. and Bosier, O. (1988) "Serotonin innervation of neuropeptide Y containing neurons in the rat arcuate nucleus", Neuroscience Letters 85, 9-13.
20. Halford, J.C.G., Heal, D.J. and Blundell, J.E. (1995) "Effects in the rat of sibutramine on food intake and the behavioral satiety sequence", British Journal of Pharmacology 114, 387.
21. Heal, D.J., Cheetham, S.C., Prow, M.R., Martin, K.F. and Buckett, W.R. (1998) "A comparison of the effects on central 5-HT function of sibutramine hydrochloride and other weight-modifying agents", British Journal of Pharmacology 125, 301-308.
22. Jackson, H.C., Bearham, M.C., Hutchins, L.J., Mazurkiewicz, S.E., Needham, A.M. and Heal, D.J. (1997) "Investigation of the mechanism underlying the hypophagic effects of 5-HT and noradrenaline reuptake inhibitor sibutramine, in the rat", British Journal of Pharmacology 121, 1613-1618.
23. Jhanwar-Uniyal, M., Awad, I.R., Gearhart, G.M., Finkelstein, J.A. and Leibowitz, S.F. (1991), Pharmacology, Biochemistry and Behavior 40, 853-859.
24. Jung, R.T. (1997) "Obesity and nutritional factors in the pathogenesis of non-insulin dependent diabetes mellitus", In: Pickup, J.C. and Williams, G., eds, Textbook of Diabetes (Blackwell Science, Oxford), pp. 17-23.
25. Le Feuvre, R.A., Aisenthal, L. and Rothwell, N.J. (1991) "Involvement of corticotropin-releasing factor (CRF) in the thermogenic and anorectic actions of serotonine (5-HT) and related compounds", Brain Research 555, 245-250.
26. Leibowitz, S.F., Weiss, G.F. and Suh, J. (1990) "Medium hypothalamic nuclei mediate serotonin's inhibitory effect on feeding behaviour", Pharmacology, Biochemistry and Behavior 37, 735-742.
27. Lungdberg, J.M., Terenius, L., Hokfelt, T., Martling, C.R., Tatemoto, K., Mutt, V., Polak, J., Bloom, S. and Goldstein, M. (1982) "Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects on NPY on sympathetic function", Acta Physiologica Scandinavica 116, 479-480.
28. Luscombe, G.P., Hopcroft, R.H., Thomas, P.C. and Burckett, W.R. (1989) "The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochloride", Neuropharmacology 28, 129-134.
29. McKibbin, P.E., Cotton, S.J., McMillan, S., Holloway, B., Mayers, R., McCarthy, H.D. and Williams, G. (1991) "Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats. Possible relationship to obesity and neuroendocrine disturbances", Diabetes 40, 1423-1429.
30. Orosco, M., Rouch, C., Meile, M.J. and Nicolaidis, S. (1995) "Spontaneous feeding-related monoamine changes in rostromedial hypothalamus of the obese Zucker rat: a microdialysis study", Physiology and Behavior 57, 1103-1106.
31. Phillips, M.S., Liu, Q.Y, Hammond, H.A., Dugan, V., Hey, P.J., Caskey, C.T. and Hess, J.F. (1996) "Leptin receptor missense mutation in fatty Zucker rat", Nature Genetics 13, 18-19.
32. Rogers, P., McKibbin, P.E. and Williams, G. (1991) "Acute fenfluramine administration reduces neuropeptide Y concentration in specific hypothalamic regions of the rat. Possible implications for the anorectic effect of fenfluramine", Peptides 12, 251-255.
33. Rohner-Jenrenaud, F., Cusin, I., Sainsbury, A., Zakrzewska, K.E. and Jeanrenaud, B. (1996) "The loop system between neuropeptide Y and leptin in normal and obese rodents", Hormone and Metabolic Research 28, 642-648.
34. Routh, V.H., Murakami, D.M., Stern, J.S., Fuller, C.A. and Horwitz, B.A. (1990) "Neuronal activity, in hypothalamic nuclei of obese and lean Zucker rats", International Journal of Obesity 14, 879-891.
35. Routh, V.H., Stern, J.S. and Horwitz, B.A. (1994) "Serotonergic activity is depressed in the ventromedial hypothalamic nucleus of 12-day-old obese Zucker rats", American Journal of Physiology 267, R712-R7119.
36. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richardson, J.A., Kozlowski, G.P., Wilson, S., Arch, J.R.S., Buckingham, R.E., Haynes, A.C., Carr, S.A., Annan, R.S., McNulty, D.E., Liu, W.S., Terrett, J.A., Elshourbagy, N.A., Bergsma, D.J. and Yanagisawa, M. (1998) "Orexins and orexin receptors. A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour", Cell 92, 573-585.
37. Sawchencko, P.E., Swanson, L.W., Steinbush, H.W.M. and Verhofstad, A.J. (1983) "The distribution and cells of origin of serotoninergic inputs to the paraventricular and supraoptic nuclei of the rat", Brain Research 277, 355-360.
38. Schwartz, M.W., Baskin, D.G., Bukowski, T.R., Kuijper, J.L., Foster, D., Lasser, G., Prunkard, E., Porte, D., Woods, S.C., Seeley, R. and Weigle, D.S. (1996) "Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice", Diabetes 45, 531-535.
39. Stricker-Kongrad, A., Souquet, A.M. and Burlet, C. (1995) "Effects of sibutramine on feeding behaviour in obese and lean Zucker rats", International Journal of Obesity 19(Suppl. 2), 398.
40. Svec, F., Thompson, C., Corll, C. and Porter, J. (2002) "Levels of hypothalamic neurotransmitters in lean and obese Zucker rats", Nutritional Neuroscience 5, 321-326.
41. Vasselli, J.R., Fiene, J.A. and Maggio, C.A. (1992) "Relationship of adipocyte size to hyperphagia in developing male obese Zucker rats", American Journal of Physiology 262, R33-R38.
42. 2-adrenergic receptors", Life Sciences 53, 669-679.
43. Wellman, P.J. (2000) "Norepinephrine and the control of food intake", Nutrition 16, 837-842.
44. White, B.D. and Martin, R.J. (1997) "Evidence for a central mechanism of obesity in the Zucker rat: role of neuropeptide Y and leptin", Proceedings of Society of Experimental Biology and Medicine 214, 222-232.
45. Widdowson, P.S. (1995) "Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat. Relationship to the Y5 feeding receptor", Brain Research 758, 17-25.
46. Wilding, J.P., Gilbey, S.G., Jones, S.G., Mannan, M.M., Ghatei, M.A. and Bloom, S.R. (1992) "Dexfenfluramine treatment and hypothalamic neuropeptides in diet-induced obesity in rats", Peptides 13, 557-563.
47. Wolf, G. (1997) "Neuropeptides responding to leptin", Nutrition Reviews 55, 85-88.
48. Yarnell, D.O., Knight, D.S., Hamilton, K., Tulp, O. and Tso, P. (1998) "Localization of leptin receptor immunoreactivity in the lean and obese Zucker rat brain", Brain Research 758, 80-90.
49. Zarjevski, N., Cusin, I., Vettor, R., Rhoner-Jeanrenaud, F. and Jeanrenaud, B. (1993) "Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity", Endocrinology 133, 1756-1758.