Piperine, an LXRα antagonist, protects against hepatic steatosis and improves insulin signaling in mice fed a high-fat diet

Biochemical Pharmacology

Volumn 84, Issue 11, 2012, Pages 1501-1510

  Jwa, Hyejeong ^a   Choi, Youngshim ^a   Park, Ui Hyun ^b   Um, Soo Jong ^b   Yoon, Seung Kew ^c   Park, Taesun ^a  

^a Yonsei University   (South Korea)

^b Sejong University   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

ER stress; Fatty liver; GLUT2; Hyperlipidemia; Insulin resistance

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CCAAT ENHANCER BINDING PROTEIN ALPHA; CD36 ANTIGEN; FATTY ACID SYNTHASE; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE TRANSPORTER 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INITIATION FACTOR 2ALPHA; INSULIN; LIGAND; LIPID; LIVER X RECEPTOR ALPHA; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PIPERINE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; X BOX BINDING PROTEIN 1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; DIET SUPPLEMENTATION; DOSE RESPONSE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; GENE; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPID DIET; LIPID LIVER LEVEL; LIPID STORAGE; LIPOGENESIS; LIVER PROTECTION; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ALKALOIDS; ANIMALS; BASE SEQUENCE; BENZODIOXOLES; BLOTTING, WESTERN; DIETARY FATS; DNA PRIMERS; FATTY LIVER; HEK293 CELLS; HUMANS; INSULIN; MICE; PIPERIDINES; POLYMERASE CHAIN REACTION; POLYUNSATURATED ALKAMIDES; SIGNAL TRANSDUCTION;

EID: 84868461692     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.09.009     Document Type: Article

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