Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in Bacillus subtilis

Applied Microbiology and Biotechnology

Volumn 85, Issue 6, 2010, Pages 1907-1914

  Duan, Yun Xia ^a,b,c   Chen, Tao ^a,b   Chen, Xun ^a,b   Zhao, Xue Ming ^a,b  

^a TIANJIN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c TIANJIN ACADEMY OF ENVIRONMENTAL SCIENCES   (China)

Author keywords

Bacillus subtilis; Glucose 6 phosphate dehydrogenase; Metabolic flux analysis; Riboflavin; Ribulose 5 phosphate

Indexed keywords

BACILLUS SUBTILIS; GLUCOSE-6-PHOSPHATE DEHYDROGENASE; METABOLIC FLUX ANALYSIS; RIBOFLAVIN; RIBULOSE;

BACTERIOLOGY; BIOCHEMISTRY; METABOLISM;

GLUCOSE;

ACETIC ACID; ACETOIN; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; PYRUVIC ACID; RIBOFLAVIN;

BACTERIUM; BIOCHEMISTRY; CARBON; GENE EXPRESSION; GLUCOSE; GROWTH RATE; METABOLISM;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL GENE; BACTERIAL GROWTH; BIOSYNTHESIS; CELL GROWTH; CONTROLLED STUDY; GENE OVEREXPRESSION; GLUCOSE INTAKE; GROWTH RATE; NONHUMAN; PROMOTER REGION;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GLUCOSE; GLUCOSEPHOSPHATE DEHYDROGENASE; PENTOSE PHOSPHATE PATHWAY; PYRUVATES; RIBOFLAVIN; RIBULOSEPHOSPHATES;

BACILLUS SUBTILIS;

EID: 76849109846     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-2247-6     Document Type: Article

References (41)

1. C Anagnostopoulos J Spizizen 1961 Requirements for transformation in Bacillus subtilis J Bacteriol 81 741 746 1:CAS:528:DyaF3MXpsVSnsg%3D%3D
2. AA Aristidou GN Bennett KY San 1994 Modification of the central metabolic pathways Escherichia coli to reduce the acetate accumulation by the heterologous expression of the bacillus subtilis acetolactate synthase gene Biotechnol Bioeng 44 944 951 10.1002/bit.260440810 1:CAS:528:DyaK2cXmt1Kjurk%3D (Pubitemid 24308542)
3. L(+)-lactic acid and metabolic flux analysis of mutants Biochem Eng J 18 41 48 10.1016/S1369-703X(03)00126-8 1:CAS:528:DC%2BD2cXhvVygsLg%3D (Pubitemid 38317126)
4. Bergmeyer HU (1984) Methods of enzymatic analysis, chapter 2. Verlag Chemie GmbH, Weinheim, pp 141-498
5. MJ Butler P Bruheim S Jovetic, et al. 2002 Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividans Appl Environ Microbiol 68 4731 4739 10.1128/AEM.68.10.4731-4739.2002 1:CAS:528:DC%2BD38XnvFClt7w%3D (Pubitemid 35154775)
6. Chen X (1997) New approaches to construction of recombinant strains-riboflavin producers. Dissertation for Academic Degree of Candidate of Biological Sciences. State Scientific research institute of genetics and selection of industrial microorganisms. MOSCOW
7. T Chen X Chen JG Wang R Ban XM Zhao 2005 Effect of riboflavin operon dosage on riboflavin productivity in Bacillus subtilis Transactions of Tianjin University 11 1 5 1:CAS:528:DC%2BD2MXkt1GhsL0%3D
8. M Dauner U Sauer 2002 Stoichiometric growth model for riboflavin-producing Bacillus subtilis Biotech Bioeng 76 32 143
9. M Dauner M Sonderegger M Hochuli T Szyperski K Wüthrich HP Hohmann U Sauer JE Bailey 2002 Intracellular carbon fluxes in riboflavin-producing Bacillus subtilis during growth on two-carbon substrate mixtures Appl Environ Microbiol 68 1760 1771 10.1128/AEM.68.4.1760-1771.2002 1:CAS:528: DC%2BD38XivFGltLc%3D (Pubitemid 34279983)
10. AL Demain 1972 Riboflavin oversynthesis Ann Rev Microbiol 26 369 388 10.1146/annurev.mi.26.100172.002101 1:CAS:528:DyaE3sXhtlGkuw%3D%3D
11. A Feucht PJ Lewis 2001 Improved plasmid vectors for the production of multiple fluorescent protein fusions in Bacillus subtilis Gene 264 289 297 10.1016/S0378-1119(01)00338-9 1:CAS:528:DC%2BD3MXhsleks7c%3D (Pubitemid 32206650)
12. SH Fisher B Mangasanik 1984 Synthesis of oxaloacetate in Bacillus subtilis mutants lacking the 2-ketoglutarate dehydrogenase enzymatic complex J Bacteriol 158 5 62
13. H Geckil Z Barak DM Chipmannn SO Erenler DA Webster BC Stark 2004 Enhanced production of acetoin and butanediol in recombinant Enterobacter aerogenes carrying Vitreoscilla hemoglobin gene Bioprocess Biosys Eng 26 325 330 10.1007/s00449-004-0373-1 1:CAS:528:DC%2BD2cXotlKnsrc%3D (Pubitemid 39517867)
14. A Goel J Ferrance J Jeong MM Ataai 1993 Analysis of metabolic fluxes in batch and continuous cultures of Bacillus subtilis Biotechnol Bioeng 42 686 696 10.1002/bit.260420603 1:STN:280:DC%2BD1cvjvFyrsw%3D%3D
15. FJ Grundy DA Waters TY Takova TM Henkin 1993 Indetification of genes involved in utilization of acetate and acetoin in Bacillus subtilis Mol Microbiol 10 259 271 10.1111/j.1365-2958.1993.tb01952.x 1:CAS:528: DyaK2cXkslSktQ%3D%3D (Pubitemid 23316736)
16. RN Horne WB Anderson RC Nordlie 1970 Glucose dehydrogenase activity of yeast glucose-6-phosphate dehydrogenase. Inhibition by adenosine 5′-triphosphate and other nucleoside 5′-triphosphates and diphosphates Biochemistry 9 3 610 616 10.1021/bi00805a023 1:CAS:528: DyaE3cXps12jtw%3D%3D
17. M Hümbelin V Griesser T Keller W Schurter M Haiker HP Hohmann H Ritz G Richter A Bacher 1999 GTP cyclohydrolase II and 3, 4-dihydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrial Bacillus subtilis strain used for riboflavin production J Ind Microbiol Biotechnol 22 1 7 10.1038/sj.jim.2900590
18. S Koizumi Y Yonetani A Maruyama S Teshiba 2000 Production of riboflavin by metabolically engineered orynebacterium ammoniagenes Appl Microbiol Biotechnol 53 674 679 10.1007/s002539900295 1:CAS:528:DC%2BD3cXkvVyhurg%3D (Pubitemid 30430222)
19. XJ Li T Chen X Chen XM Zhao 2006 Redirection electron flow to high coupling efficiency of terminal oxidase to enhance riboflavin biosynthesis Appl Microbiol Biotechnol 73 374 383 10.1007/s00253-006-0482-7 1:CAS:528: DC%2BD28XhtlGiurrN (Pubitemid 350262614)
20. SJ Lim YM Jung HD Shin YH Lee 2002 Amplification of the NADPH-Related genes zwf and gnd for the oddball biosynthesis of PHB in an E.coli thansformant harboring a cloned phbCAB operon J Biosci Bioeng 93 543 549 1:CAS:528: DC%2BD38XlvFKisrc%3D
21. Lowry OH, Passonneau JV (1973) A flexible system of enzymatic analysis. Academic, Inc., New York, NY
22. CR Maria N Najimudin RW Leslie SA Zahler 1993 Regulation of the Bacillus subtilis alsD, and alsR genes involved in post-exponential-phase production of acetoin J Bacteriol 175 3863 3874
23. RH Müller N Loffhagen W Nabel 1996 Rapid extraction of (di) nucleotides from bacterial cells and determination by ion-pair reversed-phase HPLC J Microbiol Methods 25 29 35 10.1016/0167-7012(95)00078-X (Pubitemid 26157732)
24. Perkins JB, Pero JG, Sloma A (1991) Riboflavin overproducing strains of bacteria. European patent application number 0405370
25. JB Perkins A Sloma T Hermann K Theriault E Zachgo T Erdenberger N Hannett NP Chatterjeel V Williams GA Rufo Jr R Hatch J Perol 1999 Genetic engineering of Bacillus subtilis for the commercial production of riboflavin J Ind Microbiol Biotechnol 22 8 18 10.1038/sj.jim.2900587 1:CAS:528:DyaK1MXitVKis74%3D
26. X Qin HW Taber 1996 Transcriptional regulation of the Bacillus subtilis menp1 promoter J Bacteriol 178 705 713 1:CAS:528:DyaK28XnsFSqtA%3D%3D
27. DL Rowley RE Wolf Jr 1991 Molecular characterization of the Escherichia coli K-12 zwf gene encoding glucose 6-phosphate dehydrogenase J Bacteriol 173 968 977 1:CAS:528:DyaK3MXks1GlsL8%3D
28. DL Rowley AJ Pease RE Wolf Jr 1991 Genetic and physical analyses of the growth rate-dependent regulation of Escherichia coli zwf expression J Bacteriol 173 4660 4667 1:CAS:528:DyaK3MXlsFajtb0%3D
29. AM Sánchez GN Bennettb KY Sana 2006 Batch culture characterization and metabolic flux analysis of succinate-producing Escherichia coli strains Metab Eng 8 209 226 10.1016/j.ymben.2005.11.004 (Pubitemid 44382420)
30. U Sauer V Hatzimanikatis HP Hohmann, et al. 1996 Physiology and metabolic fluxes of wild-type and riboflavin-producing Bacillus subtilis Appl Environ Microbiol 62 3687 3696 1:CAS:528:DyaK28XmtVGks7k%3D
31. U Sauer DC Cameron JE Baily 1998 Metabolic capacity of Bacillus subtilis for the production of purine nucleosides, riboflavin, and folic acid Biotechnol Bioeng 59 227 238 10.1002/(SICI)1097-0290(19980720)59:2<227::AID-BIT10>3. 0.CO;2-B 1:CAS:528:DyaK1cXjvVGisLg%3D (Pubitemid 28277749)
32. JJ Sedmak SE Grossberg 1977 A rapid sensitive and versatile assay for protein using coomassie brilliant blue G250 Anal Biochem 79 544 552 10.1016/0003-2697(77)90428-6 1:CAS:528:DyaE2sXhs1Ogtr4%3D
33. SB Shi T Chen ZG Zhang X Chen XM Zhao 2009 Transcriptome analysis guided metabolic engineering of Bacillus subtilis for riboflavin production Metab Eng 11 243 252 10.1016/j.ymben.2009.05.002 1:CAS:528:DC%2BD1MXps1Wqu7g%3D
34. KP Stahmann JL Revuelta H Seulberger 2000 Three biotechnical processes using Ashbya gossypii, Candida famata, or Bacillus subtilis compete with chemical riboflavin production Appl Microbiol Biotechnol 53 509 516 10.1007/s002530051649 1:CAS:528:DC%2BD3cXktVCqsbw%3D
35. Stephanopoulos GN, Aristidou AA, Nielsen J (1998) Metabolic engineering. Academic, San Diego
36. M Young 1983 The mechanism of insertion of a heterologous DNA into the chromosome of Bacillus subtilis J Gen Microbiol 129 1497 1512 1:CAS:528:DyaL3sXksVynurw%3D
37. N Zamboni N Mouncey HP Hohmann, et al. 2003 Reducing maintenance metabolism by metabolic engineering of respiration improves riboflavin by Bacillus subtilis Metab Eng 5 49 55 10.1016/S1096-7176(03)00007-7 1:CAS:528:DC%2BD3sXjs1Wnu74%3D (Pubitemid 36599680)
38. +-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway J Bacteriol 14 4528 4534 10.1128/JB.186.14.4528-4534.2004 (Pubitemid 38891016)
39. J Zhao T Baba H Mori K Shimizu 2004 Effect of zwf gene knockout on the metabolism of Escherichia coli. grown on glucose or acetate Metab Eng 6 164 174 10.1016/j.ymben.2004.02.004 1:CAS:528:DC%2BD2cXjtl2mt74%3D (Pubitemid 38601069)
40. YB Zhu X Chen T Chen SB Shi XM Zhao 2006 Over-expression of glucose dehydrogenase improves cell growth and riboflavin production in Bacilla subtilis Biotechnol Lett 28 1667 1672 10.1007/s10529-006-9143-2 1:CAS:528: DC%2BD28XptF2rs7k%3D (Pubitemid 44369331)
41. YB Zhu X Chen T Chen XM Zhao 2007 Enhancement of riboflavin production by overexpression of acetolactate synthase in a pta mutant of Bacillus subtilis FEMS Microbiol Lett 266 24 230 10.1111/j.1574-6968.2006.00528.x (Pubitemid 44952570)