Structure-guided peptidomimetic design leads to nanomolar β-hairpin inhibitors of the Tat-TAR interaction of bovine immunodeficiency virus

Biochemistry

Volumn 46, Issue 3, 2007, Pages 741-751

  Athanassiou, Zafiria ^a   Patora, Krystyna ^b   Dias, Ricardo L A ^b   Moehle, Kerstin ^b   Robinson, John A ^b   Varani, Gabriele ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE IMMUNODEFICIENCY VIRUS (BIV); IMMUNODEFICIENCY; LIGANDS; MOLECULAR RECOGNITION;

ENZYME INHIBITION; GENETIC ENGINEERING; MOLECULAR STRUCTURE; RNA; VIRUSES;

AMINO ACIDS;

ANTIVIRUS AGENT; LIGAND; PEPTIDE DERIVATIVE; PROTEIN BIV2; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; ARTICLE; BOVINE IMMUNODEFICIENCY LIKE VIRUS; COMPLEX FORMATION; DNA RESPONSIVE ELEMENT; DRUG BINDING SITE; DRUG DESIGN; DRUG SELECTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TRANSACTIVATOR RESPONSE ELEMENT;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; GENE PRODUCTS, TAT; IMMUNODEFICIENCY VIRUS, BOVINE; MOLECULAR MIMICRY; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, TERTIARY; RNA, VIRAL; RNA-BINDING PROTEINS;

BOVINE IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33846391016     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0619371     Document Type: Article

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