The cystic fibrosis transmembrane conductance regulator (CFTR) inhibits ENaC through an increase in the intracellular C1- concentration

EMBO Reports

Volumn 2, Issue 11, 2001, Pages 1047-1051

  König, Jens ^a   Schreiber, Rainer ^a   Voelcker, Thilo ^a   Mall, Marcus ^b   Kunzelmann, Karl ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE ION; SODIUM CHANNEL; SODIUM ION; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL SPECIFICITY; CHLORIDE CURRENT; CONCENTRATION (PARAMETERS); EPITHELIUM CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

ANIMALIA;

EID: 0035203716     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve232     Document Type: Article

References (23)

1. + permeability in cystic fibrosis human primary cell cultures
2. + channels in Xenopus ooyctes coexpressing CFTR and ENaC
3. i2-proteins
4. Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulator
5. The cytosolic termini of the β and γ-ENaC subunits are involved in the functional interactions between CFTR and ENaC
6. Epithelial sodium channels regulate cystic fibrosis transmembrane conductance regulator chloride channels in Xenopus oocytes
7. Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system
8. Two highly homologous members of the CIC chloride channel family in both rat and human kidney
9. Inhibition of epithelial sodium currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator
10. + channels in mouse CCD cells
11. + conductance when coexpressed in Xenopus oocytes
12. + conductance is reduced by CFTR in normal but not in CF airways
13. CFTR-mediated inhibition of amiloride sensitive sodium conductance by CFTR in human colon is defective in cystic fibrosis
14. + absorption by extracellular nucleotides in human normal and CF airways
15. + secretion in rectal biopsies from cystic fibrosis patients
16. Non-specific activation of the epithelial sodium channel by the CFTR chloride channel
17. Low access resistance perforated patch recordings using amphotericin. B.
18. - absorption in sweat duct
19. - channel function
20. + channel
21. CFTR as a cAMP-dependent regulator of sodium channels
22. - transport in cultured cystic fibrosis airway epithelium
23. - pathways in cultured human airway epithelium