The cystic fibrosis transmembrane conductance regulator impedes proteolytic stimulation of the epithelial Na+ channel

Journal of Biological Chemistry

Volumn 285, Issue 42, 2010, Pages 32227-32232

  Gentzsch, Martina ^a,b   Dang, Hong ^a   Dang, Yan ^a   Garcia Caballero, Agustin ^a   Suchindran, Hamsa ^a   Boucher, Richard C ^a   Stutts, M Jackson ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIRWAY EPITHELIAL CELLS; AIRWAY SURFACES; APICAL MEMBRANES; CO-IMMUNOPRECIPITATIONS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; ENDOPROTEOLYSIS; EPITHELIAL CELLS; EXTRACELLULAR DOMAINS; IMMUNOPRECIPITATES; MAMMALIAN CELLS; MECHANISTIC LINK; MUTANT PROTEINS; PROTEOLYTIC CLEAVAGE; TRANS-MEMBRANE CONDUCTANCE; WILD TYPES;

ABSORPTION; CELLS; FETAL MONITORING; GLYCOSYLATION; HYDRATES; MAMMALS; SODIUM;

CELL CULTURE;

SODIUM CHANNEL; SODIUM ION; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MAMMAL CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; RESPIRATORY EPITHELIUM; WILD TYPE; XENOPUS LAEVIS;

ANIMALS; CELLS, CULTURED; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL CELLS; EPITHELIAL SODIUM CHANNEL; HUMANS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RATS; SODIUM;

MAMMALIA;

EID: 77957767326     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.155259     Document Type: Article

References (47)

1. Knowles, M., Gatzy, J., and Boucher, R. (1983) J. Clin. Invest. 71, 1410-1417
2. Matsui, H., Grubb, B. R., Tarran, R., Randell, S. H., Gatzy, J. T., Davis, C. W., and Boucher, R. C. (1998) Cell 95, 1005-1015
3. Riordan, J. R. (1999) Am. J. Hum. Genet. 64, 1499-1504
4. Boucher, R. C. (2003) Pflugers Arch. 445, 495-498
5. Stutts, M. J., Canessa, C. M., Olsen, J. C., Hamrick, M., Cohn, J. A., Rossier, B. C., and Boucher, R. C. (1995) Science 269, 847-850
6. Mall, M., Hipper, A., Greger, R., and Kunzelmann, K. (1996) FEBS Lett. 381, 47-52
7. Kunzelmann, K., Kiser, G. L., Schreiber, R., and Riordan, J. R. (1997) FEBS Lett. 400, 341-344
8. Mall, M., Bleich, M., Kuehr, J., Brandis, M., Greger, R., and Kunzelmann, K. (1999) Am. J. Physiol. Gastroentest. Liver Physiol. 277, G709-G716
9. Ji, H. L., Chalfant, M. L., Jovov, B., Lockhart, J. P., Parker, S. B., Fuller, C. M., Stanton, B. A., and Benos, D. J. (2000) J. Biol. Chem. 275, 27947-27956
10. Jiang, Q., Li, J., Dubroff, R., Ahn, Y. J., Foskett, J. K., Engelhardt, J., and Kleyman, T. R. (2000) J. Biol. Chem. 275, 13266-13274
11. Konstas, A. A., Koch, J. P., and Korbmacher, C. (2003) Pflugers Arch. 445, 513-521
12. Tarran, R., Trout, L., Donaldson, S. H., and Boucher, R. C. (2006) J. Gen. Physiol. 127, 591-604
13. Lu, C., Jiang, C., Pribanic, S., and Rotin, D. (2007) J. Cyst. Fibros. 6, 419-422
14. Nagel, G., Barbry, P., Chabot, H., Brochiero, E., Hartung, K., and Grygorczyk, R. (2005) J. Physiol. 564, 671-682
15. Reddy, M. M., Light, M. J., and Quinton, P. M. (1999) Nature 402, 301-304
16. Caldwell, R. A., Boucher, R. C., and Stutts, M. J. (2004) Am. J. Physiol. Cell Physiol. 286, C190-C194
17. Hughey, R. P., Bruns, J. B., Kinlough, C. L., Harkleroad, K. L., Tong, Q., Carattino, M. D., Johnson, J. P., Stockand, J. D., and Kleyman, T. R. (2004) J. Biol. Chem. 279, 18111-18114
18. Kleyman, T. R., Carattino, M. D., and Hughey, R. P. (2009) J. Biol. Chem. 284, 20447-20451
19. Rossier, B. C., and Stutts, M. J. (2009) Annu. Rev. Physiol. 71, 361-379
20. Berdiev, B. K., Cormet-Boyaka, E., Tousson, A., Qadri, Y. J., Oosterveld-Hut, H. M., Hong, J. S., Gonzales, P. A., Fuller, C. M., Sorscher, E. J., Lukacs, G. L., and Benos, D. J. (2007) J. Biol. Chem. 282, 36481-36488
21. Berdiev, B. K., Qadri, Y. J., and Benos, D. J. (2009) Mol. BioSyst. 5, 123-127
22. Fulcher, M. L., Gabriel, S., Burns, K. A., Yankaskas, J. R., and Randell, S. H. (2005) Methods Mol. Med. 107, 183-206
23. Garciá-Caballero, A., Dang, Y., He, H., and Stutts, M. J. (2008) J. Gen. Physiol. 132, 521-535
24. Cholon, D. M., O'Neal, W. K., Randell, S. H., Riordan, J. R., and Gentzsch, M. (2010) Am. J. Physiol. Lung Cell. Mol. Physiol. 298, L304-L314
25. Cui, L., Aleksandrov, L., Chang, X. B., Hou, Y. X., He, L., Hegedus, T., Gentzsch, M., Aleksandrov, A., Balch, W. E., and Riordan, J. R. (2007) J. Mol. Biol. 365, 981-994
26. Hou, Y., Cui, L., Riordan, J. R., and Chang, X. (2000) J. Biol. Chem. 275, 20280-20287
27. Kartner, N., Hanrahan, J. W., Jensen, T. J., Naismith, A. L., Sun, S. Z., Ackerley, C. A., Reyes, E. F., Tsui, L. C., Rommens, J. M., Bear, C. E., and Riordan, J. R. (1991) Cell 64, 681-691
28. Yang, L. M., Rinke, R., and Korbmacher, C. (2006) J. Biol. Chem. 281, 9859-9868
29. Benharouga, M., Sharma, M., and Lukacs, G. L. (2002) Methods Mol. Med. 70, 229-243
30. Bruns, J. B., Carattino, M. D., Sheng, S., Maarouf, A. B., Weisz, O. A., Pilewski, J. M., Hughey, R. P., and Kleyman, T. R. (2007) J. Biol. Chem. 282, 6153-6160
31. Hughey, R. P., Mueller, G. M., Bruns, J. B., Kinlough, C. L., Poland, P. A., Harkleroad, K. L., Carattino, M. D., and Kleyman, T. R. (2003) J. Biol. Chem. 278, 37073-37082
32. Carattino, M. D., Hughey, R. P., and Kleyman, T. R. (2008) J. Biol. Chem. 283, 25290-25295
33. Sheng, S., Li, J., McNulty, K. A., Kieber-Emmons, T., and Kleyman, T. R. (2001) J. Biol. Chem. 276, 1326-1334
34. Vuagniaux, G., Vallet, V., Jaeger, N. F., Hummler, E., and Rossier, B. C. (2002) J. Gen. Physiol. 120, 191-201
35. Klein, I., Sarkadi, B., and Váradi, A. (1999) Biochim. Biophys. Acta 1461, 237-262
36. Kopito, R. R. (1999) Physiol. Rev. 79, S167-S173
37. Planès, C., Randrianarison, N. H., Charles, R. P., Frateschi, S., Cluzeaud, F., Vuagniaux, G., Soler, P., Clerici, C., Rossier, B. C., and Hummler, E. (2010) EMBO Mol. Med. 2, 26-37
38. Boucher, R. C., Stutts, M. J., Knowles, M. R., Cantley, L., and Gatzy, J. T. (1986) J. Clin. Invest. 78, 1245-1252
39. Planès, C., Leyvraz, C., Uchida, T., Angelova, M. A., Vuagniaux, G., Hummler, E., Matthay, M., Clerici, C., and Rossier, B. (2005) Am. J. Physiol. Lung Cell. Mol. Physiol 288, L1099-L1109
40. Coote, K., Atherton-Watson, H. C., Sugar, R., Young, A., MacKenzie-Beevor, A., Gosling, M., Bhalay, G., Bloomfield, G., Dunstan, A., Bridges, R. J., Sabater, J. R., Abraham, W. M., Tully, D., Pacoma, R., Schumacher, A., Harris, J., and Danahay, H. (2009) J. Pharmacol. Exp. Ther. 329, 764-774
41. Myerburg, M. M., McKenna, E. E., Luke, C. J., Frizzell, R. A., Kleyman, T. R., and Pilewski, J. M. (2008) Am. J. Physiol. Lung Cell. Mol. Physiol. 294, L932-L941
42. Garcia-Caballero, A., Rasmussen, J. E., Gaillard, E., Watson, M. J., Olsen, J. C., Donaldson, S. H., Stutts, M. J., and Tarran, R. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 11412-11417
43. Chinet, T. C., Fullton, J. M., Yankaskas, J. R., Boucher, R. C., and Stutts, M. J. (1994) Am. J. Physiol. Cell Physiol. 266, C1061-C1068
44. Coakley, R. D., Grubb, B. R., Paradiso, A. M., Gatzy, J. T., Johnson, L. G., Kreda, S. M., O'Neal, W. K., and Boucher, R. C. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 16083-16088
45. Verkman, A. S. (2001) Am. J. Physiol. Lung Cell. Mol. Physiol. 281, L306-L308
46. Bachhuber, T., König, J., Voelcker, T., Mürle, B., Schreiber, R., and Kunzelmann, K. (2005) J. Biol. Chem. 280, 31587-31594
47. König, J., Schreiber, R., Voelcker, T., Mall, M., and Kunzelmann, K. (2001) EMBO Rep. 2, 1047-1051