Gating of amiloride-sensitive Na+ channels: Subunit-subunit interactions and inhibition by the cystic fibrosis transmembrane conductance regulator

Biophysical Journal

Volumn 78, Issue 4, 2000, Pages 1881-1894

  Berdiev, Bakhrom K ^a   Shlyonsky, Vadim Gh ^b   Karlson, Katherine H ^c   Stanton, Bruce A ^c   Ismailov, Iskander I ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b Institute of Bioorganic Chemistry Uzbekistan Academy of Sciences   (Uzbekistan)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; SODIUM CHANNEL; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CYTOPLASM; KINETICS; LIPID BILAYER; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

EID: 0034127017     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(00)76737-3     Document Type: Article

References (46)

1. Adams, C. M., P. M. Snyder, and M. J. Welsh. 1997. Interactions between subunits of the human epithelial sodium channel. J. Biol. Chem. 272: 27295-27300.
2. + channel protein displays stretch activation in planar lipid bilayers. Am. J. Physiol. 268:C1450-C1459.
3. + channel by its β-and γ-subunits. Am. J. Physiol. 273: C1889-C1899.
4. Baker, E., X. Jeunemaitre, A. J. Portal, P. Grimbert, N. Markandu, A. Persu, P. Corvol, and G. MacGregor. 1998. Abnormalities of nasal potential difference measurement in Liddle's syndrome. J. Clin. Invest. 102:10-14.
5. + channel. Biophys. J. 75: 2292-2301.
6. + channels. Nat. Struct. Biol. 6:38-43.
7. + channel (ENaCs) in Xenopus oocytes coexpressing CFTR and ENaC. J. Physiol. 508:825-836.
8. Canessa, C. M., J.-D. Horisberger, and B. C. Rossier. 1993. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature. 361:467-470.
9. + channel is made of three homologous subunits. Nature. 367:463-467.
10. - conductance. J. Membr. Biol. 169:175-188.
11. Chang, S. S., S. Grander, S., A. Hanukoglu, A. Rosier, P. M. Mathew, I. Hanukoglu, L. Schild, Y. Lu, R. A. Shimkets, C. Nelson-Williams, B. C. Rossier, and R. P. Lifton. 1996. Mutations in subunits ot the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nature Genet. 12:248-253.
12. - channel evaluated using sucrose gradient sedimentation analysis. J. Biol. Chem. 273:22693-22700.
13. Coscoy, S., E. Lingueglia, M. Lazdunski, and P. Barbry. 1998. The Phe-Met-Arg-Phe-amide-activated sodium channel is a tetramer. J. Biol. Chem. 273:8317-8322
14. Firsov, D., I. Gautschi, A. M. Merillat, B. Rossier, and L. Schild. 1998. The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J. 17:344-352.
15. Firsov, D., L. Schild, I. Gautschi, A. M. Merillat, E. Schneeberger, and B. C. Rossier. 1996. Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach. Proc. Natl. Acad. Sci. USA. 93:15370-15375.
16. Gründer, S., D. Firsov, S. S. Chang, N. F. Jaeger, I. Gautschi, L. Schild, R. P. Lifton, and B. Rossier. 1997. A mutation causing pseudohypoaldesteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel. EMBO J. 16:899-907.
17. Hansson, J. H., C. Nelson-Williams, H. Suzuki, L. Schild, R. Shimkets, Y. Lu, C. Canessa, T. Iwasaki, B. Rossier, and R. P. Lifton. 1995a. Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome. Nature Genet. 11:76-82.
18. Hansson, J. H., L. Schild, Y. Lu, T. Wilson, I. Gautschi, R. Shimkets, C. Nelson-Williams, B. Rossier, and R. Lifton. 1995b. A de novo missense mutation of the β subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a praline-rich segment critical for regulation of channel activity. Proc. Natl. Acad. Sci. USA. 92:11495-11499.
19. + channels carrying Liddle's syndrome mutations. J. Biol. Chem. 274:13894-13899.
20. Hoshi, T., W. N. Zagotta, and R. W. Aldrich. 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science. 250:533-538.
21. + channel. J. Biol. Chem. 271:807-816.
22. + channels by cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 271:4725-4732.
23. Ismailov, I. I., B. K. Berdiev, V. Gh. Shlyonsky, C. M. Fuller, A. G. Prat, B. Jovov, H. F. Cantiello, D. A. Ausiello, and D. J. Benos. 1997a. Role of actin in regulation of epithelial sodium channels by CFTR. Am. J. Physiol. 272:C1077-C1086.
24. + channel, α, β,γ-rENaC. J. Physiol. (Lond). 504:287-300.
25. Ismailov, I. I., V. Gh. Shlyonsky, E. H. Serpersu, C. M. Fuller, H. C. Cheung, D. Muccio, B. K. Berdiev, and D. J. Benos. 1999. Peptide inhibition of ENaC. Biochemistry, 38:354-363.
26. Jovov, B., I. I. Ismailov, B. K. Berdiev, C. M. Fuller, E. J. Sorscher, J. R. Dedman, M. A. Kaetzel, and D. J. Benos. 1995. Interaction between cystic fibrosis transmembrane conductance regulator and outwardly rectified chloride channels. J. Biol. Chem. 270:29194-29200.
27. Kizer, N., X.-L. Guo, and K. Hruska. 1997. Reconstitution of stretch-activated cation channels by expression of the α-subunit of the epithelial sodium channel cloned from osteoblasts. Proc. Natl. Acad. Sci. USA. 94:1013-1018.
28. Kosari, F., S. Sheng, J. Li, D. O. Mak, J. K. Foskett, and T. R. Kleyman. 1998. Subunit stoichiometry of the epithelial sodium channel. J. Biol. Chem. 273:13469-13474.
29. Kunzelmann, K., G. L. Kiser, R. Schreiber, and J. R. Riordan. 1997. Inhibition of epithelial Na currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator. FEBS Lett. 400: 341-344.
30. Li, M., Y. N. Jan, and L. Y. Jan. 1992. Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science. 257:1225-1230.
31. Ling, B. N., J. B. Zuckerman, C. Lin, B. J. Harte, K. A. McNulty, P. R. Smith, L. M. Gomez, R. T. Worrell, D. C Eaton, and T. R. Kleyman. 1997. Expression of the cystic fibrosis phenotype in a renal amphibian epithelial cell line. J. Biol. Chem. 272:594-600.
32. + channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett. 318:95-99.
33. + conductance when coexpressed in Xenopus oocytes. FEBS Lett. 381:47-52.
34. + channels. Biochem. J. 336:705-710.
35. Prince, L. S., and M. J. Welsh. 1999. Effect of subunit composition and Liddle's syndrome mutations on biosynthesis of ENaC. Am. J. Physiol. 276:C1346-C1351.
36. Rosenberg, R. L., and J. E. East. 1992. Cell-free expression of functional Shaker potassium channels. Nature. 360:166-169.
37. Schild, L., C. M. Canessa, R. A. Shimkets, I. Gautschi, R. P. Liflon, and B. C. Rossier. 1995. A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc. Natl. Acad Sci. USA. 92:5699-5703.
38. + channel assembly. Neuron. 11:67-76.
39. + channel subunit proteins. Neuron. 14:625-633.
40. Shimkets, R. A., D. G. Warnock, C. M. Bositis, C. Nelson-Williams, J. H. Hansson, M. Schambelan, J. R. Gill, Jr., S. Ulick, R. V. Milora, and J. W. Findling. 1994. Liddle's syndrome: heritable human hypertension caused by mutations in the subunit of the epithelial sodium channel. Cell. 79:407-414.
41. Stutts, M. J., C. M. Canessa, J. C. Olsen, M. Hamrick, J. A. Cohn, B. C. Rossier, and R. C. Boucher. 1995. CFTR as a cAMP-dependent regulator of sodium channels. Science. 269:847-850.
42. Stutts, M. J., B. C. Rossier, and R. C. Boucher. 1997. Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics. J. Biol. Chem. 272:14037-14040.
43. Valentijn, J. A., G. K. Fyfe, and C. M. Canessa. 1998. Biosynthesis and processing of epithelial sodium channels in Xenopus oocytes. J. Biol Chem. 273:30344-30351.
44. Verrall, S., and Z. W. Hall. 1992. The N-terminal domains of acetylcholine receptor subunits contain recognition signals for the initial steps of receptor assembly. Cell. 68:23-31.
45. Woolson, R. F. 1987. Statistical Methods for the Analysis of Biomedical Data (Wiley Series in Probability and Mathematical Statistics). John Wiley and Sons, New York.
46. Zagotta, W. N., T. Hoshi, and R. W. Aldrich. 1990. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science. 250:568-571.