Receptor signaling integration by TRP channelsomes

Advances in Experimental Medicine and Biology

Volumn 704, Issue , 2011, Pages 373-389

  Mori, Yasuo ^a   Kajimoto, Taketoshi ^a   Nakao, Akito ^a   Takahashi, Nobuaki ^a   Kiyonaka, Shigeki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

ADP ribose (ADPR); Caveolin; Cellular signal; channelsome; Chemokine; Diacylglycerol (DAG); H 2O 2; Nitric oxide (NO); Oxidative stress; Phospholipase C (PLC); Protein complex; Protein kinase C (PKC); Reactive oxygen species (ROS); Receptor; Vasodilation

Indexed keywords

CALCIUM ION; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

CALCIUM SIGNALING; CALCIUM TRANSPORT; CARDIOVASCULAR DISEASE; CELL ORGANELLE; CHANNELSOME; CONFERENCE PAPER; ELECTRON MICROSCOPY; FEEDBACK SYSTEM; HUMAN; MOLECULAR INTERACTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SHEAR STRESS; SIGNAL TRANSDUCTION; SIGNALSOME; THREE DIMENSIONAL IMAGING; ANIMAL; PHYSIOLOGY; REVIEW; ARTICLE; BINDING AFFINITY; CHANNEL GATING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SECOND MESSENGER;

ANIMALS; HUMANS; SIGNAL TRANSDUCTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 79959777289     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-0265-3_21     Document Type: Conference Paper

References (108)

1. Tominaga M, Wada M, Masu M (2001) Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci USA 98:6951-6956
2. Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413:203-210
3. Chuang H, Neuhausser WM, Julius D (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron 43:859-869
4. Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, Birnbaumer L (1996) trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell 85:661-671
5. Parekh AB, Putney JW Jr (2005) Store-operated calcium chanels. Physiol Rev 85:757-810
6. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259-263
7. Bird GS, Aziz O, Lievremont JP, Wedel BJ, Trebak M, Vazquez G, Putney JW Jr (2004) Mechanisms of phospholipase C-regulated calcium entry. Curr Mol Med 4:291-301
8. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, Mori Y (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. J Biol Chem 274: 27359-27370
9. Lucas P, Ukhanov K, Leinders-Zufall T, Zufall F (2003) A diacylglycerolgated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: Mechanism of pheromone transduction. Neuron 40:551-561
10. Gallo EM, Canté-Barrett K, Crabtree GR (2006) Lymphocyte calcium signaling from membrane to nucleus. Nat Immunol 7:25-32
11. Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, Mori Y (2001) The transient receptor potential protein homologue TRP6 is the essential component of vascular a1-adrenoceptor-activated Ca2+-permeable cation channel. Circ Res 88:325-332
12. Welsh DG, Morielli AD, Nelson MT, Brayden JE (2002) Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 90:248-250
13. Thebault S, Flourakis M, Vanoverberghe K, Vandermoere F, Roudbaraki M, Lehen'kyi V, Slomianny C, Beck B, Mariot P, Bonnal JL, Mauroy B, Shuba Y, Capiod T, Skryma R, Prevarskaya N (2006) Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. Cancer Res 66:2038-2047
14. Onohara N, Nishida M, Inoue R, Kobayashi H, Sumimoto H, Sato Y, Mori Y, Nagao T, Kurose H (2006) TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J 25:5305-5316
15. Nishida M, Sugimoto K, Hara Y, Mori E, Morii T, Kurosaki T, Mori Y (2003) Amplification of receptor signaling by entry-mediated translocation and activation of PLC?2 in B lymphocytes. EMBO J 22:4677-4688
16. Sugimoto K, Nishida M, Otsuka M, Makino K, Ohkubo K, Mori Y, Morii T (2004) Novel real-time sensors to quantitatively assess in vivo inositol 1,4,5-trisphosphate production in intact cells. Chem Biol 11:475-485
17. Patterson RL, van Rossum DB, Ford DL, Hurt KJ, Bae SS, Suh PG, Kurosaki T, Snyder SH, Gill DL (2002) Phospholipase C-? is required for agonist-induced Ca2+ entry. Cell 111: 529-541
18. van Rossum DB, Patterson RL, Sharma S, Barrow RK, Kornberg M, Gill DL, Snyder SH (2005) Phospholipase C?1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature 434:99-104
19. Numaga T, Nishida M, Kiyonaka S, Kato K, Katano M, Mori E, Kurosaki T, Inoue R, Hikida M, Putney JW Jr, Mori Y (2010) Ca2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B Cells. J Cell Sci 123:927-938
20. Singh I, Knezevic N, Ahmmed GU, Kini V, Malik AB, Mehta D (2007) Gaq-TRPC6- mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin. J Biol Chem 282:7833-7843
21. Boulay G, Brown DM, Qin N, Jiang M, Dietrich A, Zhu MX, Chen Z, Birnbaumer M, Mikoshiba K, Birnbaumer L (1999) Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-triphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry. Proc Natl Acad Sci USA 96:14955-14960
22. Bandyopadhyay BC, Ong HL, Lockwich TP, Liu X, Paria BC, Singh BB, Ambudkar IS (2008) TRPC3 controls agonist-stimulated intracellular Ca2+ release by mediating the interaction between inositol 1,4,5-triphosphate receptor and RACK1. J Biol Chem 283: 32821-32830
23. Woodard GE, López JJ, Jardín I, Salido GM, Rosado JA (2010) TRPC3 regulates agoniststimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5- triphosphate receptor, RACK1, and Orai1. J Biol Chem 285:8045-8053
24. Frey N, Olson EN (2003) Cardiac hypertrophy: The good, the bad, and the ugly. Annu Rev Physiol 65:45-79
25. Molkentin JD, Dorn GW II (2001) Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol 63:391-426
26. Brenner J, Dolmetsch RE (2007) TrpC3 regulates hypertrophy-associated gene expression without affecting myocyte beating or cell size. PLoS One 2:e802
27. Bush EQ, Hood DB, Papst PJ, Chapo JA, MinobeW, Bristow MR, Olson EN, McKinsey TA (2006) Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling. J Biol Chem 281:33487-33496
28. Kuwahara K, Wang Y, McAnally J, Richardson JA, Bassel-Duby R, Hill JA, Olson EN (2006) TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest 116:3114-3126
29. Nakayama H,Wilkin BJ, Bodi I, Molkentin JD (2006) Calcineurin-dependent cardiomyopathy is activated by TRPC3 in the adult mouse heart. FASEB J 20:1660-1670
30. Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, Sawaguchi Y, Yoshida T,Wakamori M, Mori E, Numata T, Ishii M, Takemoto H, Ojida A, Watanabe K, Uemura A, Kurose H, Morii T, Kobayashi T, Sato Y, Sato C, Hamachi I, Mori Y (2009) Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci USA 106:5400-5405
31. Okada T, Shimizu S, Wakamori M, Maeda A, Kurosaki T, Takada N, Imoto K, Mori Y (1998) Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J Biol Chem 273:10279-10287
32. Philipp S, Hambrecht J, Braslavski L, Schroth G, Freichel M, Murakami M, Cavalié A, Flockerzi V (1998) A novel capacitative calcium entry channel expressed in excitable cells. EMBO J 17:4274-4282
33. Ordaz B, Tang J, Xiao R, Salgado A, Sampieri A, Zhu MX, Vaca L (2005) Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation. J Biol Chem 280: 30788-30796
34. Shimizu S, Yoshida T, Wakamori M, Ishii M, Okada T, Takahashi M, Seto M, Sakurada K, Kiuchi Y, Mori Y (2006) Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK 293 cells. J Physiol 570:219-235
35. Blair NT, Kaczmarek JS, Clapham DE (2009) Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol 133:525-546
36. Gross SA, GuzmÁn GA, Wissenbach U, Philipp SE, Zhu MX, Bruns D, Cavalié A (2009) TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels. J Biol Chem 284:34423-34432
37. Trebak M, Lemonnier L, DeHaven WI, Wedel BJ, Bird GS, Putney JW Jr (2009) Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels. Pflügers Arch 457:757-769
38. Lockwich TP, Liu X, Singh BB, Jadlowiec J, Weiland S, Ambudkar IS (2000) Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. J Biol Chem 275:11934-11942
39. Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX (2000) Association of mammalian Trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem 275:37559-37564
40. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114:777-789
41. Obukhov AG, Nowycky MC (2004) TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50). J Cell Physiol 201:227-235
42. Goel M, Sinkins W, Keightley A, Kinter M, Schilling WP (2005) Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na+/K+- ATPase. Pflügers Arch 451:87-98
43. Schindl R, Frischauf I, Kahr H, Fritsch R, Krenn M, Derndl A, Vales E, Muik M, Derler I, Groschner K, Romanin C (2008) The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels. Cell Calcium 43:260-269
44. Miehe S, Bieberstein A, Arnould I, Ihdene O, Rütten H, Strübing C (2010) The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. J Biol Chem 285:12426-12434
45. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645-655
46. Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Hara Y, Tominaga M, Shimizu S, Sato Y, Mori Y (2006) Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol 2:596-607
47. Bergdahl A, Gomez MF, Dreja K, Xu SZ, Adner M, Beech DJ, Broman J, Hellstrand P, Swärd K (2003) Cholesterol depletion impairs vascular reactivity to endothelin-1 by reducing store-operated Ca2+ Entry dependent on TRPC1. Circ Res 93:839-847
48. Brazer SC, Singh BB, Liu X, Swaim W, Ambudkar IS (2003) Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1. J Biol Chem 278:27208-27215
49. Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP (1997) Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem 272:6525-6533
50. García-Cardeña G, Martasek P, Masters BS, Skidd PM, Couet J, Li S, Lisanti MP, Sessa WC (1997) Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem 272:25437-25440
51. Sato Y, Sagami I, Shimizu T (2004) Identification of caveolin-1- interacting sites in neuronal nitric-oxide synthase. Molecular mechanism for inhibition of NO formation. J Biol Chem 279:8827-8836
52. Quest AF, Gutierrez-Pajares JL, Torres VA (2008) Caveolin-1: An ambiguous partner in cell signalling and cancer. J Cell Mol Med 12:1130-1150
53. Kone BC, Kuncewicz T, Zhang W, Yu ZY (2003) Protein interactions with nitric oxide synthases: Controlling the right time, the right place, and the right amount of nitric oxide. Am J Physiol Renal Physiol 285:F178-F190
54. Michel JB, Feron O, Sacks D, Michel T (1997) Reciprocal regulation of endothelial nitricoxide synthase by Ca2+-calmodulin and caveolin. J Biol Chem 272:15583-15586
55. Michel JB, Feron O, Sase K, Prabhakar P, Michel T (1997) Caveolin versus calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase. J Biol Chem 272:25907-25912
56. Ju H, Zou R, Venema VJ, Venema RC (1997) Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity. J Biol Chem 272:18522-18525
57. Rizzo V, McIntosh DP, Oh P, Schnitzer JE (1998) In situ flow activates endothelial nitric oxide synthase in luminal caveolae of endothelium with rapid caveolin dissociation and calmodulin association. J Biol Chem 273:34724-34729
58. Bernatchez PN, Bauer PM, Yu J (2005) Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides. Proc Natl Acad Sci USA 102:761-766
59. García-Cardeña G, Fan R, Stern DF, Liu J, Sessa WC (1996) Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem 271:27237-27240
60. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399:597-601
61. Michell BJ, Zp C, Tiganis T, Stapleton D, Katsis F, Power DA, Sim AT, Kemp BE (2001) Coordinated Control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent Protein Kinase. J Biol Chem 276:17625-17628
62. Boo YC, Jo H (2003) Flow-dependent regulation of endothelial nitric oxide synthase: Role of protein kinases. Am J Physiol Cell Physiol 285:C499-C508
63. Heijnen HF, Waaijenborg S, Crapo JD, Bowler RP, Akkerman JW, Slot JW (2004) Colocalization of eNOS and the catalytic subunit of PKA in endothelial cell junctions: A clue for regulated NO production. J Histochem Cytochem 52:1277-1285
64. Foster MW, Hess DT, Stamler JS (2006) S-nitrosylation TRiPs a calcium Switch. Nat Chem Biol 2:570-571
65. Fulton D, Fontana J, Sowa G, Gratton JP, Lin M, Li KX, Michell B, Kemp BE, Rodman D, Sessa WC (2002) Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem 277:4277-4284
66. Freichel M, Suh SH, Pfeifer A, Schweig U, Trost C, Weissgerber P, Biel M, Philipp S, Freise D, Droogmans G, Hofmann F, Flockerzi V, Nilius B (2001) Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol 3:121-127
67. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (2003) TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci 6:837-845
68. Zhang N, Beuve A, Townes-Anderson E (2005) The nitric oxide-cGMP signaling pathway differentially regulates presynaptic structural plasticity in cone and rod cells. J Neurosci 25:2761-2770
69. Boo YC, Hwang J, Sykes M, Michell BJ, Kemp BE, Lum H, Jo H (2002) Shear stress stimulates phosphorylation of eNOS at Ser635 by a protein kinase A-dependent mechanism. Am J Physiol Heart Circ Physiol 283:H1819-H1828
70. Gomis A, Soriano S, Belmonte C, Viana F (2008) Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. J Physiol 586:5633-5649
71. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y (2002) LTRPC2 Ca2+- permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163-173
72. Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (2001) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411: 595-599
73. Sano Y, Inamura K, Miyake A, Mochizuki S, Yokoi H, Matsushime H, Furuichi K (2001) Immunocyte Ca2+ influx system mediated by LTRPC2. Science 293:1327-1330
74. Kolisek M, Beck A, Fleig A, Penner R (2005) Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol Cell 18:61-69
75. Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM (2005) Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem 280:6138-6148
76. Ishii M, Shimizu S, Hagiwara T, Wajima T, Miyazaki A, Mori Y, Kiuchi Y (2006) Extracellular-added ADP-ribose increases intracellular free Ca2+ concentration through Ca2+ release from stores, but not through TRPM2-mediated Ca2+ entry, in rat beta-cell line RIN-5F. J Pharmacol Sci 101:174-178
77. IshiiM, Shimizu S, Hara Y, Hagiwara T, Miyazaki A, Mori Y, Kiuchi Y (2006) Intracellularproduced hydroxyl radical mediates H2O2-induced Ca2+ influx and cell death in rat beta-cell line RIN-5F. Cell Calcium 39:487-494
78. Wehage E, Eisfeld J, Heiner I, Jüngling E, Zitt C, Lückhoff A (2002) Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J Biol Chem 277:23150-23156
79. Beck A, Kolisek M, Bagley LA, Fleig A, Penner R (2006) Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J 20:962-964
80. Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig A, Penner R (2009) TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal 2:ra23
81. Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R,Wang C, Zhu Y, Lin Y,Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX (2009) NAADP mobilizes calcium from acidic organelles through twopore channels. Nature 459:596-600
82. Massullo P, Sumoza-Toledo A, Bhagat H, Partida-SÁnchez S (2006) TRPM channels, calcium and redox sensors during innate immune responses. Semin Cell Dev Biol 17:654-666
83. Grubisha O, Rafty LA, Takanishi CL, Xu X, Tong L, Perraud AL, Scharenberg AM, Denu JM (2006) Metabolite of SIR2 reaction modulates TRPM2 ion channel. J Biol Chem 281:14057-14065
84. McHugh D, Flemming R, Xu SZ, Perraud AL, Beech DJ (2003) Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem 278:11002-11006
85. Hill K, Tigue NJ, Kelsell RE, Benham CD, McNulty S, Schaefer M, Randall AD (2006) Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology 50:89-97
86. Starkus J, Beck A, Fleig A, Penner R (2007) Regulation of TRPM2 by extra- and intracellular calcium. J Gen Physiol 130:427-440
87. Du J, Xie J, Yue L (2009) Intracellular calcium activates TRPM2 and its alternative spliced isoforms. Proc Natl Acad Sci USA 106:7239-7244
88. Olah ME, Jackson MF, Li H, Perez Y, Sun HS, Kiyonaka S, Mori Y, Tymianski M, MacDonald JF (2009) Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. J Physiol 587:965-979
89. Tong Q, Zhang W, Conrad K, Mostoller K, Cheung JY, Peterson BZ, Miller BA (2006) Regulation of the transient receptor potential channel TRPM2 by the Ca2+ sensor calmodulin. J Biol Chem 281:9076-9085
90. Zhang W, Tong Q, Conrad K, Wozney J, Cheung JY, Miller BA (2007) Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1. Am J Physiol Cell Physiol 292: C1746-C1758
91. Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M (2006) TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J 25:1804-1815
92. Du J, Xie J, Yue L (2009) Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity. J Gen Physiol 134:471-488
93. Starkus JG, Fleig A, Penner R (2010) The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification. J Physiol 588:1227-1240
94. Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y (2008) TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med 14: 738-747
95. Fonfria E, Marshall IC, Boyfield I, Skaper SD, Hughes JP, Owen DE, Zhang W, Miller BA, Benham CD, McNulty S (2005) Amyloid beta-peptide(1-42) and hydrogen peroxideinduced toxicity are mediated by TRPM2 in rat primary striatal cultures. J Neurochem 95:715-723
96. Bari MR, Akbar S, Eweida M, Kühn FJ, Gustafsson AJ, Lückhoff A, Islam MS (2009) H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl)anthranilic acid in the beta-cells: Involvement of TRPM2 channels. J Cell Mol Med 13:3260-3267
97. Zeng X, Sikka SC, Huang L, Sun C, Xu C, Jia D, Abdel-Mageed AB, Pottle JE, Taylor JT, LiM(2009) Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation. Prostate Cancer Prostatic Dis 13:195-201
98. HermosuraMC, Cui AM, Go RC, Davenport B, Shetler CM, Heizer JW, Schmitz C, Mocz G, Garruto RM, Perraud AL (2008) Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proc Natl Acad Sci USA 105:18029-18034
99. Xu C, Macciardi F, Li PP, Yoon IS, Cooke RG, Hughes B, Parikh SV, McIntyre RS, Kennedy JL, Warsh JJ (2006) Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 141B:36-43
100. Xu C, Li PP, Cooke RG, Parikh SV,Wang K, Kennedy JL,Warsh JJ (2009) TRPM2 variants and bipolar disorder risk: Confirmation in a family-based association study. Bipolar Disord 11:1-10
101. Lishko PV, Procko E, Jin X, Phelps CB, Gaudet R (2007) The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron 54:905-918
102. Fujiwara Y, Minor DL Jr (2008) X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil. J Mol Biol 383:854-870
103. Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R (2008) Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry 47: 2476-2484
104. Yu Y, Ulbrich MH, Li MH, Buraei Z, Chen XZ, Ong AC, Tong L, Isacoff EY, Yang J (2009) Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci USA 106:11558-11563
105. Mio K, Ogura T, Hara Y, Mori Y, Sato C (2005) The non-selective cation-permeable channel TRPC3 is a tetrahedron with a cap on the large cytoplasmic end. Biochem Biophys Res Commun 333:768-777
106. Mio K, Ogura T, Kiyonaka S, Hiroaki Y, Tanimura Y, Fujiyoshi Y, Mori Y, Sato C (2007) The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. J Mol Biol 367:373-383
107. Maruyama Y, Ogura T, Mio K, Kiyonaka S, Kato K, Mori Y, Sato C (2007) Threedimensional reconstruction using transmission electron microscopy reveals a swollen, bell-shaped structure of transient receptor potential melastatin type 2 cation channel. J Biol Chem 282:36961-36970
108. Moiseenkova-Bell VY, Stanciu LA, Serysheva II, Tobe BJ, Wensel TG (2008) Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc Natl Acad Sci USA 105: 7451-7455