Recent advances in probiotics and biomedical applications

Journal of Medical Sciences (Faisalabad)

Volumn 13, Issue 8, 2013, Pages 601-614

  Pyar, Hassan ^a   Liong, Min Tze ^b   Peh, Koh Khiang ^a  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^b Universiti Sains Malaysia   (Malaysia)

Author keywords

Bifidobacteria; Biomedical applications; Lactobacilli; Probiotics

Indexed keywords

AMPICILLIN; CLINDAMYCIN; LAXATIVE; LINCOMYCIN; PLACEBO; PROBIOTIC AGENT;

ABDOMINAL PAIN; ANTINEOPLASTIC ACTIVITY; BIFIDOBACTERIUM; BIOMEDICINE; BLADDER CANCER; BREAST CANCER; COLON CANCER; CONSTIPATION; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; ENTEROCOLITIS; HEALTH CARE; HUMAN; HYPERCHOLESTEROLEMIA; IMMUNOSTIMULATION; INTESTINE FLORA; INTESTINE INFECTION; LACTOBACILLUS; LACTOSE INTOLERANCE; LIVER CANCER; NECROTIZING ENTEROCOLITIS; NONHUMAN; PREMATURITY; RESPIRATORY TRACT INFECTION; REVIEW; RISK REDUCTION; SEPSIS; VAGINITIS; WEIGHT GAIN;

EID: 84884247281     PISSN: 16824474     EISSN: 18125727     Source Type: Journal    
DOI: 10.3923/jms.2013.601.614     Document Type: Review

References (145)

1. Ahn, Y.T., G.B. Kim, K.S. Lim, Y.J. Baek and H.U. Kim, 2003. Deconjugation of bile salts by Lactobacillus acidophilus isolate. Int. Dairy J., 13: 303-311.
2. Allen, S.J., B. Okoko, E.G. Martinez, G.V. Gregorio and L.F. Dans, 2003. Probiotics for treating infectious diarrhoea. Cochrane Database Syst. Rev., 10.
3. Angus, D.C. and R.S. Wax, 2001. Epidemiology of sepsis: An update. Cnt. Care. Med., 29: S109-S116.
4. Asano, M., E. Karasawa and T. Takayama, 1986. Antitumor activity of Lactobacillus casei (lc 9018) against experimental mouse bladder tumor (mbt-2). J. Urol., 136: 719-721.
5. Aso, Y. and H. Akazan, 1992. Prophylactic effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer. Urol. Int., 49: 125-129.
6. Aso, Y., H. Akaza, T. Kotake, T. Tsukamoto, K. Imai and S. Naito, 1995. Preventive effect of a lactobacillus casei preparation on the recurrence of superficial bladder cancer in a double-blind trial. The BLP study group. Eur. Urol., 27: 104-109.
7. Bastani, P., A. Homayouni, V. Gasemnezhad and S. Ziyadi, 2012. Dairy Probiotic Foods and Bacterial Vaginosis: A Review on Mechanism of Action. In: Probiotics, Rigobelo, E.C. (Ed.). Tech, Rijeka, Croatia, USA., ISBN 978-953-51-0776-7.
8. Benchimol, E.I. and D.R. Mack, 2004. Probiotics in relapsing and chronic diarrhea. J. Pediatr. Hematol. Oncol., 26: 515-517.
9. Bengmark, S., 1996. Econutrition and health maintenance: A new concept to prevent GI inflammation, ulceration and sepsis. Clin. Nutr., 15: 1-10.
10. Berg, R.D., 1996. The indigenous gastrointestinal mi-croflora. Trends Microbiol., 4: 430-435.
11. Berg, R.D., 1998. Probiotics, prebiotics or conbiotics?. Trends Microbiol., 6: 89-92.
12. Berg, R.D., 1999. Bacterial translocation from the gastrointestinal tract. Adv. Exp. Med. Biol., 473: 11-30.
13. Blakey, J.L., L. Lubitz, G. Barnes, R.F. Bishop, N. Campbell and G. Gillam, 1982. Development of gut colonisation in pre-term neonates. J. Med. Microbiol., 15: 519-529.
14. Blanquet, S., G. Garrait, E. Beyssac, C. Perrier, S. Denis, G. Hebrard and M. Alric, 2005. Effects of cryoprotectants on the viability and activity of freeze dried recombinant yeasts as novel oral drug delivery systems assessed by an artificial digestive system. Eur. J. Pharm. Biopharm., 61: 32-39.
15. Borchert, D., L. Sheridan, A. Papatsoris, Z. Faruquz and J.M. Barua et al., 2008. Prevention and treatment of urinary tract infection with probiotics: Review and research perspective. Indian J. Urol., 24: 139-144.
16. Bos key, E.R, R.A. Cone, K.J. Whaley and T.R. Moench, 2001. Origins of vaginal acidity: High d/1 lactate ratio is consistent with bacteria being the primary source. Hum. Reprod., 16: 1809-1813.
17. Boyle, R., L.J. Mah, A. Chen, S. Kivivuori, R. Robins-Browne and M. Tang, 2008. Effects of Lactobacillus GG treatment during pregnancy on the development of fetal antigen-specific immune responses. Clin. Exp. Allergy, 38: 1882-1890.
18. Bras hears, M.M., S.E. Gilliland and L.M. Buck, 1998. Bile salt deconjugation and cholesterol removal from media by Lactobacillus casei. J. Dairy Sci., 81: 2103-2110.
19. Brown, L., B. Rosner, W.W. Willett and F.M. Sacks, 1999. Cholesterol-lowering effects of dietary fiber: A meta-analysis. Am. J. Clin. Nutr., 69: 30-42.
20. Caplan, M.S., R. Miller-Catchpole, S. Kaup, T. Russell and M. Lickerman et al., 1999. Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Gastroenterology, 117: 577-583.
21. Carrera-Bastos, P., M.F. Villalba, J.H. O'Keefe, S. Lindeberg and L. Cordain, 2011. The western diet and lifestyle and diseases of civilization. Res. Rep. Clin. Cardiol., 2: 215-235.
22. Chen, C.L., N.S. Weiss, P. Newcomb, W. Barlow and E. White, 2002. Hormone replacement therapy in relation to breast cancer. JAMA, 287: 734-741.
23. Cheny, J.D. and D J. Nieves, 2012. The Common Cold. In: Textbook of Pediatric Infectious Diseases, R.D. Feigin, J. Cheny, G.J. Demmler-Harrison and S.L. Kaplan (Eds.). Elsevier Inc., Saunders, USA.
24. Cheu, H.W., D.R. Brown and M.I. Rowe, 1989. Breath hydrogen excretion as a screening test for the early diagnosis of necrotizing enterocolitis. Am. J. Dis. Child, 143: 156-159.
25. Cox, A.J., D.B. Pyne, P.U. Saunders and P.A. Fricker, 2010. Oral administration of the probiotic Lactobacillus fermentum vri-003 and mucosal immunity in endurance athletes. Br. J. Sports Med., 44: 222-226.
26. Cribby, S., M. Taylor and G. Reid, 2008. Vaginal microbiota and the use of probiotics. Interdiscip. Perspect. Infect, Dis., Vol. 2008 10.1155/2008/256490
27. Cummings, J.H., H.S. Wiggins, D.J. Jenkins, H. Houston, T. Jivraj, B.S. Drasar and M.J. Hill, 1978. Influence of diets high and low in animal fat on bowel habit, gastrointestinal transit time, fecal microflora, bile acid and fat excretion. J. Clin. Invest., 61: 953-963.
28. Dam, C., R. Biadaioli, G. Bertini, E. Martelli and F. Rubaltelli, 2002. Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study. Biol. Neonate., 82: 103-108.
29. De LeBlanc, A.D.M., C. Matar and G. Perdigon, 2007. The application of probiotics in cancer. Br. J. Nutr., 98: S105-S110.
30. De Milliano, I., M.M. Tabbers, J.A. van der Post and M.A. Benninga, 2012. Is a multispecies probiotic mixture effective in constipation during pregnancy? A pilot study. Nutr. J., Vol. 11.10.1186/1475-2891-11-80
31. De-Vrese, M., P.R. Marteau, 2007 2007. Probiotics and Prebiotics: Effects on Diarrhea. J. Nutrition, 137: 803S-811S.
32. Delcenserie, V., D. Martel, M. Lamoureux, J. Amiot, Y. Boutin and D. Roy, 2008. Immunomodulatory effects of probiotics in the intestinal tract. Curr. Issues Mol. Biol., 10: 37-54.
33. Deshpande, G.C., S.C. Rao, A.D. Keil and S.K. Patole, 2011. Evidence-based guidelines for use of probiotics in preterm neonates. BMC Med., Vol. 9.10.1186/1741-7015-9-92
34. Donaldson, M.S., 2004. Nutrition and cancer: A review of the evidence for an anti-cancer diet. Nutr. J., Vol. 3. 10.1186/1475-2891-3-19
35. Duijvestijn, Y., N. Mourdi, J. Smucny, G. Pons and M. Chalumeau, 2009. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease. Cochrane Database Syst. Rev. 10.1002/14651858.CD003124.pub3
36. El-Nezami, H., P. Kankaanpaa, S. Salminen and J. Ahokas, 1998. Ability of dairy strains of lactic acid bacteria to bind a common food carcinogen, aflatoxin B1. Food Chem. Toxicol., 36: 321-326.
37. El-Nezami, H.S., N.N. Polychronaki, J. Ma, H. Zhuand, W. Ling et al., 2006. Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from southern China. Am. J. Clin. Nutr., 83: 1199-1203.
38. Elias, J., P. Bozzo and A. Einarson, 2011. Are probiotics safe for use during pregnancy and lactation? Can. Family Physician, 57: 299-301.
39. FAO/WHO, 2001. Evaluation of health and nutritional properties of powder milk and live lactic acid bacteria. Report from FAO/WHO Expert Consultation October, 1-4, 2001. Cordoba, Argentina,
40. Ferguson, L.R. and M. Philpott, 2007. Cancer prevention by dietary bioactive components that target the immune response. Curr. Cancer Drug Targets, 7: 459-464.
41. Forestier, C., C. De Champs, C. Vatoux and B. Joly, 2001. Probiotic activities of Lactobacillus casei rhamnosus: In vitro adherence to intestinal cells and antimicrobial properties. Res. Microbiol., 152: 167-173.
42. Fotiadis, C.I., C.N. Stoidis, B.G. Spyropoulos and E.D. Zografos, 2008. Role of probiotics, prebiotics and synbiotics in chemoprevention of colorectal cancer. World. J. Gastroenterol., 14: 6453-6457.
43. Frank, D.N. and P.R. Norman, 2008. Gastrointestinal microbiology enters the metagenomics era. Curr. Opin. Gastroenterol., 24: 4-10.
44. Fuller, R., 1989. Probiotics in man and animals. J. Applied Microbiol., 66: 365-378.
45. Gewolb, I.H., R.S. Schwalbe, V.L. Taciak, T.S. Harrison and P. Panigrahi, 1999. Stool microflora in extremely low birthweight infants. Arch. Dis. Childhood-Fetal Neonatal Edition, 80: FI67-FI73.
46. Giannini, E.G., C. Mansi, P. Dulbecco and V. Savarino, 2006. Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome. Nutr. (Burbank, Los Angeles County, Calif), 22: 334-342.
47. Gill, H.S. and F. Guamer, 2004. Probiotics and human health: A clinical perspective. Postgrad. Med. J., 80: 516-526.
48. Glade, M.J., 1999. Food, nutrition and the prevention of cancer: A global perspective. American institute for cancer research/world cancer research fund, american institute for cancer research, 1997. Nutrition, 15: 523-526.
49. Goldin, B.R. and S.L. Gorbach, 1984. The effect of milk and Lactobacillus feeding on human intestinal bacterial enzyme activity. Am. J. Clin. Nutr., 39: 756-761.
50. Goldin, B.R., 1998. Health benefits of probiotics. Br. J. Nutr., 80: S203-S207.
51. Guandalini, S., L. Pensabene, M.A. Zikri, J.A. Dias and L.G. Casali et al., 2000. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: A multicenter european trial. J. Pediatric Gastroenterol. Nutr., 30: 54-60.
52. Guamer, F. and J.R. Malagelada, 2003. Gut flora in health and disease. Lancet, 361: 512-519.
53. Guillemard, E., F. Tondu, F. Lacoin and J. Schrezenmeir, 2010. Consumption of a fermented dairy product containing the probiotic Lactobacillus casei dn-114 001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br. J. Nutr., 103: 58-68.
54. Hajela, N., G.B. Nair and N.K. Ganguly, 2010. Are probiotics a feasible intervention for prevention of diarrhoea in the developing world? Gut Pathogens, Vol. 2 10.
55. Hao, Q., Z. Lu, B.R. Dong, C.Q. Huang and T. Wu, 2011. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst. Rev., Vol. 9 10.
56. Haskard, C., C. Binnion and J. Ahokas, 2000. Factors affecting the sequestration of aflatoxin by Lactobacillus rhamnosus strain GG. Chem. Biol. Interact., 128: 39-49.
57. Havenaar, R. and J.H. Huis, 1992. Probiotics: A General View. In: Lactic Acid Bacteria in Health and Disease, Wood, B.J. (Ed.). Vol. 1, Springer,New York, pp: 151-170.
58. Hekmat, S. and D.J. McMahon, 1992. Survival of Lactobacillus and Bifidobacterium bifidumm ice cream for use as a probiotic food. J. Dairy Sci., 75: 1415-1422.
59. Hoesl, C.E. and J.E. Altwein, 2005. The probiotic approach: An alternative treatment option in urology. Eur. Urol., 47: 288-296.
60. Holzapfel, W.H., P. Haberer, J. Snel, U. Schillinger and J.H J.H. Veld, 1998. Overview of gut flora and probiotics. Int. J. Food Microbiol., 41: 85-101.
61. Holzapfel, W.H. and U. Schillinger, 2002. Introduction to pre-and probiotics. Food Res. Int., 35: 109-116.
62. Hori, T., J. Kiyoshima, K. Shida and H. Yasui, 2001. Effect of intranasal administration of lactobacillus casei shirota on influenza virus infection of upper respiratory tract in mice. Clin. Diagnostic Lab. Immunol., 8: 593-597.
63. Hoyos, A.B., 1999. Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium inf antis to neonates in an intensive care unit. Int. J. Infect. Dis., 3: 197-202.
64. Hu, F.B., J.E. Manson and W.C. Willett, 2001. Types of dietary fat and risk of coronary heart disease: A critical review. J. Am. Coll. Nutr., 20: 5-19.
65. Isolauri, E., P.V. Kirjavainen and S. Salminen, 2002. Probiotics: A role in the treatment of intestinal infection and inflammation? Gut., 50: iii54-iii59.
66. Jeon, S.G., H. Kayama, Y. Ueda, T. Takahashi and T. Asahara et al., 2012. Probiotic Bifidobacterium breve induces il-10-producing trl cells in the colon. PLoSPathogens, Vol. 8 10.1371/joumal.ppat.l002714
67. Jousilahti, P., E. Vartiainen, J. Pekkanen, J. Tuomilehto, J. Sundvall and P. Puska, 1998. Serum cholesterol distribution and coronary heart disease risk: Observations and predictions among middle-aged population in eastern finland. Circulation, 97: 1087-1094.
68. Kailasapathy, K. and S. Rybka, 1997. L. acidophilus and Bifidobacterium spp.: Their therapeutic potential and survival in yogurt. Australian J. Dairy Technol., 52: 28-35.
69. Kajander, K., L. Krogius-Kurikka, T. Rinttila, Karjalainen, A. Palva and R. Korpela, 2007. Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. Alimentary Pharmacol. Therapeutics, 26: 463-473.
70. Kaplan, H. and R.W. Hutkins, 2000. Fermentation of fructooligosaccharides by lactic acid bacteria and bifidobacteria. Applied Environ. Microb., 66: 2682-2684.
71. Kassel, J.C., D. King and G.K. Spur ling, 2010. Saline nasal irrigation for acute upper respiratory tract infections. Cochrane Library. 10.1002/14651858.CD006821,pub2
72. Kechagia, M., D. Basoulis, S. Konstantopoulou, D. Dimitriadi, K. Gyftopoulou, N. Skarmoutsou and M. Fakiri, 2013. Health benefits of probiotics: A review. ISRNNutr., 10.
73. Kirpich, I.A. and C.J. McClain, 2012. Probiotics in the treatment of the liver diseases. J. Am. Coll. Nutr., 31: 14-23.
74. Kitajima, H., Y. Sumida, R. Tanaka, N. Yuki, H. Takayama and M. Fujimura, 1997. Early administration of Bifidobacterium breve to preterm infants: Randomised controlled trial. Arch. Dis. Childhood-Fetal Neonatal Edition, 76: FI01-FI07.
75. Kukkonen, K., E. Savilahti, T. Haahtela, K. Juntunen-Backman and R. Korpela et al., 2008. Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: Randomized, double-blind, placebo-controlled trial. Pediatrics, 122: 8-12.
76. Kumar, M., R. Nagpal, R. Kumar, R. Hemalatha and V. Verma, etal., 2012. Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. Exp. Diabetes Res., 10.1155/2012/902917
77. Lamiki, P., J. Tsuchiya, S. Pathak, R. Okura and U. Solimene et al., 2010. Probiotics in diverticular disease of the colon: An open label study. J. Gastrointestin Liver Dis., 19: 31-36.
78. Langerholc, T., P.A. Maragkoudakis, J. Wollgast, L. Gradisnik and A. Cencic, 2011. Novel and established intestinal cell line models-an indispensable tool in food science and nutrition. Trends Food Sci. Technol., 22: SI1-S20.
79. Lenoir-Wijnkoop, I., M.E. Sanders, M.D. Cabana, E. Caglar and G. Corthier et al., 2007. Probiotic and prebiotic influence beyond the intestinal tract. Nutr. Rev., 65: 469-489.
80. Levemer, P., Y. Fremont, A. Rouault, P. Boyaval and G. Jan, 2005. In vitro tolerance to digestive stresses of propionibacteria: Influence of food matrices. Food Microbiol., 22: 11-18.
81. Liberati, A., R. DAmico, S. Pifferi, V. Toni, L. Brazzi and E. Parmelli, 2009. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst. Rev., 10.1002/14651858. CD000022
82. Licciardi, P. and M. Tang, 2011. Vaccine adjuvant properties of probiotic bacteria. Discovery Med.
83. Lilly, D.M. and R.H. Stillwell, 1965. Probiotic growth promoting factors produced by microorganisms. Science, 147: 747-748.
84. Lin, H.C., B.H. Su, A.C. Chen, T.W. Lin, C.H. Tsai, T.F. Yeh and W. Oh, 2005. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics, 115: 1-4.
85. Lin, H.C., C.H. Hsu, H.L. Chen, M.Y. Chung and J.F. Hsu et al., 2008. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: A multicenter, randomized, controlled trial. Pediatrics, 122: 693-700.
86. Lin, M. Y., C.L. Yen and S.H. Chen, 1998. Management of lactose maldigestion by consuming milk containing lactobacilli. Digest. Dis. Sci., 43: 133-137.
87. Loguercio, C., T. de Simone, A. Federico, F. Terracciano and C. Tuccillo et al., 2002. Gut-liver axis: A new point of attack to treat chronic liver damage? Am. J. Gastroenterol., 97: 2144-2146.
88. Loose, D. and C. VanDe Wiele, 2009. The immune system and cancer. Cancer Biother. Radiopharmaceuticals, 24: 369-376.
89. Luoto, R., K. Laitinen, M. Nermes and E. Isolauri, 2010. Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: A double-blind, placebo-controlled study. Br. J. Nutr., 103: 1792-1799.
90. Mager, D., 2006. Bacteria and cancer: Cause, coincidence or cure? A review. J. Translational Med., 10.1186/1479-5876-4-14
91. Maldonado, J., F. Canabate, L. Sempere, F. Vela and A.R. Sanchez et al., 2012. Human milk probiotic Lactobacillus fermentum cect5716 reduces the incidence of gastrointestinal and upper respiratory tract infections in infants. J. Pediatric Gastroenterol. Nutr., 10.1097/MPG.0b013e3182333fl8
92. Marchand, J. and Y. Vandenplas, 2000. Micro-organisms administered in the benefit of the host: Myths and facts. Eur. J. Gastroenterol. Hepatol., 12: 1077-1088.
93. Marcone, V., E. Calzolari and M. Bertini, 2008. Effectiveness of vaginal administration of Lactobacillus rhamnosus following conventional metronidazole therapy: How to lower the rate of bacterial vaginosis recurrences. The New Microbiol.
94. Marteau, P.R., M. De Vrese, C.J. Cellier and J. Schrezenmeir, 2001. Protection from gastrointestinal diseases with the use of probiotics. Am. J. Clin. Nutr., 73: 430S-436S.
95. Matsuguchi, T., A. Takagi, T. Matsuzaki, M. Nagaoka, K. Ishikawa, T. Yokokura and Y. Yoshikai, 2003. Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through toll-like receptor 2. Clin. Diagnostic Lab. Immunol., 10: 259-266.
96. Matsuzaki, T. and J. Chin, 2000. Modulating immune responses with probiotic bacteria. Immunol. Cell. Biol., 78: 67-73.
97. McFarland, L.V. and S. Dublin, 2008. Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World J. Gastroenterol. 10.3748/wjg.l4. 2650
98. Millar, M., M. Wilks and K. Costeloe, 2003. Probiotics for preterm infants? Arch. Dis. Childhood-Fetal Neonatal, 88: F354-F358.
99. Mirhosaini, M., I. Nahvi, R.K. Kermanshahi and M. Tavassoli, 2006. Isolation of bacteriocin producing Lactococcus lactis strain from daily products. Int. J. Dairy Sci., 1: 51-56.
100. Mombelli, B. and M.R. Gismondo, 2000. The use of probiotics in medical practice. Int. J. Antimicrobial Agents, 16: 531-536.
101. Moore, W. and L.H. Moore, 1995. Intestinal floras of populations that have a high risk of colon cancer. Applied Environ. Microbiol., 61: 3202-3207.
102. Nagalakshmi, P., R. Sumathi, K. Kanimozhi and T. Sivakumar, 2013. Isolation of bacteriocin nisin producing lactococcus lactis from daily products. J. Acad. Indus. Res.,
103. Naidu, A.S., W.R. Bidlack and R.A. Clemens, 1999. Probiotic spectra of Lactic Acid Bacteria (LAB). Crit. Rev. Food Sci. Nutr., 38: 123-126.
104. Naito, S., 2009. Comment on does the probiotic L. casei help prevent recurrence after transurethral resection for superficial bladder cancer? Nature Clin. Practice Urol., 10.1038/ncpurol 323
105. Noh, D.O. and S.E. Gilliland, 1993. Influence of bile on cellular integrity and-galactosidase activity of Lactobacillus acidophilus. J. Daily Sci., 76: 1253-1259.
106. Ohashi, Y., S. Nakai, T. Tsukamoto, N. Masumori and H. Akaza et al., 2002. Habitual intake of lactic acid bacteria and risk reduction of bladder cancer. Urol. Int., 68: 273-280.
107. Ouwehand, A. and S. Vesterlund, 2003. Health aspects of probiotics. IDrugs: The Invest. Drugs J., 6: 573-580.
108. Parent, D., M. Bos sens, D. Bayot, C. Kirkpatrick, F. Graf, F. Wilkinson and R. Kaiser, 1996. Therapy of bacterial vaginosis using exogenously-applied Lactobacilli acidophili and a low dose of estriol: A placebo-controlled multicentric clinical trial. Arzneimittelforschung, 46: 68-73.
109. Park, S.K., D.I. Park, J.S. Choi, M.S. Kang and J.H. Park et al., 2007. The effect of probiotics on helicobacter pylori eradication. Hepato-Gastroenterology, 54: 2032-2036.
110. Parker, R.B., 1974. Probiotics: The other half of the antibiotic story. Anim. Nutr. Health, 29: 4-8.
111. Picard, C., J. Fioramonti, A. Francois, T. Robinson, F. Neant and C. Matuchansky, 2005. Review article: Bifidobacteria as probiotic agents-physiological effects and clinical benefits. Aliment Pharmacol. Ther., 22: 495-512.
112. Pineiro, M. and C. Stanton, 2007. Probiotic bacteria: Legislative framework-requirements to evidence basis. J. Nutrition, 137: 850S-853S.
113. Rafii, F., J.B. Sutherland and C.E. Cemiglia, 2008. Effects of treatment with antimicrobial agents on the human colonic microflora. Therapeut. Clin. Risk. Manage., 4: 1348-1358.
114. Raftaniamiri, Z., P. Khandelwal and B.R. Aruna, 2010. Development of acidophilus milk via selected probiotics and prebiotics using artificial neural network. Adv. Biosci. Biotechnol., Vol. 1. 10.4236/ abb. 2010.13031
115. Reid, G., A.W. Bruce, J.A. McGroarty, K. J. Cheng and J.W. Costerton, 1990. Is there a role for lactobacilli in prevention of urogenital and intestinal infections? Clin. Microbiol. Rev., 3: 335-344.
116. Rescigno, M., 2009. Gut commensal flora: Tolerance and homeostasis. FI 000 Biology Reports, 1.
117. Saarela, M., G. Mogensen, R. Fonden, J. Matto and T. Mattila-Sandholm, 2000. Probiotic bacteria: Safety, functional and technological properties. J. Biotechnol., 84: 197-215.
118. Saavedra, J.M., 2007. Use of probiotics in pediatrics: Rationale, mechanisms of action and practical aspects. Nutr. Clin. Pract., 22: 351-365.
119. Salminen, S., 2001. Human studies on probiotics: Aspects of scientific documentation. Scand. J. Nutr., 45: 8-12.
120. Salminen, S., C. Bouley, M.C. Boutron-Ruault, J.H. Cummings and A. Franck et al., 1998. Functional food science and gastrointestinal physiology function. J. Nut., 80: S147-S171.
121. Salminen, S., Y.K. Lee andM. Playne, 2003. Successful Probiotic Lactobacilli: Human Studies on Probiotic Efficacy. In: Handbook of Functional Daily Products, Shortt, C. and J.O. AoBnen (Eds.). CRC Press, USA.
122. Sanders, M.E., 2000. Considerations for use of probiotic bacteria to modulate human health. J. Nutr., 130: 384S-390S.
123. Sazawal, S., G. Hiremath, U. Dhingra, P. Malik, S. Deb and R.E. Black, 2006. Efficacy of probiotics in prevention of acute diarrhoea: A meta-analysis of masked, randomised, placebo-controlled trials. Lancet Infect. Dis., 6: 374-382.
124. Schrezenmeir, J. and M. de Vrese, 2001. Probiotics, prebiotics and synbiotics-approaching a definition. Am. J. Clin. Nutr., 73: 361-364.
125. Schrezenmeir, J., K. Heller, M. McCue, C. Llamas and W. Lam et al., 2004. Benefits of oral supplementation with and without synbiotics in young children with acute bacterial infections. Clin. Pediatrics, 43: 239-249.
126. Shalev, E., S. Battino, E. Weiner, R. Colodner and Y. Keness, 1996. Ingestion of yogurt containing Lactobacillus acidophilus compared with pasteurized yogurt as prophylaxis for recurrent candidal vaginitis and bacterial vaginosis. Arch. Family Med., 5: 593-596.
127. Sheth, A. A. and G. Garcia-Tsao, 2008. Probiotics and liver disease. J. Clin. Gastroenterol., 42: S80-S84.
128. Shomikova, A.V., I. A. Casas, H. Mykkanen, E. Salo and T. Vesikari, 1997. Bacteriotherapy with Lactobacillus reuteri in rotavirus gastroenteritis. Pediatric Infect. Dis. J., 16: 1103-1107.
129. Simon, G.L. and S.L. Gorbach, 1983. Intestinal flora in health and disease. Gastroenterology, 86: 174-193.
130. Sleator, R.D. and C. Hill, 2008. New frontiers in probiotic research. Lett. Applied Microbiol., 46: 143-147.
131. Solis, B., S. Sarnartin, S. Gomez, E. Nova, B. de la Rosa and A. Marcos, 2002. Probiotics as a help in children suffering from malnutrition and diarrhoea. Eur. J. Clin. Nutr., 56: S57-S59.
132. Szajewska, H. and J.Z. Mrukowicz, 2001. Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: A systematic review of published randomized, double-blind, placebo-controlled trials. J. Pediatr. Gastroenterol. Nutr., 33: S17-S25.
133. Takeda, K. and K. Okumura, 2007. Effects of a fermented milk drink containing Lactobacillus casei strain shirota on the human NK-cell activity. J. Nutr., 137: 791S-793S.
134. Tannock, G.W., 1994. Normal Microflora: An Introduction to Microbes Inhabiting the Human Body. Springer, USA.
135. Thomas, C.M., T. Hong, J.P. vanPijkeren, P. Hemarajata and D.V. Trinh et al., 2012. Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PloS One, Vol. 7. 10.1371/journal.pone.0031951
136. Tuomola, E.M., A.C. Ouwehand and S J. Salminen, 2006. The effect of probiotic bacteria on the adhesion of pathogens to human intestinal mucus. FEMS Immunol. Med. Microbiol., 26: 137-142.
137. Tytgat, G.N., R.C. Heading, S. Muller-Lissner, M.A. Kamm and J. Scholmerich et al., 2003. Contemporary understanding and management of reflux and constipation in the general population and pregnancy: A consensus meeting. Aliment. Pharmacol. Ther., 18: 291-301.
138. Van Neil, C.W., C. Feudtner, M.M. Garrison and D.A. Christakis, 2002. Lactobacillus therapy for acute infectious diarrhea in children: A meta-analysis. Pediatrics, 109: 678-684.
139. Vanderhoof, J.A., 2000. Probiotics and intestinal inflammatory disorders in infants and children. J. Pediatr. Gastroenterol. Nutr., 30: S34-S38.
140. Vazquez, J.C., 2010. Constipation, haemorrhoids and heartburn in pregnancy. Clin. Evid.
141. Vendt, N., H. Grunberg, T. Tuure, O. Malminiemi and E. Wuolijoki et al., 2006. Growth during the first 6 months of life in infants using formula enriched with Lactobacillus rhamnosus GG: Double-blind, randomized trial. J. Hum. Nutr. Diet., 19: 51-58.
142. Vouloumanou, E.K., G.C. Makris, D.E. Karageorgopoulos, and M.E. Falagas, 2009. Probiotics for the prevention of respiratory tract infections: A systematic review. Int. J. Antimicrob. Agents, 34: 197. el-197. elO.
143. Walker, W.A. and L.C. Duffy, 1998. Diet and bacterial colonization: Role of probiotics and prebiotics. Rev. J. Nutr. Biochem., 9: 668-675.
144. Youn, H.N., D.H. Lee, Y.N. Lee, J.K. Park and S. S. Yuk et al, 2012. Intranasal administration of live Lactobacillus species facilitates protection against influenza virus infection in mice. Antiviral Res., 93: 138-143.
145. Zimmer, C.J. and G.R. Gibson, 1998. An overview of probiotics, prebiotics and synbiotics in the functional food concept: Perspectives and future strategies. Int. Daily J., 8: 473-479.