Evidence-based guidelines for use of probiotics in preterm neonates

BMC Medicine

Volumn 9, Issue , 2011, Pages

  Deshpande, Girish C ^a,b   Rao, Shripada C ^c,d,e   Keil, Anthony D ^c,f   Patole, Sanjay K ^c,e  

^a NEPEAN HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c KEM Hospital for Women   (Australia)

^d PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^f PathWest Laboratory Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; PREBIOTIC AGENT; PROBIOTIC AGENT; SYNBIOTIC AGENT;

BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; CLINICAL DECISION MAKING; CLINICAL PRACTICE; EVIDENCE BASED PRACTICE; HUMAN; LABORATORY TEST; LETTER; NONHUMAN; PATIENT MONITORING; PATIENT SAFETY; PRACTICE GUIDELINE; PREMATURITY; INFANT; NEWBORN; REVIEW;

HUMANS; INFANT; INFANT, NEWBORN; PRACTICE GUIDELINES AS TOPIC; PROBIOTICS;

EID: 79960890579     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-9-92     Document Type: Letter

References (154)

1. Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet 2006, 368:1271-1283. 10.1016/S0140-6736(06)69525-1, 17027734.
2. Cotten CM, Oh W, McDonald S. Prolonged hospital stay for extremely premature infants: risk factors, center differences, and the impact of mortality on selecting a best-performing center. J Perinatol 2005, 25:650-655. 10.1038/sj.jp.7211369, 16079906.
3. Wales PW, Christison-Lagay ER. Short bowel syndrome: epidemiology and etiology. Semin Pediatr Surg 2010, 19:3-9. 10.1053/j.sempedsurg.2009.11.001, 20123268.
4. Salvia G, Guarino A, Terrin G, Cascioli C, Paludetto R, Indrio F, Lega L, Fanaro S, Stronati M, Corvaglia L, Tagliabue P, De Curtis M, . Working Group on Neonatal Gastroenterology of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition Neonatal onset intestinal failure: an Italian multicenter study. J Pediatr 2008, 153:674-676. 10.1016/j.jpeds.2008.05.017, 18589446, Working Group on Neonatal Gastroenterology of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition.
5. Schulzke SM, Deshpande GC, Patole SK. Neurodevelopmental outcome of very low birth weight infants with necrotizing enterocolitis - A systematic review of observational studies. Arch of Pediatr Adolesc Med 2007, 161:583-590.
6. Hintz SR, Kendrick DE, Stoll BJ, Vohr BR, Fanaroff AA, Donovan EF, Poole WK, Blakely ML, Wright L, Higgins R, . NICHD Neonatal Research Network Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics 2005, 115:696-703. 10.1542/peds.2004-0569, 15741374, NICHD Neonatal Research Network.
7. Stoll BJ. Epidemiology of necrotizing enterocolitis. Clin Perinatol 1994, 21:205-218.
8. Patole S. Prevention and treatment of necrotising enterocolitis in preterm neonates. Early Hum Dev 2007, 83:635-642. 10.1016/j.earlhumdev.2007.07.007, 17826009.
9. Deshpande G, Rao S, Patole S. Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birthweight: a systematic review of randomised controlled trials. Lancet 2007, 369:1614-1620. 10.1016/S0140-6736(07)60748-X, 17499603.
10. Barclay AR, Stenson B, Simpson JH, Weaver LT, Wilson DC. Probiotics for necrotizing enterocolitis: a systematic review. J Pediatr Gastroenterol Nutr 2007, 45:569-576. 10.1097/MPG.0b013e3181344694, 18030235.
11. Alfaleh K, Bassler D. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev 2008, 1:CD005496.
12. Deshpande G, Rao S, Patole S. Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birthweight: a systematic review of randomised controlled trials. Year book of Pediatrics 2009, Chapter 14:441-443. Elsevier Mosby, Newborn Stockman JA III.
13. Indrio F, Riezzo G, Raimond F, Bisceglia M, Cavallo L, Francavilla R. The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns. The Year book of Neonatal and Perinatal medicine Gastroenterology and nutrition 2009, Chapter 14:138-139. Elsevier Mosby, Fanaroff AA, Benitz W, Neu J, Papille L.
14. Deshpande G, Rao S, Patole S, Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics 2010, 125:921-930. 10.1542/peds.2009-1301, 20403939.
15. Satoh Y, Shinohara K, Umezaki H, Shoji H, Satoh H, Ohtsuka Y, Shiga S, Nagata S, Shimizu T, Yamashiro Y. Bifidobacteria prevents necrotising enterocolitis and infection. Int J Probiot Prebiot 2007, 2:149-154.
16. Chou IC, Kuo HT, Chang JS, Wu SF, Chiu HY, Su BH, Lin HC. Lack of effects of oral probiotics on growth and neurodevelopmental outcomes in preterm very low birth weight infants. J Pediatr 2010, 156:393-396. 10.1016/j.jpeds.2009.09.051, 19914635.
17. Romeo MG, Romeo DM, Trovato L, Oliveri S, Palermo F, Cota F, Betta P. Role of probiotics in the prevention of the enteric colonization by Candida in preterm newborns: incidence of late-onset sepsis and neurological outcome. J Perinatol 2011, 31:63-69. 10.1038/jp.2010.57, 3016918, 20410904.
18. Tarnow-Mordi WO, Wilkinson D, Trivedi A, Brok J. Probiotics reduce all-cause mortality and necrotizing enterocolitis: it is time to change practice. Pediatrics 2010, 125:1068-1070. 10.1542/peds.2009-2151, 20403934.
19. Soll RF. Probiotics: are we ready for routine use?. Pediatrics 2010, 125:1071-1072. 10.1542/peds.2010-0643, 20421256.
20. Neu J, Shuster J. Nonadministration of routine probiotics unethical--really?. Pediatrics 2010, 126:e740-e741. Author reply e743-745, 10.1542/peds.2010-1949A, 20810713.
21. Garland SM, Jacobs S, Tobin J, . on behalf of Proprems study group A cautionary note on instituting probiotics into routine clinical care for premature infants. Pediatrics 2010, 126:e741-e742. 10.1542/peds.2010-1949B, 20810714, on behalf of Proprems study group.
22. Beattie LM, Hansen R, Barclay A. Probiotics for preterm infants: confounding features warrant caution. Pediatrics 2010, 126:e742-e743. 10.1542/peds.2010-1949C, 20810715.
23. Millar M, Wilks M, Fleming P, Costeloe K. Should the use of probiotics in the preterm be routine?. Arch Dis Child Fetal Neonatal Ed 2010,
24. Deshpande G, Rao S, Patole S, Bulsara M. Probiotics for preterm neonates - time to acknowledge the elephant in the room and call the parents. Pediatrics 2010, 126:e744-e745.
25. Caplan MS, Miller-Catchpole R, Kaup S, Russell T, Lickerman M, Amer M, Xiao Y, Thomson R. Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Gastroenterology 1999, 117:577-583. 10.1016/S0016-5085(99)70450-6, 10464133.
26. Hoyos AB. Reduced incidence of necrotising enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit. Int J Infect Dis 1999, 3:197-202. 10.1016/S1201-9712(99)90024-3, 10575148.
27. Luoto R, Matomäki J, Isolauri E, Lehtonen L. Incidence of necrotizing enterocolitis in very-low-birth-weight infants related to the use of Lactobacillus GG. Acta Paediatr 2010, 99:1135-1138. Erratum in: Acta Paediatr 2011, 100:631, 10.1111/j.1651-2227.2010.01795.x, 20219023.
28. Luoto R, Isolauri E, Lehtonen L. Safety of Lactobacillus GG probiotic in infants with very low birth weight: twelve years of experience. Clin Infect Dis 2010, 50:1327-1328. 10.1086/651694, 20367236.
29. Moher D, Liberati A, Tetzlaff J, Altman DG, . The PRISMA Group Preferred Reporting items for systematic reviews and meta-analyses: The PRISMA Statement. PLoS Med 2009, 6:e1000097. 10.1371/journal.pmed.1000097, 2707599, 19621072, The PRISMA Group.
30. Gugiu PC, Gugiu MR. A critical appraisal of standard guidelines for grading levels of evidence. Eval Health Prof 2010, 33:233-255. 10.1177/0163278710373980, 20801972.
31. Berger VW, Knoll D. Levels of evidence: further insight on Gugiu and Gugiu. Eval Health Prof 2011, 34:124-126. Discussion: 127-130, 10.1177/0163278710391466, 21177639.
32. Petrisor BA, Keating J, Schemitsch E. Grading the evidence: levels of evidence and grades of recommendation. Injury 2006, 37:321-327. 10.1016/j.injury.2006.02.001, 16488417.
33. Merlin T, Weston A, Tooher R. Extending an evidence hierarchy to include topics other than treatment: revising the Australian 'levels of evidence'. BMC Med Res Methodol 2009, 9:34. 10.1186/1471-2288-9-34, 2700132, 19519887.
34. Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, Hill S, Jaeschke R, Leng G, Liberati A, Magrini N, Mason J, Middleton P, Mrukowicz J, O'Connell D, Oxman AD, Phillips B, Schünemann HJ, Edejer TT, Varonen H, Vist GE, Williams JW, Zaza S, . GRADE Working Group Grading quality of evidence and strength of recommendations. BMJ 2004, 328:1490-1494. 428525, 15205295, GRADE Working Group.
35. Upshur RE. Are all evidence-based practices alike? Problems in the ranking of evidence. CMAJ 2003, 169:672-673. 202284, 14517125.
36. Deeks JJ, Dinnes J, D'Amico R, Sowden AJ, Sakarovitch C, Song F, Petticrew M, Altman DG. International Stroke Trial Collaborative Group; European Carotid Surgery Trial Collaborative Group. Health Technol Assess 2003, 7:iii-x. 1-173.
37. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010, 25:603-605. 10.1007/s10654-010-9491-z, 20652370.
38. Cochrane Handbook for Systematic Reviews of Interventions. (accessed March 2011)., http://www.cochrane-handbook.org/
39. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: Is blinding necessary?. Controlled Clin Trials 1996, 17:1-12. 10.1016/0197-2456(95)00134-4, 8721797.
40. Salminen S, Isolauri E. Intestinal colonisation, microbiota and probiotics. J Pediatr 2006, 149:S115-S120.
41. Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, Wagendorp AA, Klijn N, Bindels JG, Welling GW. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr 2000, 30:61-67. 10.1097/00005176-200001000-00019, 10630441.
42. Mshvildadze M, Neu J. Probiotics and prevention of necrotizing enterocolitis. Early Hum Dev 2009, 85(Suppl 10):S71-74.
43. Ohashi Y, Ushida K. Health-beneficial effects of probiotics: Its mode of action. Animal Science Journal 2009, 80:361-371. 10.1111/j.1740-0929.2009.00645.x, 20163595.
44. Rautava S, Walker WA. Probiotics. Nutrition and Health, Probiotics in Pediatric Medicine 2009, 41-52. Humana Press NJ USA, Michail S, Sherman MC.
45. Morelli L. In vitro selection of probiotic lactobacilli: a critical appraisal. Curr Issues Intest Microbiol 2000, 1:59-67.
46. Kosin B, Rakshit S. Microbial and processing criteria for production of probiotics: a review. Food Technol Biotechnol 2006, 44:371-379.
47. Saavendra JM. Use of probiotics in pediatrics: rationale, mechanisms of action, and practical aspects. Nutr Clin Pract 2007, 22:351-365. 10.1177/0115426507022003351, 17507735.
48. Crittenden R, Bird AR, Gopal P, Henriksson A, Lee YK, Playne MJ. Probiotic research in Australia, New Zealand and the Asia-Pacific Region. Current Pharmaceutical Design 2005, 11:37-53. 10.2174/1381612053382304, 15638751.
49. Prasad J, Gill HS, Smart J, Gopal PK. Selection and characterisation of Lactobacillus and Bifidobacterium strains for use as probiotics. Int Dairy J 1998, 8:993-1002.
50. Dunne C, O'Mahony L, Murphy L, Thornton G, Morrissey D, O'Halloran S, Feeney M, Flynn S, Fitzgerald G, Daly C, Kiely B, O'Sullivan GC, Shanahan F, Collins JK. In vitro selection criteria for probiotic bacteria of human origin: correlation with in vivo findings. Am J Clin Nutr 2001, 73(Suppl 2):386S-392S.
51. Salminen S, Collado MC, Isolauri E, Gueimonde M. Microbial-host interactions: selecting the right probiotics and prebiotics for infants. Nestle Nutr Workshop Ser Pediatr Program 2009, 64:201-13. Discussion: 213-217, 251-257.
52. Kitajima H, Sumida Y, Tanaka R, Yuki N, Takayama H, Fujimura M. Early administration of Bifidobacterium breve to preterm neonates: randomised control trial. Arch Dis Child 1997, 76:F101-107.
53. Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF. Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm neonates. A prospective double-blind study. Biol Neonate 2002, 82:103-108. 10.1159/000063096, 12169832.
54. Costalos C, Skouteri V, Gounaris A, Sevastiadou S, Triandafilidou A, Ekonomidou C, Kontaxaki F, Petrochilou V. Enteral feeding of premature neonates with Saccharomyces boulardii. Early Hum Dev 2003, 74:89-96. 10.1016/S0378-3782(03)00090-2, 14580749.
55. Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudensky B, Caplan M, Hammerman C. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr 2005, 147:192-196. 10.1016/j.jpeds.2005.03.054, 16126048.
56. Lin HC, Su BH, Chen AC, Lin TW, Tsai CH, Yeh TF, Oh W. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight neonates. Pediatrics 2005, 115:1-4.
57. Manzoni P, Mostert M, Leonessa ML, Priolo C, Farina D, Monetti C, Latino MA, Gomirato G. Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonisation by candida species in preterm neonates: a randomised study. Clin Infect Dis 2006, 42:1735-1742. 10.1086/504324, 16705580.
58. Mohan R, Koebnick C, Schildt J, Schmidt S, Mueller M, Possner M, Radke M, Blaut M. Effects of Bifidobacterium lactis Bb12 supplementation on intestinal microbiota of preterm neonates: A double placebo controlled, randomised study. J Clin Microbiol 2006, 44:4025-4031. 10.1128/JCM.00767-06, 1698302, 16971641.
59. Stratiki Z, Costalos C, Sevastiadou S, Kastanidou O, Skouroliakou M, Giakoumatou A, Petrohilou V. The effect of a bifidobacteria supplemented bovine milk on intestinal permeability of preterm infants. Early Hum Dev 2007, 83:575-579. 10.1016/j.earlhumdev.2006.12.002, 17229535.
60. Lin HC, Hsu CH, Chen HL, Chung MY, Hsu JF, Lien RI, Tsao LY, Chen CH, Su BH. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics 2008, 122:693-700. 10.1542/peds.2007-3007, 18829790.
61. Samanta M, Sarkar M, Ghosh P, Ghosh J, Sinha M, Chatterjee S. Prophylactic probiotics for prevention of necrotizing enterocolitis in very low birth weight newborns. J Trop Pediatr 2009, 55:128-131.
62. Rougé C, Piloquet H, Butel MJ, Berger B, Rochat F, Ferraris L, Des Robert C, Legrand A, de la Cochetière MF, N'Guyen JM, Vodovar M, Voyer M, Darmaun D, Rozé JC. Oral supplementation with probiotics in very-low-birth-weight preterm infants: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2009, 89:1828-1835. 10.3945/ajcn.2008.26919, 19369375.
63. Claud EC. Neonatal necrotizing enterocolitis-inflammation and intestinal immaturity. Antiinflamm Antiallergy Agents Med Chem 2009, 8:248-259. 2874244, 20498729.
64. Allen SJ, Martinez EG, Gregorio GV, Dans LF. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev 2010, 11:CD003048.
65. Vissers YM, Snel J, Zuurendonk PF, Smit BA, Wichers HJ, Savelkoul HF. Differential effects of Lactobacillus acidophilus and Lactobacillus plantarum strains on cytokine induction in human peripheral blood mononuclear cells. FEMS Immunol Med Microbiol 2010, 59:60-70. 10.1111/j.1574-695X.2010.00662.x, 20337702.
66. Agrawal R, Sharma N, Chaudry R, Deorari A, Paul VK, Gewolb IH, Panigrahi P. Effects of oral lactobacillus GG on enteric microflora in low birth weight neonates. J Pediatr Gastroenterol Nutr 2003, 36:397-402. 10.1097/00005176-200303000-00019, 12604982.
67. Salminen S, Nybom S, Meriluoto J, Collado MC, Vesterlund S, El-Nezami H. Interaction of probiotics and pathogens--benefits to human health?. Curr Opin Biotechnol 2010, 21:157-167. 10.1016/j.copbio.2010.03.016, 20413293.
68. Timmerman HM, Koning CJM, Mulder L, Rombouts FM, Beynen AC. Monostrain, multistrain and multispecies probiotics - a comparison of functionality and efficacy. Int J Food Microbiol 2004, 96:219-233. 10.1016/j.ijfoodmicro.2004.05.012, 15454313.
69. Gardiner GE, Casey PG, Casey G, Lynch PB, Lawlor PG, Hill C, Fitzgerald GF, Stanton C, Ross RP. Relative ability of orally administered Lactobacillus murinus to predominate and persist in the porcine gastrointestinal tract. Appl Environ Microbiol 2004, 70:1895-1906. 10.1128/AEM.70.4.1895-1906.2004, 383152, 15066778.
70. Vinderola CG, Mocchiutti P, Reinheimer JA. Interactions among lactic acid starter and probiotic bacteria used for fermented dairy products. J Dairy Sci 2002, 85:721-729. 10.3168/jds.S0022-0302(02)74129-5, 12018416.
71. Famularo G, De Simone C, Matteuzzi D, Pirovano F. Traditional and high potency probiotic preparations for oral bacteriotherapy. Bio Drugs 1999, 12:455-470.
72. Sanders ME, Huius in't Veld JHJ. Bringing a probiotic containing functional food to the market: microbiological, product, regulatory and labelling issues. Antonie Van Leeuwenhoek 1999, 76:293-315. 10.1023/A:1002029204834, 10532385.
73. Chapman CM, Gibson GR, Rowland I. Health benefits of probiotics: are mixtures more effective than single strains?. Eur J Nutr 2011, 50:1-17. 10.1007/s00394-010-0166-z, 21229254.
74. Savage DC. Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 1977, 31:107-133. 10.1146/annurev.mi.31.100177.000543, 334036.
75. Current level of consensus on probiotic science - Report of an expert meeting - London, 23 November 2009. Accessed on April 20, 2011., http://www.isapp.net/docs/Report_of_an_expert_meeting-V7MES.pdf
76. Szajewska H, Guandalini S, Morelli L, Van Goudoever JB, Walker A. Effect of Bifidobacterium animalis subsp lactis supplementation in preterm infants: A systematic review of randomised controlled trials. J Pediatr Gastroenterol Nutr 2010, 51:203-209. 10.1097/MPG.0b013e3181dc0d93, 20543719.
77. Collado MC, Meriluoto J, Salminen S. Development of new probiotics by strain combinations: is it possible to improve the adhesion to intestinal mucus?. J Dairy Sci 2007, 90:2710-2716. 10.3168/jds.2006-456, 17517710.
78. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998, 12:807-822. 10.1046/j.1365-2036.1998.00386.x, 9768523.
79. Martin CR, Walker AW. Probiotics: role in pathophysiology and prevention in necrotizing enterocolitis. Semin Perinatol 2008, 32:127-137. 10.1053/j.semperi.2008.01.006, 18346537.
80. Galdeano CM, Perdigón G. Role of viability of probiotic strains in their persistence in the gut and in mucosal immune stimulation. J Appl Microbiol 2004, 97:673-681. 10.1111/j.1365-2672.2004.02353.x, 15357716.
81. Shah NP, Ali JF, Ravula RK. Populations of L. acidophilus, Bifidobacterium spp., and Lactobacillus casei in commercial fermented milk products. Biosci Microflora 2000, 19:35-39.
82. Sanders ME, Akkermans LM, Haller D, Hammerman C, Heimbach J, Hörmannsperger G, Huys G, Levy DD, Lutgendorff F, Mack D, Phothirath P, Solano-Aguilar G, Vaughan E. Safety assessment of probiotics for human use. Gut Microbes 2010, 1:164-185. 10.4161/gmic.1.3.12127, 3023597, 21327023.
83. Sarker SA, Fuchs GJ. The role of probiotics in treatment and prevention of infectious diarrhea. Nutrition and Health, Probiotics in Pediatric Medicine 2009, 147-165. Humana Press, Springer, Michail S, Sherman PM.
84. Patole S. Strategies for prevention of feed intolerance in preterm neonates: a systematic review. J Matern Fetal Neonatal Med 2005, 18:67-76. 10.1080/14767050500127724, 16105795.
85. Kerac M, Bunn J, Seal A, Thindwa M, Tomkins A, Sadler K, Bahwere P, Collins S. Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi. Lancet 2009, 374:136-144. 10.1016/S0140-6736(09)60884-9, 19595348.
86. Patole SK, de Klerk N. Impact of standardised feeding regimens on incidence of neonatal necrotising enterocolitis: a systematic review and meta-analysis of observational studies. Arch Dis Child Fetal Neonatal Ed 2005, 90:F147-51. 10.1136/adc.2004.059741, 1721845, 15724039.
87. Williams AF. Role of feeding in necrotising enterocolitis. Semin Neonatol 1997, 2:263-271.
88. White KC, Harkavy KL. Hypertonic formula resulting from added oral medications. Am J Dis Child 1982, 136:931-933.
89. Clark P, Robinson MJ. Thickening milk feeds may cause necrotising enterocolitis. Arch Dis Child fetal Neonatal Ed 2004, 89:F280. 1721695, 15102740.
90. Pereira-da-Silva L, Henriques G, Videira-Amaral JM, Rodrigues R, Ribeiro L, Virella D. Osmolality of solutions, emulsions and drugs that may have a high osmolality: aspects of their use in neonatal care. J Matern Fetal Neonatal Med 2002, 11:333-338.
91. Conroy ME, Shi HN, Walker WA. The long-term health effects of neonatal microbial flora. Curr Opin Allergy Clin Immunol 2009, 9:197-201. 10.1097/ACI.0b013e32832b3f1d, 19398905.
92. Leaf A, Dorling J, Kempley S, McCormick K, Mannix P, Brocklehurst P. ADEPT - Abnormal Doppler Enteral Prescription Trial. BMC Pediatr 2009, 9:63. 10.1186/1471-2431-9-63, 2770036, 19799788.
93. Goldin BR, Gorbach SL, Saxelin M, Barakat S, Gualtieri L, Salminen S. Survival of Lactobacillus species (strain GG) in human gastrointestinal tract. Dig Dis Sci 1992, 37:121-128. 10.1007/BF01308354, 1728516.
94. Boyle RJ, Robins-Browne RM, Tang ML. Probiotic use in clinical practice: what are the risks?. Am J Clin Nutr 2006, 83:1256-1264.
95. Thompson C, McCarter YS, Krause PJ, Herson VC. Lactobacillus acidophilus sepsis in a neonate. J Perinatol 2001, 21:258-260. 10.1038/sj.jp.7200509, 11533845.
96. Broughton RA, Gruber WC, Haffar AA, Baker CJ. Neonatal meningitis due to lactobacillus. Pediatr Infect Dis 1983, 2:382-384. 10.1097/00006454-198309000-00012, 6634467.
97. Perapoch J, Planes AM, Querol A, López V, Martínez-Bendayán I, Tormo R, Fernández F, Peguero G, Salcedo S. Fungemia with Saccharomyces cerevisiae in two newborns, only one of whom had been treated with ultra-levure. Eur J Clin Microbiol Infect Dis 2000, 19:468-470. 10.1007/s100960000295, 10947224.
98. Ohishi A, Takahashi S, Ito Y, Ohishi Y, Tsukamoto K, Nanba Y, Ito N, Kakiuchi S, Saitoh A, Morotomi M, Nakamura T. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr 2010, 156:679-681. 10.1016/j.jpeds.2009.11.041, 20303445.
99. Besselink MGH, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, Nieuwenhuijs VB, Bollen TL, van Ramshorst B, Witteman BJ, Rosman C, Ploeg RJ, Brink MA, Schaapherder AF, Dejong CH, Wahab PJ, van Laarhoven CJ, van der Harst E, van Eijck CH, Cuesta MA, Akkermans LM, Gooszen HG, . Dutch Acute Pancreatitis Study Group Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo controlled trial. Lancet 2008, 371:651-659. 10.1016/S0140-6736(08)60207-X, 18279948, Dutch Acute Pancreatitis Study Group.
100. Chatterjee S, Fraser J. Probiotics: sorting the evidence from the myths. MJA 2008, 189:182.
101. Besselink MG, van Santvoort HC, Renooij W, de Smet MB, Boermeester MA, Fischer K, Timmerman HM, Ahmed Ali U, Cirkel GA, Bollen TL, van Ramshorst B, Schaapherder AF, Witteman BJ, Ploeg RJ, van Goor H, van Laarhoven CJ, Tan AC, Brink MA, van der Harst E, Wahab PJ, van Eijck CH, Dejong CH, van Erpecum KJ, Akkermans LM, Gooszen HG, . Dutch Acute Pancreatitis Study Group Intestinal barrier dysfunction in a randomized trial of a specific probiotic composition in acute pancreatitis. Dutch Acute Pancreatitis Study Group. Ann Surg 2009, 250:712-719. 10.1097/SLA.0b013e3181bce5bd, 19801929, Dutch Acute Pancreatitis Study Group.
102. Srinivasjois R, Rao S, Patole S. Prebiotic supplementation of formula in preterm neonates: a systematic review and meta-analysis of randomised controlled trials. Clin Nutr 2009, 28:237-242. 10.1016/j.clnu.2009.03.008, 19359074.
103. Salminen MK, Rautelin H, Tynkkynen S, Poussa T, Saxelin M, Valtonen V, Järvinen A. Lactobacillus bacteremia, clinical significance, and patient outcome, with special focus on probiotic L. rhamnosus GG. Clin Infect Dis 2004, 38:62-69. 10.1086/380455, 14679449.
104. Kunz AN, Noel JM, Firchok MP. Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr 2004, 38:457-458. 10.1097/00005176-200404000-00017, 15085028.
105. Land MH, Rouster-Stevens K, Woods CHR, Cannon ML, Cnota J, Shetty AK. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005, 115:178-181.
106. Mahlen SD, Clarridge JE. Site and clinical significance of Alloscardovia omnicolens and Bifidobacterium species isolated in the clinical laboratory. J Clin Microbiol 2009, 47:3289-3293. 10.1128/JCM.00555-09, 2756926, 19641056.
107. Syndman DR. The safety of probiotics. Clin Infect Dis 2008, 46:S104-S111. 10.1086/523331, 18181712.
108. Costeloe K. PiPS: trial of probiotic administered early to prevent infection and necrotising enterocolitis protocol--version. 3.1. Accessed October 20, 2010., http://www.hta.ac.uk/protocols/200505010004.pdf
109. Mayrhofer S, Domig KJ, Mair C, Zitz U, Huys G, Kneifel W. Comparison of broth microdilution, etest, and agar disk diffusion methods for antimicrobial susceptibility testing of Lactobacillus acidophilus group members. Appl Environ Microbiol 2008, 74:3745-3748. 10.1128/AEM.02849-07, 2446536, 18441109.
110. Huys G, D'Haene K, Cnockaert M, Tosi L, Danielsen M, Flórez AB, Mättö J, Axelsson L, Korhonen J, Mayrhofer S, Egervärn M, Giacomini M, Vandamme P. Intra- and Interlaboratory performance of two commercial antimicrobial susceptibility testing methods for bifidobacteria and non-enterococcal lactic acid bacteria. Antimicrob Agents Chemother 2010, 54:2567-2574. 10.1128/AAC.00407-10, 2876413, 20385863.
111. Masco L, Huys G, De Brandt E, Temmerman R, Swings J. Culture-dependent and culture-independent qualitative analysis of probiotic products claimed to contain bifidobacteria. Int J Food Microbiol 2005, 102:221-230. 10.1016/j.ijfoodmicro.2004.11.018, 15992621.
112. Tuomola E, Crittenden R, Playne M, Isolauri E, Salminen S. Quality assurance criteria for probiotic bacteria. Am J Clin Nutr 2001, 73(Suppl 2):S393S-S398.
113. Clancy RL, Pang G. Probiotics--industry myth or a practical reality?. J Am Coll Nutr 2007, 26:S691S-S694.
114. Grzeskowiak L, Isolauri E, Salminen S, Gueimonde M. Manufacturing process influences properties of probiotic bacteria. Br J Nutr 2011, 105:887-894. 10.1017/S0007114510004496, 21059281.
115. Lo KH. Dietary supplements - are they dangerous?. accessed on 20/04/2011., http://www.buzzle.com/articles/dietary-supplements-dangerous.html
116. Green A. How do you choose a good probiotic?. accessed on 20/04/2011., http://www.protexin.com/userfiles/file/how_do_you_choose_a_good_probiotic__aileen_green_final_lowres.pdf
117. Patole S, Deshpande G, Abernethy G, Conway P, Keil T, Simmer K. Selecting a probiotic product for preterm neonates: A note of caution. J Pediatr Child Health 2010, 46(S1):64-65.
118. Awad H, Mokhtar H, Imam SS, Gad GI, Hafez H, Aboushady N. Comparison between killed and living probiotic usage versus placebo for the prevention of necrotizing enterocolitis and sepsis in neonates. Pak J Biol Sci 2010, 13:253-262.
119. Adams CA. The probiotic paradox: live and dead cells are biological response modifiers. Nutr Res Rev 2010, 23:37-46. 10.1017/S0954422410000090, 20403231.
120. Kataria J, Li N, Wynn JL, Neu J. Probiotic microbes: do they need to be alive to be beneficial?. Nutr Rev 2009, 67:546-550. 10.1111/j.1753-4887.2009.00226.x, 19703261.
121. Olivares M, Díaz-Ropero MP, Martín R, Rodríguez JM, Xaus J. Antimicrobial potential of four Lactobacillus strains isolated from breast milk. J Appl Microbiol 2006, 101:72-79. 10.1111/j.1365-2672.2006.02981.x, 16834593.
122. Boehm G. Oligosacharides in milk. J Nutr 2007, 137(Suppl 3):S847-S849.
123. Su P, Henriksson A, Mitchell H. Prebiotics enhance survival and prolong the retention period of specific probiotic inocula in an in vivo murine model. J Appl Microbiol 2007, 103:2392-2400. 10.1111/j.1365-2672.2007.03469.x, 18045424.
124. Panigrahi P, Parida S, Pradhan L, Mohapatra SS, Misra PR, Johnson JA, Chaudhry R, Taylor S, Hansen NI, Gewolb IH. Long-term colonization of a Lactobacillus plantarum synbiotic preparation in the neonatal gut. J Pediatr Gastroenterol Nutr 2008, 47:45-53. 10.1097/MPG.0b013e31815a5f2c, 18607268.
125. Gueimonde M, Kalliomäki M, Isolauri E, Salminen S. Probiotic intervention in neonates--will permanent colonization ensue?. J Pediatr Gastroenterol Nutr 2006, 42:604-606. 10.1097/01.mpg.0000221897.45910.d3, 16707993.
126. Canganella F, Paganani S, Ovidi M, Vettraino AM, Bevilacqua L, Massa S, Trovatelli LD. A microbiological investigation on probiotic pharmaceutical products used for human health. Microbiol Res 1997, 152:171-179.
127. Drago L, Rodighiero V, Celeste T, Rovetto L, DE Vecchi E. Microbiological evaluation of commercial probiotic products available in the USA in 2009. J Chemother 2011, 22:373-377.
128. Mattia A, Merker R. Regulation of probiotic substances as ingredients in foods: premarket approval or "generally recognized as safe" notification. Clin Infect Dis 2008, 46(Suppl 2):S115-S118. Discussion: S144-151.
129. Hoffman FA. Development of probiotics as biologic drugs. Clin Infect Dis 2008, 46(Suppl 2):S125-S127. Discussion: 144-151.
130. Degnan FH. The US Food and Drug Administration and probiotics: regulatory categorization. Clin Infect Dis 2008, 46(Suppl 2):S133-S136. Discussion: S144-S151.
131. Hibberd PL, Davidson L. Probiotic foods and drugs: impact of US regulatory status on design of clinical trials. Clin Infect Dis 2008, 46(Suppl 2):S137-140. Discussion: S144-151.
132. Henriksson A, Borody T, Clancy R. Probiotics under the regulatory microscope. Expert Opin Drug Saf 2005, 4:1135-1143. 10.1517/14740338.4.6.1135, 16255670.
133. Amagase H. Current marketplace for probiotics: a Japanese perspective. Clin Infect Dis 2008, 46(Suppl 2):S73-S75. Discussion: S144-S151.
134. Tamayo C. Clinical research on probiotics: the interface between science and regulation. Clin Infect Dis 2008, 46(Suppl 2):S101-S103.
135. Gewolb IH, Schwalbe RS, Taciak VL, Harrison TS, Panigrahi P. Stool microflora in ELBW infants. Archives Fetal Neonatal Ed 1999, 80:F167-F173.
136. Saiman L. Strategies for prevention of nosocomial sepsis in the neonatal intensive care unit. Current Opinion in Pediatrics 2006, 18:101-106. 10.1097/01.mop.0000193300.25141.c5, 16601486.
137. Patole S, de Clerk N. Impact of standardised feeding regimen on incidence of neonatal necrotising enterocolitis - a systematic review and meta analysis of observational studies. Arch Dis Child Fetal Neonatal Ed 2005, 90:F147-151. 10.1136/adc.2004.059741, 1721845, 15724039.
138. Premji S. Standardised feeding regimens-hope for reducing the risk of necrotising enterocolitis. Arch Dis Child Fetal Neonatal Ed 2005, 90:F192-193. 10.1136/adc.2004.063198, 1721883, 15846005.
139. Christensen RD, Gordon PV, Besner GE. Can we cut the incidence of necrotising enterocolitis in half-today?. Fetal and Pediatr Pathol 2010, 29:185-198.
140. Indrio F, Riezzo G, Raimondi F, Bisceglia M, Cavallo L, Francavilla R. Effect of probiotic and prebiotic on gastrointestinal motility in newborns. J Physiol Pharmacol 2009, 60(Suppl 6):S27-S31.
141. Indrio F, Riezzo G, Raimondi F, Francavilla R, Montagna O, Valenzano ML, Cavallo L, Boehm G. Prebiotics improve gastric motility and gastric electrical activity in preterm newborns. J Pediatr Gastroenterol Nutr 2009, 49:258-261. 10.1097/MPG.0b013e3181926aec, 19561548.
142. Indrio F, Riezzo G, Raimondi F, Bisceglia M, Cavallo L, Francavilla R. The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns. J Pediatr 2008, 152:801-806. 10.1016/j.jpeds.2007.11.005, 18492520.
143. Lara-Villoslada F, Olivares M, Sierra S, Rodríguez JM, Boza J, Xaus J. Beneficial effects of probiotic bacteria isolated from breast milk. Br J Nutr 2007, 98(Suppl 1):S96-S100.
144. Bertino E, Coppa GV, Giuliani F, Coscia A, Gabrielli O, Sabatino G, Sgarrella M, Testa T, Zampini L, Fabris C. Effects of Holder pasteurization on human milk oligosaccharides. Int J Immunopathol Pharmacol 2008, 21:381-385.
145. Hammerman C, Bin-Nun A, Kaplan M. Safety of probiotics: comparison of two popular strains. BMJ 2006, 333:1006-1008. 10.1136/bmj.39010.630799.BE, 1635619, 17095783.
146. Guidelines for the Evaluation of Probiotics in Food Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food London Ontario, Canada April 30 and May 1, 2002. Accessed on April 25, 2011., http://www.who.int/foodsafety/fs_management/en/probiotic guidelines.pdf
147. Kataria J, Li N, Wynn JL, Neu J. Probiotic microbes: do they need to be alive to be beneficial?. Nutr Rev 2009, 67:546-550. 10.1111/j.1753-4887.2009.00226.x, 19703261.
148. Tao Y, Drabik KA, Waypa TS, Musch MW, Alverdy JC, Schneewind O, Chang EB, Petrof EO. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol 2006, 290:C1018-C1030.
149. Kelly P, Maguire PB, Bennett M, Fitzgerald DJ, Edwards RJ, Thiede B, Treumann A, Collins JK, O Sullivan GC, Shanahan F, Dunne C. Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome. FEMS Microbiology Letters 2005, 252:153-159. 10.1016/j.femsle.2005.08.051, 16214296.
150. Mogna G, Strozzi GP, Mogna L. Allergen-free probiotics. J Clin Gastroenterol 2008, 42(Suppl 3 Pt 2):S201-S204.
151. Ananta E. Impact of environmental factors on viability and stability and high pressure pretreatment on stress tolerance of Lactobacillus rhamnosus GG (ATCC 53103) during spray drying. accessed on April 20, 2011., http://deposit.ddb.de/cgibin/dokserv?idn=976924277&dok_var=d1&dok_ext=pdf&filename=976924277.pdf
152. Danish National Guideline: probiotics for preterm GA 30 weeks [in Danish]. Accessed October 20, 2010., http://www.rh-vejledninger.dk/C1256FF60 028FE3A/0/FADF649DDFCAFF2FC12576AB0030868D? OpenDocument&Highlight_2
153. Kuzma-O'Reilly B, Duenas ML, Greecher C, Kimberlin L, Mujsce D, Miller D, Walker DJ. Evaluation, development, and implementation of potentially better practices in neonatal intensive care nutrition. Pediatrics 2003, 111:e461-e470. 10.1542/peds.111.3.461, 12671166.
154. Schmolzer G, Urlesberger B, Haim M, Kutschera J, Pichler G, Ritschl E, Resch B, Reiterer F, Müller W. Multi-modal approach to prophylaxis of necrotizing enterocolitis: clinical report and review of literature. Pediatr Surg Int 2006, 22:573-580. 10.1007/s00383-006-1709-5, 16775708.