-
1
-
-
73349094086
-
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
-
doi: 10.1056/NEJMoa0908492
-
Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, Chiu J, et al. (2009) Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 361: 2209-2220. doi:10.1056/NEJMoa0908492. PubMed: 19843557.
-
(2009)
N Engl J Med
, vol.361
, pp. 2209-2220
-
-
Rerks-Ngarm, S.1
Pitisuttithum, P.2
Nitayaphan, S.3
Kaewkungwal, J.4
Chiu, J.5
-
2
-
-
79958226287
-
MVA and NYVAC as vaccines against emergent infectious diseases and cancer
-
doi: 10.2174/156652311795684731
-
Gómez CE, Nájera JL, Krupa M, Perdiguero B, Esteban M, (2011) MVA and NYVAC as vaccines against emergent infectious diseases and cancer. Curr Gene Ther 11: 189-217. doi:10.2174/156652311795684731. PubMed: 21453284.
-
(2011)
Curr Gene Ther
, vol.11
, pp. 189-217
-
-
Gómez, C.E.1
Nájera, J.L.2
Krupa, M.3
Perdiguero, B.4
Esteban, M.5
-
3
-
-
0026669995
-
Highly attenuated poxvirus vectors
-
doi: 1466978
-
Tartaglia J, Cox WI, Taylor J, Perkus M, Riviere M, et al. (1992) Highly attenuated poxvirus vectors. AIDS Res Hum Retroviruses 8: 1445-1447. PubMed: 1466978.
-
(1992)
AIDS Res Hum Retroviruses
, vol.8
, pp. 1445-1447
-
-
Tartaglia, J.1
Cox, W.I.2
Taylor, J.3
Perkus, M.4
Riviere, M.5
-
4
-
-
79955551576
-
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
-
doi: 10.1073/pnas.1103869108
-
Flynn BJ, Kastenmüller K, Wille-Reece U, Tomaras GD, Alam M, et al. (2011) Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates. Proc Natl Acad Sci U S A 108: 7131-7136. doi:10.1073/pnas.1103869108. PubMed: 21467219.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 7131-7136
-
-
Flynn, B.J.1
Kastenmüller, K.2
Wille-Reece, U.3
Tomaras, G.D.4
Alam, M.5
-
5
-
-
0029957222
-
Applications of pox virus vectors to vaccination: an update
-
doi: 10.1073/pnas.93.21.11349
-
Paoletti E, (1996) Applications of pox virus vectors to vaccination: an update. Proc Natl Acad Sci U S A 93: 11349-11353. doi:10.1073/pnas.93.21.11349. PubMed: 8876138.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 11349-11353
-
-
Paoletti, E.1
-
6
-
-
0029156806
-
Poxvirus-based vaccine candidates for cancer, AIDS, and other infectious diseases
-
doi: 7616101
-
Perkus ME, Tartaglia J, Paoletti E, (1995) Poxvirus-based vaccine candidates for cancer, AIDS, and other infectious diseases. J Leukoc Biol 58: 1-13. PubMed: 7616101.
-
(1995)
J Leukoc Biol
, vol.58
, pp. 1-13
-
-
Perkus, M.E.1
Tartaglia, J.2
Paoletti, E.3
-
7
-
-
65649141586
-
Pathogen recognition in the innate immune response
-
doi: 10.1042/BJ20090272
-
Kumar H, Kawai T, Akira S, (2009) Pathogen recognition in the innate immune response. Biochem J 420: 1-16. doi:10.1042/BJ20090272. PubMed: 19382893.
-
(2009)
Biochem J
, vol.420
, pp. 1-16
-
-
Kumar, H.1
Kawai, T.2
Akira, S.3
-
8
-
-
32944464648
-
Pathogen recognition and innate immunity
-
doi: 10.1016/j.cell.2006.02.015
-
Akira S, Uematsu S, Takeuchi O, (2006) Pathogen recognition and innate immunity. Cell 124: 783-801. doi:10.1016/j.cell.2006.02.015. PubMed: 16497588.
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
9
-
-
70349260534
-
The interferon system and vaccinia virus evasion mechanisms
-
doi: 10.1089/jir.2009.0073
-
Perdiguero B, Esteban M, (2009) The interferon system and vaccinia virus evasion mechanisms. J Interferon Cytokine Res 29: 581-598. doi:10.1089/jir.2009.0073. PubMed: 19708815.
-
(2009)
J Interferon Cytokine Res
, vol.29
, pp. 581-598
-
-
Perdiguero, B.1
Esteban, M.2
-
10
-
-
81355146737
-
Cytosolic DNA sensors regulating type I interferon induction
-
doi: 10.1016/j.it.2011.08.004
-
Keating SE, Baran M, Bowie AG, (2011) Cytosolic DNA sensors regulating type I interferon induction. Trends Immunol 32: 574-581. doi:10.1016/j.it.2011.08.004. PubMed: 21940216.
-
(2011)
Trends Immunol
, vol.32
, pp. 574-581
-
-
Keating, S.E.1
Baran, M.2
Bowie, A.G.3
-
11
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
-
doi: 10.1038/ni.1863
-
Kawai T, Akira S, (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384. doi:10.1038/ni.1863. PubMed: 20404851.
-
(2010)
Nat Immunol
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
12
-
-
56549116047
-
Toll-like receptor and RIG-I-like receptor signaling
-
doi: 10.1196/annals.1443.020
-
Kawai T, Akira S, (2008) Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci 1143: 1-20. doi:10.1196/annals.1443.020. PubMed: 19076341.
-
(2008)
Ann N Y Acad Sci
, vol.1143
, pp. 1-20
-
-
Kawai, T.1
Akira, S.2
-
13
-
-
16844379118
-
The role of Toll-like receptors in the host response to viruses
-
doi: 10.1016/j.molimm.2004.11.007
-
Bowie AG, Haga IR, (2005) The role of Toll-like receptors in the host response to viruses. Mol Immunol 42: 859-867. doi:10.1016/j.molimm.2004.11.007. PubMed: 15829275.
-
(2005)
Mol Immunol
, vol.42
, pp. 859-867
-
-
Bowie, A.G.1
Haga, I.R.2
-
14
-
-
79959634861
-
Pattern recognition receptors and the innate immune response to viral infection
-
doi: 10.3390/v3060920
-
Thompson MR, Kaminski JJ, Kurt-Jones EA, Fitzgerald KA, (2011) Pattern recognition receptors and the innate immune response to viral infection. Viruses 3: 920-940. doi:10.3390/v3060920. PubMed: 21994762.
-
(2011)
Viruses
, vol.3
, pp. 920-940
-
-
Thompson, M.R.1
Kaminski, J.J.2
Kurt-Jones, E.A.3
Fitzgerald, K.A.4
-
15
-
-
70350441863
-
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
-
doi: 10.1038/ni.1792
-
Barbalat R, Lau L, Locksley RM, Barton GM, (2009) Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol 10: 1200-1207. doi:10.1038/ni.1792. PubMed: 19801985.
-
(2009)
Nat Immunol
, vol.10
, pp. 1200-1207
-
-
Barbalat, R.1
Lau, L.2
Locksley, R.M.3
Barton, G.M.4
-
16
-
-
63849167957
-
A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection
-
doi: 10.1182/blood-2008-03-148809
-
Quigley M, Martinez J, Huang X, Yang Y, (2009) A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood 113: 2256-2264. doi:10.1182/blood-2008-03-148809. PubMed: 18948575.
-
(2009)
Blood
, vol.113
, pp. 2256-2264
-
-
Quigley, M.1
Martinez, J.2
Huang, X.3
Yang, Y.4
-
17
-
-
33846232145
-
Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta
-
doi: 10.1182/blood-2006-06-027136
-
Zhu J, Martinez J, Huang X, Yang Y, (2007) Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta. Blood 109: 619-625. doi:10.1182/blood-2006-06-027136. PubMed: 16973959.
-
(2007)
Blood
, vol.109
, pp. 619-625
-
-
Zhu, J.1
Martinez, J.2
Huang, X.3
Yang, Y.4
-
18
-
-
53049104310
-
Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection
-
doi: 18802464
-
Hutchens MA, Luker KE, Sonstein J, Núñez G, Curtis JL, et al. (2008) Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection. PLOS Pathog 4: e1000153. PubMed: 18802464.
-
(2008)
PLOS Pathog
, vol.4
-
-
Hutchens, M.A.1
Luker, K.E.2
Sonstein, J.3
Núñez, G.4
Curtis, J.L.5
-
19
-
-
79952100792
-
What the Myddosome structure tells us about the initiation of innate immunity
-
doi: 10.1016/j.it.2010.12.005
-
Gay NJ, Gangloff M, O'Neill LA, (2011) What the Myddosome structure tells us about the initiation of innate immunity. Trends Immunol 32: 104-109. doi:10.1016/j.it.2010.12.005. PubMed: 21269878.
-
(2011)
Trends Immunol
, vol.32
, pp. 104-109
-
-
Gay, N.J.1
Gangloff, M.2
O'Neill, L.A.3
-
20
-
-
73949133993
-
The molecular basis of the host response to lipopolysaccharide
-
doi: 19946286
-
Bryant CE, Spring DR, Gangloff M, Gay NJ, (2010) The molecular basis of the host response to lipopolysaccharide. Nat Rev Microbiol 8: 8-14. PubMed: 19946286.
-
(2010)
Nat Rev Microbiol
, vol.8
, pp. 8-14
-
-
Bryant, C.E.1
Spring, D.R.2
Gangloff, M.3
Gay, N.J.4
-
21
-
-
48749128643
-
Structures of the toll-like receptor family and its ligand complexes
-
doi: 10.1016/j.immuni.2008.07.007
-
Jin MS, Lee JO, (2008) Structures of the toll-like receptor family and its ligand complexes. Immunity 29: 182-191. doi:10.1016/j.immuni.2008.07.007. PubMed: 18701082.
-
(2008)
Immunity
, vol.29
, pp. 182-191
-
-
Jin, M.S.1
Lee, J.O.2
-
22
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
doi: 10.1038/nri2079
-
O'Neill LA, Bowie AG, (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7: 353-364. doi:10.1038/nri2079. PubMed: 17457343.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.1
Bowie, A.G.2
-
23
-
-
0036448929
-
MyD88 as a bottle neck in Toll/IL-1 signaling
-
doi: 10.1007/978-3-642-59430-4_10
-
Takeuchi O, Akira S, (2002) MyD88 as a bottle neck in Toll/IL-1 signaling. Curr Top Microbiol Immunol 270: 155-167. doi:10.1007/978-3-642-59430-4_10. PubMed: 12467250.
-
(2002)
Curr Top Microbiol Immunol
, vol.270
, pp. 155-167
-
-
Takeuchi, O.1
Akira, S.2
-
24
-
-
34548418935
-
Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response
-
doi: 10.1038/sj.icb.7100100
-
Thompson AJ, Locarnini SA, (2007) Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response. Immunol Cell Biol 85: 435-445. doi:10.1038/sj.icb.7100100. PubMed: 17667934.
-
(2007)
Immunol Cell Biol
, vol.85
, pp. 435-445
-
-
Thompson, A.J.1
Locarnini, S.A.2
-
25
-
-
0034597766
-
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
-
doi: 10.1038/35040600
-
Xu Y, Tao X, Shen B, Horng T, Medzhitov R, et al. (2000) Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408: 111-115. doi:10.1038/35040600. PubMed: 11081518.
-
(2000)
Nature
, vol.408
, pp. 111-115
-
-
Xu, Y.1
Tao, X.2
Shen, B.3
Horng, T.4
Medzhitov, R.5
-
26
-
-
45549086115
-
The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer
-
doi: 10.1074/jbc.C800001200
-
Nyman T, Stenmark P, Flodin S, Johansson I, Hammarström M, et al. (2008) The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. J Biol Chem 283: 11861-11865. doi:10.1074/jbc.C800001200. PubMed: 18332149.
-
(2008)
J Biol Chem
, vol.283
, pp. 11861-11865
-
-
Nyman, T.1
Stenmark, P.2
Flodin, S.3
Johansson, I.4
Hammarström, M.5
-
27
-
-
3843055773
-
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL
-
doi: 10.1074/jbc.M403434200
-
Khan JA, Brint EK, O'Neill LA, Tong L, (2004) Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. J Biol Chem 279: 31664-31670. doi:10.1074/jbc.M403434200. PubMed: 15123616.
-
(2004)
J Biol Chem
, vol.279
, pp. 31664-31670
-
-
Khan, J.A.1
Brint, E.K.2
O'Neill, L.A.3
Tong, L.4
-
28
-
-
84859227566
-
Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling
-
doi: 10.1371/journal.pone.0034202
-
Lin Z, Lu J, Zhou W, Shen Y, (2012) Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling. PLOS ONE 7: e34202. doi:10.1371/journal.pone.0034202. PubMed: 22485159.
-
(2012)
PLOS ONE
, vol.7
-
-
Lin, Z.1
Lu, J.2
Zhou, W.3
Shen, Y.4
-
29
-
-
80052578340
-
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
-
doi: 10.1073/pnas.1104780108
-
Valkov E, Stamp A, Dimaio F, Baker D, Verstak B, et al. (2011) Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci U S A 108: 14879-14884. doi:10.1073/pnas.1104780108. PubMed: 21873236.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 14879-14884
-
-
Valkov, E.1
Stamp, A.2
Dimaio, F.3
Baker, D.4
Verstak, B.5
-
30
-
-
67649865588
-
Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
-
doi: 10.1073/pnas.0812956106
-
Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, et al. (2009) Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. Proc Natl Acad Sci U S A 106: 10260-10265. doi:10.1073/pnas.0812956106. PubMed: 19506249.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 10260-10265
-
-
Ohnishi, H.1
Tochio, H.2
Kato, Z.3
Orii, K.E.4
Li, A.5
-
31
-
-
16744364738
-
Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88
-
doi: 10.1074/jbc.M301742200
-
Dunne A, Ejdeback M, Ludidi PL, O'Neill LA, Gay NJ, (2003) Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88. J Biol Chem 278: 41443-41451. doi:10.1074/jbc.M301742200. PubMed: 12888566.
-
(2003)
J Biol Chem
, vol.278
, pp. 41443-41451
-
-
Dunne, A.1
Ejdeback, M.2
Ludidi, P.L.3
O'Neill, L.A.4
Gay, N.J.5
-
32
-
-
40749097627
-
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
-
doi: 10.1371/journal.pone.0000788
-
Núñez Miguel R, Wong J, Westoll JF, Brooks HJ, O'Neill LA, et al. (2007) A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLOS ONE 2: e788. doi:10.1371/journal.pone.0000788. PubMed: 17726518.
-
(2007)
PLOS ONE
, vol.2
-
-
Núñez Miguel, R.1
Wong, J.2
Westoll, J.F.3
Brooks, H.J.4
O'Neill, L.A.5
-
33
-
-
34548415806
-
Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound
-
doi: 10.1189/jlb.1206746
-
Loiarro M, Capolunghi F, Fantò N, Gallo G, Campo S, et al. (2007) Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound. J Leukoc Biol 82: 801-810. doi:10.1189/jlb.1206746. PubMed: 17548806.
-
(2007)
J Leukoc Biol
, vol.82
, pp. 801-810
-
-
Loiarro, M.1
Capolunghi, F.2
Fantò, N.3
Gallo, G.4
Campo, S.5
-
34
-
-
18144362027
-
Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B
-
doi: 10.1074/jbc.C400613200
-
Loiarro M, Sette C, Gallo G, Ciacci A, Fantò N, et al. (2005) Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B. J Biol Chem 280: 15809-15814. doi:10.1074/jbc.C400613200. PubMed: 15755740.
-
(2005)
J Biol Chem
, vol.280
, pp. 15809-15814
-
-
Loiarro, M.1
Sette, C.2
Gallo, G.3
Ciacci, A.4
Fantò, N.5
-
35
-
-
33746631265
-
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis
-
doi: 10.1073/pnas.0603804103
-
Jiang Z, Georgel P, Li C, Choe J, Crozat K, et al. (2006) Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci U S A 103: 10961-10966. doi:10.1073/pnas.0603804103. PubMed: 16832055.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 10961-10966
-
-
Jiang, Z.1
Georgel, P.2
Li, C.3
Choe, J.4
Crozat, K.5
-
36
-
-
56749133272
-
Viral evasion and subversion of pattern-recognition receptor signalling
-
doi: 10.1038/nri2436
-
Bowie AG, Unterholzner L, (2008) Viral evasion and subversion of pattern-recognition receptor signalling. Nat Rev Immunol 8: 911-922. doi:10.1038/nri2436. PubMed: 18989317.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 911-922
-
-
Bowie, A.G.1
Unterholzner, L.2
-
37
-
-
17144366260
-
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
-
doi: 10.1084/jem.20041442
-
Stack J, Haga IR, Schröder M, Bartlett NW, Maloney G, et al. (2005) Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J Exp Med 201: 1007-1018. doi:10.1084/jem.20041442. PubMed: 15767367.
-
(2005)
J Exp Med
, vol.201
, pp. 1007-1018
-
-
Stack, J.1
Haga, I.R.2
Schröder, M.3
Bartlett, N.W.4
Maloney, G.5
-
38
-
-
0037415598
-
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense
-
doi: 10.1084/jem.20021652
-
Harte MT, Haga IR, Maloney G, Gray P, Reading PC, et al. (2003) The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J Exp Med 197: 343-351. doi:10.1084/jem.20021652. PubMed: 12566418.
-
(2003)
J Exp Med
, vol.197
, pp. 343-351
-
-
Harte, M.T.1
Haga, I.R.2
Maloney, G.3
Gray, P.4
Reading, P.C.5
-
39
-
-
4344600796
-
Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors
-
doi: 10.1074/jbc.M400567200
-
DiPerna G, Stack J, Bowie AG, Boyd A, Kotwal G, et al. (2004) Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors. J Biol Chem 279: 36570-36578. doi:10.1074/jbc.M400567200. PubMed: 15215253.
-
(2004)
J Biol Chem
, vol.279
, pp. 36570-36578
-
-
DiPerna, G.1
Stack, J.2
Bowie, A.G.3
Boyd, A.4
Kotwal, G.5
-
40
-
-
40349085775
-
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14
-
doi: 10.1371/journal.ppat.0040022
-
Chen RA, Ryzhakov G, Cooray S, Randow F, Smith GL, (2008) Inhibition of IkappaB kinase by vaccinia virus virulence factor B14. PLOS Pathog 4: e22. doi:10.1371/journal.ppat.0040022. PubMed: 18266467.
-
(2008)
PLOS Pathog
, vol.4
-
-
Chen, R.A.1
Ryzhakov, G.2
Cooray, S.3
Randow, F.4
Smith, G.L.5
-
41
-
-
49149113373
-
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation
-
doi: 10.1038/emboj.2008.143
-
Schröder M, Baran M, Bowie AG, (2008) Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation. EMBO J 27: 2147-2157. doi:10.1038/emboj.2008.143. PubMed: 18636090.
-
(2008)
EMBO J
, vol.27
, pp. 2147-2157
-
-
Schröder, M.1
Baran, M.2
Bowie, A.G.3
-
42
-
-
80053455599
-
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7
-
doi: 21931555
-
Unterholzner L, Sumner RP, Baran M, Ren H, Mansur DS, et al. (2011) Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. PLOS Pathog 7: e1002247. PubMed: 21931555.
-
(2011)
PLOS Pathog
, vol.7
-
-
Unterholzner, L.1
Sumner, R.P.2
Baran, M.3
Ren, H.4
Mansur, D.S.5
-
43
-
-
0034730146
-
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
-
doi: 10.1073/pnas.160027697
-
Bowie A, Kiss-Toth E, Symons JA, Smith GL, Dower SK, et al. (2000) A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc Natl Acad Sci U S A 97: 10162-10167. doi:10.1073/pnas.160027697. PubMed: 10920188.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10162-10167
-
-
Bowie, A.1
Kiss-Toth, E.2
Symons, J.A.3
Smith, G.L.4
Dower, S.K.5
-
44
-
-
77958127248
-
Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule
-
doi: 10.4049/jimmunol.1002013
-
Lysakova-Devine T, Keogh B, Harrington B, Nagpal K, Halle A, et al. (2010) Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule. J Immunol 185: 4261-4271. doi:10.4049/jimmunol.1002013. PubMed: 20802145.
-
(2010)
J Immunol
, vol.185
, pp. 4261-4271
-
-
Lysakova-Devine, T.1
Keogh, B.2
Harrington, B.3
Nagpal, K.4
Halle, A.5
-
45
-
-
80051922422
-
Poxvirus A46 protein binds to TIR domain-containing Mal/TIRAP via an α-helical sub-domain
-
doi: 10.1016/j.molimm.2011.07.014
-
Oda S, Franklin E, Khan AR, (2011) Poxvirus A46 protein binds to TIR domain-containing Mal/TIRAP via an α-helical sub-domain. Mol Immunol 48: 2144-2150. doi:10.1016/j.molimm.2011.07.014. PubMed: 21831443.
-
(2011)
Mol Immunol
, vol.48
, pp. 2144-2150
-
-
Oda, S.1
Franklin, E.2
Khan, A.R.3
-
46
-
-
84863324227
-
Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions
-
doi: 10.1074/jbc.M112.349225
-
Stack J, Bowie AG, (2012) Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions. J Biol Chem 287: 22672-22682. doi:10.1074/jbc.M112.349225. PubMed: 22593572.
-
(2012)
J Biol Chem
, vol.287
, pp. 22672-22682
-
-
Stack, J.1
Bowie, A.G.2
-
47
-
-
67650915065
-
Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome
-
doi: 19543380
-
Delaloye J, Roger T, Steiner-Tardivel QG, Le Roy D, Knaup Reymond M, et al. (2009) Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLOS Pathog 5: e1000480. PubMed: 19543380.
-
(2009)
PLOS Pathog
, vol.5
-
-
Delaloye, J.1
Roger, T.2
Steiner-Tardivel, Q.G.3
Le Roy, D.4
Knaup Reymond, M.5
-
48
-
-
33846876318
-
Generation and immunogenicity of novel HIV/AIDS vaccine candidates targeting HIV-1 Env/Gag-Pol-Nef antigens of clade C
-
doi: 10.1016/j.vaccine.2006.11.051
-
Gómez CE, Nájera JL, Jiménez V, Bieler K, Wild J, et al. (2007) Generation and immunogenicity of novel HIV/AIDS vaccine candidates targeting HIV-1 Env/Gag-Pol-Nef antigens of clade C. Vaccine 25: 1969-1992. doi:10.1016/j.vaccine.2006.11.051. PubMed: 17224219.
-
(2007)
Vaccine
, vol.25
, pp. 1969-1992
-
-
Gómez, C.E.1
Nájera, J.L.2
Jiménez, V.3
Bieler, K.4
Wild, J.5
-
49
-
-
33947151927
-
Head-to-head comparison on the immunogenicity of two HIV/AIDS vaccine candidates based on the attenuated poxvirus strains MVA and NYVAC co-expressing in a single locus the HIV-1BX08 gp120 and HIV-1(IIIB) Gag-Pol-Nef proteins of clade B
-
doi: 10.1016/j.vaccine.2006.09.090
-
Gómez CE, Nájera JL, Jiménez EP, Jiménez V, Wagner R, et al. (2007) Head-to-head comparison on the immunogenicity of two HIV/AIDS vaccine candidates based on the attenuated poxvirus strains MVA and NYVAC co-expressing in a single locus the HIV-1BX08 gp120 and HIV-1(IIIB) Gag-Pol-Nef proteins of clade B. Vaccine 25: 2863-2885. doi:10.1016/j.vaccine.2006.09.090. PubMed: 17113200.
-
(2007)
Vaccine
, vol.25
, pp. 2863-2885
-
-
Gómez, C.E.1
Nájera, J.L.2
Jiménez, E.P.3
Jiménez, V.4
Wagner, R.5
-
50
-
-
37549023073
-
Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells
-
doi: 10.1089/aid.2007.0165
-
Robinson HL, Sharma S, Zhao J, Kannanganat S, Lai L, et al. (2007) Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells. AIDS Res Hum Retroviruses 23: 1555-1562. doi:10.1089/aid.2007.0165. PubMed: 18160013.
-
(2007)
AIDS Res Hum Retroviruses
, vol.23
, pp. 1555-1562
-
-
Robinson, H.L.1
Sharma, S.2
Zhao, J.3
Kannanganat, S.4
Lai, L.5
-
51
-
-
25444461647
-
Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L
-
doi: 16177116
-
Bachmann MF, Wolint P, Schwarz K, Jäger P, Oxenius A, (2005) Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L. J Immunol 175: 4686-4696. PubMed: 16177116.
-
(2005)
J Immunol
, vol.175
, pp. 4686-4696
-
-
Bachmann, M.F.1
Wolint, P.2
Schwarz, K.3
Jäger, P.4
Oxenius, A.5
-
52
-
-
33745281933
-
Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice
-
doi: 10.1128/JVI.00427-06
-
Tscharke DC, Woo WP, Sakala IG, Sidney J, Sette A, et al. (2006) Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice. J Virol 80: 6318-6323. doi:10.1128/JVI.00427-06. PubMed: 16775319.
-
(2006)
J Virol
, vol.80
, pp. 6318-6323
-
-
Tscharke, D.C.1
Woo, W.P.2
Sakala, I.G.3
Sidney, J.4
Sette, A.5
-
53
-
-
84866998507
-
Poxvirus vectors as HIV/AIDS vaccines in humans. Hum Vaccin
-
Gomez CE, Perdiguero B, Garcia-Arriaza J, Esteban M, (2012) Poxvirus vectors as HIV/AIDS vaccines in humans. Hum Vaccin. J Immunother 8: 1192-1207.
-
(2012)
J Immunother
, vol.8
, pp. 1192-1207
-
-
Gomez, C.E.1
Perdiguero, B.2
Garcia-Arriaza, J.3
Esteban, M.4
-
54
-
-
77957872381
-
Immunogenic profiling in mice of a HIV/AIDS vaccine candidate (MVA-B) expressing four HIV-1 antigens and potentiation by specific gene deletions
-
doi: 10.1371/journal.pone.0012395
-
García-Arriaza J, Nájera JL, Gómez CE, Sorzano CO, Esteban M, (2010) Immunogenic profiling in mice of a HIV/AIDS vaccine candidate (MVA-B) expressing four HIV-1 antigens and potentiation by specific gene deletions. PLOS ONE 5: e12395. doi:10.1371/journal.pone.0012395. PubMed: 20811493.
-
(2010)
PLOS ONE
, vol.5
-
-
García-Arriaza, J.1
Nájera, J.L.2
Gómez, C.E.3
Sorzano, C.O.4
Esteban, M.5
-
55
-
-
80052326758
-
A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses
-
doi: 10.1371/journal.pone.0024244
-
García-Arriaza J, Nájera JL, Gómez CE, Tewabe N, Sorzano CO, et al. (2011) A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses. PLOS ONE 6: e24244. doi:10.1371/journal.pone.0024244. PubMed: 21909386.
-
(2011)
PLOS ONE
, vol.6
-
-
García-Arriaza, J.1
Nájera, J.L.2
Gómez, C.E.3
Tewabe, N.4
Sorzano, C.O.5
-
56
-
-
84868305785
-
Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens
-
doi: 10.1371/journal.pone.0048524
-
Perdiguero B, Gómez CE, Nájera JL, Sorzano CO, Delaloye J, et al. (2012) Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens. PLOS ONE 7: e48524. doi:10.1371/journal.pone.0048524. PubMed: 23119046.
-
(2012)
PLOS ONE
, vol.7
-
-
Perdiguero, B.1
Gómez, C.E.2
Nájera, J.L.3
Sorzano, C.O.4
Delaloye, J.5
-
57
-
-
84857494918
-
Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding protein
-
doi: 10.1371/journal.pone.0032220
-
Falivene J, Del Médico Zajac MP, Pascutti MF, Rodríguez AM, Maeto C, et al. (2012) Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding protein. PLOS ONE 7: e32220. doi:10.1371/journal.pone.0032220. PubMed: 22384183.
-
(2012)
PLOS ONE
, vol.7
-
-
Falivene, J.1
Del Médico Zajac, M.P.2
Pascutti, M.F.3
Rodríguez, A.M.4
Maeto, C.5
-
58
-
-
45749084868
-
Recombination-mediated genetic engineering of a bacterial artificial chromosome clone of modified vaccinia virus Ankara (MVA)
-
doi: 10.1371/journal.pone.0001638
-
Cottingham MG, Andersen RF, Spencer AJ, Saurya S, Furze J, et al. (2008) Recombination-mediated genetic engineering of a bacterial artificial chromosome clone of modified vaccinia virus Ankara (MVA). PLOS ONE 3: e1638. doi:10.1371/journal.pone.0001638. PubMed: 18286194.
-
(2008)
PLOS ONE
, vol.3
-
-
Cottingham, M.G.1
Andersen, R.F.2
Spencer, A.J.3
Saurya, S.4
Furze, J.5
-
59
-
-
84869232606
-
Deletion of specific immune-modulatory genes from modified vaccinia virus Ankara-based HIV vaccines engenders improved immunogenicity in rhesus macaques
-
doi: 10.1128/JVI.00246-12
-
Garber DA, O'Mara LA, Gangadhara S, McQuoid M, Zhang X, et al. (2012) Deletion of specific immune-modulatory genes from modified vaccinia virus Ankara-based HIV vaccines engenders improved immunogenicity in rhesus macaques. J Virol 86: 12605-12615. doi:10.1128/JVI.00246-12. PubMed: 22973033.
-
(2012)
J Virol
, vol.86
, pp. 12605-12615
-
-
Garber, D.A.1
O'Mara, L.A.2
Gangadhara, S.3
McQuoid, M.4
Zhang, X.5
-
60
-
-
65549092767
-
Expanding the repertoire of Modified Vaccinia Ankara-based vaccine vectors via genetic complementation strategies
-
doi: 10.1371/journal.pone.0005445
-
Garber DA, O'Mara LA, Zhao J, Gangadhara S, An I, et al. (2009) Expanding the repertoire of Modified Vaccinia Ankara-based vaccine vectors via genetic complementation strategies. PLOS ONE 4: e5445. doi:10.1371/journal.pone.0005445. PubMed: 19421328.
-
(2009)
PLOS ONE
, vol.4
-
-
Garber, D.A.1
O'Mara, L.A.2
Zhao, J.3
Gangadhara, S.4
An, I.5
-
61
-
-
84861304314
-
Removal of vaccinia virus genes that block interferon type I and II pathways improves adaptive and memory responses of the HIV/AIDS vaccine candidate NYVAC-C in mice
-
doi: 10.1128/JVI.06684-11
-
Gómez CE, Perdiguero B, Nájera JL, Sorzano CO, Jiménez V, et al. (2012) Removal of vaccinia virus genes that block interferon type I and II pathways improves adaptive and memory responses of the HIV/AIDS vaccine candidate NYVAC-C in mice. J Virol 86: 5026-5038. doi:10.1128/JVI.06684-11. PubMed: 22419805.
-
(2012)
J Virol
, vol.86
, pp. 5026-5038
-
-
Gómez, C.E.1
Perdiguero, B.2
Nájera, J.L.3
Sorzano, C.O.4
Jiménez, V.5
-
62
-
-
77954994086
-
Selective induction of host genes by MVA-B, a candidate vaccine against HIV/AIDS
-
doi: 10.1128/JVI.00749-10
-
Guerra S, González JM, Climent N, Reyburn H, López-Fernández LA, et al. (2010) Selective induction of host genes by MVA-B, a candidate vaccine against HIV/AIDS. J Virol 84: 8141-8152. doi:10.1128/JVI.00749-10. PubMed: 20534857.
-
(2010)
J Virol
, vol.84
, pp. 8141-8152
-
-
Guerra, S.1
González, J.M.2
Climent, N.3
Reyburn, H.4
López-Fernández, L.A.5
-
63
-
-
61949216736
-
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
-
doi: 10.1038/nm.1935
-
Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, et al. (2009) Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med 15: 293-299. doi:10.1038/nm.1935. PubMed: 19219024.
-
(2009)
Nat Med
, vol.15
, pp. 293-299
-
-
Hansen, S.G.1
Vieville, C.2
Whizin, N.3
Coyne-Johnson, L.4
Siess, D.C.5
-
64
-
-
79957618772
-
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
-
doi: 10.1038/nature10003
-
Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, et al. (2011) Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473: 523-527. doi:10.1038/nature10003. PubMed: 21562493.
-
(2011)
Nature
, vol.473
, pp. 523-527
-
-
Hansen, S.G.1
Ford, J.C.2
Lewis, M.S.3
Ventura, A.B.4
Hughes, C.M.5
-
65
-
-
84862015359
-
High quality long-term CD4+ and CD8+ effector memory populations stimulated by DNA-LACK/MVA-LACK regimen in Leishmania major BALB/c model of infection
-
doi: 10.1371/journal.pone.0038859
-
Sánchez-Sampedro L, Gómez CE, Mejías-Pérez E, Sorzano CO, Esteban M, (2012) High quality long-term CD4+ and CD8+ effector memory populations stimulated by DNA-LACK/MVA-LACK regimen in Leishmania major BALB/c model of infection. PLOS ONE 7: e38859. doi:10.1371/journal.pone.0038859. PubMed: 22715418.
-
(2012)
PLOS ONE
, vol.7
-
-
Sánchez-Sampedro, L.1
Gómez, C.E.2
Mejías-Pérez, E.3
Sorzano, C.O.4
Esteban, M.5
-
66
-
-
80055105592
-
Isolation of mouse peritoneal cavity cells
-
doi: 20110936
-
Ray A, Dittel BN, (2010) Isolation of mouse peritoneal cavity cells. J Vis Exp (35):: 1488. PubMed: 20110936.
-
(2010)
J Vis Exp
, vol.35
, pp. 1488
-
-
Ray, A.1
Dittel, B.N.2
-
67
-
-
0342470981
-
Biology of attenuated modified vaccinia virus Ankara recombinant vector in mice: virus fate and activation of B- and T-cell immune responses in comparison with the Western Reserve strain and advantages as a vaccine
-
doi: 10.1128/JVI.74.2.923-933.2000
-
Ramírez JC, Gherardi MM, Esteban M, (2000) Biology of attenuated modified vaccinia virus Ankara recombinant vector in mice: virus fate and activation of B- and T-cell immune responses in comparison with the Western Reserve strain and advantages as a vaccine. J Virol 74: 923-933. doi:10.1128/JVI.74.2.923-933.2000. PubMed: 10623755.
-
(2000)
J Virol
, vol.74
, pp. 923-933
-
-
Ramírez, J.C.1
Gherardi, M.M.2
Esteban, M.3
-
68
-
-
80655128531
-
Improved NYVAC-based vaccine vectors
-
doi: 10.1371/journal.pone.0025674
-
Kibler KV, Gomez CE, Perdiguero B, Wong S, Huynh T, et al. (2011) Improved NYVAC-based vaccine vectors. PLOS ONE 6: e25674. doi:10.1371/journal.pone.0025674. PubMed: 22096477.
-
(2011)
PLOS ONE
, vol.6
-
-
Kibler, K.V.1
Gomez, C.E.2
Perdiguero, B.3
Wong, S.4
Huynh, T.5
-
69
-
-
0035924325
-
MIF regulates innate immune responses through modulation of Toll-like receptor 4
-
doi: 10.1038/414920a
-
Roger T, David J, Glauser MP, Calandra T, (2001) MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature 414: 920-924. doi:10.1038/414920a. PubMed: 11780066.
-
(2001)
Nature
, vol.414
, pp. 920-924
-
-
Roger, T.1
David, J.2
Glauser, M.P.3
Calandra, T.4
-
70
-
-
77956194962
-
Insertion of vaccinia virus C7L host range gene into NYVAC-B genome potentiates immune responses against HIV-1 antigens
-
doi: 10.1371/journal.pone.0011406
-
Nájera JL, Gómez CE, García-Arriaza J, Sorzano CO, Esteban M, (2010) Insertion of vaccinia virus C7L host range gene into NYVAC-B genome potentiates immune responses against HIV-1 antigens. PLOS ONE 5: e11406. doi:10.1371/journal.pone.0011406. PubMed: 20613977.
-
(2010)
PLOS ONE
, vol.5
-
-
Nájera, J.L.1
Gómez, C.E.2
García-Arriaza, J.3
Sorzano, C.O.4
Esteban, M.5
-
71
-
-
79251515158
-
SPICE: exploration and analysis of post-cytometric complex multivariate datasets
-
doi: 21265010
-
Roederer M, Nozzi JL, Nason MC, (2011) SPICE: exploration and analysis of post-cytometric complex multivariate datasets. Cytometry A 79: 167-174. PubMed: 21265010.
-
(2011)
Cytometry A
, vol.79
, pp. 167-174
-
-
Roederer, M.1
Nozzi, J.L.2
Nason, M.C.3
|