Vaccinia virus protein c6 is a virulence factor that binds tbk-1 adaptor proteins and inhibits activation of irf3 and irf7

PLoS Pathogens

Volumn 7, Issue 9, 2011, Pages

  Unterholzner, Leonie ^a   Sumner, Rebecca P ^b   Baran, Marcin ^a   Ren, Hongwei ^b   Mansur, Daniel S ^b   Bourke, Nollaig M ^a   Randow, Felix ^c   Smith, Geoffrey L ^b   Bowie, Andrew G ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BETA INTERFERON; I KAPPA B KINASE EPSILON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; NUCLEOSOME ASSEMBLY PROTEIN 1; PATTERN RECOGNITION RECEPTOR; PHOSPHOTRANSFERASE; PROTEIN C6; PROTEIN SINTBAD; PROTEIN TANK; RANTES; SCAFFOLD PROTEIN; TANK BINDING KINASE 1; UNCLASSIFIED DRUG; VIRUS PROTEIN; I KAPPA B KINASE; IRF3 PROTEIN, HUMAN; IRF7 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, HUMAN; VIRULENCE FACTOR;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; ENZYME PHOSPHORYLATION; FEMALE; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VIVO STUDY; INHIBITION KINETICS; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVERTANT; VACCINIA VIRUS; VIRUS ATTENUATION; VIRUS INFECTION; VIRUS VIRULENCE; WILD TYPE; CELL STRAIN HEK293; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNE EVASION; INNATE IMMUNITY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PLASMID; REGULATOR GENE; SIGNAL TRANSDUCTION; VIRUS REPLICATION;

MAMMALIA; POXVIRIDAE; VACCINIA VIRUS;

GENE EXPRESSION REGULATION, VIRAL; GENES, REGULATOR; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; IMMUNE EVASION; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTOR-7; INTERFERON-BETA; NF-KAPPA B; OPEN READING FRAMES; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, PATTERN RECOGNITION; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; VACCINIA VIRUS; VIRAL PROTEINS; VIRULENCE FACTORS; VIRUS REPLICATION;

EID: 80053455599     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002247     Document Type: Article

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