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Volumn 7, Issue 10, 2012, Pages

Deletion of the Viral Anti-Apoptotic Gene F1L in the HIV/AIDS Vaccine Candidate MVA-C Enhances Immune Responses against HIV-1 Antigens

Author keywords

[No Author keywords available]

Indexed keywords

BCL 2 LIKE PROTEIN F1; CYTOKINE; GAG PROTEIN; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERFERON; NEF PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEPTIDES AND PROTEINS; POL PROTEIN; POXVIRUS VECTOR; RECOMBINANT HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 C MODIFIED VACCINIA ANKARA VIRUS VACCINE; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; VIRUS VECTOR;

EID: 84868305785     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048524     Document Type: Article
Times cited : (31)

References (89)
  • 2
    • 79956200639 scopus 로고    scopus 로고
    • Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individuals
    • Climent N, Guerra S, Garcia F, Rovira C, Miralles L, et al. (2011) Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individuals. PLoS One 6: e19644.
    • (2011) PLoS One , vol.6
    • Climent, N.1    Guerra, S.2    Garcia, F.3    Rovira, C.4    Miralles, L.5
  • 3
    • 80052326758 scopus 로고    scopus 로고
    • A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses
    • Garcia-Arriaza J, Najera JL, Gomez CE, Tewabe N, Sorzano CO, et al. (2011) A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses. PLoS One 6: e24244.
    • (2011) PLoS One , vol.6
    • Garcia-Arriaza, J.1    Najera, J.L.2    Gomez, C.E.3    Tewabe, N.4    Sorzano, C.O.5
  • 4
    • 40149094782 scopus 로고    scopus 로고
    • Differential CD4+ versus CD8+ T-cell responses elicited by different poxvirus-based human immunodeficiency virus type 1 vaccine candidates provide comparable efficacies in primates
    • Mooij P, Balla-Jhagjhoorsingh SS, Koopman G, Beenhakker N, van Haaften P, et al. (2008) Differential CD4+ versus CD8+ T-cell responses elicited by different poxvirus-based human immunodeficiency virus type 1 vaccine candidates provide comparable efficacies in primates. J Virol 82: 2975-2988.
    • (2008) J Virol , vol.82 , pp. 2975-2988
    • Mooij, P.1    Balla-Jhagjhoorsingh, S.S.2    Koopman, G.3    Beenhakker, N.4    van Haaften, P.5
  • 5
    • 54949106244 scopus 로고    scopus 로고
    • Broad immunogenicity of a multigene, multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modified vaccinia virus Ankara
    • Sandstrom E, Nilsson C, Hejdeman B, Brave A, Bratt G, et al. (2008) Broad immunogenicity of a multigene, multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modified vaccinia virus Ankara. J Infect Dis 198: 1482-1490.
    • (2008) J Infect Dis , vol.198 , pp. 1482-1490
    • Sandstrom, E.1    Nilsson, C.2    Hejdeman, B.3    Brave, A.4    Bratt, G.5
  • 6
    • 77954364931 scopus 로고    scopus 로고
    • Strong HIV-specific CD4+ and CD8+ T-lymphocyte proliferative responses in healthy individuals immunized with an HIV-1 DNA vaccine and boosted with recombinant modified vaccinia virus ankara expressing HIV-1 genes
    • Aboud S, Nilsson C, Karlen K, Marovich M, Wahren B, et al. (2010) Strong HIV-specific CD4+ and CD8+ T-lymphocyte proliferative responses in healthy individuals immunized with an HIV-1 DNA vaccine and boosted with recombinant modified vaccinia virus ankara expressing HIV-1 genes. Clin Vaccine Immunol 17: 1124-1131.
    • (2010) Clin Vaccine Immunol , vol.17 , pp. 1124-1131
    • Aboud, S.1    Nilsson, C.2    Karlen, K.3    Marovich, M.4    Wahren, B.5
  • 7
    • 78649733251 scopus 로고    scopus 로고
    • Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate
    • Currier JR, Ngauy V, de Souza MS, Ratto-Kim S, Cox JH, et al. (2010) Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate. PLoS One 5: e13983.
    • (2010) PLoS One , vol.5
    • Currier, J.R.1    Ngauy, V.2    de Souza, M.S.3    Ratto-Kim, S.4    Cox, J.H.5
  • 8
    • 77749321171 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine
    • Vasan S, Schlesinger SJ, Chen Z, Hurley A, Lombardo A, et al. (2010) Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine. PLoS One 5: e8816.
    • (2010) PLoS One , vol.5
    • Vasan, S.1    Schlesinger, S.J.2    Chen, Z.3    Hurley, A.4    Lombardo, A.5
  • 9
    • 71949091412 scopus 로고    scopus 로고
    • A Phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 subtype C-modified vaccinia Ankara virus vaccine candidate in Indian volunteers
    • Ramanathan VD, Kumar M, Mahalingam J, Sathyamoorthy P, Narayanan PR, et al. (2009) A Phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 subtype C-modified vaccinia Ankara virus vaccine candidate in Indian volunteers. AIDS Res Hum Retroviruses 25: 1107-1116.
    • (2009) AIDS Res Hum Retroviruses , vol.25 , pp. 1107-1116
    • Ramanathan, V.D.1    Kumar, M.2    Mahalingam, J.3    Sathyamoorthy, P.4    Narayanan, P.R.5
  • 10
    • 80054003999 scopus 로고    scopus 로고
    • Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02)
    • Garcia F, Bernaldo de Quiros JC, Gomez CE, Perdiguero B, Najera JL, et al. (2011) Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02). Vaccine 29: 8309-8316.
    • (2011) Vaccine , vol.29 , pp. 8309-8316
    • Garcia, F.1    Bernaldo de Quiros, J.C.2    Gomez, C.E.3    Perdiguero, B.4    Najera, J.L.5
  • 11
    • 80055120690 scopus 로고    scopus 로고
    • The HIV/AIDS vaccine candidate MVA-B administered as a single immunogen in humans triggers robust, polyfunctional, and selective effector memory T cell responses to HIV-1 antigens
    • Gomez CE, Najera JL, Perdiguero B, Garcia-Arriaza J, Sorzano CO, et al. (2011) The HIV/AIDS vaccine candidate MVA-B administered as a single immunogen in humans triggers robust, polyfunctional, and selective effector memory T cell responses to HIV-1 antigens. J Virol 85: 11468-11478.
    • (2011) J Virol , vol.85 , pp. 11468-11478
    • Gomez, C.E.1    Najera, J.L.2    Perdiguero, B.3    Garcia-Arriaza, J.4    Sorzano, C.O.5
  • 12
    • 79751487021 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles
    • Goepfert PA, Elizaga ML, Sato A, Qin L, Cardinali M, et al. (2011) Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles. J Infect Dis 203: 610-619.
    • (2011) J Infect Dis , vol.203 , pp. 610-619
    • Goepfert, P.A.1    Elizaga, M.L.2    Sato, A.3    Qin, L.4    Cardinali, M.5
  • 13
    • 0032503233 scopus 로고    scopus 로고
    • The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses
    • Antoine G, Scheiflinger F, Dorner F, Falkner FG, (1998) The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses. Virology 244: 365-396.
    • (1998) Virology , vol.244 , pp. 365-396
    • Antoine, G.1    Scheiflinger, F.2    Dorner, F.3    Falkner, F.G.4
  • 14
    • 0025876805 scopus 로고
    • Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence
    • Meyer H, Sutter G, Mayr A, (1991) Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence. J Gen Virol 72 (Pt 5): 1031-1038.
    • (1991) J Gen Virol , vol.72 , Issue.Pt 5 , pp. 1031-1038
    • Meyer, H.1    Sutter, G.2    Mayr, A.3
  • 15
    • 0031585552 scopus 로고    scopus 로고
    • Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line
    • Carroll MW, Moss B, (1997) Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line. Virology 238: 198-211.
    • (1997) Virology , vol.238 , pp. 198-211
    • Carroll, M.W.1    Moss, B.2
  • 16
    • 0026442276 scopus 로고
    • Nonreplicating vaccinia vector efficiently expresses recombinant genes
    • Sutter G, Moss B, (1992) Nonreplicating vaccinia vector efficiently expresses recombinant genes. Proc Natl Acad Sci U S A 89: 10847-10851.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10847-10851
    • Sutter, G.1    Moss, B.2
  • 17
    • 0141761519 scopus 로고    scopus 로고
    • Vaccinia vectors as candidate vaccines: the development of modified vaccinia virus Ankara for antigen delivery
    • Sutter G, Staib C, (2003) Vaccinia vectors as candidate vaccines: the development of modified vaccinia virus Ankara for antigen delivery. Curr Drug Targets Infect Disord 3: 263-271.
    • (2003) Curr Drug Targets Infect Disord , vol.3 , pp. 263-271
    • Sutter, G.1    Staib, C.2
  • 18
    • 4043063635 scopus 로고    scopus 로고
    • Attenuated poxviruses expressing a synthetic HIV protein stimulate HLA-A2-restricted cytotoxic T-cell responses
    • Didierlaurent A, Ramirez JC, Gherardi M, Zimmerli SC, Graf M, et al. (2004) Attenuated poxviruses expressing a synthetic HIV protein stimulate HLA-A2-restricted cytotoxic T-cell responses. Vaccine 22: 3395-3403.
    • (2004) Vaccine , vol.22 , pp. 3395-3403
    • Didierlaurent, A.1    Ramirez, J.C.2    Gherardi, M.3    Zimmerli, S.C.4    Graf, M.5
  • 19
    • 0038714287 scopus 로고    scopus 로고
    • Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans
    • McConkey SJ, Reece WH, Moorthy VS, Webster D, Dunachie S, et al. (2003) Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nat Med 9: 729-735.
    • (2003) Nat Med , vol.9 , pp. 729-735
    • McConkey, S.J.1    Reece, W.H.2    Moorthy, V.S.3    Webster, D.4    Dunachie, S.5
  • 20
    • 0035046214 scopus 로고    scopus 로고
    • Immunology 102 at poxvirus U: avoiding apoptosis
    • Shisler JL, Moss B, (2001) Immunology 102 at poxvirus U: avoiding apoptosis. Semin Immunol 13: 67-72.
    • (2001) Semin Immunol , vol.13 , pp. 67-72
    • Shisler, J.L.1    Moss, B.2
  • 21
    • 29144495592 scopus 로고    scopus 로고
    • Near death experiences: poxvirus regulation of apoptotic death
    • Taylor JM, Barry M, (2006) Near death experiences: poxvirus regulation of apoptotic death. Virology 344: 139-150.
    • (2006) Virology , vol.344 , pp. 139-150
    • Taylor, J.M.1    Barry, M.2
  • 24
    • 0142027948 scopus 로고    scopus 로고
    • Ways of dying: multiple pathways to apoptosis
    • Adams JM, (2003) Ways of dying: multiple pathways to apoptosis. Genes Dev 17: 2481-2495.
    • (2003) Genes Dev , vol.17 , pp. 2481-2495
    • Adams, J.M.1
  • 25
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO, (2000) The biochemistry of apoptosis. Nature 407: 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 26
    • 8444220527 scopus 로고    scopus 로고
    • Molecular mechanisms of caspase regulation during apoptosis
    • Riedl SJ, Shi Y, (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5: 897-907.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 897-907
    • Riedl, S.J.1    Shi, Y.2
  • 27
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
    • Albert ML, Sauter B, Bhardwaj N, (1998) Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392: 86-89.
    • (1998) Nature , vol.392 , pp. 86-89
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 28
    • 0344198504 scopus 로고    scopus 로고
    • Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis
    • Wasilenko ST, Stewart TL, Meyers AF, Barry M, (2003) Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis. Proc Natl Acad Sci U S A 100: 14345-14350.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14345-14350
    • Wasilenko, S.T.1    Stewart, T.L.2    Meyers, A.F.3    Barry, M.4
  • 29
    • 11144245597 scopus 로고    scopus 로고
    • Vaccinia virus F1L protein is a tail-anchored protein that functions at the mitochondria to inhibit apoptosis
    • Stewart TL, Wasilenko ST, Barry M, (2005) Vaccinia virus F1L protein is a tail-anchored protein that functions at the mitochondria to inhibit apoptosis. J Virol 79: 1084-1098.
    • (2005) J Virol , vol.79 , pp. 1084-1098
    • Stewart, T.L.1    Wasilenko, S.T.2    Barry, M.3
  • 30
    • 27644535708 scopus 로고    scopus 로고
    • The Vaccinia Virus F1L Protein Interacts with the Proapoptotic Protein Bak and Inhibits Bak Activation
    • Wasilenko ST, Banadyga L, Bond D, Barry M, (2005) The Vaccinia Virus F1L Protein Interacts with the Proapoptotic Protein Bak and Inhibits Bak Activation. J Virol 79: 14031-14043.
    • (2005) J Virol , vol.79 , pp. 14031-14043
    • Wasilenko, S.T.1    Banadyga, L.2    Bond, D.3    Barry, M.4
  • 31
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: opposing activities that mediate cell death
    • Youle RJ, Strasser A, (2008) The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9: 47-59.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 32
    • 33745961009 scopus 로고    scopus 로고
    • Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis
    • Postigo A, Cross JR, Downward J, Way M, (2006) Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis. Cell Death Differ 13: 1651-1662.
    • (2006) Cell Death Differ , vol.13 , pp. 1651-1662
    • Postigo, A.1    Cross, J.R.2    Downward, J.3    Way, M.4
  • 33
    • 77951180715 scopus 로고    scopus 로고
    • Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1
    • Campbell S, Hazes B, Kvansakul M, Colman P, Barry M, (2010) Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1. J Biol Chem 285: 4695-4708.
    • (2010) J Biol Chem , vol.285 , pp. 4695-4708
    • Campbell, S.1    Hazes, B.2    Kvansakul, M.3    Colman, P.4    Barry, M.5
  • 34
    • 52149113769 scopus 로고    scopus 로고
    • Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
    • Kvansakul M, Yang H, Fairlie WD, Czabotar PE, Fischer SF, et al. (2008) Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands. Cell Death Differ 15: 1564-1571.
    • (2008) Cell Death Differ , vol.15 , pp. 1564-1571
    • Kvansakul, M.1    Yang, H.2    Fairlie, W.D.3    Czabotar, P.E.4    Fischer, S.F.5
  • 35
    • 33845972661 scopus 로고    scopus 로고
    • The Vaccinia Virus Protein F1L Interacts with Bim and Inhibits Activation of the Pro-apoptotic Protein Bax
    • Taylor JM, Quilty D, Banadyga L, Barry M, (2006) The Vaccinia Virus Protein F1L Interacts with Bim and Inhibits Activation of the Pro-apoptotic Protein Bax. J Biol Chem 281: 39728-39739.
    • (2006) J Biol Chem , vol.281 , pp. 39728-39739
    • Taylor, J.M.1    Quilty, D.2    Banadyga, L.3    Barry, M.4
  • 36
    • 33644993374 scopus 로고    scopus 로고
    • Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis
    • Fischer SF, Ludwig H, Holzapfel J, Kvansakul M, Chen L, et al. (2006) Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis. Cell Death Differ 13: 109-118.
    • (2006) Cell Death Differ , vol.13 , pp. 109-118
    • Fischer, S.F.1    Ludwig, H.2    Holzapfel, J.3    Kvansakul, M.4    Chen, L.5
  • 37
    • 84855928932 scopus 로고    scopus 로고
    • The vaccinia virus-encoded Bcl-2 homologues do not act as direct Bax inhibitors
    • Postigo A, Way M, (2012) The vaccinia virus-encoded Bcl-2 homologues do not act as direct Bax inhibitors. J Virol 86: 203-213.
    • (2012) J Virol , vol.86 , pp. 203-213
    • Postigo, A.1    Way, M.2
  • 38
    • 77949325150 scopus 로고    scopus 로고
    • Vaccinia virus protein F1L is a caspase-9 inhibitor
    • Zhai D, Yu E, Jin C, Welsh K, Shiau CW, et al. (2010) Vaccinia virus protein F1L is a caspase-9 inhibitor. J Biol Chem 285: 5569-5580.
    • (2010) J Biol Chem , vol.285 , pp. 5569-5580
    • Zhai, D.1    Yu, E.2    Jin, C.3    Welsh, K.4    Shiau, C.W.5
  • 39
    • 80052216444 scopus 로고    scopus 로고
    • Structural determinants of caspase-9 inhibition by the vaccinia virus protein, F1L
    • Yu E, Zhai D, Jin C, Gerlic M, Reed JC, et al. (2011) Structural determinants of caspase-9 inhibition by the vaccinia virus protein, F1L. J Biol Chem 286: 30748-30758.
    • (2011) J Biol Chem , vol.286 , pp. 30748-30758
    • Yu, E.1    Zhai, D.2    Jin, C.3    Gerlic, M.4    Reed, J.C.5
  • 40
    • 79959838502 scopus 로고    scopus 로고
    • Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-beta-dependent induction of pro-apoptotic Noxa
    • Eitz Ferrer P, Potthoff S, Kirschnek S, Gasteiger G, Kastenmuller W, et al. (2011) Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-beta-dependent induction of pro-apoptotic Noxa. PLoS Pathog 7: e1002083.
    • (2011) PLoS Pathog , vol.7
    • Eitz Ferrer, P.1    Potthoff, S.2    Kirschnek, S.3    Gasteiger, G.4    Kastenmuller, W.5
  • 41
    • 33750088696 scopus 로고    scopus 로고
    • The highly attenuated vaccinia virus strain modified virus Ankara induces apoptosis in melanoma cells and allows bystander dendritic cells to generate a potent anti-tumoral immunity
    • Greiner S, Humrich JY, Thuman P, Sauter B, Schuler G, et al. (2006) The highly attenuated vaccinia virus strain modified virus Ankara induces apoptosis in melanoma cells and allows bystander dendritic cells to generate a potent anti-tumoral immunity. Clin Exp Immunol 146: 344-353.
    • (2006) Clin Exp Immunol , vol.146 , pp. 344-353
    • Greiner, S.1    Humrich, J.Y.2    Thuman, P.3    Sauter, B.4    Schuler, G.5
  • 42
    • 79958226287 scopus 로고    scopus 로고
    • MVA and NYVAC as vaccines against emergent infectious diseases and cancer
    • Gomez CE, Najera JL, Krupa M, Perdiguero B, Esteban M, (2011) MVA and NYVAC as vaccines against emergent infectious diseases and cancer. Curr Gene Ther 11: 189-217.
    • (2011) Curr Gene Ther , vol.11 , pp. 189-217
    • Gomez, C.E.1    Najera, J.L.2    Krupa, M.3    Perdiguero, B.4    Esteban, M.5
  • 44
    • 33846876318 scopus 로고    scopus 로고
    • Generation and immunogenicity of novel HIV/AIDS vaccine candidates targeting HIV-1 Env/Gag-Pol-Nef antigens of clade C
    • Gomez CE, Najera JL, Jimenez V, Bieler K, Wild J, et al. (2007) Generation and immunogenicity of novel HIV/AIDS vaccine candidates targeting HIV-1 Env/Gag-Pol-Nef antigens of clade C. Vaccine. 25: 1969-1992.
    • (2007) Vaccine , vol.25 , pp. 1969-1992
    • Gomez, C.E.1    Najera, J.L.2    Jimenez, V.3    Bieler, K.4    Wild, J.5
  • 45
    • 67650424327 scopus 로고    scopus 로고
    • Elucidating and minimizing the loss by recombinant vaccinia virus of human immunodeficiency virus gene expression resulting from spontaneous mutations and positive selection
    • Wyatt LS, Earl PL, Xiao W, Americo JL, Cotter CA, et al. (2009) Elucidating and minimizing the loss by recombinant vaccinia virus of human immunodeficiency virus gene expression resulting from spontaneous mutations and positive selection. J Virol 83: 7176-7184.
    • (2009) J Virol , vol.83 , pp. 7176-7184
    • Wyatt, L.S.1    Earl, P.L.2    Xiao, W.3    Americo, J.L.4    Cotter, C.A.5
  • 46
    • 0029068871 scopus 로고
    • Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    • Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, et al. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43.
    • (1995) Nature , vol.376 , pp. 37-43
    • Nicholson, D.W.1    Ali, A.2    Thornberry, N.A.3    Vaillancourt, J.P.4    Ding, C.K.5
  • 47
    • 70349785029 scopus 로고    scopus 로고
    • Viral inhibitors reveal overlapping themes in regulation of cell death and innate immunity
    • Postigo A, Ferrer PE, (2009) Viral inhibitors reveal overlapping themes in regulation of cell death and innate immunity. Microbes Infect 11: 1071-1078.
    • (2009) Microbes Infect , vol.11 , pp. 1071-1078
    • Postigo, A.1    Ferrer, P.E.2
  • 48
    • 33947151927 scopus 로고    scopus 로고
    • Head-to-head comparison on the immunogenicity of two HIV/AIDS vaccine candidates based on the attenuated poxvirus strains MVA and NYVAC co-expressing in a single locus the HIV-1BX08 gp120 and HIV-1(IIIB) Gag-Pol-Nef proteins of clade B
    • Gomez CE, Najera JL, Jimenez EP, Jimenez V, Wagner R, et al. (2007) Head-to-head comparison on the immunogenicity of two HIV/AIDS vaccine candidates based on the attenuated poxvirus strains MVA and NYVAC co-expressing in a single locus the HIV-1BX08 gp120 and HIV-1(IIIB) Gag-Pol-Nef proteins of clade B. Vaccine. 25: 2863-2885.
    • (2007) Vaccine , vol.25 , pp. 2863-2885
    • Gomez, C.E.1    Najera, J.L.2    Jimenez, E.P.3    Jimenez, V.4    Wagner, R.5
  • 49
    • 37549023073 scopus 로고    scopus 로고
    • Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells
    • Robinson HL, Sharma S, Zhao J, Kannanganat S, Lai L, et al. (2007) Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells. AIDS Res Hum Retroviruses 23: 1555-1562.
    • (2007) AIDS Res Hum Retroviruses , vol.23 , pp. 1555-1562
    • Robinson, H.L.1    Sharma, S.2    Zhao, J.3    Kannanganat, S.4    Lai, L.5
  • 50
    • 70350097940 scopus 로고    scopus 로고
    • Preclinical evaluation of the immunogenicity of C-type HIV-1-based DNA and NYVAC vaccines in the Balb/C mouse model
    • Wild J, Bieler K, Kostler J, Frachette MJ, Jeffs S, et al. (2009) Preclinical evaluation of the immunogenicity of C-type HIV-1-based DNA and NYVAC vaccines in the Balb/C mouse model. Viral Immunol 22: 309-319.
    • (2009) Viral Immunol , vol.22 , pp. 309-319
    • Wild, J.1    Bieler, K.2    Kostler, J.3    Frachette, M.J.4    Jeffs, S.5
  • 51
    • 33846101731 scopus 로고    scopus 로고
    • CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
    • Kiepiela P, Ngumbela K, Thobakgale C, Ramduth D, Honeyborne I, et al. (2007) CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nat Med 13: 46-53.
    • (2007) Nat Med , vol.13 , pp. 46-53
    • Kiepiela, P.1    Ngumbela, K.2    Thobakgale, C.3    Ramduth, D.4    Honeyborne, I.5
  • 52
    • 15244348992 scopus 로고    scopus 로고
    • Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7
    • Unsoeld H, Pircher H, (2005) Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7. J Virol 79: 4510-4513.
    • (2005) J Virol , vol.79 , pp. 4510-4513
    • Unsoeld, H.1    Pircher, H.2
  • 53
    • 77958490167 scopus 로고    scopus 로고
    • Induction of immunity to human immunodeficiency virus type-1 by vaccination
    • McElrath MJ, Haynes BF, (2010) Induction of immunity to human immunodeficiency virus type-1 by vaccination. Immunity 33: 542-554.
    • (2010) Immunity , vol.33 , pp. 542-554
    • McElrath, M.J.1    Haynes, B.F.2
  • 54
    • 30344463834 scopus 로고    scopus 로고
    • Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy
    • Clark RH, Kenyon JC, Bartlett NW, Tscharke DC, Smith GL, (2006) Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy. J Gen Virol 87: 29-38.
    • (2006) J Gen Virol , vol.87 , pp. 29-38
    • Clark, R.H.1    Kenyon, J.C.2    Bartlett, N.W.3    Tscharke, D.C.4    Smith, G.L.5
  • 55
    • 21444435368 scopus 로고    scopus 로고
    • Inactivation of the viral interleukin 1beta receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara
    • Staib C, Kisling S, Erfle V, Sutter G, (2005) Inactivation of the viral interleukin 1beta receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara. J Gen Virol 86: 1997-2006.
    • (2005) J Gen Virol , vol.86 , pp. 1997-2006
    • Staib, C.1    Kisling, S.2    Erfle, V.3    Sutter, G.4
  • 56
    • 45749084868 scopus 로고    scopus 로고
    • Recombination-Mediated Genetic Engineering of a Bacterial Artificial Chromosome Clone of Modified Vaccinia virus Ankara (MVA)
    • Cottingham MG, Andersen RF, Spencer AJ, Saurya S, Furze J, et al. (2008) Recombination-Mediated Genetic Engineering of a Bacterial Artificial Chromosome Clone of Modified Vaccinia virus Ankara (MVA). PLoS ONE 3: e1638.
    • (2008) PLoS ONE , vol.3
    • Cottingham, M.G.1    Andersen, R.F.2    Spencer, A.J.3    Saurya, S.4    Furze, J.5
  • 57
    • 77957872381 scopus 로고    scopus 로고
    • Immunogenic profiling in mice of a HIV/AIDS vaccine candidate (MVA-B) expressing four HIV-1 antigens and potentiation by specific gene deletions
    • Garcia-Arriaza J, Najera JL, Gomez CE, Sorzano CO, Esteban M, (2010) Immunogenic profiling in mice of a HIV/AIDS vaccine candidate (MVA-B) expressing four HIV-1 antigens and potentiation by specific gene deletions. PLoS One 5: e12395.
    • (2010) PLoS One , vol.5
    • Garcia-Arriaza, J.1    Najera, J.L.2    Gomez, C.E.3    Sorzano, C.O.4    Esteban, M.5
  • 58
    • 84857494918 scopus 로고    scopus 로고
    • Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding protein
    • Falivene J, Del Medico Zajac MP, Pascutti MF, Rodriguez AM, Maeto C, et al. (2012) Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding protein. PLoS One 7: e32220.
    • (2012) PLoS One , vol.7
    • Falivene, J.1    Del Medico Zajac, M.P.2    Pascutti, M.F.3    Rodriguez, A.M.4    Maeto, C.5
  • 59
    • 79951911508 scopus 로고    scopus 로고
    • Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors
    • Quakkelaar ED, Redeker A, Haddad EK, Harari A, McCaughey SM, et al. (2011) Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors. PLoS One 6: e16819.
    • (2011) PLoS One , vol.6
    • Quakkelaar, E.D.1    Redeker, A.2    Haddad, E.K.3    Harari, A.4    McCaughey, S.M.5
  • 61
    • 84861304314 scopus 로고    scopus 로고
    • Removal of vaccinia virus genes that block interferon type I and II pathways improves adaptive and memory responses of the HIV/AIDS vaccine candidate NYVAC-C in mice
    • Gomez CE, Perdiguero B, Najera JL, Sorzano CO, Jimenez V, et al. (2012) Removal of vaccinia virus genes that block interferon type I and II pathways improves adaptive and memory responses of the HIV/AIDS vaccine candidate NYVAC-C in mice. J Virol 86: 5026-5038.
    • (2012) J Virol , vol.86 , pp. 5026-5038
    • Gomez, C.E.1    Perdiguero, B.2    Najera, J.L.3    Sorzano, C.O.4    Jimenez, V.5
  • 62
    • 0036188469 scopus 로고    scopus 로고
    • Induction of anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) and CD4(+) T-cell reactivity by dendritic cells loaded with HIV-1 X4-infected apoptotic cells
    • Zhao XQ, Huang XL, Gupta P, Borowski L, Fan Z, et al. (2002) Induction of anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) and CD4(+) T-cell reactivity by dendritic cells loaded with HIV-1 X4-infected apoptotic cells. J Virol 76: 3007-3014.
    • (2002) J Virol , vol.76 , pp. 3007-3014
    • Zhao, X.Q.1    Huang, X.L.2    Gupta, P.3    Borowski, L.4    Fan, Z.5
  • 63
    • 84859856404 scopus 로고    scopus 로고
    • Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C
    • Gomez CE, Perdiguero B, Jimenez V, Filali-Mouhim A, Ghneim K, et al. (2012) Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C. PLoS One. 7: e35485.
    • (2012) PLoS One , vol.7
    • Gomez, C.E.1    Perdiguero, B.2    Jimenez, V.3    Filali-Mouhim, A.4    Ghneim, K.5
  • 64
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM, (1998) Dendritic cells and the control of immunity. Nature 392: 245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 65
    • 16544382157 scopus 로고    scopus 로고
    • Lead and follow: the dance of the dendritic cell and T cell
    • Lanzavecchia A, Sallusto F, (2004) Lead and follow: the dance of the dendritic cell and T cell. Nat Immunol 5: 1201-1202.
    • (2004) Nat Immunol , vol.5 , pp. 1201-1202
    • Lanzavecchia, A.1    Sallusto, F.2
  • 66
    • 0034676087 scopus 로고    scopus 로고
    • Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation
    • Sigal LJ, Rock KL, (2000) Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and-independent pathways of antigen presentation. J Exp Med 192: 1143-1150.
    • (2000) J Exp Med , vol.192 , pp. 1143-1150
    • Sigal, L.J.1    Rock, K.L.2
  • 67
    • 0035525290 scopus 로고    scopus 로고
    • Cross-presentation in viral immunity and self-tolerance
    • Heath WR, Carbone FR, (2001) Cross-presentation in viral immunity and self-tolerance. Nat Rev Immunol 1: 126-134.
    • (2001) Nat Rev Immunol , vol.1 , pp. 126-134
    • Heath, W.R.1    Carbone, F.R.2
  • 68
    • 33745269769 scopus 로고    scopus 로고
    • Infection of human dendritic cells with recombinant vaccinia virus MVA reveals general persistence of viral early transcription but distinct maturation-dependent cytopathogenicity
    • Kastenmuller W, Drexler I, Ludwig H, Erfle V, Peschel C, et al. (2006) Infection of human dendritic cells with recombinant vaccinia virus MVA reveals general persistence of viral early transcription but distinct maturation-dependent cytopathogenicity. Virology 350: 276-288.
    • (2006) Virology , vol.350 , pp. 276-288
    • Kastenmuller, W.1    Drexler, I.2    Ludwig, H.3    Erfle, V.4    Peschel, C.5
  • 69
    • 35448974187 scopus 로고    scopus 로고
    • Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus Ankara vector vaccines
    • Gasteiger G, Kastenmuller W, Ljapoci R, Sutter G, Drexler I, (2007) Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus Ankara vector vaccines. J Virol 81: 11925-11936.
    • (2007) J Virol , vol.81 , pp. 11925-11936
    • Gasteiger, G.1    Kastenmuller, W.2    Ljapoci, R.3    Sutter, G.4    Drexler, I.5
  • 70
    • 33748642155 scopus 로고    scopus 로고
    • Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus
    • Chahroudi A, Garber DA, Reeves P, Liu L, Kalman D, et al. (2006) Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus. J Virol 80: 8469-8481.
    • (2006) J Virol , vol.80 , pp. 8469-8481
    • Chahroudi, A.1    Garber, D.A.2    Reeves, P.3    Liu, L.4    Kalman, D.5
  • 71
    • 0035425003 scopus 로고    scopus 로고
    • Cross-presentation by dendritic cells of tumor antigen expressed in apoptotic recombinant canarypox virus-infected dendritic cells
    • Motta I, Andre F, Lim A, Tartaglia J, Cox WI, et al. (2001) Cross-presentation by dendritic cells of tumor antigen expressed in apoptotic recombinant canarypox virus-infected dendritic cells. J Immunol 167: 1795-1802.
    • (2001) J Immunol , vol.167 , pp. 1795-1802
    • Motta, I.1    Andre, F.2    Lim, A.3    Tartaglia, J.4    Cox, W.I.5
  • 72
    • 0035666519 scopus 로고    scopus 로고
    • Efficiency of cross presentation of vaccinia virus-derived antigens by human dendritic cells
    • Larsson M, Fonteneau JF, Somersan S, Sanders C, Bickham K, et al. (2001) Efficiency of cross presentation of vaccinia virus-derived antigens by human dendritic cells. Eur J Immunol 31: 3432-3442.
    • (2001) Eur J Immunol , vol.31 , pp. 3432-3442
    • Larsson, M.1    Fonteneau, J.F.2    Somersan, S.3    Sanders, C.4    Bickham, K.5
  • 73
    • 80055105592 scopus 로고    scopus 로고
    • Isolation of mouse peritoneal cavity cells
    • doi: 10.3791/1488
    • Ray A, Dittel BN (2010) Isolation of mouse peritoneal cavity cells. J Vis Exp 35: doi: 10.3791/1488.
    • (2010) J Vis Exp , vol.35
    • Ray, A.1    Dittel, B.N.2
  • 74
    • 22544471603 scopus 로고    scopus 로고
    • Vaccinia virus tropism for primary hematolymphoid cells is determined by restricted expression of a unique virus receptor
    • Chahroudi A, Chavan R, Kozyr N, Waller EK, Silvestri G, et al. (2005) Vaccinia virus tropism for primary hematolymphoid cells is determined by restricted expression of a unique virus receptor. J Virol 79: 10397-10407.
    • (2005) J Virol , vol.79 , pp. 10397-10407
    • Chahroudi, A.1    Chavan, R.2    Kozyr, N.3    Waller, E.K.4    Silvestri, G.5
  • 75
    • 15744394459 scopus 로고    scopus 로고
    • Susceptibility of different leukocyte cell types to Vaccinia virus infection
    • Sanchez-Puig JM, Sanchez L, Roy G, Blasco R, (2004) Susceptibility of different leukocyte cell types to Vaccinia virus infection. Virol J 1: 10.
    • (2004) Virol J , vol.1 , pp. 10
    • Sanchez-Puig, J.M.1    Sanchez, L.2    Roy, G.3    Blasco, R.4
  • 76
    • 42949155679 scopus 로고    scopus 로고
    • Dendritic cells are preferentially targeted among hematolymphocytes by Modified Vaccinia Virus Ankara and play a key role in the induction of virus-specific T cell responses in vivo
    • Liu L, Chavan R, Feinberg MB, (2008) Dendritic cells are preferentially targeted among hematolymphocytes by Modified Vaccinia Virus Ankara and play a key role in the induction of virus-specific T cell responses in vivo. BMC Immunol 9: 15.
    • (2008) BMC Immunol , vol.9 , pp. 15
    • Liu, L.1    Chavan, R.2    Feinberg, M.B.3
  • 77
    • 79959198504 scopus 로고    scopus 로고
    • Uptake of antigens from modified vaccinia Ankara virus-infected leukocytes enhances the immunostimulatory capacity of dendritic cells
    • Flechsig C, Suezer Y, Kapp M, Tan SM, Loffler J, et al. (2011) Uptake of antigens from modified vaccinia Ankara virus-infected leukocytes enhances the immunostimulatory capacity of dendritic cells. Cytotherapy 13: 739-752.
    • (2011) Cytotherapy , vol.13 , pp. 739-752
    • Flechsig, C.1    Suezer, Y.2    Kapp, M.3    Tan, S.M.4    Loffler, J.5
  • 78
    • 25444519428 scopus 로고    scopus 로고
    • The nonreplicating smallpox candidate vaccines defective vaccinia Lister (dVV-L) and modified vaccinia Ankara (MVA) elicit robust long-term protection
    • Coulibaly S, Bruhl P, Mayrhofer J, Schmid K, Gerencer M, et al. (2005) The nonreplicating smallpox candidate vaccines defective vaccinia Lister (dVV-L) and modified vaccinia Ankara (MVA) elicit robust long-term protection. Virology 341: 91-101.
    • (2005) Virology , vol.341 , pp. 91-101
    • Coulibaly, S.1    Bruhl, P.2    Mayrhofer, J.3    Schmid, K.4    Gerencer, M.5
  • 79
    • 12144290086 scopus 로고    scopus 로고
    • Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox
    • Earl PL, Americo JL, Wyatt LS, Eller LA, Whitbeck JC, et al. (2004) Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox. Nature 428: 182-185.
    • (2004) Nature , vol.428 , pp. 182-185
    • Earl, P.L.1    Americo, J.L.2    Wyatt, L.S.3    Eller, L.A.4    Whitbeck, J.C.5
  • 80
    • 0035852350 scopus 로고    scopus 로고
    • Enhanced CD8+ T cell immune response against a V3 loop multi-epitope polypeptide (TAB13) of HIV-1 Env after priming with purified fusion protein and booster with modified Vaccinia virus Ankara (MVA-TAB) recombinant: a comparison of humoral and cellular immune responses with thw vaccinia virus Western Reserve (WR) vector
    • Gomez CE, Rodriguez D, Rodriguez JR, Abaitua F, Duarte C, Esteban M, (2002) Enhanced CD8+ T cell immune response against a V3 loop multi-epitope polypeptide (TAB13) of HIV-1 Env after priming with purified fusion protein and booster with modified Vaccinia virus Ankara (MVA-TAB) recombinant: a comparison of humoral and cellular immune responses with thw vaccinia virus Western Reserve (WR) vector. Vaccine 20: 961-971.
    • (2002) Vaccine , vol.20 , pp. 961-971
    • Gomez, C.E.1    Rodriguez, D.2    Rodriguez, J.R.3    Abaitua, F.4    Duarte, C.5    Esteban, M.6
  • 81
    • 0342470981 scopus 로고    scopus 로고
    • Biology of attenuated modified vaccinia virus Ankara recombinant vector in mice: virus fate and activation of B- and T-cell immune responses in comparison with the Western Reserve strain and advantages as a vaccine
    • Ramirez JC, Gherardi MM, Esteban M, (2000) Biology of attenuated modified vaccinia virus Ankara recombinant vector in mice: virus fate and activation of B- and T-cell immune responses in comparison with the Western Reserve strain and advantages as a vaccine. J Virol 74: 923-933.
    • (2000) J Virol , vol.74 , pp. 923-933
    • Ramirez, J.C.1    Gherardi, M.M.2    Esteban, M.3
  • 82
    • 67650915065 scopus 로고    scopus 로고
    • Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome
    • Delaloye J, Roger T, Steiner-Tardivel QG, Le Roy D, Knaup Reymond M, et al. (2009) Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathog 5: e1000480.
    • (2009) PLoS Pathog , vol.5
    • Delaloye, J.1    Roger, T.2    Steiner-Tardivel, Q.G.3    Le Roy, D.4    Knaup Reymond, M.5
  • 83
    • 62749084521 scopus 로고    scopus 로고
    • Modified vaccinia virus ankara triggers chemotaxis of monocytes and early respiratory immigration of leukocytes by induction of CCL2 expression
    • Lehmann MH, Kastenmuller W, Kandemir JD, Brandt F, Suezer Y, et al. (2009) Modified vaccinia virus ankara triggers chemotaxis of monocytes and early respiratory immigration of leukocytes by induction of CCL2 expression. J Virol 83: 2540-2552.
    • (2009) J Virol , vol.83 , pp. 2540-2552
    • Lehmann, M.H.1    Kastenmuller, W.2    Kandemir, J.D.3    Brandt, F.4    Suezer, Y.5
  • 84
    • 61949216736 scopus 로고    scopus 로고
    • Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
    • Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, et al. (2009) Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med 15: 293-299.
    • (2009) Nat Med , vol.15 , pp. 293-299
    • Hansen, S.G.1    Vieville, C.2    Whizin, N.3    Coyne-Johnson, L.4    Siess, D.C.5
  • 85
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    • Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, et al. (2011) Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473: 523-527.
    • (2011) Nature , vol.473 , pp. 523-527
    • Hansen, S.G.1    Ford, J.C.2    Lewis, M.S.3    Ventura, A.B.4    Hughes, C.M.5
  • 86
    • 29744465281 scopus 로고    scopus 로고
    • The vaccinia virus N1L protein influences cytokine secretion in vitro after infection
    • Zhang Z, Abrahams MR, Hunt LA, Suttles J, Marshall W, et al. (2005) The vaccinia virus N1L protein influences cytokine secretion in vitro after infection. Ann N Y Acad Sci 1056: 69-86.
    • (2005) Ann N Y Acad Sci , vol.1056 , pp. 69-86
    • Zhang, Z.1    Abrahams, M.R.2    Hunt, L.A.3    Suttles, J.4    Marshall, W.5
  • 87
    • 4344600796 scopus 로고    scopus 로고
    • Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors
    • DiPerna G, Stack J, Bowie AG, Boyd A, Kotwal G, et al. (2004) Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors. J Biol Chem 279: 36570-36578.
    • (2004) J Biol Chem , vol.279 , pp. 36570-36578
    • DiPerna, G.1    Stack, J.2    Bowie, A.G.3    Boyd, A.4    Kotwal, G.5
  • 89
    • 77956194962 scopus 로고    scopus 로고
    • Insertion of vaccinia virus C7L host range gene into NYVAC-B genome potentiates immune responses against HIV-1 antigens
    • Najera JL, Gomez CE, Garcia-Arriaza J, Sorzano CO, Esteban M, (2010) Insertion of vaccinia virus C7L host range gene into NYVAC-B genome potentiates immune responses against HIV-1 antigens. PLoS One 5: e11406.
    • (2010) PLoS One , vol.5
    • Najera, J.L.1    Gomez, C.E.2    Garcia-Arriaza, J.3    Sorzano, C.O.4    Esteban, M.5


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