메뉴 건너뛰기




Volumn 38, Issue 6, 2012, Pages 662-672

Biomarkers in the development of anti-angiogenic therapies for ovarian cancer

Author keywords

Angiogenesis; Biomarkers; Ovarian cancer; VEGF

Indexed keywords

ANGIOGENESIS INHIBITOR; BEVACIZUMAB; BIOLOGICAL MARKER; CA 125 ANTIGEN; CARBOPLATIN; CD31 ANTIGEN; CEDIRANIB; COMBRETASTATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ERLOTINIB; GEMCITABINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NINTEDANIB; PACLITAXEL; PAZOPANIB; PLATINUM; PROTEIN KINASE B; PROTEIN P27; TAXANE DERIVATIVE; THALIDOMIDE; TREBANANIB; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

EID: 84861661737     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2011.11.009     Document Type: Review
Times cited : (15)

References (84)
  • 1
    • 84861669802 scopus 로고    scopus 로고
    • GLOBOCAN 2008 v1.2, Cancer incidence and mortality worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer, Available from [accessed 20.11.11].
    • Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer incidence and mortality worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer, 2010. Available from [accessed 20.11.11]. http://globocan.iarc.fr.
    • (2010)
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 2
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 3
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D., Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 4
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin D.J., Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005, 23:1011-1027.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 5
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2002, 2:795-803.
    • (2002) Nat Rev Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 6
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumour activity
    • Ellis L.M., Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 2008, 8:579-591.
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 7
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker S., Takashima S., Miao H.Q., et al. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998, 92:735-745.
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3
  • 8
    • 33750069768 scopus 로고    scopus 로고
    • Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas
    • Osada R., Horiuchi A., Kikuchi N., et al. Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas. Hum Pathol 2006, 37:1414-1425.
    • (2006) Hum Pathol , vol.37 , pp. 1414-1425
    • Osada, R.1    Horiuchi, A.2    Kikuchi, N.3
  • 9
    • 0035862972 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in ovarian cyst fluid
    • Boss E.A., Massuger L.F., Thomas C.M., et al. Vascular endothelial growth factor in ovarian cyst fluid. Cancer 2001, 91:371-377.
    • (2001) Cancer , vol.91 , pp. 371-377
    • Boss, E.A.1    Massuger, L.F.2    Thomas, C.M.3
  • 10
    • 0034072645 scopus 로고    scopus 로고
    • Suppression of ascites formation and re-accumulation associated with human ovarian cancer by an anti-VPF monoclonal antibody in vivo
    • Yukita A., Asano M., Okamoto T., et al. Suppression of ascites formation and re-accumulation associated with human ovarian cancer by an anti-VPF monoclonal antibody in vivo. Anticancer Res 2000, 20:155-160.
    • (2000) Anticancer Res , vol.20 , pp. 155-160
    • Yukita, A.1    Asano, M.2    Okamoto, T.3
  • 11
    • 0345060442 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
    • Byrne A.T., Ross L., Holash J., et al. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res 2003, 9:5721-5728.
    • (2003) Clin Cancer Res , vol.9 , pp. 5721-5728
    • Byrne, A.T.1    Ross, L.2    Holash, J.3
  • 12
    • 0036793818 scopus 로고    scopus 로고
    • Preoperative serum vascular endothelial growth factor levels: significance in ovarian cancer
    • Cooper B.C., Ritchie J.M., Broghammer C.L.W., et al. Preoperative serum vascular endothelial growth factor levels: significance in ovarian cancer. Clin Cancer Res 2002, 8:3193-3197.
    • (2002) Clin Cancer Res , vol.8 , pp. 3193-3197
    • Cooper, B.C.1    Ritchie, J.M.2    Broghammer, C.L.W.3
  • 13
    • 1842850792 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients
    • Kassim S.K., El-Salahy E.M., Fayed S.T., et al. Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients. Clin Biochem 2004, 37:363-369.
    • (2004) Clin Biochem , vol.37 , pp. 363-369
    • Kassim, S.K.1    El-Salahy, E.M.2    Fayed, S.T.3
  • 14
    • 3242658330 scopus 로고    scopus 로고
    • Correlation of serum VEGF levels with clinical stage, therapy efficacy, tumor metastasis and patient survival in ovarian cancer
    • Li L., Wang L., Zhang W., et al. Correlation of serum VEGF levels with clinical stage, therapy efficacy, tumor metastasis and patient survival in ovarian cancer. Anticancer Res 2004, 24:1973-1979.
    • (2004) Anticancer Res , vol.24 , pp. 1973-1979
    • Li, L.1    Wang, L.2    Zhang, W.3
  • 15
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 16
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
    • Jain R.K. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001, 7:987-989.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 17
    • 36849019301 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group study
    • Burger R.A., Sill M.W., Monk B.J., et al. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group study. J Clin Oncol 2007, 25:5165-5171.
    • (2007) J Clin Oncol , vol.25 , pp. 5165-5171
    • Burger, R.A.1    Sill, M.W.2    Monk, B.J.3
  • 18
    • 36849056497 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
    • Cannistra S.A., Matulonis U.A., Penson R.T., et al. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol 2007, 25:5180-5186.
    • (2007) J Clin Oncol , vol.25 , pp. 5180-5186
    • Cannistra, S.A.1    Matulonis, U.A.2    Penson, R.T.3
  • 19
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital Phase II consortia
    • Garcia A.A., Hirte H., Fleming G., et al. Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital Phase II consortia. J Clin Oncol 2008, 26:76-82.
    • (2008) J Clin Oncol , vol.26 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3
  • 20
    • 33947311852 scopus 로고    scopus 로고
    • What is the risk of bowel perforation associated with bevacizumab therapy in ovarian cancer?
    • Han E.S., Monk B.J. What is the risk of bowel perforation associated with bevacizumab therapy in ovarian cancer?. Gynecol Oncol 2007, 105:3-6.
    • (2007) Gynecol Oncol , vol.105 , pp. 3-6
    • Han, E.S.1    Monk, B.J.2
  • 21
    • 77954499682 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab (BEV) in the primary treatment of advanced epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC), or fallopian tube cancer (FTC): A Gynecologic Oncology Group study
    • [suppl; abstr LBA1]
    • Burger R.A., Brady M.F., Bookman M.A., et al. Phase III trial of bevacizumab (BEV) in the primary treatment of advanced epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC), or fallopian tube cancer (FTC): A Gynecologic Oncology Group study. J Clin Oncol 2010, 28:18s. [suppl; abstr LBA1].
    • (2010) J Clin Oncol , vol.28
    • Burger, R.A.1    Brady, M.F.2    Bookman, M.A.3
  • 22
    • 78650450402 scopus 로고    scopus 로고
    • ICON7: a phase III randomised Gynaecologic Cancer Intergroup trial of concurrent bevacizumab and chemotherapy followed by maintenance bevacizumab, versus chemotherapy alone in women with newly diagnosed epithelial ovarian (EOC), primary peritoneal (PPC) or fallopian tube cancer (FTC)
    • Perren T., Swart A.M., Pfisterer J., et al. ICON7: a phase III randomised Gynaecologic Cancer Intergroup trial of concurrent bevacizumab and chemotherapy followed by maintenance bevacizumab, versus chemotherapy alone in women with newly diagnosed epithelial ovarian (EOC), primary peritoneal (PPC) or fallopian tube cancer (FTC). Ann Oncol 2010, 21(Suppl. 8):viii2-viii3.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Perren, T.1    Swart, A.M.2    Pfisterer, J.3
  • 24
    • 80051883913 scopus 로고    scopus 로고
    • Role of molecular agents and targeted therapy in clinical trials for women with ovarian cancer
    • Ledermann J.A., Marth C., Carey M.S., et al. Role of molecular agents and targeted therapy in clinical trials for women with ovarian cancer. Int J Gynecol Cancer 2011, 21:763-770.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 763-770
    • Ledermann, J.A.1    Marth, C.2    Carey, M.S.3
  • 25
    • 80053229517 scopus 로고    scopus 로고
    • OCEANS: a randomized, double-blinded, placebo-controlled phase III trial of chemotherapy with or without bevacizumab (BEV) in patients with platinum-sensitive recurrent epithelial ovarian (EOC), primary peritoneal (PPC), or fallopian tube cancer (FTC)
    • [suppl; abstr LBA5007]
    • Aghajanian C., Finkler N., Rutherford T., et al. OCEANS: a randomized, double-blinded, placebo-controlled phase III trial of chemotherapy with or without bevacizumab (BEV) in patients with platinum-sensitive recurrent epithelial ovarian (EOC), primary peritoneal (PPC), or fallopian tube cancer (FTC). J Clin Oncol 2011, 29:18s. [suppl; abstr LBA5007].
    • (2011) J Clin Oncol , vol.29
    • Aghajanian, C.1    Finkler, N.2    Rutherford, T.3
  • 26
    • 73949123481 scopus 로고    scopus 로고
    • Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer
    • Matulonis U.A., Berlin S., Ivy P., et al. Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer. J Clin Oncol 2009, 27:5601-5606.
    • (2009) J Clin Oncol , vol.27 , pp. 5601-5606
    • Matulonis, U.A.1    Berlin, S.2    Ivy, P.3
  • 27
    • 58149219264 scopus 로고    scopus 로고
    • A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: final results of a PMH, Chicago and California consortia trial
    • [suppl; abstr 5521]
    • Hirte H.W., Vidal L., Fleming G.F., et al. A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: final results of a PMH, Chicago and California consortia trial. J Clin Oncol 2008, 26:15s. [suppl; abstr 5521].
    • (2008) J Clin Oncol , vol.26
    • Hirte, H.W.1    Vidal, L.2    Fleming, G.F.3
  • 28
    • 77956649079 scopus 로고    scopus 로고
    • A phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer
    • Friedlander M., Hancock K.C., Rischin D., et al. A phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer. Gynecol Oncol 2010, 119:32-37.
    • (2010) Gynecol Oncol , vol.119 , pp. 32-37
    • Friedlander, M.1    Hancock, K.C.2    Rischin, D.3
  • 29
    • 80053561888 scopus 로고    scopus 로고
    • A randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 following chemotherapy for relapsed ovarian cancer
    • Ledermann J.A., Hackshaw A., Kaye S., et al. A randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 following chemotherapy for relapsed ovarian cancer. J Clin Oncol 2011, 29:3798-3804.
    • (2011) J Clin Oncol , vol.29 , pp. 3798-3804
    • Ledermann, J.A.1    Hackshaw, A.2    Kaye, S.3
  • 30
    • 79953648492 scopus 로고    scopus 로고
    • Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer
    • Zweifel M., Jayson G.C., Reed N.S., et al. Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer. Ann Oncol 2011, 22:2036-2041.
    • (2011) Ann Oncol , vol.22 , pp. 2036-2041
    • Zweifel, M.1    Jayson, G.C.2    Reed, N.S.3
  • 31
    • 77954522477 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients (pts) with recurrent ovarian carcinoma
    • [suppl; abstr5000]
    • Karlan B.Y., Oza A.M., Hansen V.L., et al. Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients (pts) with recurrent ovarian carcinoma. J Clin Oncol 2001, 28:15s. [suppl; abstr5000].
    • (2001) J Clin Oncol , vol.28
    • Karlan, B.Y.1    Oza, A.M.2    Hansen, V.L.3
  • 32
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints; preferred definitions and conceptual framework
    • Atkinson A.J., Colburn W., De Gruttola V., et al. Biomarkers and surrogate endpoints; preferred definitions and conceptual framework. Clin Pharmacol Ther 2001, 69:89-95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
    • Atkinson, A.J.1    Colburn, W.2    De Gruttola, V.3
  • 33
    • 79956076619 scopus 로고    scopus 로고
    • Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA125 agreed by the Gynecological Cancer Intergroup (GCIG)
    • Rustin G.J., Vergote I., Eisenhauer E., et al. Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA125 agreed by the Gynecological Cancer Intergroup (GCIG). Int J Gynecol Cancer 2011, 21:419-423.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 419-423
    • Rustin, G.J.1    Vergote, I.2    Eisenhauer, E.3
  • 34
    • 77957684487 scopus 로고    scopus 로고
    • Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trial
    • Rustin G.J.S., van der Burg M.E.L., Griffin C.L., et al. Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trial. Lancet 2010, 376:1155-1163.
    • (2010) Lancet , vol.376 , pp. 1155-1163
    • Rustin, G.J.S.1    van der Burg, M.E.L.2    Griffin, C.L.3
  • 35
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
    • Eisenhauer E.A., Therasse P., Bogaerts J., et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 2009, 45:228-247.
    • (2009) Eur J Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 36
    • 42149169074 scopus 로고    scopus 로고
    • Lack of reliability of CA125 response criteria with anti-VEGF molecularly targeted therapy
    • Azad N.S., Annunziata C.M., Steinberg S.M., et al. Lack of reliability of CA125 response criteria with anti-VEGF molecularly targeted therapy. Cancer 2008, 112:1726-1732.
    • (2008) Cancer , vol.112 , pp. 1726-1732
    • Azad, N.S.1    Annunziata, C.M.2    Steinberg, S.M.3
  • 37
    • 84861695029 scopus 로고    scopus 로고
    • Predictive value of serum CA125 levels in women with persistent or recurrent epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC) treated with bevacizumab (BEV) on a Gynecologic Oncology Group (GOG) phase II trial
    • [suppl; abstr e16505]
    • Randall-Whitis L., Burger R.A., Sill M., et al. Predictive value of serum CA125 levels in women with persistent or recurrent epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC) treated with bevacizumab (BEV) on a Gynecologic Oncology Group (GOG) phase II trial. J Clin Oncol 2009, 27:15s. [suppl; abstr e16505].
    • (2009) J Clin Oncol , vol.27
    • Randall-Whitis, L.1    Burger, R.A.2    Sill, M.3
  • 38
    • 67650380136 scopus 로고    scopus 로고
    • Biomarkers of response and resistance to antiangiogenic therapy
    • Jain R.K., Duda D.G., Willett C.G., et al. Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol 2009, 6:327-338.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 327-338
    • Jain, R.K.1    Duda, D.G.2    Willett, C.G.3
  • 39
    • 69849108427 scopus 로고    scopus 로고
    • Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges
    • Mandrekar S.J., Sargent D.J. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J Clin Oncol 2009, 27:4027-4034.
    • (2009) J Clin Oncol , vol.27 , pp. 4027-4034
    • Mandrekar, S.J.1    Sargent, D.J.2
  • 40
    • 49249113484 scopus 로고    scopus 로고
    • Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
    • Azad N.S., Posadas E.M., Kwitkowski V.E., et al. Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin Oncol 2008, 26:3709-3714.
    • (2008) J Clin Oncol , vol.26 , pp. 3709-3714
    • Azad, N.S.1    Posadas, E.M.2    Kwitkowski, V.E.3
  • 41
    • 45549099056 scopus 로고    scopus 로고
    • Et al.: Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California phase II consortia
    • Nimeiri H., Oza A., Morgan R. Et al.: Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California phase II consortia. Gynecol Oncol 2008, 110:49-55.
    • (2008) Gynecol Oncol , vol.110 , pp. 49-55
    • Nimeiri, H.1    Oza, A.2    Morgan, R.3
  • 42
    • 58149346076 scopus 로고    scopus 로고
    • Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab
    • Schultheis A.M., Lurje G., Rhodes K.E., et al. Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab. Clin Cancer Res 2008, 14:7554-7563.
    • (2008) Clin Cancer Res , vol.14 , pp. 7554-7563
    • Schultheis, A.M.1    Lurje, G.2    Rhodes, K.E.3
  • 43
    • 74549205168 scopus 로고    scopus 로고
    • Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2
    • Annunziata C.M., Walker A.J., Minasian L., et al. Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2. Clin Cancer Res 2010, 16:664-672.
    • (2010) Clin Cancer Res , vol.16 , pp. 664-672
    • Annunziata, C.M.1    Walker, A.J.2    Minasian, L.3
  • 44
    • 78049477139 scopus 로고    scopus 로고
    • Overexpression of tumor vascular endothelial growth factor a may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer
    • Chambers S.K., Clouser M.C., Baker A.F., et al. Overexpression of tumor vascular endothelial growth factor a may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer. Clin Cancer Res 2010, 16:5320-5328.
    • (2010) Clin Cancer Res , vol.16 , pp. 5320-5328
    • Chambers, S.K.1    Clouser, M.C.2    Baker, A.F.3
  • 45
    • 78149359739 scopus 로고    scopus 로고
    • Predictive and prognostic angiogenic markers in a Gynecologic Oncology Group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer
    • Han E.S., Burger R.A., Darcy K.M., et al. Predictive and prognostic angiogenic markers in a Gynecologic Oncology Group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer. Gynecol Oncol 2010, 119:484-490.
    • (2010) Gynecol Oncol , vol.119 , pp. 484-490
    • Han, E.S.1    Burger, R.A.2    Darcy, K.M.3
  • 46
    • 78149358809 scopus 로고    scopus 로고
    • Randomized phase III trial of tamoxifen versus thalidomide in women with biochemical-recurrent-only epithelial ovarian, fallopian tube or primary peritoneal carcinoma after a complete response to first-line platinum/taxane chemotherapy with an evaluation of serum vascular endothelial growth factor (VEGF): a Gynecologic Oncology Group study
    • Hurteau J.A., Brady M.F., Darcy K.M., et al. Randomized phase III trial of tamoxifen versus thalidomide in women with biochemical-recurrent-only epithelial ovarian, fallopian tube or primary peritoneal carcinoma after a complete response to first-line platinum/taxane chemotherapy with an evaluation of serum vascular endothelial growth factor (VEGF): a Gynecologic Oncology Group study. Gynecol Oncol 2010, 119:444-450.
    • (2010) Gynecol Oncol , vol.119 , pp. 444-450
    • Hurteau, J.A.1    Brady, M.F.2    Darcy, K.M.3
  • 47
    • 77954243581 scopus 로고    scopus 로고
    • The predictive value of serum VEGF in multiresistant ovarian cancer patients treated with bevacizumab
    • Smerdel M.P., Steffensen K.D., Waldstrøm M., et al. The predictive value of serum VEGF in multiresistant ovarian cancer patients treated with bevacizumab. Gynecol Oncol 2010, 118:167-171.
    • (2010) Gynecol Oncol , vol.118 , pp. 167-171
    • Smerdel, M.P.1    Steffensen, K.D.2    Waldstrøm, M.3
  • 48
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma
    • Weidner N., Semple J.P., Welch W.R., et al. Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med 1991, 324:1-8.
    • (1991) N Engl J Med , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3
  • 49
    • 0029044875 scopus 로고
    • Tumor angiogenesis in advanced stage ovarian carcinoma
    • Hollingsworth H.C., Kohn E.C., Steinberg S.M., et al. Tumor angiogenesis in advanced stage ovarian carcinoma. Am J Pathol 1995, 147:33-41.
    • (1995) Am J Pathol , vol.147 , pp. 33-41
    • Hollingsworth, H.C.1    Kohn, E.C.2    Steinberg, S.M.3
  • 50
    • 0032995287 scopus 로고    scopus 로고
    • The prognostic significance of angiogenesis in epithelial ovarian carcinoma
    • Alvarez A.A., Krigman H.R., Whitaker R.S., et al. The prognostic significance of angiogenesis in epithelial ovarian carcinoma. Clin Cancer Res 1999, 5:587-591.
    • (1999) Clin Cancer Res , vol.5 , pp. 587-591
    • Alvarez, A.A.1    Krigman, H.R.2    Whitaker, R.S.3
  • 51
    • 0142009696 scopus 로고    scopus 로고
    • The influence of microvessel density on ovarian carcinogenesis
    • Stone P.J., Goodheart M.J., Rose S.L., et al. The influence of microvessel density on ovarian carcinogenesis. Gynecol Oncol 2003, 90:566-571.
    • (2003) Gynecol Oncol , vol.90 , pp. 566-571
    • Stone, P.J.1    Goodheart, M.J.2    Rose, S.L.3
  • 52
    • 78651481637 scopus 로고    scopus 로고
    • Antiangiogenic therapies in epithelial ovarian cancer
    • Teoh D.G., Secord A.A. Antiangiogenic therapies in epithelial ovarian cancer. Cancer Control 2011, 18:31-43.
    • (2011) Cancer Control , vol.18 , pp. 31-43
    • Teoh, D.G.1    Secord, A.A.2
  • 53
    • 27644479545 scopus 로고    scopus 로고
    • Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors
    • Thaker P.H., Yazici S., Nilsson M.B., et al. Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors. Clin Cancer Res 2005, 11:4923-4933.
    • (2005) Clin Cancer Res , vol.11 , pp. 4923-4933
    • Thaker, P.H.1    Yazici, S.2    Nilsson, M.B.3
  • 54
    • 33644823334 scopus 로고    scopus 로고
    • Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer
    • Jubb A.M., Hurwitz H.I., Bai W., et al. Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer. J Clin Oncol 2006, 24:217-227.
    • (2006) J Clin Oncol , vol.24 , pp. 217-227
    • Jubb, A.M.1    Hurwitz, H.I.2    Bai, W.3
  • 55
    • 4444324696 scopus 로고    scopus 로고
    • VEGF, VEGFRs expressions and activated STATS in ovarian epithelial carcinoma
    • Chen H., Ye D., Xie X., et al. VEGF, VEGFRs expressions and activated STATS in ovarian epithelial carcinoma. Gynecol Oncol 2004, 94:630-635.
    • (2004) Gynecol Oncol , vol.94 , pp. 630-635
    • Chen, H.1    Ye, D.2    Xie, X.3
  • 56
    • 53749093040 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
    • Schneider B.P., Wang M., Radovich M., et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 2008, 26:4672-4678.
    • (2008) J Clin Oncol , vol.26 , pp. 4672-4678
    • Schneider, B.P.1    Wang, M.2    Radovich, M.3
  • 57
    • 39049088616 scopus 로고    scopus 로고
    • Should tumor VEGF expression influence decisions on combining low-dose chemotherapy with antiangiogenic therapy? Preclinical modeling in ovarian cancer
    • Holtz D.O., Krafty R.T., Mohamed-Hadley A., et al. Should tumor VEGF expression influence decisions on combining low-dose chemotherapy with antiangiogenic therapy? Preclinical modeling in ovarian cancer. J Transl Med 2008, 6:2.
    • (2008) J Transl Med , vol.6 , pp. 2
    • Holtz, D.O.1    Krafty, R.T.2    Mohamed-Hadley, A.3
  • 58
    • 58749097443 scopus 로고    scopus 로고
    • Functional significance of VEGFR-2 on ovarian cancer cells
    • Spannuth W.A., Nick A.M., Jennings N.B., et al. Functional significance of VEGFR-2 on ovarian cancer cells. Int J Cancer 2009, 124:1045-1053.
    • (2009) Int J Cancer , vol.124 , pp. 1045-1053
    • Spannuth, W.A.1    Nick, A.M.2    Jennings, N.B.3
  • 59
    • 39049165334 scopus 로고    scopus 로고
    • Vascular endothelial growth factor mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth
    • Ebos J.M.L., Lee C.R., Bogdanovic E., et al. Vascular endothelial growth factor mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth. Cancer Res 2008, 68:521-529.
    • (2008) Cancer Res , vol.68 , pp. 521-529
    • Ebos, J.M.L.1    Lee, C.R.2    Bogdanovic, E.3
  • 60
    • 33846149645 scopus 로고    scopus 로고
    • Et al.: Azd2171, a pan-vegf receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor T.T., Sorensen A.G., di Tomaso E. Et al.: Azd2171, a pan-vegf receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007, 11:83-95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 61
    • 49249087039 scopus 로고    scopus 로고
    • Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
    • Rini B.I., Michaelson M.D., Rosenberg J.E., et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol 2008, 26:3743-3748.
    • (2008) J Clin Oncol , vol.26 , pp. 3743-3748
    • Rini, B.I.1    Michaelson, M.D.2    Rosenberg, J.E.3
  • 62
    • 33750286135 scopus 로고    scopus 로고
    • The multifaceted circulating endothelial cell in cancer: towards marker and target identification
    • Bertolini F., Shaked Y., Mancuso P., et al. The multifaceted circulating endothelial cell in cancer: towards marker and target identification. Nat Rev Cancer 2006, 6:835-845.
    • (2006) Nat Rev Cancer , vol.6 , pp. 835-845
    • Bertolini, F.1    Shaked, Y.2    Mancuso, P.3
  • 63
    • 77951574916 scopus 로고    scopus 로고
    • Quantity and clinical relevance of circulating endothelial progenitor cells in human ovarian cancer
    • Su Y., Zheng L., Wang Q., et al. Quantity and clinical relevance of circulating endothelial progenitor cells in human ovarian cancer. J Exp Clin Cancer Res 2010, 1-7.
    • (2010) J Exp Clin Cancer Res , pp. 1-7
    • Su, Y.1    Zheng, L.2    Wang, Q.3
  • 64
    • 20944436688 scopus 로고    scopus 로고
    • Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity
    • Beaudry P., Force J., Naumov G.N., et al. Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity. Clin Cancer Res 2005, 11:3514-3522.
    • (2005) Clin Cancer Res , vol.11 , pp. 3514-3522
    • Beaudry, P.1    Force, J.2    Naumov, G.N.3
  • 65
    • 33846441659 scopus 로고    scopus 로고
    • Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer
    • Kamat A.A., Kim T.J., Landen C.N., et al. Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer. Cancer Res 2007, 67:281-288.
    • (2007) Cancer Res , vol.67 , pp. 281-288
    • Kamat, A.A.1    Kim, T.J.2    Landen, C.N.3
  • 66
    • 41849092178 scopus 로고    scopus 로고
    • Angiogenesis as a strategic target for ovarian cancer therapy
    • Spannuth W.A., Sood A.K., Coleman R.L. Angiogenesis as a strategic target for ovarian cancer therapy. Nat Clin Prac Oncol 2008, 5:194-204.
    • (2008) Nat Clin Prac Oncol , vol.5 , pp. 194-204
    • Spannuth, W.A.1    Sood, A.K.2    Coleman, R.L.3
  • 67
    • 76049086838 scopus 로고    scopus 로고
    • Inherited determinants of ovarian cancer survival
    • Goode E.L., Maurer M.J., Sellers T.A., et al. Inherited determinants of ovarian cancer survival. Clin Cancer Res 2010, 16:995-1007.
    • (2010) Clin Cancer Res , vol.16 , pp. 995-1007
    • Goode, E.L.1    Maurer, M.J.2    Sellers, T.A.3
  • 68
    • 78149362120 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival
    • Lose F., Nagle C.M., O'Mara T., et al. Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival. Gynecol Oncol 2010, 119:479-483.
    • (2010) Gynecol Oncol , vol.119 , pp. 479-483
    • Lose, F.1    Nagle, C.M.2    O'Mara, T.3
  • 69
    • 77949304088 scopus 로고    scopus 로고
    • The relationship of VEGF polymorphisms with serum VEGF levels and progression-free survival in patients with epithelial ovarian cancer
    • Steffensen K.D., Waldstrøm M., Brandslund I., et al. The relationship of VEGF polymorphisms with serum VEGF levels and progression-free survival in patients with epithelial ovarian cancer. Gynecol Oncol 2010, 117:109-116.
    • (2010) Gynecol Oncol , vol.117 , pp. 109-116
    • Steffensen, K.D.1    Waldstrøm, M.2    Brandslund, I.3
  • 70
    • 67651055473 scopus 로고    scopus 로고
    • Prognostic importance of vascular endothelial growth factor-A expression and vascular endothelial growth factor polymorphisms in epithelial ovarian cancer
    • Smerdel M.P., Waldstrøm M., Brandslund I., et al. Prognostic importance of vascular endothelial growth factor-A expression and vascular endothelial growth factor polymorphisms in epithelial ovarian cancer. Int J Gynecol Cancer 2009, 19:578-584.
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 578-584
    • Smerdel, M.P.1    Waldstrøm, M.2    Brandslund, I.3
  • 71
    • 33846478656 scopus 로고    scopus 로고
    • DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
    • O'Connor J.P.B., Jackson A., Parker G.J.M., et al. DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. Br J Cancer 2007, 96:189-195.
    • (2007) Br J Cancer , vol.96 , pp. 189-195
    • O'Connor, J.P.B.1    Jackson, A.2    Parker, G.J.M.3
  • 72
    • 77955428008 scopus 로고    scopus 로고
    • Identification of early predictive imaging biomarkers and their relationship to serological angiogenic markers in patients with ovarian cancer with residual disease following cytotoxic therapy
    • Mitchell C.L., O'Connor J.P., Jackson A., et al. Identification of early predictive imaging biomarkers and their relationship to serological angiogenic markers in patients with ovarian cancer with residual disease following cytotoxic therapy. Ann Oncol 2010, 21:1982-1989.
    • (2010) Ann Oncol , vol.21 , pp. 1982-1989
    • Mitchell, C.L.1    O'Connor, J.P.2    Jackson, A.3
  • 73
    • 19944394201 scopus 로고    scopus 로고
    • The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations
    • Leach M.O., Brindle K.M., Evelhoch J.L., et al. The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations. Br J Cancer 2005, 92:1599-1610.
    • (2005) Br J Cancer , vol.92 , pp. 1599-1610
    • Leach, M.O.1    Brindle, K.M.2    Evelhoch, J.L.3
  • 74
    • 46949084994 scopus 로고    scopus 로고
    • Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations?
    • Sessa C., Guibal A., Del Conte G., et al. Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations?. Nat Clin Pract Oncol 2008, 5:378-391.
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 378-391
    • Sessa, C.1    Guibal, A.2    Del Conte, G.3
  • 75
    • 36048955738 scopus 로고    scopus 로고
    • Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study
    • Chen W., Delaloye S., Silverman D.H., et al. Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study. J Clin Oncol 2007, 25:4714-4721.
    • (2007) J Clin Oncol , vol.25 , pp. 4714-4721
    • Chen, W.1    Delaloye, S.2    Silverman, D.H.3
  • 76
    • 73249128451 scopus 로고    scopus 로고
    • Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 study
    • Zhu A.X., Meyerhardt J.A., Blaszkowsky L.S., et al. Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 study. Lancet Oncol 2010, 11:48-54.
    • (2010) Lancet Oncol , vol.11 , pp. 48-54
    • Zhu, A.X.1    Meyerhardt, J.A.2    Blaszkowsky, L.S.3
  • 77
    • 78649537524 scopus 로고    scopus 로고
    • Biomarkers to predict the clinical efficacy of bevacizumab in cancer
    • Jubb A., Harris A. Biomarkers to predict the clinical efficacy of bevacizumab in cancer. Lancet Oncol 2010, 11:1172-1183.
    • (2010) Lancet Oncol , vol.11 , pp. 1172-1183
    • Jubb, A.1    Harris, A.2
  • 78
    • 77949894217 scopus 로고    scopus 로고
    • Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599
    • Dahlberg S.E., Sandler A.B., Brahmer J.R., et al. Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599. J Clin Oncol 2010, 28:949-954.
    • (2010) J Clin Oncol , vol.28 , pp. 949-954
    • Dahlberg, S.E.1    Sandler, A.B.2    Brahmer, J.R.3
  • 79
    • 78049399444 scopus 로고    scopus 로고
    • Analysis of early hypertension (HTN) and clinical outcome with bevacizumab (BV)
    • [suppl; abstr 3039]
    • Hurwitz H., Douglas P.S., Middleton J.P., et al. Analysis of early hypertension (HTN) and clinical outcome with bevacizumab (BV). J Clin Oncol 2010, 28:15s. [suppl; abstr 3039].
    • (2010) J Clin Oncol , vol.28
    • Hurwitz, H.1    Douglas, P.S.2    Middleton, J.P.3
  • 80
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado R.G., Wolf M., Peeters M., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26:1626-1634.
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 81
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis C.S., Khambata-Ford S., Jonker D.J., et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008, 359:1757-1765.
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 83
    • 77956285631 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer
    • Vergote I., Trope C.G., Amant F., et al. Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med 2010, 363:943-953.
    • (2010) N Engl J Med , vol.363 , pp. 943-953
    • Vergote, I.1    Trope, C.G.2    Amant, F.3
  • 84
    • 79960975329 scopus 로고    scopus 로고
    • Window of opportunity trials to evaluate clinical activity of new molecular entities in oncology
    • Glimelius B., Lahn M. Window of opportunity trials to evaluate clinical activity of new molecular entities in oncology. Ann Oncol 2011, 22:1717-1725.
    • (2011) Ann Oncol , vol.22 , pp. 1717-1725
    • Glimelius, B.1    Lahn, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.