-
1
-
-
33847405376
-
Pazopanib: A novel multitargeted tyrosine kinase inhibitor
-
DOI 10.1007/s11912-007-0007-2
-
Sonpavde G, Hutson TE: Pazopanib: A novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep 9:115-119, 2007 (Pubitemid 46332383)
-
(2007)
Current Oncology Reports
, vol.9
, Issue.2
, pp. 115-119
-
-
Sonpavde, G.1
Hutson, T.E.2
-
2
-
-
79959319505
-
-
U.S. Department of Health and Human Services Food & Drug Administration: Pazopanib. http://www.fda.gov/AboutFDA/CentersOffices/CDER/ ucm187509.htm
-
Pazopanib
-
-
-
5
-
-
79959313587
-
-
Australian Government Department of Health and Ageing
-
Australian Government Department of Health and Ageing: Drugs designated as orphan drugs: Pazopanib (PATORMA). http://www.tga.gov.au/docs/html/orphand2. htm#p
-
Drugs Designated As Orphan Drugs: Pazopanib (PATORMA)
-
-
-
6
-
-
79959323545
-
-
Instituto de Salud Publica de Chile
-
Instituto de Salud Publica de Chile: Votrient coated tablets. http://200.68.11.21/RegistrosISP/fiFichaProducto.asp?RegistroISP=F-18018/10
-
Votrient Coated Tablets
-
-
-
7
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
-
Sternberg CN, Davis ID, Mardiak J, et al: Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. J Clin Oncol 28:1061-1068, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
-
8
-
-
0032772880
-
Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
-
Motzer RJ, Mazumdar M, Bacik J, et al: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 17:2530-2540, 1999 (Pubitemid 29368255)
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.8
, pp. 2530-2540
-
-
Motzer, R.J.1
Mazumdar, M.2
Bacik, J.3
Berg, W.4
Amsterdam, A.5
Ferrara, J.6
-
9
-
-
53749093040
-
Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
-
Schneider BP, Wang M, Radovich M, et al: Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 26: 4672-4678, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 4672-4678
-
-
Schneider, B.P.1
Wang, M.2
Radovich, M.3
-
10
-
-
58149346076
-
Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab
-
Schultheis AM, Lurje G, Rhodes KE, et al: Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab. Clin Cancer Res 14:7554-7563, 2008
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7554-7563
-
-
Schultheis, A.M.1
Lurje, G.2
Rhodes, K.E.3
-
11
-
-
77951666852
-
Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism
-
Xu CF, Reck BH, Xue Z, et al: Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. Br J Cancer 102: 1371-1377, 2010
-
(2010)
Br J Cancer
, vol.102
, pp. 1371-1377
-
-
Xu, C.F.1
Reck, B.H.2
Xue, Z.3
-
12
-
-
79956146844
-
Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma
-
Epub ahead of print on February 12
-
Xu CF, Reck BH, Goodman VL, et al: Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma. J Hepatol [Epub ahead of print on February 12, 2011]
-
(2011)
J Hepatol
-
-
Xu, C.F.1
Reck, B.H.2
Goodman, V.L.3
-
13
-
-
75749090050
-
Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma
-
Hutson TE, Davis ID, Machiels JP, et al: Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma. J Clin Oncol 28:475-480, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 475-480
-
-
Hutson, T.E.1
Davis, I.D.2
Machiels, J.P.3
-
14
-
-
27544486754
-
Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles
-
DOI 10.1016/j.bbrc.2005.09.020, PII S0006291X0502019X
-
Rodriguez-Antona C, Sayi JG, Gustafsson LL, et al: Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles. Biochem Biophys Res Commun 338:299-305, 2005 (Pubitemid 41540570)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.338
, Issue.1
, pp. 299-305
-
-
Rodriguez-Antona, C.1
Sayi, J.G.2
Gustafsson, L.L.3
Bertilsson, L.4
Ingelman-Sundberg, M.5
-
15
-
-
2942560581
-
CYP3A5 genotype and midazolam clearance in Australian patients receiving chemotherapy
-
DOI 10.1016/j.clpt.2004.02.005, PII S0009923604000669
-
Wong M, Balleine RL, Collins M, et al: CYP3A5 genotype and midazolam clearance in Australian patients receiving chemotherapy. Clin Pharmacol Ther 75:529-538, 2004 (Pubitemid 38746603)
-
(2004)
Clinical Pharmacology and Therapeutics
, vol.75
, Issue.6
, pp. 529-538
-
-
Wong, M.1
Balleine, R.L.2
Collins, M.3
Liddle, C.4
Clarke, C.L.5
Gurney, H.6
-
16
-
-
70349342710
-
Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity
-
van Erp NP, Eechoute K, van der Veldt AA, et al: Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity. J Clin Oncol 27:4406-4412, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 4406-4412
-
-
Van Erp, N.P.1
Eechoute, K.2
Van Der Veldt, A.A.3
-
17
-
-
37549010733
-
Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression
-
Lamba J, Lamba V, Strom S, et al: Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression. Drug Metab Dispos 36:169-181, 2008
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 169-181
-
-
Lamba, J.1
Lamba, V.2
Strom, S.3
-
18
-
-
77951434185
-
A role for the pregnane X receptor in flucloxacillin-induced liver injury
-
Andrews E, Armstrong M, Tugwood J, et al: A role for the pregnane X receptor in flucloxacillin-induced liver injury. Hepatology 51:1656-1664, 2010
-
(2010)
Hepatology
, vol.51
, pp. 1656-1664
-
-
Andrews, E.1
Armstrong, M.2
Tugwood, J.3
-
19
-
-
33644781452
-
Implications of genetic polymorphisms in drug transporters for pharmacotherapy
-
Kerb R: Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett 234:4-33, 2006
-
(2006)
Cancer Lett
, vol.234
, pp. 4-33
-
-
Kerb, R.1
-
20
-
-
1242319383
-
Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2
-
DOI 10.1002/ijc.11669
-
Mizuarai S, Aozasa N, Kotani H: Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2. Int J Cancer 109:238-246, 2004 (Pubitemid 38240926)
-
(2004)
International Journal of Cancer
, vol.109
, Issue.2
, pp. 238-246
-
-
Mizuarai, S.1
Aozasa, N.2
Kotani, H.3
-
21
-
-
35248815945
-
The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine
-
DOI 10.1111/j.1365-2125.2007.02944.x
-
Kim HS, Sunwoo YE, Ryu JY, et al: The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine. Br J Clin Pharmacol 64:645-654, 2007 (Pubitemid 47568815)
-
(2007)
British Journal of Clinical Pharmacology
, vol.64
, Issue.5
, pp. 645-654
-
-
Kim, H.-S.1
Sunwoo, Y.E.2
Ryu, J.Y.3
Kang, H.-J.4
Jung, H.-E.5
Song, I.-S.6
Kim, E.-Y.7
Shim, J.-C.8
Shon, J.-H.9
Shin, J.-G.10
-
22
-
-
34547849753
-
Polymorphisms of KDR Gene Are Associated with Coronary Heart Disease
-
DOI 10.1016/j.jacc.2007.04.074, PII S0735109707017834
-
Wang Y, Zheng Y, Zhang W, et al: Polymorphisms of KDR gene are associated with coronary heart disease. J Am Coll Cardiol 50:760-767, 2007 (Pubitemid 47243798)
-
(2007)
Journal of the American College of Cardiology
, vol.50
, Issue.8
, pp. 760-767
-
-
Wang, Y.1
Zheng, Y.2
Zhang, W.3
Yu, H.4
Lou, K.5
Zhang, Y.6
Qin, Q.7
Zhao, B.8
Yang, Y.9
Hui, R.10
-
23
-
-
79151468933
-
Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors
-
Steeghs N, Gelderblom H, Wessels J, et al: Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors. Invest New Drugs 29:137-143, 2011
-
(2011)
Invest New Drugs
, vol.29
, pp. 137-143
-
-
Steeghs, N.1
Gelderblom, H.2
Wessels, J.3
-
24
-
-
14144253078
-
Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q
-
Kawahara C, Forster T, Chapman K, et al: Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. Ann Rheum Dis 64:474-476, 2005
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 474-476
-
-
Kawahara, C.1
Forster, T.2
Chapman, K.3
-
25
-
-
0033666337
-
Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families
-
Hull J, Thomson A, Kwiatkowski D: Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax 55:1023-1027, 2000
-
(2000)
Thorax
, vol.55
, pp. 1023-1027
-
-
Hull, J.1
Thomson, A.2
Kwiatkowski, D.3
-
26
-
-
69049090737
-
Effect of basic fibroblast growth factor (FGF2) gene polymorphisms on SSRIs treatment response and side effects
-
Kato M, Okugawa G, Wakeno M, et al: Effect of basic fibroblast growth factor (FGF2) gene polymorphisms on SSRIs treatment response and side effects. Eur Neuropsychopharmacol 19:718-725, 2009
-
(2009)
Eur Neuropsychopharmacol
, vol.19
, pp. 718-725
-
-
Kato, M.1
Okugawa, G.2
Wakeno, M.3
-
27
-
-
70450225529
-
Association of FGFR2 gene polymorphisms with the risk of breast cancer in population of West Siberia
-
Boyarskikh UA, Zarubina NA, Biltueva JA, et al: Association of FGFR2 gene polymorphisms with the risk of breast cancer in population of West Siberia. Eur J Hum Genet 17:1688-1691, 2009
-
(2009)
Eur J Hum Genet
, vol.17
, pp. 1688-1691
-
-
Boyarskikh, U.A.1
Zarubina, N.A.2
Biltueva, J.A.3
-
28
-
-
0242559086
-
Hypoxia-inducible factor-1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance
-
DOI 10.1093/carcin/bgg132
-
Tanimoto K, Yoshiga K, Eguchi H, et al: Hypoxia-inducible factor-1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance. Carcinogenesis 24: 1779-1783, 2003 (Pubitemid 37408141)
-
(2003)
Carcinogenesis
, vol.24
, Issue.11
, pp. 1779-1783
-
-
Tanimoto, K.1
Yoshiga, K.2
Eguchi, H.3
Kaneyasu, M.4
Ukon, K.5
Kumazaki, T.6
Oue, N.7
Yasui, W.8
Imai, K.9
Nakachi, K.10
Poellinger, L.11
Nishiyama, M.12
-
29
-
-
24744438663
-
Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells
-
DOI 10.1038/nm1294
-
Mizukami Y, Jo WS, Duerr EM, et al: Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. Nat Med 11:992-997, 2005 (Pubitemid 41294446)
-
(2005)
Nature Medicine
, vol.11
, Issue.9
, pp. 992-997
-
-
Mizukami, Y.1
Jo, W.-S.2
Duerr, E.-M.3
Gala, M.4
Li, J.5
Zhang, X.6
Zimmer, M.A.7
Iliopoulos, O.8
Zukerberg, L.R.9
Kohgo, Y.10
Lynch, M.P.11
Rueda, B.R.12
Chung, D.C.13
-
30
-
-
76249133170
-
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
-
Huang D, Ding Y, Zhou M, et al: Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res 70:1063-1071, 2010
-
(2010)
Cancer Res
, vol.70
, pp. 1063-1071
-
-
Huang, D.1
Ding, Y.2
Zhou, M.3
-
31
-
-
77957980222
-
Identification of prognostic genomic markers in patients with localized clear cell renal cell carcinoma (ccRCC)
-
abstr 4501
-
Rini BI, Zhou M, Aydin H, et al: Identification of prognostic genomic markers in patients with localized clear cell renal cell carcinoma (ccRCC). J Clin Oncol 28:342s, 2010 (suppl; abstr 4501)
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Rini, B.I.1
Zhou, M.2
Aydin, H.3
-
32
-
-
3242666120
-
Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility
-
DOI 10.1038/sj.gene.6364067
-
Hacking D, Knight JC, Rockett K, et al: Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility. Genes Immun 5:274-282, 2004 (Pubitemid 38961160)
-
(2004)
Genes and Immunity
, vol.5
, Issue.4
, pp. 274-282
-
-
Hacking, D.1
Knight, J.C.2
Rockett, K.3
Brown, H.4
Frampton, J.5
Kwiatkowski, D.P.6
Hull, J.7
Udalova, I.A.8
-
33
-
-
28644442435
-
Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan
-
DOI 10.1158/1055-9965.EPI-05-0326
-
Taguchi A, Ohmiya N, Shirai K, et al: Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. Cancer Epidemiol Biomarkers Prev 14:2487-2493, 2005 (Pubitemid 41752706)
-
(2005)
Cancer Epidemiology Biomarkers and Prevention
, vol.14
, Issue.11 I
, pp. 2487-2493
-
-
Taguchi, A.1
Ohmiya, N.2
Shirai, K.3
Mabuchi, N.4
Itoh, A.5
Hirooka, Y.6
Niwa, Y.7
Goto, H.8
-
34
-
-
79957497622
-
VEGF -460T -> C polymorphism and its association with VEGF expression and outcome to FOLFOX-4 treatment in patients with colorectal carcinoma
-
Epub ahead of print on June 8
-
Chen MH, Tzeng CH, Chen PM, et al: VEGF -460T -> C polymorphism and its association with VEGF expression and outcome to FOLFOX-4 treatment in patients with colorectal carcinoma. Pharmacogenomics J [Epub ahead of print on June 8, 2010]
-
(2010)
Pharmacogenomics J
-
-
Chen, M.H.1
Tzeng, C.H.2
Chen, P.M.3
-
35
-
-
8444239305
-
VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer
-
DOI 10.1016/j.lungcan.2004.04.037, PII S0169500204002053
-
Koukourakis MI, Papazoglou D, Giatromanolaki A, et al: VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. Lung Cancer 46: 293-298, 2004 (Pubitemid 39487303)
-
(2004)
Lung Cancer
, vol.46
, Issue.3
, pp. 293-298
-
-
Koukourakis, M.I.1
Papazoglou, D.2
Giatromanolaki, A.3
Bougioukas, G.4
Maltezos, E.5
Siviridis, E.6
-
36
-
-
0037442985
-
Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter
-
Stevens A, Soden J, Brenchley PE, et al: Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter. Cancer Res 63:812-816, 2003 (Pubitemid 36231981)
-
(2003)
Cancer Research
, vol.63
, Issue.4
, pp. 812-816
-
-
Stevens, A.1
Soden, J.2
Brenchley, P.E.3
Ralph, S.4
Ray, D.W.5
-
37
-
-
0036799870
-
The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism
-
DOI 10.1210/er.2001-0038
-
Kliewer SA, Goodwin B, Willson TM: The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism. Endocr Rev 23:687-702, 2002 (Pubitemid 35191629)
-
(2002)
Endocrine Reviews
, vol.23
, Issue.5
, pp. 687-702
-
-
Kliewer, S.A.1
Goodwin, B.2
Willson, T.M.3
-
38
-
-
0034785945
-
The human pregnane X receptor: Genomic structure and identification and functional characterization of natural allelic variants
-
DOI 10.1097/00008571-200110000-00003
-
Zhang J, Kuehl P, Green ED, et al: The human pregnane X receptor: Genomic structure and identification and functional characterization of natural allelic variants. Pharmacogenetics 11:555-572, 2001 (Pubitemid 32953582)
-
(2001)
Pharmacogenetics
, vol.11
, Issue.7
, pp. 555-572
-
-
Zhang, J.1
Kuehl, P.2
Green, E.D.3
Touchman, J.W.4
Watkins, P.B.5
Daly, A.6
Hall, S.D.7
Maurel, P.8
Relling, M.9
Brimer, C.10
Yasuda, K.11
Wrighton, S.A.12
Hancock, M.13
Kim, R.B.14
Strom, S.15
Thummel, K.16
Russell, C.G.17
Hudson Jr., J.R.18
Schuetz, E.G.19
Boguski, M.S.20
more..
-
40
-
-
0001677717
-
Controlling the false discovery rate: A practical and powerful approach to multiple testing
-
Benjamini Y, Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Statist Soc B 57:289-300, 1995
-
(1995)
J R Statist Soc B
, vol.57
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
41
-
-
73349084973
-
Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: Results from a large, multicenter study
-
Heng DY, Xie W, Regan MM, et al: Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: Results from a large, multicenter study. J Clin Oncol 27: 5794-5799, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 5794-5799
-
-
Heng, D.Y.1
Xie, W.2
Regan, M.M.3
-
42
-
-
77953127347
-
Biomarkers and surrogate end points-the challenge of statistical validation
-
Buyse M, Sargent DJ, Grothey A, et al: Biomarkers and surrogate end points-the challenge of statistical validation. Nat Rev Clin Oncol 7:309-317, 2010
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 309-317
-
-
Buyse, M.1
Sargent, D.J.2
Grothey, A.3
-
43
-
-
84870445213
-
-
National Library of Medicine, National Institutes of Health: htt://hapmap.ncbi.nlm.nih.gov
-
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health: International HapMap Project. htt://hapmap.ncbi.nlm.nih.gov
-
International HapMap Project
-
-
|