Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) pathway initiated by t cell antigen receptor (TCRγλ) activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γλT cell cytotoxicity

Journal of Biological Chemistry

Volumn 288, Issue 37, 2013, Pages 26448-26462

  Yin, Shanshan ^a   Zhang, Jianmin ^a   Mao, Yujia ^a   Hu, Yu ^a   Cui, Lianxian ^a   Kang, Ning ^a   He, Wei ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR MECHANISM; PHOSPHOLIPASE C; STRONG SIGNAL; T-CELL ANTIGEN RECEPTORS; THRESHOLD SETS; UBIQUITIN LIGASES;

CYTOLOGY; CYTOTOXICITY;

CELLS;

CBL B PROTEIN; NATURAL KILLER CELL RECEPTOR NKG2D; PHOSPHOLIPASE C GAMMA1; T LYMPHOCYTE RECEPTOR; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; VAV PROTEIN;

ARTICLE; CANCER IMMUNOTHERAPY; CELL KILLING; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; GAMMA DELTA T LYMPHOCYTE; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOLECULAR MECHANICS; NORMAL HUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CANCER THERAPY; CELL SIGNALING; INNATE IMMUNITY; PHOSPHOLIPASE C; T CELL;

CALCIUM; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; PHOSPHOLIPASE C GAMMA; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS C-VAV; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84884191416     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.484600     Document Type: Article

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