Negative regulation of lymphocyte development and function by the Cbl family of proteins

Immunological Reviews

Volumn 224, Issue 1, 2008, Pages 229-238

  Huang, Fang ^a   Gu, Hua ^b  

^a FUDAN UNIVERSITY   (China)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Anergy; B cells; Cell activation; Signal transduction; T cells; Tumor immunity

Indexed keywords

B LYMPHOCYTE ANTIGEN; B LYMPHOCYTE RECEPTOR; CBL B ENZYME; CBL PROTEIN; DOUBLE STRANDED DNA; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN PROTEIN LIGASE;

AUTOIMMUNE DISEASE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL STIMULATION; DISEASE SEVERITY; DOWN REGULATION; FLOW CYTOMETRY; GENE MUTATION; GENE REARRANGEMENT; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOREGULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE; UBIQUITINATION;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; FEEDBACK, BIOCHEMICAL; HUMANS; IMMUNE TOLERANCE; IMMUNOLOGIC SURVEILLANCE; LYMPHOCYTE ACTIVATION; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR PROTEIN-TYROSINE KINASES; T-LYMPHOCYTES; THYMUS GLAND;

EID: 49249103760     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2008.00655.x     Document Type: Review

References (53)

1. Robey E, Fowlkes BJ. Selective events in T cell development. Annu Rev Immunol 1994 12 : 675 705.
2. Benoist C, Mathis D. Positive selection of T cells: fastidious or promiscuous? Curr Opin Immunol 1997 9 : 245 249.
3. Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996 381 : 751 758.
4. Healy JI, Goodnow CC. Positive versus negative signaling by lymphocyte antigen receptors. Annu Rev Immunol 1998 16 : 645 670.
5. Su IH, Tarakhovsky A. Lysine methylation and 'signaling memory'. Curr Opin Immunol 2006 18 : 152 157.
6. Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. Cell 1994 76 : 263 274.
7. Liu Y, Gu H. Cbl and Cbl-b in T-cell regulation. Trends Immunol 2002 23 : 140 143.
8. Fang S, Weissman AM. A field guide to ubiquitylation. Cell Mol Life Sci 2004 61 : 1546 1561.
9. Liu YC. Ubiquitin ligases and the immune response. Annu Rev Immunol 2004 22 : 81 127.
10. Duan L, Reddi AL, Ghosh A, Dimri M, Band H. The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity 2004 21 : 7 17.
11. Rao N, Dodge I, Band H. The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J Leukoc Biol 2002 71 : 753 763.
12. Lupher ML Jr., Rao N, Eck MJ, Band H. The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction. Immunol Today 1999 20 : 375 382.
13. Ashton-Rickardt PG, et al. Evidence for a differential avidity model of T cell selection in the thymus. Cell 1994 76 : 651 663.
14. Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR. T cell receptor antagonist peptides induce positive selection. Cell 1994 76 : 17 27.
15. Sebzda E, Wallace VA, Mayer J, Yeung RS, Mak TW, Ohashi PS. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 1994 263 : 1615 1618.
16. Murphy MA, et al. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol 1998 18 : 4872 4882.
17. + T cells from T cell receptor transgenic mice. J Exp Med 1992 176 : 1091 1098.
18. + thymocytes. Nature 1988 333 : 742 746.
19. Naramura M, Kole HK, Hu RJ, Gu H. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci USA 1998 95 : 15547 15552.
20. Tarakhovsky A, et al. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 1995 269 : 535 537.
21. Wang HY, et al. Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70. J Biol Chem 2001 276 : 26004 26011.
22. von Boehmer H, Fehling HJ. Structure and function of the pre-T cell receptor. Annu Rev Immunol 1997 15 : 433 452.
23. Yamasaki S, et al. Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat Immunol 2006 7 : 67 75.
24. Naramura M, Jang IK, Kole H, Huang F, Haines D, Gu H. c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol 2002 3 : 1192 1199.
25. + T cells by the Cbl family proteins. Immunity 2006 25 : 571 581.
26. Panigada M, et al. Constitutive endocytosis and degradation of the pre-T cell receptor. J Exp Med 2002 195 : 1585 1597.
27. Gounari F, et al. Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development. Nat Immunol 2001 2 : 863 869.
28. Schmedt C, Tarakhovsky A. Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk). J Exp Med 2001 193 : 815 826.
29. Janeway CA Jr., Bottomly K. Signals and signs for lymphocyte responses. Cell 1994 76 : 275 285.
30. Schwartz RH. Models of T cell anergy: is there a common molecular mechanism? J Exp Med 1996 184 : 1 8.
31. Chiang YJ, et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 2000 403 : 216 220.
32. Bachmaier K, et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 2000 403 : 211 216.
33. Fischer KD, et al. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol 1998 8 : 554 562.
34. Tarakhovsky A, et al. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 1995 374 : 467 470.
35. Zhang R, Alt FW, Davidson L, Orkin SH, Swat W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 1995 374 : 470 473.
36. Fang D, Liu YC. Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat Immunol 2001 2 : 870 875.
37. Thomas ML. The regulation of antigen-receptor signaling by protein tyrosine phosphatases: a hole in the story. Curr Opin Immunol 1999 11 : 270 276.
38. Dustin ML. Impact of the immunological synapse on T cell signaling. Res Probl Cell Diff 2006 43 : 175 198.
39. Liu H, Rhodes M, Wiest DL, Vignali DA. On the dynamics of TCR: CD3 complex cell surface expression and downmodulation. Immunity 2000 13 : 665 675.
40. Yasuda T, et al. Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. J Exp Med 2002 196 : 51 63.
41. Yasuda T, et al. Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma 2 activation by regulating B cell linker protein-PLC-gamma 2 binding. J Exp Med 2000 191 : 641 650.
42. Sohn HW, Gu H, Pierce SK. Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. J Exp Med 2003 197 : 1511 1524.
43. Kitaura Y, et al. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 2007 26 : 567 578.
44. Goodnow CC, et al. Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways. Cold Spring Harb Symp Quant Biol 1999 64 : 313 322.
45. Monroe JG. Ligand-independent tonic signaling in B-cell receptor function. Curr Opin Immunol 2004 16 : 288 295.
46. Nemazee D, Buerki K. Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras. Proc Natl Acad Sci USA 1989 86 : 8039 8043.
47. Goodnow CC. Transgenic mice and analysis of B-cell tolerance. Annu Rev Immunol 1992 10 : 489 518.
48. Allman D, Li J, Hardy RR. Commitment to the B lymphoid lineage occurs before DH-JH recombination. J Exp Med 1999 189 : 735 740.
49. Carsetti R, Kohler G, Lamers MC. Transitional B cells are the target of negative selection in the B cell compartment. J Exp Med 1995 181 : 2129 2140.
50. Monroe JG. B-cell positive selection and peripheral homeostasis. Immunol Rev 2004 197 : 5 9.
51. Mecklenbrauker I, Saijo K, Zheng NY, Leitges M, Tarakhovsky A. Protein kinase C delta controls self-antigen-induced B-cell tolerance. Nature 2002 416 : 860 865.
52. Chiang JY, Jang IK, Hodes R, Gu Ablation of Cbl-b provides protection against transplanted and spontaneous tumors. J Clin Invest 2007 117 : 1029 1036.
53. + T cells. J Exp Med 2007 204 : 879 891.