Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation

Journal of Biological Chemistry

Volumn 287, Issue 23, 2012, Pages 19725-19735

  Knyazhitsky, Mira ^a   Moas, Etay ^a   Shaginov, Ekaterina ^a   Luria, Anna ^a   Braiman, Alex ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATED SIGNALING; CALCIUM FLUX; CALCIUM MOBILIZATION; CONFORMATIONAL CHANGE; CYTOSOLIC CALCIUM; FINE STRUCTURES; HEMATOPOIETIC CELL; MICRO-CLUSTERS; MULTIPLE INTERACTIONS; N-TERMINALS; PHOSPHOLIPASE C; PROTEIN COMPLEXES; SIGNALING CASCADES; T CELL ACTIVATION; T CELL RECEPTOR; T CELLS; T-CELL ANTIGEN RECEPTORS; TRANSDUCING;

CELL MEMBRANES; CYTOLOGY; PHOSPHORYLATION; SIGNALING; SUGARS;

CALCIUM;

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATASE; PHOSPHOLIPASE C GAMMA1; PROTEIN VAV1; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VAV PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

CALCIUM; CELL LINE; ENZYME ACTIVATION; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; LYMPHOCYTE ACTIVATION; MUTATION; PHOSPHOLIPASE C GAMMA; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-VAV; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 84861731097     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.309799     Document Type: Article

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