Activation of T cells: Releasing the brakes by proteolytic elimination of Cbl-b

Science Signaling

Volumn 2, Issue 76, 2009, Pages

  Schmitz, M Lienhard ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASITAS B LINEAGE LYMPHOMA ENZYME; CD28 ANTIGEN; ENZYME; T LYMPHOCYTE RECEPTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CBL PROTEIN; CBLB PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

BIOCHEMISTRY; CLONAL ANERGY; ENZYME ACTIVITY; ENZYME SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SHORT SURVEY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; ENZYMOLOGY; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; REVIEW;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD28; CLONAL ANERGY; HUMANS; LYMPHOCYTE ACTIVATION; MICE; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; UBIQUITIN-PROTEIN LIGASES;

EID: 70349577982     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.276pe38     Document Type: Short Survey

References (29)

1. R. H. Schwartz, A cell culture model for T lymphocyte clonal anergy. Science 248, 1349-1356 (1990).
2. L. J. Appleman, V. A. Boussiotis, T cell anergy and costimulation. Immunol. Rev. 192, 161-180 (2003).
3. K. A. Frauwirth, C. B. Thompson, Activation and inhibition of lymphocytes by costimulation. J. Clin. Invest. 109, 295-299 (2002).
4. A. Rao, Signaling to gene expression: Calcium, calcineurin and NFAT. Nat. Immunol. 10, 3-5 (2009).
5. Y. Huang, R. L. Wange, T cell receptor signaling: Beyond complex complexes. J. Biol. Chem. 279, 28827-28830 (2004).
6. F. Macian, F. Garcia-Cozar, S. H. Im, H. F. Horton, M. C. Byrne, A. Rao, Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109, 719-731 (2002).
7. V. Heissmeyer, F. Macian, S. H. Im, R. Varma, S. Feske, K. Venuprasad, H. Gu, Y. C. Liu, M. L. Dustin, A. Rao, Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5, 255-265 (2004).
8. K. Bachmaier, C. Krawczyk, I. Kozieradzki, Y. Y. Kong, T. Sasaki, A. Oliveira-dos-Santos, S. Mariathasan, D. Bouchard, A.Wakeham, A. Itie, J. Le, P. S. Ohashi, I. Sarosi, H. Nishina, S. Lipkowitz, J. M. Penninger, Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403, 211-216 (2000).
9. Y. J. Chiang, H. K. Kole, K. Brown, M. Naramura, S. Fukuhara, R. J. Hu, I. K. Jang, J. S. Gutkind, E. Shevach, H. Gu, Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403, 216-220 (2000).
10. A. E. Lin, T.W. Mak, The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells. Curr. Opin. Immunol. 19, 665-673 (2007).
11. S. Loeser, J. M. Penninger, Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b. Semin. Immunol. 19, 206-214 (2007). (Pubitemid 46810290)
12. C. B. F. Thien, W. Y. Langdon, c-Cbl and Cbl-b ubiquitin ligases: Substrate diversity and the negative regulation of signalling responses. Biochem. J. 391, 153-166 (2005).
13. Y. C. Liu, J. Penninger, M. Karin, Immunity by ubiquitylation: A reversible process of modification. Nat. Rev. Immunol. 5, 941-952 (2005).
14. M. A. Gronski, J. M. Boulter, D. Moskophidis, L. T. Nguyen, K. Holmberg, A. R. Elford, E. K. Deenick, H. O. Kim, J. M. Penninger, B. Odermatt, A. Gallimore, N. R. Gascoigne, P. S. Ohashi, TCR affinity and negative regulation limit autoimmunity. Nat. Med. 10, 1234-1239 (2004).
15. D. Fang, H.Y.Wang, N. Fang, Y. Altman, C. Elly, Y. C. Liu, Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. J. Biol. Chem. 276, 4872-4878 (2001).
16. D. Fang, Y. C. Liu, Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat. Immunol. 2, 870-875 (2001).
17. M. S. Jeon, A. Atfield, K. Venuprasad, C. Krawczyk, R. Sarao, C. Elly, C. Yang, S. Arya, K. Bachmaier, L. Su, D. Bouchard, R. Jones, M. Gronski, P. Ohashi, T. Wada, D. Bloom, C. G. Fathman, Y. C. Liu, J. M. Penninger, Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 21, 167-177 (2004).
18. + mobilization and NFAT cell activation in primary mouse T cells. J. Exp. Med. 197, 1525-1535 (2003).
19. Z. Sun, C.W. Arendt, W. Ellmeier, E. M. Schaeffer, M. J. Sunshine, L. Gandhi, J. Annes, D. Petrzilka, A. Kupfer, P. L. Schwartzberg, D. R. Littman, PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes. Nature 404, 402-407 (2000).
20. N. N. Berg-Brown, M. A. Gronski, R. G. Jones, A. R. Elford, E. K. Deenick, B. Odermatt, D. R. Littman, P. S. Ohashi, PKCθ signals activation versus tolerance in vivo. J. Exp. Med. 199, 743-752 (2004).
21. J. Zhang, T. Bardos, D. Li, I. Gal, C. Vermes, J. Xu, K. Mikecz, A. Finnegan, S. Lipkowitz, T. T. Glant, Cutting edge: Regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination. J. Immunol. 169, 2236-2240 (2002).
22. T. Gruber, N. Hermann-Kleiter, R. Hinterleitner, F. Fresser, R. Schneider, G. Gastl, J. M. Penninger, G. Baier, PKC-θ?modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Sci. Signal. 2, ra30 (2009).
23. G. Qiao, Z. Li, L. Molinero, M. L. Alegre, H. Ying, Z. Sun, J. M. Penninger, J. Zhang, T-cell receptorinduced NF-κB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol. Cell. Biol. 28, 2470-2480 (2008).
24. B. Yang, D. L. Gay, M. K. MacLeod, X. Cao, T. Hala, E. M. Sweezer, J. Kappler, P. Marrack, P. M. Oliver, Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat. Immunol. 9, 1356-1363 (2008).
25. A. Wiedemann, S. Muller, B. Favier, D. Penna, M. Guiraud, C. Delmas, E. Champagne, S. Valitutti, T-cell activation is accompanied by an ubiquitination process occurring at the immunological synapse. Immunol. Lett. 98, 57-61 (2005).
26. C. R. F. Monks, B. A. Freiberg, H. Kupfer, N. Sciaky, A. Kupfer, Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82-86 (1998).
27. N. Thuille, I. Heit, F. Fresser, N. Krumbock, B. Bauer, S. Leuthaeusser, S. Dammeier, C. Graham, T. D. Copeland, S. Shaw, G. Baier, Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCθ?in T lymphocytes. EMBO J. 24, 3869-3880 (2005).
28. A.Yaron, A. Hatzubai, M. Davis, I. Lavon, S. Amit, A. M. Manning, J. S. Andersen, M. Mann, F. Mercurio, Y. Ben-Neriah, Identification of the receptor component of the IκBα-ubiquitin ligase. Nature 396, 590-594 (1998).
29. Supported by grants from the Deutsche Forschungsgemeinschaft projects SCHM 1417/4-1, SCHM 1417/5-1, SFB 547, and the ECCPS-Excellence Cluster Cardio-Pulmonary System.