Redox signaling in pathophysiology of hypertension

Journal of Biomedical Science

Volumn 20, Issue 1, 2013, Pages

  Majzunova, Miroslava ^a   Dovinova, Ima ^a   Barancik, Miroslav ^a   Chan, Julie Y H ^b  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Antioxidant response; Hypertension; Kinase pathway; Radical signaling; Reactive oxygen species; Redox sensitive signaling; Transcriptional factor

Indexed keywords

ANGIOTENSIN II; ANTIOXIDANT; ENDOTHELIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NORADRENALIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; TETRAHYDROBIOPTERIN; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTERIAL PRESSURE; CALCIUM CELL LEVEL; CELL STRESS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL PROGENITOR CELL; ENZYME ACTIVITY; GENE TARGETING; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HOMEOSTASIS; HYPERINSULINEMIA; HYPERTENSION; HYPOXIC LUNG VASOCONSTRICTION; IN VIVO GENE TRANSFER; INTRACELLULAR SIGNALING; INTRACELLULAR SPACE; LONG TERM CARE; LUNG INJURY; MATERNAL DIABETES MELLITUS; MECHANICAL STRESS; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHENOTYPE; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN; REVIEW; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR SMOOTH MUSCLE; VASCULAR TISSUE; VASOPRESSIN RELEASE; ANIMAL; CARDIOVASCULAR SYSTEM; HUMAN; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOVASCULAR SYSTEM; HUMANS; HYPERTENSION; MICE; OXIDATION-REDUCTION; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84884189408     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-20-69     Document Type: Review

References (102)

1. Manipulation of gene expression by oxygen: a primer from bedside to bench. Wright CJ, Dennery PA, Pediatr Res 2009 66 3 10 10.1203/PDR. 0b013e3181a2c184 19287338
2. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Paravicini TM, Touyz RM, Diabetes Care 2008 31 Suppl 2 170 S180 18227481
3. The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal. Forman HJ, Fukuto JM, Miller T, Zhang H, Rinna A, Levy S, Arch Biochem Biophys 2008 477 183 195 10.1016/j.abb.2008.06.011 18602883
4. Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration. Greene EL, Lu G, Zhang D, Egan BM, Hypertension 2001 37 308 312 10.1161/01.HYP.37.2.308 11230290 (Pubitemid 32199092)
5. Involvement of reactive oxygen species in thrombin-induced pulmonary vasoconstriction. Maki J, Hirano M, Hoka S, Kanaide H, Hirano K, Am J Respir Crit Care Med 2010 182 1435 1444 10.1164/rccm.201002-0255OC 20639439
6. Reactive oxygen species are involved in regulating alpha1-adrenoceptor- activated vascular smooth muscle contraction. Tsai MH, Jiang MJ, J Biomed Sci 2010 17 67 10.1186/1423-0127-17-67 20727219
7. Angiotensin-generated reactive oxygen species in brain and pathogenesis of cardiovascular diseases. Chan SH, Chan JY, Antioxid Redox Signal 2013 19 1074 1084 10.1089/ars.2012.4585 22429119
8. Oxidative stress and hypertension. Harrison DG, Gongora MC, Med Clin North Am 2009 93 621 635 10.1016/j.mcna.2009.02.015 19427495
9. Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension. Hirooka Y, Kishi T, Sakai K, Takeshita A, Sunagawa K, Am J Physiol Regul Integr Comp Physiol 2011 300 818 R826 10.1152/ajpregu.00426.2010 21289238
10. Oxidative stress and endothelial dysfunction in hypertension. Schulz E, Gori T, Munzel T, Hypertens Res 2011 34 665 673 10.1038/hr.2011.39 21512515
11. Differential roles of NADPH oxidases in vascular physiology and pathophysiology. Amanso AM, Griendling KK, Front Biosci (Schol Ed) 2012 4 1044 1064 22202108
12. Reactive oxygen species and endothelial function-role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases. Montezano AC, Touyz RM, Basic Clin Pharmacol Toxicol 2012 110 87 94 10.1111/j.1742-7843.2011.00785.x 21883939
13. The role of oxidative stress in the pathophysiology of hypertension. Rodrigo R, Gonzalez J, Paoletto F, Hypertens Res 2011 34 431 440 10.1038/hr.2010.264 21228777
14. Reactive oxygen species and vascular biology: implications in human hypertension. Touyz RM, Briones AM, Hypertens Res 2011 34 5 14 10.1038/hr.2010.201 20981034
15. Sad heart from no SOD. Gongora MC, Harrison DG, Hypertension 2008 51 28 30 10.1161/HYPERTENSIONAHA.107.101162 18025292 (Pubitemid 350307096)
16. Regulation of endothelial cell tetrahydrobiopterin pathophysiological and therapeutic implications. Harrison DG, Chen W, Dikalov S, Li L, Adv Pharmacol 2010 60 107 132 21081217
17. Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Griendling KK, Sorescu D, Lassegue B, Ushio-Fukai M, Arterioscler Thromb Vasc Biol 2000 20 2175 2183 10.1161/01.ATV.20.10.2175 11031201
18. Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta. Loomis ED, Sullivan JC, Osmond DA, Pollock DM, Pollock JS, J Pharmacol Exp Ther 2005 315 1058 1064 10.1124/jpet.105.091728 16144972 (Pubitemid 41635391)
19. Interactions between vasoconstrictors and vasodilators in regulating hemodynamics of distinct vascular beds. Gomez-Alamillo C, Juncos LA, Cases A, Haas JA, Romero JC, Hypertension 2003 42 831 836 10.1161/01.HYP.0000088854. 04562.DA 12925563 (Pubitemid 37237332)
20. Multifarious molecular signaling cascades of cardiac hypertrophy: can the muddy waters be cleared? Balakumar P, Jagadeesh G, Pharmacol Res 2010 62 365 383 10.1016/j.phrs.2010.07.003 20643208
21. Endothelins and NADPH oxidases in the cardiovascular system. Dammanahalli KJ, Sun Z, Clin Exp Pharmacol Physiol 2008 35 2 6 10.1111/j.1440-1681.2007. 04830.x 18047620 (Pubitemid 350197691)
22. Role of reactive oxygen species in brainstem in neural mechanisms of hypertension. Hirooka Y, Auton Neurosci 2008 142 20 24 10.1016/j.autneu.2008.06. 001 18650132
23. Cell signaling of angiotensin II on vascular tone: novel mechanisms. Nguyen Dinh Cat A, Touyz RM, Curr Hypertens Rep 2011 13 122 128 10.1007/s11906-011-0187-x 21274755
24. S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling. Zweier JL, Chen CA, Druhan LJ, Antioxid Redox Signal 2011 14 1769 1775 10.1089/ars.2011.3904 21261471
25. Tetrahydrobiopterin and cardiovascular disease. Moens AL, Kass DA, Arterioscler Thromb Vasc Biol 2006 26 2439 2444 10.1161/01.ATV.0000243924.00970. cb 16946131 (Pubitemid 44607463)
26. Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets? Rochette L, Lorin J, Zeller M, Guilland JC, Lorgis L, Cottin Y, Vergely C, Pharmacol Ther 2013 in press
27. Nitric oxide synthase uncoupling: a therapeutic target in cardiovascular diseases. Roe ND, Ren J, Vascul Pharmacol 2012 57 168 172 10.1016/j.vph.2012.02. 004 22361333
28. Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling. Zuckerbraun BS, George P, Gladwin MT, Cardiovasc Res 2011 89 542 552 10.1093/cvr/cvq370 21177703
29. Peroxynitrite reactions and formation in mitochondria. Radi R, Cassina A, Hodara R, Quijano C, Castro L, Free Radic Biol Med 2002 33 1451 1464 10.1016/S0891-5849(02)01111-5 12446202 (Pubitemid 35351588)
30. Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues. MacMillan-Crow LA, Crow JP, Thompson JA, Biochemistry 1998 37 1613 1622 10.1021/bi971894b 9484232 (Pubitemid 28093677)
31. Opening mitoKATP increases superoxide generation from complex I of the electron transport chain. Andrukhiv A, Costa AD, West IC, Garlid KD, Am J Physiol Heart Circ Physiol 2006 291 2067 H2074 10.1152/ajpheart.00272.2006 16798828
32. Triggering mitochondrial radical release: a new function for NADPH oxidases. Brandes RP, Hypertension 2005 45 847 848 10.1161/01.HYP.0000165019. 32059.b2 15837827 (Pubitemid 40628925)
33. Oxidative impairment of mitochondrial electron transport chain complexes in rostral ventrolateral medulla contributes to neurogenic hypertension. Chan SH, Wu KL, Chang AY, Tai MH, Chan JY, Hypertension 2009 53 217 227 10.1161/HYPERTENSIONAHA.108.116905 19114648
34. Hyperinsulinemia-induced vascular smooth muscle cell (VSMC) migration and proliferation is mediated by converging mechanisms of mitochondrial dysfunction and oxidative stress. Abhijit S, Bhaskaran R, Narayanasamy A, Chakroborty A, Manickam N, Dixit M, Mohan V, Balasubramanyam M, Mol Cell Biochem 2013 373 95 105 10.1007/s11010-012-1478-5 23073711
35. Losartan improved respiratory function and coenzyme Q content in brain mitochondria of young spontaneously hypertensive rats. Sumbalova Z, Kucharska J, Kristek F, Cell Mol Neurobiol 2010 30 751 758 10.1007/s10571-010-9501-4 20145991
36. Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Waypa GB, Marks JD, Guzy R, Mungai PT, Schriewer J, Dokic D, Schumacker PT, Circ Res 2010 106 526 535 10.1161/CIRCRESAHA.109.206334 20019331
37. Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation. Waypa GB, Marks JD, Guzy RD, Mungai PT, Schriewer JM, Dokic D, Ball MK, Schumacker PT, Am J Respir Crit Care Med 2013 187 424 432 10.1164/rccm.201207-1294OC 23328522
38. Cross-talk between mitochondria and NADPH oxidase: effects of mild mitochondrial dysfunction on angiotensin II-mediated increase in Nox isoform expression and activity in vascular smooth muscle cells. Wosniak J Jr, Santos CX, Kowaltowski AJ, Laurindo FR, Antioxid Redox Signal 2009 11 1265 1278 10.1089/ars.2009.2392 19281299
39. Transcriptional upregulation of brain-derived neurotrophic factor in rostral ventrolateral medulla by angiotensin II: significance in superoxide homeostasis and neural regulation of arterial pressure. Chan SH, Wu CW, Chang AY, Hsu KS, Chan JY, Circ Res 2010 107 1127 1139 10.1161/CIRCRESAHA.110.225573 20814019
40. Redox signaling and protein phosphorylation in mitochondria: progress and prospects. Foster DB, Van Eyk JE, Marban E, O'Rourke B, J Bioenerg Biomembr 2009 41 159 168 10.1007/s10863-009-9217-7 19440831
41. Signal transduction by reactive oxygen species. Finkel T, J Cell Biol 2011 194 7 15 10.1083/jcb.201102095 21746850
42. Redox control of renal function and hypertension. Nistala R, Whaley-Connell A, Sowers JR, Antioxid Redox Signal 2008 10 2047 2089 10.1089/ars.2008.2034 18821850
43. NADPH oxidases of the brain: distribution, regulation, and function. Infanger DW, Sharma RV, Davisson RL, Antioxid Redox Signal 2006 8 1583 1596 10.1089/ars.2006.8.1583 16987013 (Pubitemid 44726333)
44. Redox signaling in central neural regulation of cardiovascular function. Zimmerman MC, Davisson RL, Prog Biophys Mol Biol 2004 84 125 149 10.1016/j.pbiomolbio.2003.11.009 14769433 (Pubitemid 38215209)
45. Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Irani K, Circ Res 2000 87 179 183 10.1161/01.RES.87.3.179 10926866 (Pubitemid 30626423)
46. Redox signaling, vascular function, and hypertension. Lee MY, Griendling KK, Antioxid Redox Signal 2008 10 1045 1059 10.1089/ars.2007.1986 18321201 (Pubitemid 351451709)
47. cAMP attenuates the enhanced expression of Gi proteins and hyperproliferation of vascular smooth muscle cells from SHR: role of ROS and ROS-mediated signaling. Gusan S, Anand-Srivastava MB, Am J Physiol Cell Physiol 2013 304 1198 C1209 10.1152/ajpcell.00269.2012 23576581
48. Oxidative stress in the brain and arterial hypertension. Campos RR, Hypertens Res 2009 32 1047 1048 10.1038/hr.2009.180 19893566
49. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Boutros T, Chevet E, Metrakos P, Pharmacol Rev 2008 60 261 310 10.1124/pr.107.00106 18922965
50. The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment. Haagenson KK, Wu GS, Cancer Metastasis Rev 2010 29 143 149 10.1007/s10555-010-9208-5 20111893
51. Redox signaling in hypertension. Paravicini TM, Touyz RM, Cardiovasc Res 2006 71 247 258 10.1016/j.cardiores.2006.05.001 16765337
52. Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways? Son Y, Cheong YK, Kim NH, Chung HT, Kang DG, Pae HO, J Signal Transduct 2011 2011 792639 21637379
53. Redox signaling and the MAP kinase pathways. Torres M, Forman HJ, Biofactors 2003 17 287 296 10.1002/biof.5520170128 12897450 (Pubitemid 37267162)
54. MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets. Muslin AJ, Clin Sci (Lond) 2008 115 203 218 10.1042/CS20070430 18752467
55. Fyn and JAK2 mediate Ras activation by reactive oxygen species. Abe J, Berk BC, J Biol Chem 1999 274 21003 21010 10.1074/jbc.274.30.21003 10409649 (Pubitemid 29350562)
56. Involvement of reactive oxygen species in the activation of tyrosine kinase and extracellular signal-regulated kinase by angiotensin II. Frank GD, Eguchi S, Yamakawa T, Tanaka S, Inagami T, Motley ED, Endocrinology 2000 141 3120 3126 10.1210/en.141.9.3120 10965882 (Pubitemid 32268999)
57. Reactive oxygen species contribute to the induction of superoxide dismutase during heat shock in cultured rat neonatal cardiomyocytes. Wang S, Zhu H, Chen C, Chin Med J (Engl) 2000 113 606 609 11776028
58. Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt. Eguchi S, Iwasaki H, Ueno H, Frank GD, Motley ED, Eguchi K, Marumo F, Hirata Y, Inagami T, J Biol Chem 1999 274 36843 36851 10.1074/jbc.274.52.36843 10601235 (Pubitemid 30016749)
59. Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway. Madamanchi NR, Li S, Patterson C, Runge MS, J Biol Chem 2001 276 18915 18924 10.1074/jbc.M008802200 11278437
60. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Coffer PJ, Jin J, Woodgett JR, Biochem J 1998 335 Pt 1 1 13 9742206 (Pubitemid 28477043)
61. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. Ushio-Fukai M, Alexander RW, Akers M, Yin Q, Fujio Y, Walsh K, Griendling KK, J Biol Chem 1999 274 22699 22704 10.1074/jbc.274.32.22699 10428852 (Pubitemid 29379317)
62. Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart. Ravingerova T, Matejikova J, Neckar J, Andelova E, Kolar F, Mol Cell Biochem 2007 297 111 120 10.1007/s11010-006- 9335-z 17016676 (Pubitemid 46443535)
63. Akt signalling in health and disease. Hers I, Vincent EE, Tavare JM, Cell Signal 2011 23 1515 1527 10.1016/j.cellsig.2011.05.004 21620960
64. Mechanisms and consequences of activation of protein kinase B/Akt. Downward J, Curr Opin Cell Biol 1998 10 262 267 10.1016/S0955-0674(98)80149-X 9561851 (Pubitemid 28174769)
65. The role of mitochondria in protection of the heart by preconditioning. Halestrap AP, Clarke SJ, Khaliulin I, Biochim Biophys Acta 2007 1767 1007 1031 10.1016/j.bbabio.2007.05.008 17631856 (Pubitemid 47101788)
66. Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats. Wu KL, Wu CA, Wu CW, Chan SH, Chang AY, Chan JY, Antioxid Redox Signal 2013 18 36 50 10.1089/ars.2011.4457 22746319
67. Chronic cardiotoxicity of doxorubicin involves activation of myocardial and circulating matrix metalloproteinases in rats. Ivanova M, Dovinova I, Okruhlicova L, Tribulova N, Simoncikova P, Barte-kova M, Vlkovicova J, Barancik M, Acta Pharmacol Sin 2012 33 459 469 10.1038/aps.2011.194 22447222
68. Rho-kinase: regulation, (dys)function, and inhibition. Amin E, Dubey BN, Zhang SC, Gremer L, Dvorsky R, Moll JM, Taha MS, Nagel-Steger L, Piekorz RP, Somlyo AV, Ahmadian MR, Biol Chem 2013 in press
69. Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Wolfrum S, Dendorfer A, Rikitake Y, Stalker TJ, Gong Y, Scalia R, Dominiak P, Liao JK, Arterioscler Thromb Vasc Biol 2004 24 1842 1847 10.1161/01.ATV. 0000142813.33538.82 15319269 (Pubitemid 39350301)
70. Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase. Eto M, Barandier C, Rathgeb L, Kozai T, Joch H, Yang Z, Luscher TF, Circ Res 2001 89 583 590 10.1161/hh1901.097084 11577023 (Pubitemid 32924212)
71. Rho kinase and hypertension. Wirth A, Biochim Biophys Acta 1802 2010 1276 1284
72. Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans. Smith CJ, Santhanam L, Alexander LM, Microvasc Res 2013 87 58 64 23481864
73. Upregulation of AT1 receptor gene on activation of protein kinase Cbeta/nicotinamide adenine dinucleotide diphosphate oxidase/ERK1/2/c-fos signaling cascade mediates long-term pressor effect of angiotensin II in rostral ventrolateral medulla. Chan SH, Wang LL, Tseng HL, Chan JY, J Hypertens 2007 25 1845 1861 10.1097/HJH.0b013e328217b286 17762649 (Pubitemid 47356625)
74. Interaction among heme oxygenase, nuclear factor-kappaB, and transcription activating factors in cardiac hypertrophy in hypertension. Jadhav A, Torlakovic E, Ndisang JF, Hypertension 2008 52 910 917 10.1161/ HYPERTENSIONAHA.108.114801 18824663
75. Endothelin 1 activation of endothelin A receptor/NADPH oxidase pathway and diminished antioxidants critically contribute to endothelial progenitor cell reduction and dysfunction in salt-sensitive hypertension. Chen DD, Dong YG, Yuan H, Chen AF, Hypertension 2012 59 1037 1043 10.1161/HYPERTENSIONAHA.111. 183368 22431579
76. Chronic NF-{kappa}B blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR. Elks CM, Mariappan N, Haque M, Guggilam A, Majid DS, Francis J, Am J Physiol Renal Physiol 2009 296 298 F305 19073636
77. Practical approaches to investigate redox regulation of heat shock protein expression and intracellular glutathione redox state. Calabrese V, Signorile A, Cornelius C, Mancuso C, Scapagnini G, Ventimiglia B, Ragusa N, Dinkova-Kostova A, Methods Enzymol 2008 441 83 110 18554531
78. A small-molecule inducer of the antioxidant response element. Hur W, Sun Z, Jiang T, Mason DE, Peters EC, Zhang DD, Luesch H, Schultz PG, Gray NS, Chem Biol 2010 17 537 547 10.1016/j.chembiol.2010.03.013 20534351
79. Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Venugopal R, Jaiswal AK, Oncogene 1998 17 3145 3156 10.1038/sj.onc.1202237 9872330 (Pubitemid 29020810)
80. Small molecule modulators of antioxidant response pathway. Hur W, Gray NS, Curr Opin Chem Biol 2011 15 162 173 10.1016/j.cbpa.2010.12.009 21195017
81. Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells. Apopa PL, He X, Ma Q, J Biochem Mol Toxicol 2008 22 63 76 10.1002/jbt.20212 18273910 (Pubitemid 351360163)
82. Mechanism of the Nrf2/Keap1/ARE signaling system. Tkachev VO, Menshchikova EB, Zenkov NK, Biochemistry (Mosc) 2011 76 407 422 10.1134/S0006297911040031 21585316
83. GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2. Jain AK, Jaiswal AK, J Biol Chem 2007 282 16502 16510 10.1074/jbc.M611336200 17403689 (Pubitemid 47100395)
84. Targeting glycogen synthase kinase-3beta for therapeutic benefit against oxidative stress in alzheimer's disease: involvement of the Nrf2-ARE pathway. Kanninen K, White AR, Koistinaho J, Malm T, Int J Alzheimers Dis 2011 2011 985085 21629716
85. Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Schroder K, Zhang M, Benkhoff S, Mieth A, Pliquett R, Kosowski J, Kruse C, Luedike P, Michaelis UR, Weissmann N, et al. Circ Res 2012 110 1217 1225 10.1161/CIRCRESAHA.112.267054 22456182
86. Catalase prevents maternal diabetes-induced perinatal programming via the Nrf2-HO-1 defense system. Chang SY, Chen YW, Zhao XP, Chenier I, Tran S, Sauve A, Ingelfinger JR, Zhang SL, Diabetes 2012 61 2565 2574 10.2337/db12-0248 22733796
87. Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. Reddy NM, Kleeberger SR, Cho HY, Yamamoto M, Kensler TW, Biswal S, Reddy SP, Am J Respir Cell Mol Biol 2007 37 3 8 10.1165/rcmb.2007-0004RC 17413030 (Pubitemid 46999531)
88. The effect of an NO donor, pentaerythrityl tetranitrate, on biochemical, functional, and morphological attributes of cardiovascular system of spontaneously hypertensive rats. Dovinova I, Cacanyiova S, Faberova V, Kristek F, Gen Physiol Biophys 2009 28 86 93 10.4149/gpb-2009-01-86 19390141
89. Modulation of antioxidative response in the therapy of hypertension and other cardiovascular diseases. Dovinova I, Gardlik R, Palffy R, Kristek F, Cacanyiova S, Vantova Z, Paulikova H, Neuro Endocrinol Lett 2009 30 Suppl 1 32 35
90. Vascular protection: superoxide dismutase isoforms in the vessel wall. Faraci FM, Didion SP, Arterioscler Thromb Vasc Biol 2004 24 1367 1373 10.1161/01.ATV.0000133604.20182.cf 15166009 (Pubitemid 39050427)
91. SOD isoforms and signaling in blood vessels: evidence for the importance of ROS compartmentalization. Mendez JI, Nicholson WJ, Taylor WR, Arterioscler Thromb Vasc Biol 2005 25 887 888 10.1161/01.ATV.0000164043.24549.50 15863719 (Pubitemid 40627829)
92. Antioxidant gene therapy for cardiovascular disease: current status and future perspectives. Levonen AL, Vahakangas E, Koponen JK, Yla-Herttuala S, Circulation 2008 117 2142 2150 10.1161/CIRCULATIONAHA.107.718585 18427144 (Pubitemid 351572172)
93. Approaches in gene therapy of cancer and cardiovascular diseases. Gardlik R, Dovinová I, Chan JY, Gene Therapy Applications Croatia: InTech, Rijeka CK, 2011 59 84
94. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Zimmerman MC, Lazartigues E, Sharma RV, Davisson RL, Circ Res 2004 95 210 216 10.1161/01.RES.0000135483. 12297.e4 15192025 (Pubitemid 38988688)
95. Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. Chan SH, Tai MH, Li CY, Chan JY, Free Radic Biol Med 2006 40 2028 2039 10.1016/j.freeradbiomed.2006.01.032 16716903 (Pubitemid 43728865)
96. Antioxidant gene treatment of hypertension in spontaneously hypertensive rats. Dovinová I, Pálffy R, Gardlik R, Vrankova S, Jendekova L, Kristek F, Sumbalova Z, Paulíkova H, Abstract Book of Satellite symposium to the 22nd Scientific Meeting of International Society of Hypertension: 12-13 June 2008 Bratislava: Institute of Normal and Pathological Physiology SAS, Pechanova O, 2008 47 48
97. Superoxide dismutase 1 limits renal microvascular remodeling and attenuates arteriole and blood pressure responses to angiotensin II via modulation of nitric oxide bioavailability. Carlstrom M, Lai EY, Ma Z, Steege A, Patzak A, Eriksson UJ, Lundberg JO, Wilcox CS, Persson AE, Hypertension 2010 56 907 913 10.1161/HYPERTENSIONAHA.110.159301 20876452
98. Therapeutic targeting of mitochondrial superoxide in hypertension. Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann L, Lewis W, Harrison DG, Dikalov SI, Circ Res 2010 107 106 116 10.1161/CIRCRESAHA.109.214601 20448215
99. Changes in antioxidant response and ROS signaling in different experimental hypertension models. Dovinova I, Barančík M, Čačányiová S, Kristek F, Gajdošechová L, Gardlík R, J Hypertens 2011 29 Suppl B 45
100. Extracellular superoxide dismutase and cardiovascular disease. Fukai T, Folz RJ, Landmesser U, Harrison DG, Cardiovasc Res 2002 55 239 249 10.1016/S0008-6363(02)00328-0 12123763 (Pubitemid 34775274)
101. Role of extracellular superoxide dismutase in hypertension. Gongora MC, Qin Z, Laude K, Kim HW, McCann L, Folz JR, Dikalov S, Fukai T, Harrison DG, Hypertension 2006 48 473 481 10.1161/01.HYP.0000235682.47673.ab 16864745 (Pubitemid 44253743)
102. Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain. Chu Y, Iida S, Lund DD, Weiss RM, DiBona GF, Watanabe Y, Faraci FM, Heistad DD, Circ Res 2003 92 461 468 10.1161/01.RES.0000057755.02845.F9 12600899 (Pubitemid 36298207)