Endothelin 1 activation of endothelin a receptor/NADPH oxidase pathway and diminished antioxidants critically contribute to endothelial progenitor cell reduction and dysfunction in salt-sensitive hypertension

Hypertension

Volumn 59, Issue 5, 2012, Pages 1037-1043

  Chen, Dan Dan ^a,b,c   Dong, Yu Gang ^c   Yuan, Hong ^d   Chen, Alex F ^a,b,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SUN YAT SEN UNIVERSITY   (China)

^d CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Endothelial progenitor cell; Endothelin 1; Hypertension; NADPH oxidase; Oxidative stress

Indexed keywords

ANTIOXIDANT; APOCYNIN; ATRASENTAN; COPPER ZINC SUPEROXIDE DISMUTASE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; GLUTATHIONE PEROXIDASE 1; MACROGOL; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE P22PHOX; SUPEROXIDE DISMUTASE; TELOMERASE; TRICHLORMETHIAZIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW CELL; CAPILLARY DENSITY; CELL COUNT; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIAL PROGENITOR CELL TRANSPLANTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; HINDLIMB; HYPERTENSION; LIMB ISCHEMIA; LIMB PERFUSION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SENESCENCE; STEM CELL TRANSPLANTATION; SYSTOLIC BLOOD PRESSURE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; HYPERTENSION; MALE; NADPH OXIDASE; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTOR, ENDOTHELIN A; REFERENCE VALUES; SIGNAL TRANSDUCTION; SODIUM CHLORIDE; STEM CELLS; SUPEROXIDE DISMUTASE;

EID: 84862807380     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.183368     Document Type: Article

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