Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases

Science Signaling

Volumn 6, Issue 290, 2013, Pages

  Joseph, Raji E ^a   Kleino, Iivari ^b   Wales, Thomas E ^c   Xie, Qian ^a   Fulton, D Bruce ^a   Engen, John R ^c   Berg, Leslie J ^b   Andreotti, Amy H ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRUTONS TYROSINE KINASE; INTERLEUKIN 2 INDUCIBLE T CELL KINASE; PHOSPHOTRANSFERASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; B LYMPHOCYTE; CATALYSIS; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; KINETICS; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE; PRESSURE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BIOCATALYSIS; BLOTTING, WESTERN; DEUTERIUM EXCHANGE MEASUREMENT; KINETICS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, ANTIGEN, T-CELL; SEQUENCE HOMOLOGY, AMINO ACID; SF9 CELLS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TYROSINE;

EID: 84884137684     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2004298     Document Type: Article

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