A FLIPR-based assay to assess potency and selectivity of inhibitors of the TEC family kinases Btk and Itk

Assay and Drug Development Technologies

Volumn 5, Issue 6, 2007, Pages 751-758

  Douhan III, John ^a   Miyashiro, Joy S ^a   Zhou, Xiaochuan ^a   Cole, Derek C ^b   Wu, Paul W ^a   Collins, Mary ^a   Dunussi Joannopoulos, Kyriaki ^a  

^a PFIZER INC   (United States)

^b WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; BMS 509744; BRUTON TYROSINE KINASE; INTERLEUKIN 2 INDUCIBLE T CELL KINASE; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CALCIUM MOBILIZATION; CONTROLLED STUDY; DEVICE; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; FLUORESCENT IMAGING PLATE READER; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; NONHUMAN; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; CALCIUM; CHICKENS; DATA INTERPRETATION, STATISTICAL; DNA, COMPLEMENTARY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FLUORESCENT DYES; FLUOROMETRY; FREEZE DRYING; GENETIC VECTORS; IMMUNOBLOTTING; LASERS; ORGANISMS, GENETICALLY MODIFIED; PROMOTER REGIONS (GENETICS); PROTEIN ENGINEERING; PROTEIN-TYROSINE KINASES;

EID: 38049088961     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2007.093     Document Type: Article

References (23)

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