Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry

Protein Science

Volumn 19, Issue 4, 2010, Pages 703-715

  Zhang, Hui Min ^a,b   Yu, Xiu ^c   Greig, Michael J ^c   Gajiwala, Ketan S ^c   Wu, Joe C ^c   Diehl, Wade ^c   Lunney, Elizabeth A ^c   Emmett, Mark R ^a,b   Marshall, Alan G ^a,b  

^a FLORIDA STATE UNIVERSITY   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

^c PFIZER INC   (United States)

Author keywords

Conformation; Drug resistance; Hydrogen deuterium exchange; Mass spectrometry; Tyrosine kinase

Indexed keywords

AMINO ACID; IMATINIB; MUTANT PROTEIN; PROTEIN TYROSINE KINASE; PROTEINASE; STEM CELL FACTOR; SUNITINIB;

ARTICLE; DEUTERIUM HYDROGEN EXCHANGE; DRUG BINDING; DRUG INHIBITION; DRUG RESISTANCE; DRUG SENSITIVITY; ENZYME DEGRADATION; ENZYME KINETICS; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; MASS SPECTROMETRY; MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; WILD TYPE;

AMINO ACID SUBSTITUTION; BINDING SITES; DEUTERIUM EXCHANGE MEASUREMENT; DRUG RESISTANCE; INDOLES; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; PYRROLES;

EID: 77950201397     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.347     Document Type: Article

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