Acid-cleavable ketal containing poly(β-amino ester) for enhanced siRNA delivery

International Journal of Pharmaceutics

Volumn 453, Issue 2, 2013, Pages 541-550

  Guk, Kyeonghye ^a   Lim, Hyungsuk ^a   Kim, Byungkuk ^a   Hong, Minsung ^a   Khang, Gilson ^a   Lee, Dongwon ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Biodegradable polymer; Gene silencing; pH sensitive; Poly( amino esters); siRNA

Indexed keywords

ACETAL; ACID; CALCEIN; ESTER DERIVATIVE; LIPOPOLYSACCHARIDE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CHEMICAL STRUCTURE; COLUMN CHROMATOGRAPHY; CONFOCAL LASER MICROSCOPY; CYTOTOXICITY; ENDOSOME; FLUORESCENCE IMAGING; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; MACROPHAGE; MICHAEL ADDITION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONCOTIC PRESSURE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON TRANSPORT; STATIC ELECTRICITY; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

EID: 84884133930     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.06.021     Document Type: Article

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