Branched multifunctional polyether polyketals: Variation of ketal group structure enables unprecedented control over polymer degradation in solution and within cells

Journal of the American Chemical Society

Volumn 134, Issue 36, 2012, Pages 14945-14957

  Shenoi, Rajesh A ^a   Narayanannair, Jayaprakash K ^b   Hamilton, Jasmine L ^a   Lai, Benjamin F L ^a   Horte, Sonja ^a   Kainthan, Rajesh K ^b   Varghese, Jos P ^c   Rajeev, Kallanthottathil G ^b   Manoharan, Muthiah ^b   Kizhakkedathu, Jayachandran N ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ALNYLAM PHARMACEUTICALS   (United States)

^c Sanmar Speciality Chemicals Ltd   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC PH VALUES; AMINE GROUPS; BLOOD COMPATIBILITY; CELL VIABILITY; COAGULATION ASSAYS; CYTOSOLS; DEGRADABLE LINKAGES; DEGRADATION PRODUCTS; DEGRADATION PROFILES; FLUORESCENT MARKERS; FUNCTIONALIZATIONS; GROUP STRUCTURE; HALF LIVES; HIGH MOLECULAR WEIGHT; HYDROXYETHERS; LIVE CELL; MAIN CHAINS; PLATELET ACTIVATION; POLYMER DEGRADATION; POLYMER PROPERTIES; RING OPENING; TORSIONAL STRAIN;

ANIONIC POLYMERIZATION; ASSAYS; CELLS; COAGULATION; CONFOCAL MICROSCOPY; CYTOLOGY; ETHERS; FLUORESCENCE SPECTROSCOPY; HYDROPHOBICITY; MEDICAL NANOTECHNOLOGY; MONOMERS; RING OPENING POLYMERIZATION;

DEGRADATION;

ACETAL; AMINE; AZIDE; FLUORESCENT DYE; MONOMER; POLY(KETAL HYDROXYETHER); POLYETHER DERIVATIVE; POLYMER; PYRENE; UNCLASSIFIED DRUG;

ACIDITY; AQUEOUS SOLUTION; ARTICLE; BIODEGRADABILITY; BLOOD CLOTTING; BLOOD COMPATIBILITY; CELL VIABILITY; CHEMICAL STRUCTURE; COMPLEMENT ACTIVATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DEGRADATION; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHOBICITY; MOLECULAR WEIGHT; NANOMEDICINE; POLYMERIZATION; RING OPENING; SYNTHESIS; THROMBOCYTE ACTIVATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ALCOHOLS; ANIMALS; BIOCOMPATIBLE MATERIALS; BLOOD COAGULATION; CELL SURVIVAL; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ETHERS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR STRUCTURE; POLYMERS; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 84866405843     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja305080f     Document Type: Article

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