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Volumn 4, Issue MAR, 2013, Pages

Do HIV-specific CTL continue to have an antiviral function during antiretroviral therapy? If not, why not, and what can be done about it?

Author keywords

CTL antiretroviral therapy; HIV

Indexed keywords

CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; HLA B27 ANTIGEN; HLA B57 ANTIGEN; INTERLEUKIN 2; JANUS KINASE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PERFORIN; STAT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VORINOSTAT;

EID: 84883869700     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00052     Document Type: Article
Times cited : (7)

References (84)
  • 1
    • 41849143395 scopus 로고    scopus 로고
    • CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals
    • Ahuja, S. K., Kulkarni, H., Catano, G., Agan, B. K., Camargo, J. F., He, W., et al. (2008). CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals. Nat. Med. 14, 413-420.
    • (2008) Nat. Med. , vol.14 , pp. 413-420
    • Ahuja, S.K.1    Kulkarni, H.2    Catano, G.3    Agan, B.K.4    Camargo, J.F.5    He, W.6
  • 2
    • 19944427724 scopus 로고    scopus 로고
    • Persistent low viral load on antiretroviral therapy is associated with T cell-mediated control of HIV replication
    • Alatrakchi, N., Duvivier, C., Costagliola, D., Samri, A., Marcelin, A. G., Kamkamidze, G., et al. (2005). Persistent low viral load on antiretroviral therapy is associated with T cell-mediated control of HIV replication. AIDS 19, 25-33.
    • (2005) AIDS , vol.19 , pp. 25-33
    • Alatrakchi, N.1    Duvivier, C.2    Costagliola, D.3    Samri, A.4    Marcelin, A.G.5    Kamkamidze, G.6
  • 3
    • 27144513224 scopus 로고    scopus 로고
    • Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution
    • Allen, T. M., Altfeld, M., Geer, S. C., Kalife, E. T., Moore, C., O'Sullivan, K. M., et al. (2005). Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J. Virol. 79, 13239-13249.
    • (2005) J. Virol. , vol.79 , pp. 13239-13249
    • Allen, T.M.1    Altfeld, M.2    Geer, S.C.3    Kalife, E.T.4    Moore, C.5    O'Sullivan, K.M.6
  • 4
    • 67650581553 scopus 로고    scopus 로고
    • Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    • Almeida, J. R., Sauce, D., Price, D. A., Papagno, L., Shin, S. Y., Moris, A., et al. (2009). Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity. Blood 113, 6351-6360.
    • (2009) Blood , vol.113 , pp. 6351-6360
    • Almeida, J.R.1    Sauce, D.2    Price, D.A.3    Papagno, L.4    Shin, S.Y.5    Moris, A.6
  • 5
    • 0037169261 scopus 로고    scopus 로고
    • Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression
    • Appay, V., Hansasuta, P., Sutton, J., Schrier, R. D., Wong, J. K., Furtado, M., et al. (2002). Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression. AIDS 16, 161-170.
    • (2002) AIDS , vol.16 , pp. 161-170
    • Appay, V.1    Hansasuta, P.2    Sutton, J.3    Schrier, R.D.4    Wong, J.K.5    Furtado, M.6
  • 6
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin, N. M., Liberty, A. L., Kashuba, A. D., Choudhary, S. K., Kuruc, J. D., Crooks, A. M., et al. (2012). Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 487, 482-485.
    • (2012) Nature , vol.487 , pp. 482-485
    • Archin, N.M.1    Liberty, A.L.2    Kashuba, A.D.3    Choudhary, S.K.4    Kuruc, J.D.5    Crooks, A.M.6
  • 7
    • 77954685640 scopus 로고    scopus 로고
    • Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs
    • doi: 10.1371/journal.ppat.1000803
    • Berger, E. A., and Pastan, I. (2010). Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs. PLoS Pathog. 6:e1000803. doi: 10.1371/journal.ppat.1000803
    • (2010) PLoS Pathog. , vol.6
    • Berger, E.A.1    Pastan, I.2
  • 8
    • 84855909205 scopus 로고    scopus 로고
    • Short-course raltegravir intensification does not increase 2 long terminal repeat episomal HIV-1 DNA in patients on effective antiretroviral therapy
    • Besson, G. J., McMahon, D., Maldarelli, F., and Mellors, J. W. (2012). Short-course raltegravir intensification does not increase 2 long terminal repeat episomal HIV-1 DNA in patients on effective antiretroviral therapy. Clin. Infect. Dis. 54, 451-453.
    • (2012) Clin. Infect. Dis. , vol.54 , pp. 451-453
    • Besson, G.J.1    McMahon, D.2    Maldarelli, F.3    Mellors, J.W.4
  • 9
    • 33646686040 scopus 로고    scopus 로고
    • HIV non-progressors preferentially maintain highly functional HIV-specific CD8+ T cells
    • Betts, M. R., Nason, M. C., West, S. M., De Rosa, S. C., Migueles, S. A., Abraham, J., et al. (2006). HIV non-progressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107, 4781-4789.
    • (2006) Blood , vol.107 , pp. 4781-4789
    • Betts, M.R.1    Nason, M.C.2    West, S.M.3    De Rosa, S.C.4    Migueles, S.A.5    Abraham, J.6
  • 10
    • 60049097896 scopus 로고    scopus 로고
    • Ultrasensitive assessment of residual HIV viraemia in HAART-treated patients with persistently undetectable plasma HIV-RNA: a cross-sectional evaluation
    • Bonora, S., Nicastri, E., Calcagno, A., Gonzalez de Requena, D., D'Ettorre, G., Sarmati, L., et al. (2009). Ultrasensitive assessment of residual HIV viraemia in HAART-treated patients with persistently undetectable plasma HIV-RNA: a cross-sectional evaluation. J. Med. Virol. 81, 400-405.
    • (2009) J. Med. Virol. , vol.81 , pp. 400-405
    • Bonora, S.1    Nicastri, E.2    Calcagno, A.3    Gonzalez de Requena, D.4    D'Ettorre, G.5    Sarmati, L.6
  • 11
    • 0028041344 scopus 로고
    • Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
    • Borrow, P., Lewicki, H., Hahn, B. H., Shaw, G. M., and Oldstone, M. B. (1994). Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68, 6103-6110.
    • (1994) J. Virol. , vol.68 , pp. 6103-6110
    • Borrow, P.1    Lewicki, H.2    Hahn, B.H.3    Shaw, G.M.4    Oldstone, M.B.5
  • 12
    • 16944365445 scopus 로고    scopus 로고
    • Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
    • Borrow, P., Lewicki, H., Wei, X., Horwitz, M. S., Peffer, N., Meyers, H., et al. (1997). Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3, 205-211.
    • (1997) Nat. Med. , vol.3 , pp. 205-211
    • Borrow, P.1    Lewicki, H.2    Wei, X.3    Horwitz, M.S.4    Peffer, N.5    Meyers, H.6
  • 13
    • 36048995423 scopus 로고    scopus 로고
    • Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A
    • Brockman, M. A., Schneidewind, A., Lahaie, M., Schmidt, A., Miura, T., Desouza, I., et al. (2007). Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A. J. Virol. 81, 12608-12618.
    • (2007) J. Virol. , vol.81 , pp. 12608-12618
    • Brockman, M.A.1    Schneidewind, A.2    Lahaie, M.3    Schmidt, A.4    Miura, T.5    Desouza, I.6
  • 14
    • 0141567539 scopus 로고    scopus 로고
    • Molecular characterization, reactivation, and depletion of latent HIV
    • Brooks, D. G., Hamer, D. H., Arlen, P. A., Gao, L., Bristol, G., Kitchen, C. M. R., et al. (2003). Molecular characterization, reactivation, and depletion of latent HIV. Immunity 19, 413-423.
    • (2003) Immunity , vol.19 , pp. 413-423
    • Brooks, D.G.1    Hamer, D.H.2    Arlen, P.A.3    Gao, L.4    Bristol, G.5    Kitchen, C.M.R.6
  • 15
    • 34249020136 scopus 로고    scopus 로고
    • Effects of human leukocyte antigen class I genetic parameters on clinical outcomes and survival after initiation of highly active antiretroviral therapy
    • Brumme, Z. L., Brumme, C. J., Chui, C., Mo, T., Wynhoven, B., Woods, C. K., et al. (2007). Effects of human leukocyte antigen class I genetic parameters on clinical outcomes and survival after initiation of highly active antiretroviral therapy. J. Infect. Dis. 195, 1694-1704.
    • (2007) J. Infect. Dis. , vol.195 , pp. 1694-1704
    • Brumme, Z.L.1    Brumme, C.J.2    Chui, C.3    Mo, T.4    Wynhoven, B.5    Woods, C.K.6
  • 16
    • 27844483393 scopus 로고    scopus 로고
    • Short communication. Association of the CCR5delta32 mutation with clinical response and >5-year survival following initiation of first triple antiretroviral regimen
    • Brumme, Z. L., Henrick, B. M., Brumme, C. J., Hogg, R. S., Montaner, J. S. G., and Harrigan, P. R. (2005). Short communication. Association of the CCR5delta32 mutation with clinical response and >5-year survival following initiation of first triple antiretroviral regimen. Antivir. Ther. (Lond.) 10, 849-853.
    • (2005) Antivir. Ther. , vol.10 , pp. 849-853
    • Brumme, Z.L.1    Henrick, B.M.2    Brumme, C.J.3    Hogg, R.S.4    Montaner, J.S.G.5    Harrigan, P.R.6
  • 17
    • 68949209789 scopus 로고    scopus 로고
    • HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins
    • doi: 10.1371/journal.pone.0006687
    • Brumme, Z. L., John, M., Carlson, J. M., Brumme, C. J., Chan, D., Brockman, M. A., et al. (2009). HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. PLoS ONE 4:e6687. doi: 10.1371/journal.pone.0006687
    • (2009) PLoS ONE , vol.4
    • Brumme, Z.L.1    John, M.2    Carlson, J.M.3    Brumme, C.J.4    Chan, D.5    Brockman, M.A.6
  • 18
    • 24344510547 scopus 로고    scopus 로고
    • In HIV type 1-infected children cytotoxic T lymphocyte responses are associated with greater reduction of viremia under antiretroviral therapy
    • Buseyne, F., Le Chenadec, J., Burgard, M., Bellal, N., Mayaux, M., Rouzioux, C., et al. (2005). In HIV type 1-infected children cytotoxic T lymphocyte responses are associated with greater reduction of viremia under antiretroviral therapy. AIDS Res. Hum. Retroviruses 21, 719-727.
    • (2005) AIDS Res. Hum. Retroviruses , vol.21 , pp. 719-727
    • Buseyne, F.1    Le Chenadec, J.2    Burgard, M.3    Bellal, N.4    Mayaux, M.5    Rouzioux, C.6
  • 19
    • 0036891034 scopus 로고    scopus 로고
    • Inverse correlation between memory Gag-specific cytotoxic T lymphocytes and viral replication in human immunodeficiency virus-infected children
    • Buseyne, F., Le Chenadec, J., Corre, B., Porrot, F., Burgard, M., Rouzioux, C., et al. (2002). Inverse correlation between memory Gag-specific cytotoxic T lymphocytes and viral replication in human immunodeficiency virus-infected children. J. Infect. Dis. 186, 1589-1596.
    • (2002) J. Infect. Dis. , vol.186 , pp. 1589-1596
    • Buseyne, F.1    Le Chenadec, J.2    Corre, B.3    Porrot, F.4    Burgard, M.5    Rouzioux, C.6
  • 20
    • 0141920575 scopus 로고    scopus 로고
    • Evolution of CD8+ T cell immunity and viral escape following acute HIV-1 infection
    • Cao, J., McNevin, J., Malhotra, U., and McElrath, M. J. (2003). Evolution of CD8+ T cell immunity and viral escape following acute HIV-1 infection. J. Immunol. 171, 3837-3846.
    • (2003) J. Immunol. , vol.171 , pp. 3837-3846
    • Cao, J.1    McNevin, J.2    Malhotra, U.3    McElrath, M.J.4
  • 21
    • 0038581912 scopus 로고    scopus 로고
    • The influence of HLA genotype on AIDS
    • Carrington, M., and O'Brien, S. J. (2003). The influence of HLA genotype on AIDS. Annu. Rev. Med. 54, 535-551.
    • (2003) Annu. Rev. Med. , vol.54 , pp. 535-551
    • Carrington, M.1    O'Brien, S.J.2
  • 22
    • 84855960921 scopus 로고    scopus 로고
    • Immunogenetics of spontaneous control of HIV
    • Carrington, M., and Walker, B. D. (2012). Immunogenetics of spontaneous control of HIV. Annu. Rev. Med. 63, 131-145.
    • (2012) Annu. Rev. Med. , vol.63 , pp. 131-145
    • Carrington, M.1    Walker, B.D.2
  • 23
    • 14744279782 scopus 로고    scopus 로고
    • Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy
    • Casazza, J. P., Betts, M. R., Hill, B. J., Brenchley, J. M., Price, D. A., Douek, D. C., et al. (2005). Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy. J. Virol. 79, 3653-3663.
    • (2005) J. Virol. , vol.79 , pp. 3653-3663
    • Casazza, J.P.1    Betts, M.R.2    Hill, B.J.3    Brenchley, J.M.4    Price, D.A.5    Douek, D.C.6
  • 24
    • 0034979270 scopus 로고    scopus 로고
    • Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy
    • Casazza, J. P., Betts, M. R., Picker, L. J., and Koup, R. A. (2001). Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy. J. Virol. 75, 6508-6516.
    • (2001) J. Virol. , vol.75 , pp. 6508-6516
    • Casazza, J.P.1    Betts, M.R.2    Picker, L.J.3    Koup, R.A.4
  • 25
    • 27644524761 scopus 로고    scopus 로고
    • HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    • Chun, T., Nickle, D. C., Justement, J. S., Large, D., Semerjian, A., Curlin, M. E., et al. (2005). HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J. Clin. Invest. 115, 3250-3255.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3250-3255
    • Chun, T.1    Nickle, D.C.2    Justement, J.S.3    Large, D.4    Semerjian, A.5    Curlin, M.E.6
  • 26
    • 0032490570 scopus 로고    scopus 로고
    • Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines
    • Chun, T. W., Engel, D., Mizell, S. B., Ehler, L. A., and Fauci, A. S. (1998). Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines. J. Exp. Med. 188, 83-91.
    • (1998) J. Exp. Med. , vol.188 , pp. 83-91
    • Chun, T.W.1    Engel, D.2    Mizell, S.B.3    Ehler, L.A.4    Fauci, A.S.5
  • 27
  • 28
    • 65449148344 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells
    • Contreras, X., Schweneker, M., Chen, C., McCune, J. M., Deeks, S. G., Martin, J., et al. (2009). Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. J. Biol. Chem. 284, 6782-6789.
    • (2009) J. Biol. Chem. , vol.284 , pp. 6782-6789
    • Contreras, X.1    Schweneker, M.2    Chen, C.3    McCune, J.M.4    Deeks, S.G.5    Martin, J.6
  • 29
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., et al. (2006). PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443, 350-354.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1    Kaufmann, D.E.2    Kiepiela, P.3    Brown, J.A.4    Moodley, E.S.5    Reddy, S.6
  • 31
    • 0036171258 scopus 로고    scopus 로고
    • Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma
    • Edwards, B. H., Bansal, A., Sabbaj, S., Bakari, J., Mulligan, M. J., and Goepfert, P. A. (2002). Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma. J. Virol. 76, 2298-2305.
    • (2002) J. Virol. , vol.76 , pp. 2298-2305
    • Edwards, B.H.1    Bansal, A.2    Sabbaj, S.3    Bakari, J.4    Mulligan, M.J.5    Goepfert, P.A.6
  • 32
    • 27644489746 scopus 로고    scopus 로고
    • Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment
    • Emu, B., Sinclair, E., Favre, D., Moretto, W. J., Hsue, P., Hoh, R., et al. (2005). Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J. Virol. 79, 14169-14178.
    • (2005) J. Virol. , vol.79 , pp. 14169-14178
    • Emu, B.1    Sinclair, E.2    Favre, D.3    Moretto, W.J.4    Hsue, P.5    Hoh, R.6
  • 33
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi, D., Hermankova, M., Pierson, T., Carruth, L. M., Buck, C., Chaisson, R. E., et al. (1997). Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295-1300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3    Carruth, L.M.4    Buck, C.5    Chaisson, R.E.6
  • 34
    • 84859752894 scopus 로고    scopus 로고
    • No effect of raltegravir intensification on viral replication markers in the blood of HIV-1-infected patients receiving antiretroviral therapy
    • Gandhi, R. T., Coombs, R. W., Chan, E. S., Bosch, R. J., Zheng, L., Margolis, D. M., et al. (2012). No effect of raltegravir intensification on viral replication markers in the blood of HIV-1-infected patients receiving antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 59, 229-235.
    • (2012) J. Acquir. Immune Defic. Syndr. , vol.59 , pp. 229-235
    • Gandhi, R.T.1    Coombs, R.W.2    Chan, E.S.3    Bosch, R.J.4    Zheng, L.5    Margolis, D.M.6
  • 35
    • 16944366524 scopus 로고    scopus 로고
    • Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
    • Goulder, P. J. R., Phillips, R. E., Colbert, R. A., McAdam, S., Ogg, G., Nowak, M. A., et al. (1997). Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3, 212-217.
    • (1997) Nat. Med. , vol.3 , pp. 212-217
    • Goulder, P.J.R.1    Phillips, R.E.2    Colbert, R.A.3    McAdam, S.4    Ogg, G.5    Nowak, M.A.6
  • 36
    • 84866490075 scopus 로고    scopus 로고
    • HIV and HLA class I: an evolving relationship
    • Goulder, P. J. R., and Walker, B. D. (2012). HIV and HLA class I: an evolving relationship. Immunity 37, 426-440.
    • (2012) Immunity , vol.37 , pp. 426-440
    • Goulder, P.J.R.1    Walker, B.D.2
  • 37
    • 3543078012 scopus 로고    scopus 로고
    • HIV and SIV CTL escape: implications for vaccine design
    • Goulder, P. J. R., and Watkins, D. I. (2004). HIV and SIV CTL escape: implications for vaccine design. Nat. Rev. Immunol. 4, 630-640.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 630-640
    • Goulder, P.J.R.1    Watkins, D.I.2
  • 38
    • 67651087476 scopus 로고    scopus 로고
    • Prevalence and comparative characteristics of long-term non-progressors and HIV controller patients in the French Hospital Database on HIV
    • Grabar, S., Selinger-Leneman, H., Abgrall, S., Pialoux, G., Weiss, L., and Costagliola, D. (2009). Prevalence and comparative characteristics of long-term non-progressors and HIV controller patients in the French Hospital Database on HIV. AIDS 23, 1163-1169.
    • (2009) AIDS , vol.23 , pp. 1163-1169
    • Grabar, S.1    Selinger-Leneman, H.2    Abgrall, S.3    Pialoux, G.4    Weiss, L.5    Costagliola, D.6
  • 39
    • 79953000877 scopus 로고    scopus 로고
    • A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response
    • Hatano, H., Hayes, T. L., Dahl, V., Sinclair, E., Lee, T., Hoh, R., et al. (2011). A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response. J. Infect. Dis. 203, 960-968.
    • (2011) J. Infect. Dis. , vol.203 , pp. 960-968
    • Hatano, H.1    Hayes, T.L.2    Dahl, V.3    Sinclair, E.4    Lee, T.5    Hoh, R.6
  • 40
    • 77954080011 scopus 로고    scopus 로고
    • Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control
    • doi: 10.1371/journal.ppat.1000917
    • Hersperger, A. R., Pereyra, F., Nason, M., Demers, K., Sheth, P., Shin, L. Y., et al. (2010). Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control. PLoS Pathog. 6:e1000917. doi: 10.1371/journal.ppat.1000917
    • (2010) PLoS Pathog. , vol.6
    • Hersperger, A.R.1    Pereyra, F.2    Nason, M.3    Demers, K.4    Sheth, P.5    Shin, L.Y.6
  • 41
    • 0034279805 scopus 로고    scopus 로고
    • An antigenic threshold for maintaining human immunodeficiency virus type 1-specific cytotoxic T lymphocytes
    • Jin, X., Ogg, G., Bonhoeffer, S., Safrit, J., Vesanen, M., Bauer, D., et al. (2000). An antigenic threshold for maintaining human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. Mol. Med. 6, 803-809.
    • (2000) Mol. Med. , vol.6 , pp. 803-809
    • Jin, X.1    Ogg, G.2    Bonhoeffer, S.3    Safrit, J.4    Vesanen, M.5    Bauer, D.6
  • 42
    • 23044477494 scopus 로고    scopus 로고
    • Interactive selective pressures of HLA-restricted immune responses and antiretroviral drugs on HIV-1
    • John, M., Moore, C. B., James, I. R., and Mallal, S. A. (2005). Interactive selective pressures of HLA-restricted immune responses and antiretroviral drugs on HIV-1. Antivir. Ther. (Lond.) 10, 551-555.
    • (2005) Antivir. Ther. (Lond.) , vol.10 , pp. 551-555
    • John, M.1    Moore, C.B.2    James, I.R.3    Mallal, S.A.4
  • 43
    • 58149277359 scopus 로고    scopus 로고
    • Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
    • Jones, R. B., Ndhlovu, L. C., Barbour, J. D., Sheth, P. M., Jha, A. R., Long, B. R., et al. (2008). Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J. Exp. Med. 205, 2763-2779.
    • (2008) J. Exp. Med. , vol.205 , pp. 2763-2779
    • Jones, R.B.1    Ndhlovu, L.C.2    Barbour, J.D.3    Sheth, P.M.4    Jha, A.R.5    Long, B.R.6
  • 44
    • 33846101731 scopus 로고    scopus 로고
    • CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
    • Kiepiela, P., Ngumbela, K., Thobakgale, C., Ramduth, D., Honeyborne, I., Moodley, E., et al. (2007). CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nat. Med. 13, 46-53.
    • (2007) Nat. Med. , vol.13 , pp. 46-53
    • Kiepiela, P.1    Ngumbela, K.2    Thobakgale, C.3    Ramduth, D.4    Honeyborne, I.5    Moodley, E.6
  • 45
    • 77649217418 scopus 로고    scopus 로고
    • CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells
    • doi: 10.1371/journal.ppat.1000747
    • Klatt, N. R., Shudo, E., Ortiz, A. M., Engram, J. C., Paiardini, M., Lawson, B., et al. (2010). CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. PLoS Pathog. 6:e1000747. doi: 10.1371/journal.ppat.1000747
    • (2010) PLoS Pathog. , vol.6
    • Klatt, N.R.1    Shudo, E.2    Ortiz, A.M.3    Engram, J.C.4    Paiardini, M.5    Lawson, B.6
  • 46
    • 0028950823 scopus 로고
    • Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term a symptomatics
    • Klein, M. R., van Baalen, C. A., Holwerda, A. M., Kerkhof Garde, S. R., Bende, R. J., Keet, I. P., et al. (1995). Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term a symptomatics. J. Exp. Med. 181, 1365-1372.
    • (1995) J. Exp. Med. , vol.181 , pp. 1365-1372
    • Klein, M.R.1    van Baalen, C.A.2    Holwerda, A.M.3    Kerkhof Garde, S.R.4    Bende, R.J.5    Keet, I.P.6
  • 47
    • 84861082186 scopus 로고    scopus 로고
    • Increasingly successful highly active antiretroviral therapy delays the emergence of new HLA class I-associated escape mutations in HIV-1
    • Knapp, D. J. H. F., Brumme, Z. L., Huang, S. Y., Wynhoven, B., Dong, W. W. Y., Mo, T., et al. (2012). Increasingly successful highly active antiretroviral therapy delays the emergence of new HLA class I-associated escape mutations in HIV-1. Clin. Infect. Dis. 54, 1652-1659.
    • (2012) Clin. Infect. Dis. , vol.54 , pp. 1652-1659
    • Knapp, D.J.H.F.1    Brumme, Z.L.2    Huang, S.Y.3    Wynhoven, B.4    Dong, W.W.Y.5    Mo, T.6
  • 48
    • 0036315848 scopus 로고    scopus 로고
    • Effects of prostratin on T-cell activation and human immunodeficiency virus latency
    • Korin, Y. D., Brooks, D. G., Brown, S., Korotzer, A., and Zack, J. A. (2002). Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J. Virol. 76, 8118-8123.
    • (2002) J. Virol. , vol.76 , pp. 8118-8123
    • Korin, Y.D.1    Brooks, D.G.2    Brown, S.3    Korotzer, A.4    Zack, J.A.5
  • 49
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup, R. A., Safrit, J. T., Cao, Y., Andrews, C. A., McLeod, G., Borkowsky, W., et al. (1994). Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68, 4650-4655.
    • (1994) J. Virol. , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3    Andrews, C.A.4    McLeod, G.5    Borkowsky, W.6
  • 50
    • 0035892120 scopus 로고    scopus 로고
    • Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART
    • Kulkosky, J., Culnan, D. M., Roman, J., Dornadula, G., Schnell, M., Boyd, M. R., et al. (2001). Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 98, 3006-3015.
    • (2001) Blood , vol.98 , pp. 3006-3015
    • Kulkosky, J.1    Culnan, D.M.2    Roman, J.3    Dornadula, G.4    Schnell, M.5    Boyd, M.R.6
  • 51
    • 80055003489 scopus 로고    scopus 로고
    • Human leukocyte antigen genotype and risk of HIV disease progression before and after initiation of antiretroviral therapy
    • Kuniholm, M. H., Gao, X., Xue, X., Kovacs, A., Anastos, K., Marti, D., et al. (2011). Human leukocyte antigen genotype and risk of HIV disease progression before and after initiation of antiretroviral therapy. J. Virol. 85, 10826-10833.
    • (2011) J. Virol. , vol.85 , pp. 10826-10833
    • Kuniholm, M.H.1    Gao, X.2    Xue, X.3    Kovacs, A.4    Anastos, K.5    Marti, D.6
  • 52
    • 34247848047 scopus 로고    scopus 로고
    • Improved virological response to highly active antiretroviral therapy in HIV-1-infected patients carrying the CCR5 delta32 deletion
    • Laurichesse, J. J., Persoz, A., Theodorou, I., Rouzioux, C., Delfraissy, J. F., and Meyer, L. (2007). Improved virological response to highly active antiretroviral therapy in HIV-1-infected patients carrying the CCR5 delta32 deletion. HIV Med. 8, 213-219.
    • (2007) HIV Med. , vol.8 , pp. 213-219
    • Laurichesse, J.J.1    Persoz, A.2    Theodorou, I.3    Rouzioux, C.4    Delfraissy, J.F.5    Meyer, L.6
  • 53
    • 23744500093 scopus 로고    scopus 로고
    • Depletion of latent HIV-1 infection in vivo: a proof-of-concept study
    • Lehrman, G., Hogue, I. B., Palmer, S., Jennings, C., Spina, C. A., Wiegand, A., et al. (2005). Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet 366, 549-555.
    • (2005) Lancet , vol.366 , pp. 549-555
    • Lehrman, G.1    Hogue, I.B.2    Palmer, S.3    Jennings, C.4    Spina, C.A.5    Wiegand, A.6
  • 54
    • 77749277080 scopus 로고    scopus 로고
    • Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy
    • McMahon, D., Jones, J., Wiegand, A., Gange, S. J., Kearney, M., Palmer, S., et al. (2010). Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy. Clin. Infect. Dis. 50, 912-919.
    • (2010) Clin. Infect. Dis. , vol.50 , pp. 912-919
    • McMahon, D.1    Jones, J.2    Wiegand, A.3    Gange, S.J.4    Kearney, M.5    Palmer, S.6
  • 55
    • 57449109484 scopus 로고    scopus 로고
    • Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control
    • Migueles, S. A., Osborne, C. M., Royce, C., Compton, A. A., Joshi, R. P., Weeks, K. A., et al. (2008). Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control. Immunity 29, 1009-1021.
    • (2008) Immunity , vol.29 , pp. 1009-1021
    • Migueles, S.A.1    Osborne, C.M.2    Royce, C.3    Compton, A.A.4    Joshi, R.P.5    Weeks, K.A.6
  • 56
    • 70350322293 scopus 로고    scopus 로고
    • Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy
    • Migueles, S. A., Weeks, K. A., Nou, E., Berkley, A. M., Rood, J. E., Osborne, C. M., et al. (2009). Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy. J. Virol. 83, 11876-11889.
    • (2009) J. Virol. , vol.83 , pp. 11876-11889
    • Migueles, S.A.1    Weeks, K.A.2    Nou, E.3    Berkley, A.M.4    Rood, J.E.5    Osborne, C.M.6
  • 57
    • 62749177486 scopus 로고    scopus 로고
    • HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition
    • Miura, T., Brockman, M. A., Schneidewind, A., Lobritz, M., Pereyra, F., Rathod, A., et al. (2009). HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition. J. Virol. 83, 2743-2755.
    • (2009) J. Virol. , vol.83 , pp. 2743-2755
    • Miura, T.1    Brockman, M.A.2    Schneidewind, A.3    Lobritz, M.4    Pereyra, F.5    Rathod, A.6
  • 58
    • 0037165969 scopus 로고    scopus 로고
    • Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
    • Moore, C. B., John, M., James, I. R., Christiansen, F. T., Witt, C. S., and Mallal, S. A. (2002). Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science 296, 1439-1443.
    • (2002) Science , vol.296 , pp. 1439-1443
    • Moore, C.B.1    John, M.2    James, I.R.3    Christiansen, F.T.4    Witt, C.S.5    Mallal, S.A.6
  • 59
    • 33947360754 scopus 로고    scopus 로고
    • Dual selection pressure by drugs and HLA class I-restricted immune responses on human immunodeficiency virus type 1 protease
    • Mueller, S. M., Schaetz, B., Eismann, K., Bergmann, S., Bauerle, M., Schmitt-Haendle, M., et al. (2007). Dual selection pressure by drugs and HLA class I-restricted immune responses on human immunodeficiency virus type 1 protease. J. Virol. 81, 2887-2898.
    • (2007) J. Virol. , vol.81 , pp. 2887-2898
    • Mueller, S.M.1    Schaetz, B.2    Eismann, K.3    Bergmann, S.4    Bauerle, M.5    Schmitt-Haendle, M.6
  • 60
    • 7144227284 scopus 로고    scopus 로고
    • Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
    • Ogg, G. S., Jin, X., Bonhoeffer, S., Dunbar, P. R., Nowak, M. A., Monard, S., et al. (1998). Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279, 2103-2106.
    • (1998) Science , vol.279 , pp. 2103-2106
    • Ogg, G.S.1    Jin, X.2    Bonhoeffer, S.3    Dunbar, P.R.4    Nowak, M.A.5    Monard, S.6
  • 61
    • 0006922163 scopus 로고    scopus 로고
    • Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy
    • Ogg, G. S., Jin, X., Bonhoeffer, S., Moss, P., Nowak, M. A., Monard, S., et al. (1999). Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy. J. Virol. 73, 797-800.
    • (1999) J. Virol. , vol.73 , pp. 797-800
    • Ogg, G.S.1    Jin, X.2    Bonhoeffer, S.3    Moss, P.4    Nowak, M.A.5    Monard, S.6
  • 62
    • 0037159937 scopus 로고    scopus 로고
    • Residual HIV-specific CD4 and CD8 T cell frequencies after prolonged antiretroviral therapy reflect pretreatment plasma virus load
    • Oxenius, A., Price, D. A., Dawson, S. J., Günthard, H. F., Fischer, M., Perrin, L., et al. (2002). Residual HIV-specific CD4 and CD8 T cell frequencies after prolonged antiretroviral therapy reflect pretreatment plasma virus load. AIDS 16, 2317-2322.
    • (2002) AIDS , vol.16 , pp. 2317-2322
    • Oxenius, A.1    Price, D.A.2    Dawson, S.J.3    Günthard, H.F.4    Fischer, M.5    Perrin, L.6
  • 63
  • 64
    • 30944442077 scopus 로고    scopus 로고
    • HIV-1-specific CD4+ T cell responses in chronically HIV-1 infected blippers on antiretroviral therapy in relation to viral replication following treatment interruption
    • Papasavvas, E., Kostman, J. R., Thiel, B., Pistilli, M., Mackiewicz, A., Foulkes, A., et al. (2006). HIV-1-specific CD4+ T cell responses in chronically HIV-1 infected blippers on antiretroviral therapy in relation to viral replication following treatment interruption. J. Clin. Immunol. 26, 40-54.
    • (2006) J. Clin. Immunol. , vol.26 , pp. 40-54
    • Papasavvas, E.1    Kostman, J.R.2    Thiel, B.3    Pistilli, M.4    Mackiewicz, A.5    Foulkes, A.6
  • 65
    • 0035822946 scopus 로고    scopus 로고
    • Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART
    • Patterson, B. K., McCallister, S., Schutz, M., Siegel, J. N., Shults, K., Flener, Z., et al. (2001). Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART. AIDS 15, 1635-1641.
    • (2001) AIDS , vol.15 , pp. 1635-1641
    • Patterson, B.K.1    McCallister, S.2    Schutz, M.3    Siegel, J.N.4    Shults, K.5    Flener, Z.6
  • 66
    • 77957195721 scopus 로고    scopus 로고
    • Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cells
    • Payne, R. P., Kløverpris, H., Sacha, J. B., Brumme, Z., Brumme, C., Buus, S., et al. (2010). Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cells. J. Virol. 84, 10543-10557.
    • (2010) J. Virol. , vol.84 , pp. 10543-10557
    • Payne, R.P.1    Kløverpris, H.2    Sacha, J.B.3    Brumme, Z.4    Brumme, C.5    Buus, S.6
  • 67
    • 40049094957 scopus 로고    scopus 로고
    • Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
    • Pereyra, F., Addo, M. M., Kaufmann, D. E., Liu, Y., Miura, T., Rathod, A., et al. (2008). Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J. Infect. Dis. 197, 563-571.
    • (2008) J. Infect. Dis. , vol.197 , pp. 563-571
    • Pereyra, F.1    Addo, M.M.2    Kaufmann, D.E.3    Liu, Y.4    Miura, T.5    Rathod, A.6
  • 68
    • 46249104079 scopus 로고    scopus 로고
    • HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy
    • Rauch, A., Nolan, D., Furrer, H., McKinnon, E., John, M., Mallal, S., et al. (2008). HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy. Clin. Infect. Dis. 46, 1921-1925.
    • (2008) Clin. Infect. Dis. , vol.46 , pp. 1921-1925
    • Rauch, A.1    Nolan, D.2    Furrer, H.3    McKinnon, E.4    John, M.5    Mallal, S.6
  • 69
    • 41149160165 scopus 로고    scopus 로고
    • Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy
    • Rehr, M., Cahenzli, J., Haas, A., Price, D. A., Gostick, E., Huber, M., et al. (2008). Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy. J. Virol. 82, 3391-3404.
    • (2008) J. Virol. , vol.82 , pp. 3391-3404
    • Rehr, M.1    Cahenzli, J.2    Haas, A.3    Price, D.A.4    Gostick, E.5    Huber, M.6
  • 70
    • 33847388794 scopus 로고    scopus 로고
    • Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression
    • Sacha, J. B., Chung, C., Rakasz, E. G., Spencer, S. P., Jonas, A. K., Bean, A. T., et al. (2007). Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression. J. Immunol. 178, 2746-2754.
    • (2007) J. Immunol. , vol.178 , pp. 2746-2754
    • Sacha, J.B.1    Chung, C.2    Rakasz, E.G.3    Spencer, S.P.4    Jonas, A.K.5    Bean, A.T.6
  • 71
    • 34249852256 scopus 로고    scopus 로고
    • HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    • Sáez-Cirión, A., Lacabaratz, C., Lambotte, O., Versmisse, P., Urrutia, A., Boufassa, F., et al. (2007). HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. Proc. Natl. Acad. Sci. U.S.A. 104, 6776-6781.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 6776-6781
    • Sáez-Cirión, A.1    Lacabaratz, C.2    Lambotte, O.3    Versmisse, P.4    Urrutia, A.5    Boufassa, F.6
  • 72
    • 67649213034 scopus 로고    scopus 로고
    • Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses
    • Sáez-Cirión, A., Sinet, M., Shin, S. Y., Urrutia, A., Versmisse, P., Lacabaratz, C., et al. (2009). Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses. J. Immunol. 182, 7828-7837.
    • (2009) J. Immunol. , vol.182 , pp. 7828-7837
    • Sáez-Cirión, A.1    Sinet, M.2    Shin, S.Y.3    Urrutia, A.4    Versmisse, P.5    Lacabaratz, C.6
  • 73
    • 0036893434 scopus 로고    scopus 로고
    • Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype
    • Scripture-Adams, D. D., Brooks, D. G., Korin, Y. D., and Zack, J. A. (2002). Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype. J. Virol. 76, 13077-13082.
    • (2002) J. Virol. , vol.76 , pp. 13077-13082
    • Scripture-Adams, D.D.1    Brooks, D.G.2    Korin, Y.D.3    Zack, J.A.4
  • 74
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan, L., Deng, K., Shroff, N. S., Durand, C. M., Rabi, S. A., Yang, H., et al. (2012). Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 36, 491-501.
    • (2012) Immunity , vol.36 , pp. 491-501
    • Shan, L.1    Deng, K.2    Shroff, N.S.3    Durand, C.M.4    Rabi, S.A.5    Yang, H.6
  • 75
    • 70349296826 scopus 로고    scopus 로고
    • Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy
    • Shiu, C., Cunningham, C. K., Greenough, T., Muresan, P., Sanchez-Merino, V., Carey, V., et al. (2009). Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy. J. Virol. 83, 9731-9742.
    • (2009) J. Virol. , vol.83 , pp. 9731-9742
    • Shiu, C.1    Cunningham, C.K.2    Greenough, T.3    Muresan, P.4    Sanchez-Merino, V.5    Carey, V.6
  • 76
    • 44449096577 scopus 로고    scopus 로고
    • Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
    • doi: 10.1371/journal.pmed.0050100
    • Streeck, H., Brumme, Z. L., Anastario, M., Cohen, K. W., Jolin, J. S., Meier, A., et al. (2008). Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS Med. 5:e100. doi: 10.1371/journal.pmed.0050100
    • (2008) PLoS Med. , vol.5
    • Streeck, H.1    Brumme, Z.L.2    Anastario, M.3    Cohen, K.W.4    Jolin, J.S.5    Meier, A.6
  • 77
    • 78650084232 scopus 로고    scopus 로고
    • The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    • The International HIV Controllers Study
    • The International HIV Controllers Study. (2010). The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 330, 1551-1557.
    • (2010) Science , vol.330 , pp. 1551-1557
  • 78
    • 33749009709 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    • Trautmann, L., Janbazian, L., Chomont, N., Said, E. A., Gimmig, S., Bessette, B., et al. (2006). Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat. Med. 12, 1198-1202.
    • (2006) Nat. Med. , vol.12 , pp. 1198-1202
    • Trautmann, L.1    Janbazian, L.2    Chomont, N.3    Said, E.A.4    Gimmig, S.5    Bessette, B.6
  • 79
    • 77954633050 scopus 로고    scopus 로고
    • HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals
    • Trono, D., Van Lint, C., Rouzioux, C., Verdin, E., Barré-Sinoussi, F., Chun, T., et al. (2010). HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science 329, 174-180.
    • (2010) Science , vol.329 , pp. 174-180
    • Trono, D.1    Van Lint, C.2    Rouzioux, C.3    Verdin, E.4    Barré-Sinoussi, F.5    Chun, T.6
  • 80
    • 1642506123 scopus 로고    scopus 로고
    • Impact of 5 years of maximally successful highly active antiretroviral therapy on CD4 cell count and HIV-1 DNA level
    • Viard, J., Burgard, M., Hubert, J., Aaron, L., Rabian, C., Pertuiset, N., et al. (2004). Impact of 5 years of maximally successful highly active antiretroviral therapy on CD4 cell count and HIV-1 DNA level. AIDS 18, 45-49.
    • (2004) AIDS , vol.18 , pp. 45-49
    • Viard, J.1    Burgard, M.2    Hubert, J.3    Aaron, L.4    Rabian, C.5    Pertuiset, N.6
  • 81
    • 13744259064 scopus 로고    scopus 로고
    • IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    • Wang, F., Xu, Y., Sullivan, J., Souder, E., Argyris, E. G., Acheampong, E. A., et al. (2005). IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART. J. Clin. Invest. 115, 128-137.
    • (2005) J. Clin. Invest. , vol.115 , pp. 128-137
    • Wang, F.1    Xu, Y.2    Sullivan, J.3    Souder, E.4    Argyris, E.G.5    Acheampong, E.A.6
  • 82
    • 77649193824 scopus 로고    scopus 로고
    • In vivo CD8+ T-cell suppression of SIV viremia is not mediated by CTL clearance of productively infected cells
    • doi: 10.1371/journal.ppat.1000748
    • Wong, J. K., Strain, M. C., Porrata, R., Reay, E., Sankaran-Walters, S., Ignacio, C. C., et al. (2010). In vivo CD8+ T-cell suppression of SIV viremia is not mediated by CTL clearance of productively infected cells. PLoS Pathog. 6:e1000748. doi: 10.1371/journal.ppat.1000748
    • (2010) PLoS Pathog. , vol.6
    • Wong, J.K.1    Strain, M.C.2    Porrata, R.3    Reay, E.4    Sankaran-Walters, S.5    Ignacio, C.C.6
  • 83
    • 78549245806 scopus 로고    scopus 로고
    • Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
    • Yukl, S. A., Shergill, A. K., McQuaid, K., Gianella, S., Lampiris, H., Hare, C. B., et al. (2010). Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS 24, 2451-2460.
    • (2010) AIDS , vol.24 , pp. 2451-2460
    • Yukl, S.A.1    Shergill, A.K.2    McQuaid, K.3    Gianella, S.4    Lampiris, H.5    Hare, C.B.6
  • 84
    • 33644755541 scopus 로고    scopus 로고
    • Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control
    • Zuñiga, R., Lucchetti, A., Galvan, P., Sanchez, S., Sanchez, C., Hernandez, A., et al. (2006). Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control. J. Virol. 80, 3122-3125.
    • (2006) J. Virol. , vol.80 , pp. 3122-3125
    • Zuñiga, R.1    Lucchetti, A.2    Galvan, P.3    Sanchez, S.4    Sanchez, C.5    Hernandez, A.6


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