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Volumn 6, Issue 6, 2010, Pages

Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; IMMUNOTOXIN; COMPLEMENT;

EID: 77954685640     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000803     Document Type: Article
Times cited : (44)

References (68)
  • 1
    • 73549103358 scopus 로고    scopus 로고
    • The development of antiretrovi-ral therapy and its impact on the HIV-1/AIDS pandemic
    • Broder S (2010) The development of antiretrovi-ral therapy and its impact on the HIV-1/AIDS pandemic. Antivir Res 85: 1-18.
    • (2010) Antivir Res , vol.85 , pp. 1-18
    • Broder, S.1
  • 2
    • 36049027132 scopus 로고    scopus 로고
    • HIV latency: Present knowledge and future directions
    • Contreras X, Lenasi T, Peterlin BM (2006) HIV latency: present knowledge and future directions. Future Virol 1: 733-745.
    • (2006) Future Virol , vol.1 , pp. 733-745
    • Contreras, X.1    Lenasi, T.2    Peterlin, B.M.3
  • 3
    • 39649105458 scopus 로고    scopus 로고
    • Hide-and-seek: The challenge of viral persistence in HIV-1 infection
    • Geeraert L, Kraus G, Pomerantz RJ (2008) Hide-and-seek: the challenge of viral persistence in HIV-1 infection. Annu Rev Med 59: 487-501.
    • (2008) Annu Rev Med , vol.59 , pp. 487-501
    • Geeraert, L.1    Kraus, G.2    Pomerantz, R.J.3
  • 4
    • 46049096099 scopus 로고    scopus 로고
    • Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection
    • Shen L, Siliciano RF (2008) Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection. J Allergy Clin Immunol 122: 22-28.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 22-28
    • Shen, L.1    Siliciano, R.F.2
  • 5
    • 57049090090 scopus 로고    scopus 로고
    • Can HIV be cured?
    • Stevenson M (2008) Can HIV be cured? Sci Am 299: 78-83.
    • (2008) Sci Am , vol.299 , pp. 78-83
    • Stevenson, M.1
  • 6
    • 77954679629 scopus 로고    scopus 로고
    • Mexico City, Mexico, Accessed 12 May 2010
    • Fauci A The future of AIDS research. XVII International AIDS Conference; 3-8 August 2008; Mexico City, Mexico. Avaliable: http://www.kaisernetwork.org/health_cast/hcast_in-dex.cfm?display=detail&hc=2912. Accessed 12 May 2010.
    • (2008) The Future of AIDS Research. XVII International AIDS Conference , Issue.August
    • Fauci, A.1
  • 7
    • 57649193118 scopus 로고    scopus 로고
    • Eradication of HIV: Current challenges and new directions
    • Marsden MD, Zack JA (2009) Eradication of HIV: current challenges and new directions. J Antimicrob Chemother 63: 7-10.
    • (2009) J Antimicrob Chemother , vol.63 , pp. 7-10
    • Marsden, M.D.1    Zack, J.A.2
  • 10
    • 44449085539 scopus 로고    scopus 로고
    • Paul Ehrlich's magic bullet concept: 100 years of progress
    • Strebhardt K, Ullrich A (2008) Paul Ehrlich's magic bullet concept: 100 years of progress. Nat Rev Cancer 8: 473-480.
    • (2008) Nat Rev Cancer , vol.8 , pp. 473-480
    • Strebhardt, K.1    Ullrich, A.2
  • 11
    • 64249088444 scopus 로고    scopus 로고
    • Targeted tumor therapies at a glance
    • Fuchs H, Bachran C (2009) Targeted tumor therapies at a glance. Curr Drug Targ 10: 89-93.
    • (2009) Curr Drug Targ , vol.10 , pp. 89-93
    • Fuchs, H.1    Bachran, C.2
  • 12
    • 55349100505 scopus 로고    scopus 로고
    • Optimizing denileukin diftitox (Ontak (R)) therapy
    • Duvic M, Talpur R (2008) Optimizing denileukin diftitox (Ontak (R)) therapy. Future Oncol 4: 457-469.
    • (2008) Future Oncol , vol.4 , pp. 457-469
    • Duvic, M.1    Talpur, R.2
  • 14
    • 38849103765 scopus 로고    scopus 로고
    • Host and microbial cells as targets for armed antibodies in the treatment of infectious diseases
    • Dadachova E, Casadevall A (2008) Host and microbial cells as targets for armed antibodies in the treatment of infectious diseases. Curr Opin Investig Drugs 9: 184-188.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 184-188
    • Dadachova, E.1    Casadevall, A.2
  • 15
    • 0345097633 scopus 로고    scopus 로고
    • Retrospective: The discovery of HIV as the cause of AIDS
    • Gallo RC, Montagnier L (2003) Retrospective: the discovery of HIV as the cause of AIDS. N Eng J Med 349: 2283-2285.
    • (2003) N Eng J Med , vol.349 , pp. 2283-2285
    • Gallo, R.C.1    Montagnier, L.2
  • 16
    • 0023784225 scopus 로고
    • Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein
    • Chaudhary VK, Mizukami T, Fuerst TR, FitzGerald DJ, Moss B, et al. (1988) Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein. Nature 335: 369-372.
    • (1988) Nature , vol.335 , pp. 369-372
    • Chaudhary, V.K.1    Mizukami, T.2    Fuerst, T.R.3    Fitzgerald, D.J.4    Moss, B.5
  • 18
    • 0024574345 scopus 로고
    • Treatment of HIV tissue culture infection with monoclonal antibody-ricin A chain conjugates
    • Pincus SH, Wehrly K, Chesebro B (1989) Treatment of HIV tissue culture infection with monoclonal antibody-ricin A chain conjugates. J Immunol 142: 3070-3075.
    • (1989) J Immunol , vol.142 , pp. 3070-3075
    • Pincus, S.H.1    Wehrly, K.2    Chesebro, B.3
  • 19
    • 0026508830 scopus 로고
    • A recombinant diphtheria toxin related human CD4 fusion protein specifically kills HIV infected cells which express gp120 but selects fusion toxin resistant cells which carry HIV
    • Aullo P, Alcami J, Popoff MR, Klatzmann DR, Murphy JR, et al. (1992) A recombinant diphtheria toxin related human CD4 fusion protein specifically kills HIV infected cells which express gp120 but selects fusion toxin resistant cells which carry HIV. EMBO J 11: 575-583.
    • (1992) EMBO J , vol.11 , pp. 575-583
    • Aullo, P.1    Alcami, J.2    Popoff, M.R.3    Klatzmann, D.R.4    Murphy, J.R.5
  • 20
    • 0025834347 scopus 로고
    • Selective elimination of HIV-1-infected cells with an interleukin-2 receptor-specific cytotoxin
    • Finberg RW, Wahl SM, Allen JB, Soman G, Strom TB, et al. (1991) Selective elimination of HIV-1-infected cells with an interleukin-2 receptor-specific cytotoxin. Science 252: 1703-1705.
    • (1991) Science , vol.252 , pp. 1703-1705
    • Finberg, R.W.1    Wahl, S.M.2    Allen, J.B.3    Soman, G.4    Strom, T.B.5
  • 21
    • 0027054719 scopus 로고
    • Inhibition of HIV-1 RNA Production by the Diphtheria Toxin- Related IL-2 Fusion Proteins DAB(486)IL-2 and DAB(389)IL-2
    • Zhang L, Waters C, Nichols J, Crumpacker C (1992) Inhibition of HIV-1 RNA Production by the Diphtheria Toxin- Related IL-2 Fusion Proteins DAB(486)IL-2 and DAB(389)IL-2. J Acquir Immune Defic Syndr 5: 1181-1187.
    • (1992) J Acquir Immune Defic Syndr , vol.5 , pp. 1181-1187
    • Zhang, L.1    Waters, C.2    Nichols, J.3    Crumpacker, C.4
  • 23
    • 0033613133 scopus 로고    scopus 로고
    • An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro
    • McCoig C, Van Dyke G, Chou CS, Picker LJ, Ramilo O, et al. (1999) An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro. Proc Natl Acad Sci U S A 96: 11482-11485.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 11482-11485
    • McCoig, C.1    van Dyke, G.2    Chou, C.S.3    Picker, L.J.4    Ramilo, O.5
  • 24
    • 60849116672 scopus 로고    scopus 로고
    • Pseudomonas exotoxin A: From virulence factor to anti-cancer agent
    • Wolf P, Elsasser-Beile U (2009) Pseudomonas exotoxin A: From virulence factor to anti-cancer agent. Int J Med Microbiol 299: 161-176.
    • (2009) Int J Med Microbiol , vol.299 , pp. 161-176
    • Wolf, P.1    Elsasser-Beile, U.2
  • 26
    • 0025165343 scopus 로고
    • Recombinant CD4-Pseudomonas exotoxin hybrid protein displays HIV-specific cytotoxicity without affecting MHC class II-dependent functions
    • Berger EA, Chaudhary VK, Clouse KA, Jaraquemada D, Nicholas JA, et al. (1990) Recombinant CD4-Pseudomonas exotoxin hybrid protein displays HIV-specific cytotoxicity without affecting MHC class II-dependent functions. AIDS Res Hum Retroviruses 6: 795-804.
    • (1990) AIDS Res Hum Retroviruses , vol.6 , pp. 795-804
    • Berger, E.A.1    Chaudhary, V.K.2    Clouse, K.A.3    Jaraquemada, D.4    Nicholas, J.A.5
  • 27
    • 0026500265 scopus 로고
    • Activity of CD4-Pseudomonas exotoxin against cells express-ing diverse forms of the HIV and SIV envelope glycoproteins
    • Ashorn P, Moss B, Berger EA (1992) Activity of CD4-Pseudomonas exotoxin against cells express-ing diverse forms of the HIV and SIV envelope glycoproteins. J Acquir Immune Defic Syndr 5: 70-77.
    • (1992) J Acquir Immune Defic Syndr , vol.5 , pp. 70-77
    • Ashorn, P.1    Moss, B.2    Berger, E.A.3
  • 28
    • 0031813707 scopus 로고    scopus 로고
    • Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein
    • Bera TK, Kennedy PE, Berger EA, Barbas CFI, Pastan I (1998) Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein. Mol Med 4: 384-391.
    • (1998) Mol Med , vol.4 , pp. 384-391
    • Bera, T.K.1    Kennedy, P.E.2    Berger, E.A.3    Barbas, C.F.I.4    Pastan, I.5
  • 29
    • 0024398753 scopus 로고
    • CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses
    • Berger EA, Clouse KA, Chaudhary VK, Chakrabarti S, FitzGerald DJ, et al. (1989) CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses. Proc Natl Acad Sci U S A 86: 9539-9543.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 9539-9543
    • Berger, E.A.1    Clouse, K.A.2    Chaudhary, V.K.3    Chakrabarti, S.4    Fitzgerald, D.J.5
  • 30
    • 0025225451 scopus 로고
    • Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse tran-scriptase inhibitors
    • Ashorn P, Moss B, Weinstein JN, Chaudhary VK, FitzGerald DJ, et al. (1990) Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse tran-scriptase inhibitors. Proc Natl Acad Sci U S A 87: 8889-8893.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 8889-8893
    • Ashorn, P.1    Moss, B.2    Weinstein, J.N.3    Chaudhary, V.K.4    Fitzgerald, D.J.5
  • 31
    • 0025852258 scopus 로고
    • Anti-HIV activity of CD4-Pseudomonas exotoxin on infected primary human lymphocytes and monocyte/macrophages
    • Ashorn P, Englund G, Martin MA, Moss B, Berger EA (1991) Anti-HIV activity of CD4-Pseudomonas exotoxin on infected primary human lymphocytes and monocyte/macrophages. J Infect Dis 163: 703-709.
    • (1991) J Infect Dis , vol.163 , pp. 703-709
    • Ashorn, P.1    Englund, G.2    Martin, M.A.3    Moss, B.4    Berger, E.A.5
  • 32
    • 0027306775 scopus 로고
    • Primary HIV-1 isolates refractory to neutralization by soluble CD4 are potently inhibited by CD4-Pseudomonas exotoxin
    • Kennedy PE, Moss B, Berger EA (1993) Primary HIV-1 isolates refractory to neutralization by soluble CD4 are potently inhibited by CD4-Pseudomonas exotoxin. Virology 192: 375-379.
    • (1993) Virology , vol.192 , pp. 375-379
    • Kennedy, P.E.1    Moss, B.2    Berger, E.A.3
  • 34
    • 0027438088 scopus 로고
    • Continuous Presence of CD4-PE40 Is Required for Antiviral Activity Against Single-Passage HIV Isolates and Infected Peripheral Blood Mononuclear Cells
    • Winters MA, Merigan TC (1993) Continuous Presence of CD4-PE40 Is Required for Antiviral Activity Against Single-Passage HIV Isolates and Infected Peripheral Blood Mononuclear Cells. AIDS Res Hum Retroviruses 9: 1091-1096.
    • (1993) AIDS Res Hum Retroviruses , vol.9 , pp. 1091-1096
    • Winters, M.A.1    Merigan, T.C.2
  • 36
    • 67649253072 scopus 로고    scopus 로고
    • HIV interactions with monocytes and dendritic cells: Viral latency and reservoirs
    • Coleman CM, Wu L (2009) HIV interactions with monocytes and dendritic cells: viral latency and reservoirs. Retrovirology 6: 51.
    • (2009) Retrovirology , vol.6 , pp. 51
    • Coleman, C.M.1    Wu, L.2
  • 37
    • 0028135433 scopus 로고
    • Use of recombinant soluble CD4 Pseudomonas exotoxin, a novel immunotoxin, for treatment of persons infected with human immunodeficiency virus
    • Davey RT, Boenning CM, Herpin BR, Batts DH, Metcalf JA, et al. (1994) Use of recombinant soluble CD4 Pseudomonas exotoxin, a novel immunotoxin, for treatment of persons infected with human immunodeficiency virus. J Infect Dis 170: 1180-1188.
    • (1994) J Infect Dis , vol.170 , pp. 1180-1188
    • Davey, R.T.1    Boenning, C.M.2    Herpin, B.R.3    Batts, D.H.4    Metcalf, J.A.5
  • 38
    • 0027965596 scopus 로고
    • Failure of short-term CD4-PE40 infusions to reduce virus load in human immunodeficiency virus-infected persons
    • Ramachandran RV, Katzenstein DA, Wood R, Batts DH, Merigan TC (1994) Failure of short-term CD4-PE40 infusions to reduce virus load in human immunodeficiency virus-infected persons. J Infect Dis 170: 1009-1013.
    • (1994) J Infect Dis , vol.170 , pp. 1009-1013
    • Ramachandran, R.V.1    Katzenstein, D.A.2    Wood, R.3    Batts, D.H.4    Merigan, T.C.5
  • 39
    • 0032578524 scopus 로고    scopus 로고
    • Reconsidering targeted toxins to eliminate HIV infection: You gotta have HAART
    • Berger EA, Moss B, Pastan I (1998) Reconsidering targeted toxins to eliminate HIV infection: You gotta have HAART. Proc Natl Acad SciUSA 95: 11511-11513.
    • (1998) Proc Natl Acad SciUSA , vol.95 , pp. 11511-11513
    • Berger, E.A.1    Moss, B.2    Pastan, I.3
  • 40
    • 0035954624 scopus 로고    scopus 로고
    • Efficacy of the anti-CD22 recombinant immu-notoxin BL-22 in chemotherapy-resistant hairy-cell leukemia
    • Kreitman RJ, Wilson WH, Bergeron K, Raggio M, Stetler-Stevenson M, et al. (2001) Efficacy of the anti-CD22 recombinant immu-notoxin BL-22 in chemotherapy-resistant hairy-cell leukemia. N Engl J Med 345: 241-247.
    • (2001) N Engl J Med , vol.345 , pp. 241-247
    • Kreitman, R.J.1    Wilson, W.H.2    Bergeron, K.3    Raggio, M.4    Stetler-Stevenson, M.5
  • 41
    • 67649933809 scopus 로고    scopus 로고
    • Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia
    • Kreitman RJ, Stetler-Stevenson M, Margulies I, Noel P, FitzGerald DJP, et al. (2009) Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia. J Clin Oncol 27: 2983-2990.
    • (2009) J Clin Oncol , vol.27 , pp. 2983-2990
    • Kreitman, R.J.1    Stetler-Stevenson, M.2    Margulies, I.3    Noel, P.4    Fitzgerald, D.J.P.5
  • 42
    • 0028348564 scopus 로고
    • In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity
    • Barbas CF, Hu D, Dunlop N, Sawyer L, Cababa D, et al. (1994) In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity. Proc Natl Acad Sci U S A 91: 3809-3813.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3809-3813
    • Barbas, C.F.1    Hu, D.2    Dunlop, N.3    Sawyer, L.4    Cababa, D.5
  • 43
    • 33750427894 scopus 로고    scopus 로고
    • Anti-HIV-1 immuno-toxin 3B3(Fv)-PE38: Enhanced potency against clinical isolates in human PBMCs and macro-phages, and negligible hepatotoxicity in macaques
    • Kennedy PE, Bera TK, Wang QC, Gallo M, Wagner W, et al. (2006) Anti-HIV-1 immuno-toxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macro-phages, and negligible hepatotoxicity in macaques. J Leukoc Biol 80: 1175-1182.
    • (2006) J Leukoc Biol , vol.80 , pp. 1175-1182
    • Kennedy, P.E.1    Bera, T.K.2    Wang, Q.C.3    Gallo, M.4    Wagner, W.5
  • 44
    • 0035394359 scopus 로고    scopus 로고
    • Lowering the isoelectric point of the Fv portion of recombinant immuno-toxins leads to decreased nonspecific animal toxicity without affecting antitumor activity
    • Onda M, Nagata S, Tsutsumi Y, Vincent JJ, Wang QC, et al. (2001) Lowering the isoelectric point of the Fv portion of recombinant immuno-toxins leads to decreased nonspecific animal toxicity without affecting antitumor activity. Cancer Res 61: 5070-5077.
    • (2001) Cancer Res , vol.61 , pp. 5070-5077
    • Onda, M.1    Nagata, S.2    Tsutsumi, Y.3    Vincent, J.J.4    Wang, Q.C.5
  • 45
    • 0034081778 scopus 로고    scopus 로고
    • Chimeric toxins targeted to the human immunodeficiency virus type 1 envelope glycoprotein augment the in vivo activity of combination antiretroviral therapy in thy/liv-scid-hu mice
    • Goldstein H, Pettoello-Mantovani M, Bera TK, Pastan IH, Berger EA (2000) Chimeric toxins targeted to the human immunodeficiency virus type 1 envelope glycoprotein augment the in vivo activity of combination antiretroviral therapy in thy/liv-scid-hu mice. J Infect Dis 181: 921-926.
    • (2000) J Infect Dis , vol.181 , pp. 921-926
    • Goldstein, H.1    Pettoello-Mantovani, M.2    Bera, T.K.3    Pastan, I.H.4    Berger, E.A.5
  • 46
    • 0029085036 scopus 로고
    • Animal model for the therapy of acquired-immunodefi ciency syndrom with reverse transcriptase inhib itors
    • Uberla K, Stahlhennig C, Bottiger D, Matzrensing K, Kaup FJ, et al. (1995) Animal model for the therapy of acquired-immunodefi ciency syndrom with reverse transcriptase inhib itors. Proc Natl Acad Sci U S A 92: 8210-8214.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 8210-8214
    • Uberla, K.1    Stahlhennig, C.2    Bottiger, D.3    Matzrensing, K.4    Kaup, F.J.5
  • 47
    • 0035895214 scopus 로고    scopus 로고
    • Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4(+) t cells by a highly pathogenic simian immunodeficiency virus/hiv type 1 chimera (shiv): Implications for hiv-1 infections of humans
    • Igarashi T, Brown CR, Endo Y, Buckler-White A, Plishka R, et al. (2001) Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4(+) t cells by a highly pathogenic simian immunodeficiency virus/hiv type 1 chimera (shiv): implications for hiv-1 infections of humans. Proc Natl Acad Sci U S A 98: 658-663.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 658-663
    • Igarashi, T.1    Brown, C.R.2    Endo, Y.3    Buckler-White, A.4    Plishka, R.5
  • 48
    • 36048949742 scopus 로고    scopus 로고
    • Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy
    • Ambrose Z, Palmer S, Boltz VF, Kearney M, Larsen K, et al. (2007) Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy. J Virol 81: 12145-12155.
    • (2007) J Virol , vol.81 , pp. 12145-12155
    • Ambrose, Z.1    Palmer, S.2    Boltz, V.F.3    Kearney, M.4    Larsen, K.5
  • 49
    • 34247380296 scopus 로고    scopus 로고
    • Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection
    • Van Rompay KKA, Johnson JA, Blackwood EJ, Singh RP, Lipscomb J, et al. (2007) Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. Retrovirology 4: 25.
    • (2007) Retrovirology , vol.4 , pp. 25
    • van Rompay, K.K.A.1    Johnson, J.A.2    Blackwood, E.J.3    Singh, R.P.4    Lipscomb, J.5
  • 50
    • 69449083091 scopus 로고    scopus 로고
    • A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy
    • Dinoso JB, Rabi SA, Blankson JN, Gama L, Mankowski JL, et al. (2009) A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy. J Virol 83: 9247-9257.
    • (2009) J Virol , vol.83 , pp. 9247-9257
    • Dinoso, J.B.1    Rabi, S.A.2    Blankson, J.N.3    Gama, L.4    Mankowski, J.L.5
  • 51
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso JB, Kim SY, Wiegand AM, Palmer SE, Gange SJ, et al. (2009) Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci U S A 106: 9403-9408.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9403-9408
    • Dinoso, J.B.1    Kim, S.Y.2    Wiegand, A.M.3    Palmer, S.E.4    Gange, S.J.5
  • 52
    • 77954678555 scopus 로고    scopus 로고
    • No decrease in residual viremia during raltegravir intensification in patients on standard ART. 16th Conference on Retroviruses and Opportunistic Infections; 8-11 February 2009; Montreal, Canada
    • [Abstract 423b]
    • Jones J, McMahon D, Wiegand A, Kearney M, Palmer S, et al. (2009);No decrease in residual viremia during raltegravir intensification in patients on standard ART. 16th Conference on Retroviruses and Opportunistic Infections; 8-11 February 2009; Montreal, Canada. CROI 2009. [Abstract 423b].
    • (2009) CROI , pp. 2009
    • Jones, J.1    McMahon, D.2    Wiegand, A.3    Kearney, M.4    Palmer, S.5
  • 53
    • 77954672451 scopus 로고    scopus 로고
    • Transient increase in episomal viral cDNA following raltegravir intensification of a stable HAART Regimen. 16th Conference on Retroviruses and Opportunistic Infections; 8-11 February 2009; Montreal, Canada
    • [Abstract 423a]
    • Buzon M, Llibre J, Domingo P, Paredes R, Palmer S, et al. (2009);Transient increase in episomal viral cDNA following raltegravir intensification of a stable HAART Regimen. 16th Conference on Retroviruses and Opportunistic Infections; 8-11 February 2009; Montreal, Canada. CROI 2009. [Abstract 423a].
    • (2009) CROI , pp. 2009
    • Buzon, M.1    Llibre, J.2    Domingo, P.3    Paredes, R.4    Palmer, S.5
  • 54
    • 33745245733 scopus 로고    scopus 로고
    • Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4(+) T cells
    • Bailey JR, Sedaghat AR, Kieffer T, Brennan T, Lee PK, et al. (2006) Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4(+) T cells. J Virol 80: 6441-6457.
    • (2006) J Virol , vol.80 , pp. 6441-6457
    • Bailey, J.R.1    Sedaghat, A.R.2    Kieffer, T.3    Brennan, T.4    Lee, P.K.5
  • 55
    • 69249214157 scopus 로고    scopus 로고
    • Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4(+) T cells reveals a novel source of residual viremia in patients on antiretroviral therapy
    • Brennan TP, Woods JO, Sedaghat AR, Siliciano JD, Siliciano RF, et al. (2009) Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4(+) T cells reveals a novel source of residual viremia in patients on antiretroviral therapy. J Virol 83: 8470-8481.
    • (2009) J Virol , vol.83 , pp. 8470-8481
    • Brennan, T.P.1    Woods, J.O.2    Sedaghat, A.R.3    Siliciano, J.D.4    Siliciano, R.F.5
  • 56
    • 0141567539 scopus 로고    scopus 로고
    • Molecular characterization, reactivation, and depletion of latent HIV
    • Brooks DG, Hamer DH, Arlen PA, Gao LY, Bristol G, et al. (2003) Molecular characterization, reactivation, and depletion of latent HIV. Immunity 19: 413-423.
    • (2003) Immunity , vol.19 , pp. 413-423
    • Brooks, D.G.1    Hamer, D.H.2    Arlen, P.A.3    Gao, L.Y.4    Bristol, G.5
  • 57
    • 57049168212 scopus 로고    scopus 로고
    • Activating stimuli enhance immunotoxin-mediat-ed killing of HIV-infected macrophages
    • Marsden MD, Xu J, Hamer D, Zack JA (2008) Activating stimuli enhance immunotoxin-mediat-ed killing of HIV-infected macrophages. AIDS Res Hum Retroviruses 24: 1399-1404.
    • (2008) AIDS Res Hum Retroviruses , vol.24 , pp. 1399-1404
    • Marsden, M.D.1    Xu, J.2    Hamer, D.3    Zack, J.A.4
  • 58
    • 33748906061 scopus 로고    scopus 로고
    • Elimination of HIV-1 infection by treatment with a doxorubi-cin-conjugated anti-envelope antibody
    • Johansson S, Goldenberg DM, Griffiths GL, Wahren B, Hinkula J (2006) Elimination of HIV-1 infection by treatment with a doxorubi-cin-conjugated anti-envelope antibody. AIDS 20: 1911-1915.
    • (2006) AIDS , vol.20 , pp. 1911-1915
    • Johansson, S.1    Goldenberg, D.M.2    Griffiths, G.L.3    Wahren, B.4    Hinkula, J.5
  • 59
    • 33845316055 scopus 로고    scopus 로고
    • Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins
    • doi:10.1371/journal.pmed.0030427
    • Dadachova E, Patel MC, Toussi S, Apostolidis C, Morgenstern A, et al. (2006) Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins. PLoS Med 3: e427. doi:10.1371/journal.pmed.0030427.
    • (2006) PLoS Med , vol.3
    • Dadachova, E.1    Patel, M.C.2    Toussi, S.3    Apostolidis, C.4    Morgenstern, A.5
  • 60
    • 49649091350 scopus 로고    scopus 로고
    • An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes
    • Onda M, Beers R, Xiang L, Nagata S, Wang QC, et al. (2008) An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proc Natl Acad Sci U S A 105: 11311-11316.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 11311-11316
    • Onda, M.1    Beers, R.2    Xiang, L.3    Nagata, S.4    Wang, Q.C.5
  • 61
    • 0037072948 scopus 로고    scopus 로고
    • Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure-based mutagenesis
    • McHugh L, Hu S, Lee BK, Santora K, Kennedy PE, et al. (2002) Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure-based mutagenesis. J Biol Chem 277: 34383-34390.
    • (2002) J Biol Chem , vol.277 , pp. 34383-34390
    • McHugh, L.1    Hu, S.2    Lee, B.K.3    Santora, K.4    Kennedy, P.E.5
  • 62
    • 0037442143 scopus 로고    scopus 로고
    • In vivo efficacy of anti-glycoprotein 41, but not anti- glycoprotein 120, immunotoxins in a mouse model of hiv infection
    • Pincus SH, Fang H, Wilkinson RA, Marcotte TK, Robinson JE, et al. (2003) In vivo efficacy of anti-glycoprotein 41, but not anti- glycoprotein 120, immunotoxins in a mouse model of hiv infection. J Immunol 170: 2236-2241.
    • (2003) J Immunol , vol.170 , pp. 2236-2241
    • Pincus, S.H.1    Fang, H.2    Wilkinson, R.A.3    Marcotte, T.K.4    Robinson, J.E.5
  • 63
    • 0037966960 scopus 로고    scopus 로고
    • Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein
    • Root MJ, Hamer DH (2003) Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein. Proc Natl Acad Sci U S A 100: 5016-5021.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5016-5021
    • Root, M.J.1    Hamer, D.H.2
  • 64
    • 38049094546 scopus 로고    scopus 로고
    • Antibody-based HIV-1 vaccines: Recent developments and future directions
    • doi:10.1371/journal.pmed.0040348
    • Montefiori D, Sattentau Q, Flores J, Esparza J, Mascola J (2007) Antibody-based HIV-1 vaccines: recent developments and future directions. PLoS Med 4: e348. doi:10.1371/journal.pmed.0040348.
    • (2007) PLoS Med , vol.4
    • Montefiori, D.1    Sattentau, Q.2    Flores, J.3    Esparza, J.4    Mascola, J.5
  • 65
    • 70349887757 scopus 로고    scopus 로고
    • Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    • Walker LM, Phogat SK, Chan-Hui PY, Wagner D, Phung P, et al. (2009) Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science 326: 285-289.
    • (2009) Science , vol.326 , pp. 285-289
    • Walker, L.M.1    Phogat, S.K.2    Chan-Hui, P.Y.3    Wagner, D.4    Phung, P.5
  • 66
    • 44649201289 scopus 로고    scopus 로고
    • HIV infection and the gastrointestinal immune system
    • Brenchley JM, Douek DC (2008) HIV infection and the gastrointestinal immune system. Mucosal Immunol 1: 23-30.
    • (2008) Mucosal Immunol , vol.1 , pp. 23-30
    • Brenchley, J.M.1    Douek, D.C.2
  • 67
    • 40549092339 scopus 로고    scopus 로고
    • Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy
    • Chun TW, Nickle DC, Justement JS, Meyers JH, Roby G, et al. (2008) Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy. J Infect Dis 197: 714-720.
    • (2008) J Infect Dis , vol.197 , pp. 714-720
    • Chun, T.W.1    Nickle, D.C.2    Justement, J.S.3    Meyers, J.H.4    Roby, G.5
  • 68
    • 42549131481 scopus 로고    scopus 로고
    • Inferior clinical outcome of the CD4(+) cell count guided antiretroviral treatment interruption strategy in the SMART study: Role of CD4(+) cell counts and HIV RNA levels during follow-up
    • Lundgren JD, Babiker A, El-Sadr W, Emery S, Grund B, et al. (2008) Inferior clinical outcome of the CD4(+) cell count guided antiretroviral treatment interruption strategy in the SMART study: Role of CD4(+) cell counts and HIV RNA levels during follow-up. J Infect Dis 197: 1145-1155.
    • (2008) J Infect Dis , vol.197 , pp. 1145-1155
    • Lundgren, J.D.1    Babiker, A.2    El-Sadr, W.3    Emery, S.4    Grund, B.5


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