Genetic instability of modified stem cells - a first step towards malignant transformation?

American Journal of Stem Cells

Volumn 2, Issue 1, 2013, Pages 39-51

  Steinemann, Doris ^a   Göhring, Gudrun ^a   Schlegelberger, Brigitte ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Chromosomal instability; Chromosome; Clonal evolution; Gene therapy; Genetic integrity; Induced pluripotent stem cells; Leukemia; Mutation; P53; Tumor

Indexed keywords

MISMATCH REPAIR PROTEIN; MYC PROTEIN; PROTEIN P53;

CARCINOGENESIS; CHROMOSOMAL INSTABILITY; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; DNA DAMAGE; EMBRYONIC STEM CELL; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; GENE THERAPY; GENETIC DISORDER; GENOMIC INSTABILITY; HIGH THROUGHPUT SEQUENCING; HUMAN; KARYOTYPING; MALIGNANT TRANSFORMATION; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; REVIEW; STEM CELL;

EID: 84883860888     PISSN: None     EISSN: 21604150     Source Type: Journal    
DOI: None     Document Type: Review

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