Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission

Developmental Dynamics

Volumn 209, Issue 1, 1997, Pages 85-91

  Liu, Xin ^a   Wu, Hong ^a   Loring, Janet ^a   Hormuzdi, Sheriar ^c   Disteche, Christine M ^d   Bornstein, Paul ^c   Jaenisch, Rudolf ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

ES cells; gene targeting; germ line transmission

Indexed keywords

ANIMAL CELL; ARTICLE; CELL CLONE; EMBRYO CELL; GENE TARGETING; GERM LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; TRISOMY 8; VERTICAL TRANSMISSION;

ANIMALIA;

EID: 0030944004     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0177(199705)209:1<85::AID-AJA8>3.0.CO;2-T     Document Type: Article

References (33)

1. Bradley, A. (1987) Production and analysis of chimeric mice. In: "Teratocarcinomas and Embryonic Stem Cells." Robertson, E.J. (ed). Oxford: IRL Press, pp. 113-52.
2. Bradley, A., Evans, M., Kaufman, M.H., and Robertson, E. (1984) Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309:255-256.
3. Brandon, E.P., Gerhold, K.A., Qi, M., McKnight, G.S., and Idzerda, R.L. (1995) Derivation of novel embryonic stem cell lines and targeting of cyclic AMP-dependent protein kinase genes. Recent Prog. Horm. Res. 50:403-408.
4. Capecchi, M.R. (1994) Targeted gene replacement. Sci. Am. 270:52-59.
5. Ceci, J.D., Justice, M.J., Lock, L.F., Jenkins, N.A., and Copeland, N.G. (1990) An interspecific backcross linkage map of mouse chromosome 8. Genomics 6:72-79.
6. Drivas, G., Massey, R., Chang, H.Y., Rush, M.G., and D'Eustachio, P. (1991) Ras-like genes and gene families in the mouse. Mamm. Genome 1:112-117.
7. Evans, M., Bradley, A., and Robertson, E.J. (1985) Genetic manipulation of the early mammalian embryo, p. 93. In: "Banbury Report." Jaenisch, R., and Constantin, F. (eds). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
8. Evans, M.J., and Kaufman, M.H. (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154-156.
9. Gu, H., Zou, Y.R., and Rajewsky, K. (1993) Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73:1155-1164.
10. Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A.B., and Joyner A.L. (1995) Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269:679-682.
11. Hasty, P., Ramirez-Solis, R., Krumlauf, R., and Bradley, A. (1991) Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature 350:243-6 [published erratum appears in Nature (1991) Sept. 5, 353:94].
12. Heim, S., and Mitelman, F. (1992) Cytogenetic analysis in the diagnosis of acute leukemia. Cancer 70:1701-1709.
13. Hooper, M., Hardy, K., Handyside, A., Hunter, S., and Monk, M. (1987) HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germ line colonization by cultured cells. Nature 326:292-295.
14. Howard, T.A., Rochelle, J.M., Saunders, A.M., and Seldin, M.F. (1991) A linkage map of mouse chromosome 8: Further definition of homologous linkage relationships between mouse chromosome 8 and human chromosomes 8, 16, and 19. Genomics 10:207-213.
15. Koller, B.H., Marrack, P., Kappler, J.W., and Smithies, O. (1990) Normal development of mice deficient in beta 2M, MHC class I proteins, and CDS + T cells. Science 248:1227-1230.
16. Kuo, S.S., Mellentin, J.D., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., and Cleary, M.L. (1991) Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. Oncogene 6:961-968.
17. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R., and Berns, A. (1991) Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19:4293.
18. Li, E., Bestor, T.H., and Jaenisch, R. (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:915-926.
19. Liu, X., Ernfors, P., Wu, H., and Jaenisch, R. (1995) Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature 375:238-241.
20. Liu, X., Wu, H., Byrne, M., Jeffrey, J., Krane, S., and Jaenisch, R. (1995) A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J. Cell Biol. 130:227-237.
21. Martin, G.R. (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. U.S.A. 78:7634-7638.
22. Mattei, M.G., Simon-Chazottes, D., Hirai, S., Ryseck, R.P., Galcheva-Gargova, Z., Guenet, J.L., Mattei, J.F., Bravo, R., and Yaniv, M. (1990) Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man. Oneogene 5:151-156.
23. Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., and Roder, J.C. (1993) Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 90:8424-8428.
24. Nichols, J., Evans, E.P., and Smith, A.G. (1990) Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity. Development 110:1341-1348.
25. Pettenati, M.J., Rao, N., Wofford, M., Shuster, J.J., Pullen, D.J., Ling, M.P., Steuber, C.P., and Carroll, A.J. (1994) Presenting characteristics of trisomy 8 as the primary cytogenetic abnormality associated with childhood acute lymphoblastic leukemia. A Pediatric Oncology Group (POG) Study (8600/8493). Cancer Genet. Cytogenet. 75:6-10.
26. Robertson, E.J. (1987) Embryo-derived stem cell lines. In: "Teratocarcinomas and Embryonic Stem Cells." Robertson, E.J. (ed). Oxford: IRL Press, pp. 71-112.
27. Soriano, P. (1995) Gene targeting in ES cells. Annu. Rev. Neurosci. 18:1-18.
28. Thomas, K.R., Folger, K.R., and Capecchi, M.R. (1986) High frequency targeting of genes to specific sites in the mammalian genome. Cell 44:419-428.
29. Wang, Y., Schnegelsberg, P.N., Dausman, J., and Jaenisch, R. (1996) Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin. Nature 379:823-825.
30. Williams, R.L., Hilton, D.J., Pease, S., Willson, T.A., Stewart, C.L., Gearing, D.P., Wagner, E.F., Metcalf, D., Nicola, N.A., and Gough, N.M. (1988) Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336:684-687.
31. Wu, H., Liu, X., Jaenisch, R., and Lodish, H.F. (1995) Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83:59-67.
32. Zijlstra, M., Bix, M., Simister, N.B., Loring, J.M., Raulet, D.H., and Jaenisch, R. (1990) Beta 2-microglobulin deficient mice lack CD4-8 + cytolytic T cells. Nature 344:742-746.
33. Zijlstra, M., Li, E., Sajjadi, F., Subramani, S., and Jaenisch, R. (1989) Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342:435-438.