Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells

Journal of Clinical Investigation

Volumn 122, Issue 2, 2012, Pages 569-574

  Varela, Christine ^a   Denis, Jérôme Alexandre ^b   Polentes, Jérôme ^a   Feyeux, Maxime ^b   Aubert, Sophie ^a   Champon, Benoite ^a   Piétu, Geneviève ^b   Peschanski, Marc ^b   Lefort, Nathalie ^b  

^a AFM   (France)

^b I Stem   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL AGING; CELL CULTURE; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CHROMOSOMAL INSTABILITY; CHROMOSOME 1Q; CONTROLLED STUDY; EMBRYONIC STEM CELL; FEMALE; GENE DUPLICATION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; NERVE CELL; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SOMATIC CELL;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; CHROMOSOMES, HUMAN, PAIR 1; CLINICAL TRIALS AS TOPIC; EMBRYONIC STEM CELLS; GENOMIC INSTABILITY; HUMANS; KARYOTYPING; NEURAL STEM CELLS; RATS;

EID: 84856526096     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI46268     Document Type: Article

References (30)

1. Advanced Cell Technology. Sub-retinal Transplantation of hESC Derived RPE(MA09-hRPE)Cells in Patients With Stargardt's Macular Dystrophy. NIH Web site. http://clinicaltrials.gov/ct2/show/NCT01345006. Updated November 7, 2011. Accessed December 12, 2011.
2. Advanced Cell Technology. Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt's Macular Dystrophy (SMD). NIH Web site. http://clinicaltrials.gov/ct2/show/NCT01469832. Updated November 9, 2011. Accessed December 12, 2011.
3. Advanced Cell Technology. Safety and Tolerability of Sub-retinal Transplantation of hESC Derived RPE (MA09-hRPE) Cells in Patients With Advanced Dry Age Related Macular Degeneration (Dry AMD). NIH Web site. http://clinicaltrials.gov/ct2/show/NCT01344993. Updated November 9, 2011. Accessed December 12, 2011.
4. Geron Corporation. Safety Study of GRNOPC1 in Spinal Cord Injury. NIH Web site. http://clinicaltrials.gov/ct2/show/NCT01217008. Updated December 1, 2011. Accessed December 12, 2011.
5. Draper JS, et al. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol. 2004;22(1):53-54. (Pubitemid 38057956)
6. Inzunza J, et al. Comparative genomic hybridization and karyotyping of human embryonic stem cells reveals the occurrence of an isodicentric X chromosome after long-term cultivation. Mol Hum Reprod. 2004;10(6):461-466. (Pubitemid 38714378)
7. Baker DE, et al. Adaptation to culture of human embryonic stem cells and oncogenesis in vivo. Nat Biotechnol. 2007;25(2):207-215. (Pubitemid 46227120)
8. Lefort N, et al. Human embryonic stem cells reveal recurrent genomic instability at 20q11.21. Nat Biotechnol. 2008;26(12):1364-1366.
9. Lefort N, Perrier AL, Laabi Y, Varela C, Peschanski M. Human embryonic stem cells and genomic instability. Regen Med. 2009;4(6):899-909.
10. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 1965;37:614-636.
11. Wu W, et al. Long-term cultured human neural stem cells undergo spontaneous transformation to tumor-initiating cells. Int J Biol Sci. 2011;7(6):892-901.
12. Yu J, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318(5858):1917-1920.
13. Lejeune J, Maunoury C, Prieur M, Van den Akker J. [A jumping translocation (5p;15q), (8q;15q), and (12q;15q) (author's transl)]. Ann Genet. 1979;22(4):210-213.
14. Mitelman F, Johansson B, Mertens F. Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nat Genet. 2004;36(4):331-334. (Pubitemid 38437252)
15. Faria C, et al. Pediatric brain tumors: genetics and clinical outcome. J Neurosurg Pediatr. 2010;5(3):263-270.
16. Fournier A, et al. 1q12 chromosome translocations form aberrant heterochromatic foci associated with changes in nuclear architecture and gene expression in B cell lymphoma. EMBO Mol Med. 2010;2(5):159-171.
17. Narva E, et al. High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nat Biotechnol. 2010;28(4):371-377.
18. Mayshar Y, et al. Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell. 2010;7(4):521-531.
19. Laurent LC, et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell. 2011;8(1):106-118.
20. Conti L, Cattaneo E. Neural stem cell systems: physiological players or in vitro entities? Nat Rev Neurosci. 2010;11(3):176-187.
21. Sareen D, et al. Chromosome 7 and 19 trisomy in cultured human neural progenitor cells. PLoS One. 2009;4(10):e7630.
22. Koch P, Opitz T, Steinbeck JA, Ladewig J, Brustle O. A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc Natl Acad Sci U S A. 2009;106(9):3225-3230.
23. Nemati S, et al. Long-term self-renewable feeder-free human induced pluripotent stem cell-derived neural progenitors. Stem Cells Dev. 2011;20(3):503-514.
24. Li TS, Marban E. Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells. Stem Cells. 2010;28(7):1178-1185.
25. Senda S, et al. Altered heterochromatin organization after perinatal exposure to zidovudine. Antivir Ther. 2007;12(2):179-187. (Pubitemid 46569903)
26. Sawyer JR, Tricot G, Mattox S, Jagannath S, Barlogie B. Jumping translocations of chromosome 1q in multiple myeloma: evidence for a mechanism involving decondensation of pericentromeric heterochromatin. Blood. 1998;91(5):1732-1741. (Pubitemid 28110339)
27. Ehrlich M, Jackson K, Weemaes C. Immunodeficiency, centromeric region instability, facial anomalies syndrome (ICF). Orphanet J Rare Dis. 2006;1:2.
28. Loring JF, Rao MS. Establishing standards for the characterization of human embryonic stem cell lines. Stem Cells. 2006;24(1):145-150.
29. Lapillonne H, et al. Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine. Haematologica. 2010;95(10):1651-1659.
30. Aubry L, Bugi A, Lefort N, Rousseau F, Peschanski M, Perrier AL. Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats. Proc Natl Acad Sci U S A. 2008;105(43):16707-16712.