Mismatch and base excision repair proficiency in murine embryonic stem cells

DNA Repair

Volumn 10, Issue 4, 2011, Pages 445-451

  Tichy, Elisia D ^a   Liang, Li ^b   Deng, Li ^b   Tischfield, Jay ^b   Schwemberger, Sandy ^c   Babcock, George ^c,d   Stambrook, Peter J ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c SHRINERS HOSPITALS FOR CHILDREN   (United States)

^d UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Base excision repair; DNA repair; Embryonic stem; ES; Mismatch repair

Indexed keywords

BETA ACTIN; MISMATCH REPAIR PROTEIN PMS2; OCTAMER TRANSCRIPTION FACTOR 4; OLIGONUCLEOTIDE; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; URACIL;

ANIMAL CELL; ARTICLE; CELL TYPE; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; EXCISION REPAIR; FIBROBLAST; GENETIC TRANSFECTION; GENOMICS; MISMATCH REPAIR; MOUSE; MUTATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; CELL LINE; DNA REPAIR; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; FIBROBLASTS; MICE; MICE, INBRED C3H;

MURINAE;

EID: 79952700669     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2011.01.008     Document Type: Article

References (35)

1. Hoeijmakers J.H. DNA damage, aging, and cancer. N. Engl. J. Med. 2009, 361:1475-1485.
2. Li G.M. Mechanisms and functions of DNA mismatch repair. Cell Res. 2008, 18:85-98.
3. Lutzen A., de Wind N., Georgijevic D., Nielsen F.C., Rasmussen L.J. Functional analysis of HNPCC-related missense mutations in MSH2. Mutat. Res. 2008, 645:44-55.
4. Papadopoulos N., Nicolaides N.C., Wei Y.F., Ruben S.M., Carter K.C., Rosen C.A., Haseltine W.A., Fleischmann R.D., Fraser C.M., Adams M.D., et al. Mutation of a mutL homolog in hereditary colon cancer. Science 1994, 263:1625-1629.
5. Nicolaides N.C., Papadopoulos N., Liu B., Wei Y.F., Carter K.C., Ruben S.M., Rosen C.A., Haseltine W.A., Fleischmann R.D., Fraser C.M., et al. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 1994, 371:75-80.
6. Ollikainen M., Hannelius U., Lindgren C.M., Abdel-Rahman W.M., Kere J., Peltomaki P. Mechanisms of inactivation of MLH1 in hereditary nonpolyposis colorectal carcinoma: a novel approach. Oncogene 2007, 26:4541-4549.
7. Robertson A.B., Klungland A., Rognes T., Leiros I. DNA repair in mammalian cells: base excision repair: the long and short of it. Cell. Mol. Life Sci. 2009, 66:981-993.
8. Fortini P., Pascucci B., Parlanti E., Sobol R.W., Wilson S.H., Dogliotti E. Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells. Biochemistry 1998, 37:3575-3580.
9. Cervantes R.B., Stringer J.R., Shao C., Tischfield J.A., Stambrook P.J. Embryonic stem cells and somatic cells differ in mutation frequency and type. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:3586-3590.
10. Roos W.P., Christmann M., Fraser S.T., Kaina B. Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair. Cell Death Differ. 2007, 14:1422-1432.
11. Filion T.M., Qiao M., Ghule P.N., Mandeville M., van Wijnen A.J., Stein J.L., Lian J.B., Altieri D.C., Stein G.S. Survival responses of human embryonic stem cells to DNA damage. J. Cell. Physiol. 2009, 220:586-592.
12. Corbet S.W., Clarke A.R., Gledhill S., Wyllie A.H. P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells. Oncogene 1999, 18:1537-1544.
13. Solozobova V., Blattner C. Regulation of p53 in embryonic stem cells. Exp. Cell Res. 2010, 316:2434-2446.
14. Qin H., Yu T., Qing T., Liu Y., Zhao Y., Cai J., Li J., Song Z., Qu X., Zhou P., Wu J., Ding M., Deng H. Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. J. Biol. Chem. 2007, 282:5842-5852.
15. Lin T., Chao C., Saito S., Mazur S.J., Murphy M.E., Appella E., Xu Y. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat. Cell Biol. 2005, 7:165-171.
16. Xu Y. A new role for p53 in maintaining genetic stability in embryonic stem cells. Cell Cycle 2005, 4:363-364.
17. Solozobova V., Rolletschek A., Blattner C. Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage. BMC Cell Biol. 2009, 10:46.
18. Hong Y., Stambrook P.J. Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:14443-14448.
19. Saretzki G., Armstrong L., Leake A., Lako M., von Zglinicki T. Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells. Stem Cells 2004, 22:962-971.
20. Maynard S., Swistowska A.M., Lee J.W., Liu Y., Liu S.T., Da Cruz A.B., Rao M., de Souza-Pinto N.C., Zeng X., Bohr V.A. Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. Stem Cells 2008, 26:2266-2274.
21. Tichy E.D., Pillai R., Deng L., Liang L., Tischfield J.A., Schwemberger S., Babcock G.F., Stambrook P.J. Mouse embryonic stem cells but not somatic cells predominantly use homologous recombination to repair double strand DNA breaks. Stem Cells Dev. 2010, 19:1699-1711.
22. Serrano L., Liang L., Chang Y., Deng L., Maulion C., Nguyen S.C., Tischfield J.A. Homologous recombination conserves DNA sequence integrity throughout the cell cycle in embryonic stem cells. Stem Cells Dev. 2011, 20:363-374.
23. Zhou B., Huang C., Yang J., Lu J., Dong Q., Sun L.Z. Preparation of heteroduplex enhanced green fluorescent protein plasmid for in vivo mismatch repair activity assay. Anal. Biochem. 2009, 388:167-169.
24. Liang L., Deng L., Chen Y., Li G.C., Shao C., Tischfield J.A. Modulation of DNA end joining by nuclear proteins. J. Biol. Chem. 2005, 280:31442-31449.
25. Liang L., Deng L., Mendonca M.S., Chen Y., Zheng B., Stambrook P.J., Shao C., Tischfield J.A. X-rays induce distinct patterns of somatic mutation in fetal versus adult hematopoietic cells. DNA Repair (Amst.) 2007, 6:1380-1385.
26. Dianov G., Bischoff C., Sunesen M., Bohr V.A. Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells. Nucleic Acids Res. 1999, 27:1365-1368.
27. Osman A.M., van Dartel D.A., Zwart E., Blokland M., Pennings J.L., Piersma A.H. Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and embryotoxicity. Reprod. Toxicol. 2010, 30:322-332.
28. Lin D.P., Wang Y., Scherer S.J., Clark A.B., Yang K., Avdievich E., Jin B., Werling U., Parris T., Kurihara N., Umar A., Kucherlapati R., Lipkin M., Kunkel T.A., Edelmann W. An Msh2 point mutation uncouples DNA mismatch repair and apoptosis. Cancer Res. 2004, 64:517-522.
29. Modrich P. Strand-specific mismatch repair in mammalian cells. J. Biol. Chem. 1997, 272:24727-24730.
30. Claij N., Te Riele H. Methylation tolerance in mismatch repair proficient cells with low MSH2 protein level. Oncogene 2002, 21:2873-2879.
31. de Wind N., Dekker M., Berns A., Radman M., te Riele H. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 1995, 82:321-330.
32. Bracken A.P., Ciro M., Cocito A., Helin K. E2F target genes: unraveling the biology. Trends Biochem. Sci. 2004, 29:409-417.
33. Ren B., Cam H., Takahashi Y., Volkert T., Terragni J., Young R.A., Dynlacht B.D. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev. 2002, 16:245-256.
34. Savatier P., Lapillonne H., Jirmanova L., Vitelli L., Samarut J. Analysis of the cell cycle in mouse embryonic stem cells. Methods Mol. Biol. 2002, 185:27-33.
35. White J., Dalton S. Cell cycle control of embryonic stem cells. Stem Cell Rev. 2005, 1:131-138.