Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes

Cell Death and Disease

Volumn 3, Issue 6, 2012, Pages

  Masse, I ^a   Barbollat Boutrand, L ^a   Molina, M ^a   Berthier Vergnes, O ^a   Joly Tonetti, N ^a   Martin, M T ^b   De Fromentel, C Caron ^c   Kanitakis, J ^d   Lamartine, J ^a  

^a CENTRE DE GÉNÉTIQUE MOLÉCULAIRE ET CELLULAIRE   (France)

^b DIF   (France)

^c CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^d EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

carcinoma; keratinocytes; p53; p63; RUNX1

Indexed keywords

PROTEIN P53; PROTEIN P63; TRANSCRIPTION FACTOR RUNX1; CKAP4 PROTEIN, HUMAN; MEMBRANE PROTEIN; RUNX1 PROTEIN, HUMAN;

ARTICLE; BASAL CELL CARCINOMA; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY DNA SEQUENCE; SQUAMOUS CELL CARCINOMA; CELL CULTURE; CYTOLOGY; EPIDERMIS; GENETICS; METABOLISM;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DOWN-REGULATION; EPIDERMIS; HUMANS; KERATINOCYTES; MEMBRANE PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84863458436     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.62     Document Type: Article

References (40)

1. Koster MI, Roop DR. p63 and epithelial appendage development. Differentiation 2004; 72: 364-370.
2. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999; 398: 708-713.
3. Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999; 398: 714-718.
4. Truong AB, Kretz M, Ridky TW, Kimmel R, Khavari PA. p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev 2006; 20: 3185-3197.
5. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998; 2: 305-316.
6. King KE, Ponnamperuma RM, Gerdes MJ, Tokino T, Yamashita T, Baker CC et al. Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis. Carcinogenesis 2006; 27: 53-63.
7. Kanitakis J, Chouvet B. Expression of p63 in cutaneous metastases. Am J Clin Pathol 2007; 128: 753-758.
8. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A et al. The mutational landscape of head and neck squamous cell carcinoma. Science 2011; 333: 1157-1160.
9. Ortt K, Raveh E, Gat U, Sinha S. A chromatin immunoprecipitation screen in mouse keratinocytes reveals Runx1 as a direct transcriptional target of DeltaNp63. J Cell Biochem 2008; 104: 1204-1219.
10. Pozzi S, Zambelli F, Merico D, Pavesi G, Robert A, Maltere P et al. Transcriptional network of p63 in human keratinocytes. PLoS One 2009; 4: e5008.
11. Vigano MA, Lamartine J, Testoni B, Merico D, Alotto D, Castagnoli C et al. New p63 targets in keratinocytes identified by a genome-wide approach. EMBO J 2006; 25: 5105-5116.
12. Lutterbach B, Hiebert SW. Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Gene 2000; 245: 223-235.
13. Blyth K, Cameron ER, Neil JC. The RUNX genes: gain or loss of function in cancer. Nat Rev Cancer 2005; 5: 376-387.
14. Friedman AD. Cell cycle and developmental control of hematopoiesis by Runx1. J Cell Physiol 2009; 219: 520-524.
15. Wang X, Blagden C, Fan J, Nowak SJ, Taniuchi I, Littman DR et al. Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes Dev 2005; 19: 1715-1722.
16. Theriault FM, Nuthall HN, Dong Z, Lo R, Barnabe-Heider F, Miller FD et al. Role for Runx1 in the proliferation and neuronal differentiation of selected progenitor cells in the mammalian nervous system. J Neurosci 2005; 25: 2050-2061.
17. Hoi CS, Lee SE, Lu SY, McDermitt DJ, Osorio KM, Piskun CM et al. Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin. Mol Cell Biol 2010; 30: 2518-2536.
18. Osorio KM, Lee SE, McDermitt DJ, Waghmare SK, Zhang YV, Woo HN et al. Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation. Development 2008; 135: 1059-1068.
19. Osorio KM, Lilja KC, Tumbar T. Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol 2011; 193: 235-250.
20. Soma T, Ishimatsu-Tsuji Y, Tajima M, Kishimoto J. Runx1 transcription factor is involved in the regulation of KAP5 gene expression in human hair follicles. J Dermatol Sci 2006; 41: 221-224.
21. Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT et al. Perp is a p63-regulated gene essential for epithelial integrity. Cell 2005; 120: 843-856.
22. Lapi E, Iovino A, Fontemaggi G, Soliera AR, Iacovelli S, Sacchi A et al. S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation. Oncogene 2006; 25: 3628-3637.
23. Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y, Wang XF. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 1995; 92: 5545-5549.
24. Arman M, Aguilera-Montilla N, Mas V, Puig-Kroger A, Pignatelli M, Guigo R et al. The human CD6 gene is transcriptionally regulated by RUNX and Ets transcription factors in T cells. Mol Immunol 2009; 46: 2226-2235.
25. Toulza E, Mattiuzzo NR, Galliano MF, Jonca N, Dossat C, Jacob D et al. Large-scale identification of human genes implicated in epidermal barrier function. Genome Biol 2007; 8: R107.
26. Youssef KK, Van Keymeulen A, Lapouge G, Beck B, Michaux C, Achouri Y et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol 2010; 12: 299-305.
27. Lapouge G, Youssef KK, Vokaer B, Achouri Y, Michaux C, Sotiropoulou PA et al. Identifying the cellular origin of squamous skin tumors. Proc Natl Acad Sci USA 2011; 108: 7431-7436.
28. Pfeifer GP, Besaratinia A. Mutational spectra of human cancer. Hum Genet 2009; 125: 493-506.
29. Park HR, Min SK, Cho HD, Kim KH, Shin HS, Park YE. Expression profiles of p63, p53, survivin, and hTERT in skin tumors. J Cutan Pathol 2004; 31: 544-549.
30. Kamiya M, Takeuchi Y, Katho M, Yokoo H, Sasaki A, Nakazato Y. Expression of p73 in normal skin and proliferative skin lesions. Pathol Int 2004; 54: 890-895.
31. De Laurenzi V, Rossi A, Terrinoni A, Barcaroli D, Levrero M, Costanzo A et al. p63 and p73 transactivate differentiation gene promoters in human keratinocytes. Biochem Biophys Res Commun 2000; 273: 342-346.
32. Cordani N, Pozzi S, Martynova E, Fanoni D, Borrelli S, Alotto D et al. Mutant p53 subverts p63 control over KLF4 expression in keratinocytes. Oncogene 2011; 30: 922-932.
33. Planaguma J, Gonzalez M, Doll A, Monge M, Gil-Moreno A, Baro T et al. The up-regulation profiles of p21WAF1/CIP1 and RUNX1/AML1 correlate with myometrial infiltration in endometrioid endometrial carcinoma. Hum Pathol 2006; 37: 1050-1057.
34. Huitfeldt HS, Heyden A, Clausen OP, Thrane EV, Roop D, Yuspa SH. Altered regulation of growth and expression of differentiation-Associated keratins in benign mouse skin tumors. Carcinogenesis 1991; 12: 2063-2067.
35. Ogawa E, Okuyama R, Egawa T, Nagoshi H, Obinata M, Tagami H et al. p63/p51-induced onset of keratinocyte differentiation via the c-Jun N-Terminal kinase pathway is counteracted by keratinocyte growth factor. J Biol Chem 2008; 283: 34241-34249.
36. Tsai KY, Tsao H. The genetics of skin cancer. Am J Med Genet C Semin Med Genet 2004; 131C: 82-92.
37. De Gruijl FR, Rebel H. Early events in UV carcinogenesis-DNA damage, target cells and mutant p53 foci. Photochem Photobiol 2008; 84: 382-387.
38. Lamartine J, Franco N, Le Minter P, Soularue P, Alibert O, Leplat JJ et al. Activation of an energy providing response in human keratinocytes after gamma irradiation. J Cell Biochem 2005; 95: 620-631.
39. Bonin F, Molina M, Malet C, Ginestet C, Berthier-Vergnes O, Martin MT et al. GATA3 is a master regulator of the transcriptional response to low-dose ionizing radiation in human keratinocytes. BMC Genomics 2009; 10: 417.
40. Petitjean A, Ruptier C, Tribollet V, Hautefeuille A, Chardon F, Cavard C et al. Properties of the six isoforms of p63: P53-like regulation in response to genotoxic stress and cross talk with DeltaNp73. Carcinogenesis 2008; 29: 273-281