-
1
-
-
0037029424
-
Multiple sclerosis
-
DOI 10.1016/S0140-6736(02)08220-X
-
Compston, A. & Coles, A. Multiple sclerosis. Lancet 359, 1221-1231 (2002). (Pubitemid 34304266)
-
(2002)
Lancet
, vol.359
, Issue.9313
, pp. 1221-1231
-
-
Compston, A.1
Coles, A.2
-
2
-
-
34548633861
-
Primary-progressive multiple sclerosis
-
DOI 10.1016/S1474-4422(07)70243-0, PII S1474442207702430
-
Miller, D. H. & Leary, S. M. Primary-progressive multiple sclerosis. Lancet Neurol. 6, 903-912 (2007). (Pubitemid 47405002)
-
(2007)
Lancet Neurology
, vol.6
, Issue.10
, pp. 903-912
-
-
Miller, D.H.1
Leary, S.M.2
-
3
-
-
33644974688
-
Secondary progressive multiple sclerosis: Current knowledge and future challenges
-
Rovaris, M. et al. Secondary progressive multiple sclerosis: current knowledge and future challenges. Lancet Neurol. 5, 343-354 (2006).
-
(2006)
Lancet Neurol
, vol.5
, pp. 343-354
-
-
Rovaris, M.1
-
4
-
-
0345601517
-
Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis. Prisms (prevention of relapses and disability by interferon β-1a subcutaneously in multiple sclerosis) study group
-
[No authors listed]
-
[No authors listed]. Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon β-1a Subcutaneously in Multiple Sclerosis) Study Group. Lancet 352, 1498-1504 (1998).
-
(1998)
Lancet
, vol.352
, pp. 1498-1504
-
-
-
5
-
-
0032494792
-
Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis. European study group on interferon β-1b in secondary progressive ms
-
[No authors listed]
-
[No authors listed]. Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis. European Study Group on interferon β-1b in secondary progressive MS. Lancet 352, 1491-1497 (1998).
-
(1998)
Lancet
, vol.352
, pp. 1491-1497
-
-
-
6
-
-
0029082566
-
Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase iii multicenter, double-blind placebo-controlled trial. The copolymer 1 multiple sclerosis study group
-
Johnson, K. P. et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group. Neurology 45, 1268-1276 (1995).
-
(1995)
Neurology
, vol.45
, pp. 1268-1276
-
-
Johnson, K.P.1
-
7
-
-
33644584352
-
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
-
Polman, C. H. et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 354, 899-910 (2006).
-
(2006)
N. Engl. J. Med
, vol.354
, pp. 899-910
-
-
Polman, C.H.1
-
8
-
-
80054734945
-
Oral treatment for multiple sclerosis
-
Killestein, J., Rudick, R. A. & Polman, C. H. Oral treatment for multiple sclerosis. Lancet Neurol. 10, 1026-1034 (2011).
-
(2011)
Lancet Neurol
, vol.10
, pp. 1026-1034
-
-
Killestein, J.1
Rudick, R.A.2
Polman, C.H.3
-
9
-
-
84866413167
-
Immune therapy of multiple sclerosis-future strategies
-
Meuth, S. G., Göbel, K. & Wiendl, H. Immune therapy of multiple sclerosis-future strategies. Curr. Pharm. Des. 18, 4489-4497 (2012).
-
(2012)
Curr. Pharm. des
, vol.18
, pp. 4489-4497
-
-
Meuth, S.G.1
Göbel, K.2
Wiendl, H.3
-
11
-
-
84862642769
-
Interferon beta for secondary progressive multiple sclerosis
-
Art. No.: CD005181
-
La Mantia, L. et al. Interferon beta for secondary progressive multiple sclerosis. Cochrane Database of Systematic Reviews, Issue 1. Art. No.: CD005181. http://dx.doi.org/10.1002/14651858.CD005181.pub3.
-
Cochrane Database of Systematic Reviews
, Issue.1
-
-
La Mantia, L.1
-
12
-
-
0037441487
-
Axonal loss in the pathology of MS: Consequences for understanding the progressive phase of the disease
-
DOI 10.1016/S0022-510X(02)00069-2, PII S0022510X02000692
-
Bjartmar, C., Wujek, J. R. & Trapp, B. D. Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J. Neurol. Sci. 206, 165-171 (2003). (Pubitemid 36143722)
-
(2003)
Journal of the Neurological Sciences
, vol.206
, Issue.2
, pp. 165-171
-
-
Bjartmar, C.1
Wujek, J.R.2
Trapp, B.D.3
-
13
-
-
0642345898
-
Axonal degeneration and progressive neurologic disability in multiple sclerosis
-
Bjartmar, C. & Trapp, B. D. Axonal degeneration and progressive neurologic disability in multiple sclerosis. Neurotox. Res. 5, 157-164 (2003).
-
(2003)
Neurotox. Res
, vol.5
, pp. 157-164
-
-
Bjartmar, C.1
Trapp, B.D.2
-
14
-
-
84862693197
-
Primary progressive multiple sclerosis: Part of the ms disease spectrum or separate disease entity?
-
Antel, J., Antel, S., Caramanos, Z., Arnold, D. L. & Kuhlmann, T. Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity? Acta Neuropathol. 123, 627-638 (2012).
-
(2012)
Acta Neuropathol
, vol.123
, pp. 627-638
-
-
Antel, J.1
Antel, S.2
Caramanos, Z.3
Arnold, D.L.4
Kuhlmann, T.5
-
15
-
-
27644552194
-
Cortical demyelination and diffuse white matter injury in multiple sclerosis
-
DOI 10.1093/brain/awh641
-
Kutzelnigg, A. et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 128, 2705-2712 (2005). (Pubitemid 41552953)
-
(2005)
Brain
, vol.128
, Issue.11
, pp. 2705-2712
-
-
Kutzelnigg, A.1
Lucchinetti, C.F.2
Stadelmann, C.3
Bruck, W.4
Rauschka, H.5
Bergmann, M.6
Schmidbauer, M.7
Parisi, J.E.8
Lassmann, H.9
-
16
-
-
84868535759
-
Progressive multiple sclerosis: Pathology and pathogenesis
-
Lassmann, H., Van Horssen, J. & Mahad, D. Progressive multiple sclerosis: pathology and pathogenesis. Nat. Rev. Neurol. 8, 647-656 (2012).
-
(2012)
Nat. Rev. Neurol
, vol.8
, pp. 647-656
-
-
Lassmann, H.1
Van Horssen, J.2
Mahad, D.3
-
17
-
-
84867712909
-
Cortical lesion load associates with progression of disability in multiple sclerosis
-
Calabrese, M. et al. Cortical lesion load associates with progression of disability in multiple sclerosis. Brain 135, 2952-2961 (2012).
-
(2012)
Brain
, vol.135
, pp. 2952-2961
-
-
Calabrese, M.1
-
18
-
-
0021035886
-
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
-
Kurtzke, J. F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33, 1444-1452 (1983). (Pubitemid 14237132)
-
(1983)
Neurology
, vol.33
, Issue.11
, pp. 1444-1452
-
-
Kurtzke, J.F.1
-
19
-
-
77954382272
-
Evidence for a two-stage disability progression in multiple sclerosis
-
Leray, E. et al. Evidence for a two-stage disability progression in multiple sclerosis. Brain 133, 1900-1913 (2010).
-
(2010)
Brain
, vol.133
, pp. 1900-1913
-
-
Leray, E.1
-
20
-
-
77954364428
-
The natural history of multiple sclerosis, a geographically based study 10: Relapses and long-term disability
-
Scalfari, A. et al. The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability. Brain 133, 1914-1929 (2010).
-
(2010)
Brain
, vol.133
, pp. 1914-1929
-
-
Scalfari, A.1
-
21
-
-
0037379402
-
Early clinical predictors and progression of irreversible disability in multiple sclerosis: An amnesic process
-
DOI 10.1093/brain/awg081
-
Confavreux, C., Vukusic, S. & Adeleine, P. Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process. Brain 126, 770-782 (2003). (Pubitemid 36372978)
-
(2003)
Brain
, vol.126
, Issue.4
, pp. 770-782
-
-
Confavreux, C.1
Vukusic, S.2
Adeleine, P.3
-
22
-
-
0034765063
-
Immunopathology of secondary-progressive multiple sclerosis
-
DOI 10.1002/ana.1255
-
Prineas, J. W. et al. Immunopathology of secondary-progressive multiple sclerosis. Ann. Neurol. 50, 646-657 (2001). (Pubitemid 33021923)
-
(2001)
Annals of Neurology
, vol.50
, Issue.5
, pp. 646-657
-
-
Prineas, J.W.1
Kwon, E.E.2
Cho, E.-S.3
Sharer, L.R.4
Barnett, M.H.5
Oleszak, E.L.6
Hoffman, B.7
Morgan, B.P.8
-
23
-
-
79959846854
-
Fingolimod modulates microglial activation to augment markers of remyelination
-
Jackson, S. J., Giovannoni, G. & Baker, D. Fingolimod modulates microglial activation to augment markers of remyelination. J. Neuroinflammation 8, 76 (2011).
-
(2011)
J. Neuroinflammation
, vol.8
, pp. 76
-
-
Jackson, S.J.1
Giovannoni, G.2
Baker, D.3
-
24
-
-
84865863065
-
Reduced astrocytic nf-κb activation by laquinimod protects from cuprizone-induced demyelination
-
Brück, W. et al. Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol. 124, 411-424 (2012).
-
(2012)
Acta Neuropathol
, vol.124
, pp. 411-424
-
-
Brück, W.1
-
25
-
-
77952301752
-
Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, il-1β, tnf-α and il-6 in an in-vitro model of brain inflammation
-
Wilms, H. et al. Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation. J. Neuroinflammation 7, 30 (2010).
-
(2010)
J. Neuroinflammation
, vol.7
, pp. 30
-
-
Wilms, H.1
-
26
-
-
8844254741
-
The promise of minocycline in neurology
-
DOI 10.1016/S1474-4422(04)00937-8, PII S1474442204009378
-
Yong, V. W. et al. The promise of minocycline in neurology. Lancet Neurol. 3, 744-751 (2004). (Pubitemid 39535260)
-
(2004)
Lancet Neurology
, vol.3
, Issue.12
, pp. 744-751
-
-
Yong, V.W.1
Wells, J.2
Giuliani, F.3
Casha, S.4
Power, C.5
Metz, L.M.6
-
27
-
-
84878130537
-
Activated microglia enhance neurogenesis via trypsinogen secretion
-
Nikolakopoulou, A. M., Dutta, R., Chen, Z., Miller, R. H. & Trapp, B. D. Activated microglia enhance neurogenesis via trypsinogen secretion. Proc. Natl Acad. Sci. USA http://dx.doi.org/10.1073/pnas.1218856110.
-
Proc. Natl Acad. Sci. USA
-
-
Nikolakopoulou, A.M.1
Dutta, R.2
Chen, Z.3
Miller, R.H.4
Trapp, B.D.5
-
28
-
-
53049093018
-
Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity
-
Gonsette, R. E. Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity. J. Neurol. Sci. 274, 48-53 (2008).
-
(2008)
J. Neurol. Sci
, vol.274
, pp. 48-53
-
-
Gonsette, R.E.1
-
29
-
-
29244483141
-
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury
-
DOI 10.1038/nature04301
-
Salter, M. G. & Fern, R. NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury. Nature 438, 1167-1171 (2005). (Pubitemid 41831687)
-
(2005)
Nature
, vol.438
, Issue.7071
, pp. 1167-1171
-
-
Salter, M.G.1
Fern, R.2
-
30
-
-
33644520285
-
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
-
DOI 10.1038/nature04474, PII N04474
-
Micu, I. et al. NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature 439, 988-992 (2006). (Pubitemid 43292418)
-
(2006)
Nature
, vol.439
, Issue.7079
, pp. 988-992
-
-
Micu, I.1
Jiang, Q.2
Coderre, E.3
Ridsdale, A.4
Zhang, L.5
Woulfe, J.6
Yin, X.7
Trapp, B.D.8
McRory, J.E.9
Rehak, R.10
Zamponi, G.W.11
Wang, W.12
Stys, P.K.13
-
31
-
-
62549113032
-
Glutamate receptors on myelinated spinal cord axons: Ii. ampa and glur5 receptors
-
Ouardouz, M. et al. Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors. Ann. Neurol. 65, 160-166 (2009).
-
(2009)
Ann. Neurol
, vol.65
, pp. 160-166
-
-
Ouardouz, M.1
-
32
-
-
44949177395
-
Remyelination protects axons from demyelination-associated axon degeneration
-
DOI 10.1093/brain/awn080
-
Irvine, K. A. & Blakemore, W. F. Remyelination protects axons from demyelination-associated axon degeneration. Brain 131, 1464-1477 (2008). (Pubitemid 351806463)
-
(2008)
Brain
, vol.131
, Issue.6
, pp. 1464-1477
-
-
Irvine, K.A.1
Blakemore, W.F.2
-
33
-
-
54349085579
-
LINGO-1 antagonists as therapy for multiple sclerosis: In vitro and in vivo evidence
-
Rudick, R. A., Mi, S. & Sandrock, A. W. Jr. LINGO-1 antagonists as therapy for multiple sclerosis: in vitro and in vivo evidence. Expert. Opin. Biol. Ther. 8, 1561-1570 (2008).
-
(2008)
Expert. Opin. Biol. Ther
, vol.8
, pp. 1561-1570
-
-
Rudick, R.A.1
Mi, S.2
Sandrock Jr., A.W.3
-
34
-
-
84873125752
-
Remyelination therapy for multiple sclerosis
-
Keough, M. B. & Yong, V. W. Remyelination therapy for multiple sclerosis. Neurotherapeutics 10, 44-54 (2013).
-
(2013)
Neurotherapeutics
, vol.10
, pp. 44-54
-
-
Keough, M.B.1
Yong, V.W.2
-
35
-
-
84876196550
-
Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis
-
Madeddu, R. et al. Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis. Neurol. Sci. 34, 181-186 (2013).
-
(2013)
Neurol. Sci
, vol.34
, pp. 181-186
-
-
Madeddu, R.1
-
36
-
-
84871922920
-
Epigenetic changes in patients with multiple sclerosis
-
Koch, M. W., Metz, L. M. & Kovalchuk, O. Epigenetic changes in patients with multiple sclerosis. Nat. Rev. Neurol. 9, 35-43 (2013).
-
(2013)
Nat. Rev. Neurol
, vol.9
, pp. 35-43
-
-
Koch, M.W.1
Metz, L.M.2
Kovalchuk, O.3
-
37
-
-
84871716263
-
Epigenetics and mirnas in the diagnosis and treatment of multiple sclerosis
-
Koch, M. W., Metz, L. M. & Kovalchuk, O. Epigenetics and miRNAs in the diagnosis and treatment of multiple sclerosis. Trends Mol. Med. 19, 23-30 (2013).
-
(2013)
Trends Mol. Med
, vol.19
, pp. 23-30
-
-
Koch, M.W.1
Metz, L.M.2
Kovalchuk, O.3
-
38
-
-
80052925627
-
Impaired neurosteroid synthesis in multiple sclerosis
-
Noorbakhsh, F. et al. Impaired neurosteroid synthesis in multiple sclerosis. Brain 134, 2703-2721 (2011).
-
(2011)
Brain
, vol.134
, pp. 2703-2721
-
-
Noorbakhsh, F.1
-
39
-
-
84862591045
-
From bench to ms bedside: Challenges translating biomarker discovery to clinical practice
-
Rajasekharan, S. & Bar-Or, A. From bench to MS bedside: challenges translating biomarker discovery to clinical practice. J. Neuroimmunol. 248, 66-72 (2012).
-
(2012)
J. Neuroimmunol
, vol.248
, pp. 66-72
-
-
Rajasekharan, S.1
Bar-Or, A.2
-
40
-
-
33846833929
-
Glatiramer acetate in primary progressive multiple sclerosis: Results of a multinational, multicenter, double-blind, placebo-controlled trial
-
DOI 10.1002/ana.21079
-
Wolinsky, J. S. et al. Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trial. Ann. Neurol. 61, 14-24 (2007). (Pubitemid 46214240)
-
(2007)
Annals of Neurology
, vol.61
, Issue.1
, pp. 14-24
-
-
Wolinsky, J.S.1
Narayana, P.A.2
O'Connor, P.3
Coyle, P.K.4
Ford, C.5
Johnson, K.6
Miller, A.7
Pardo, L.8
Kadosh, S.9
Ladkani, D.10
Kastrukoff, L.11
Duquette, P.12
Freedman, M.13
Debouverie, M.14
Lubetski, C.15
Edan, G.16
Roullet, E.17
Confavreux, C.18
Thompson, A.19
Blumhardt, L.20
Hawkins, S.21
Scott, T.22
Wynn, D.23
Cooper, J.24
Thurston, S.25
Elias, S.26
Markowitz, C.27
Mattson, D.28
Noseworthy, J.29
Shuster, E.30
Carter, J.31
Lublin, F.32
Stuart, W.33
Kaufman, M.34
Birnbaum, G.35
Rammohan, K.36
Whitham, R.37
Mihai, C.38
Greenberg, S.39
Smith, C.40
Agius, M.41
Van Den Noort, S.42
Myers, L.43
Nelson, J.44
Goodin, D.45
Arnason, B.46
Bashir, K.47
Lynch, S.48
Coyle, P.49
Kamin, S.50
Sheremata, W.51
Mitchell, G.52
Goodman, A.53
Kachuck, N.54
Dunne, P.55
Lindsey, J.W.56
Frohman, E.57
Bowen, J.58
Brooks, B.59
Rose, J.60
Moses, H.61
Jeffrey, D.62
Cross, A.63
Lisak, R.64
Vollmer, T.65
Antel, J.66
Cutter, G.67
Metz, L.68
McFarland, H.69
Reingold, S.70
Lublin, F.D.71
Vainrub, I.72
Lambert, L.73
Zhong, F.74
Rasmituth, J.75
Momin, S.76
Kreitman, R.77
Shifroni, G.78
Pinchasi, I.79
Stark, Y.80
more..
-
41
-
-
4644250609
-
Intravenous immunoglobulin in secondary progressive multiple sclerosis: Randomised placebo-controlled trial
-
DOI 10.1016/S0140-6736(04)17101-8, PII S0140673604171018
-
Hommes, O. R. et al. Intravenous immunoglobulin in secondary progressive multiple sclerosis: randomised placebo-controlled trial. Lancet 364, 1149-1156 (2004). (Pubitemid 39296602)
-
(2004)
Lancet
, vol.364
, Issue.9440
, pp. 1149-1156
-
-
Hommes, O.R.1
Sorensen, P.S.2
Fazekas, F.3
Enriquez, M.M.4
Koelmel, H.W.5
Fernandez, O.6
Pozzilli, C.7
O'Connor, P.8
-
42
-
-
8844222623
-
Interferon beta-1b in secondary progressive MS: Results from a 3-year controlled study
-
Panitch, H., Miller, A., Paty, D. & Weinshenker, B. Interferon β-1b in secondary progressive MS: results from a 3-year controlled study. Neurology 63, 1788-1795 (2004). (Pubitemid 39532370)
-
(2004)
Neurology
, vol.63
, Issue.10
, pp. 1788-1795
-
-
Panitch, H.1
-
43
-
-
0035849496
-
Randomized controlled trial of interferon-beta-1a in secondary progressive ms: Clinical results
-
Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-Beta-1a in MS (SPECTRIMS) Study Group
-
Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-Beta-1a in MS (SPECTRIMS) Study Group. Randomized controlled trial of interferon-beta-1a in secondary progressive MS: Clinical results. Neurology 56, 1496-1504 (2001).
-
(2001)
Neurology
, vol.56
, pp. 1496-1504
-
-
-
44
-
-
66149190708
-
The search for responsive clinical endpoints in primary progressive multiple sclerosis
-
Bosma, L. V. et al. The search for responsive clinical endpoints in primary progressive multiple sclerosis. Mult. Scler. 15, 715-720 (2009).
-
(2009)
Mult. Scler
, vol.15
, pp. 715-720
-
-
Bosma, L.V.1
-
45
-
-
84864149880
-
Revisiting the multiple sclerosis functional composite: Proceedings from the national multiple sclerosis society (nmss) task force on clinical disability measures
-
Ontaneda, D., Larocca, N., Coetzee, T. & Rudick, R. Revisiting the Multiple Sclerosis Functional Composite: proceedings from the National Multiple Sclerosis Society (NMSS) Task Force on Clinical Disability Measures. Mult. Scler. 18, 1074-1080 (2012).
-
(2012)
Mult. Scler
, vol.18
, pp. 1074-1080
-
-
Ontaneda, D.1
Larocca, N.2
Coetzee, T.3
Rudick, R.4
-
46
-
-
0023936377
-
Interrater reliability in assessing functional systems and disability on the kurtzke scale in multiple sclerosis
-
Amato, M. P., Fratiglioni, L., Groppi, C., Siracusa, G. & Amaducci, L. Interrater reliability in assessing functional systems and disability on the Kurtzke scale in multiple sclerosis. Arch. Neurol. 45, 746-748 (1988).
-
(1988)
Arch. Neurol
, vol.45
, pp. 746-748
-
-
Amato, M.P.1
Fratiglioni, L.2
Groppi, C.3
Siracusa, G.4
Amaducci, L.5
-
47
-
-
0025978558
-
An assessment of disability rating scales used in multiple sclerosis
-
Francis, D. A., Bain, P., Swan, A. V. & Hughes, R. A. An assessment of disability rating scales used in multiple sclerosis. Arch. Neurol. 48, 299-301 (1991).
-
(1991)
Arch. Neurol
, vol.48
, pp. 299-301
-
-
Francis, D.A.1
Bain, P.2
Swan, A.V.3
Hughes, R.A.4
-
48
-
-
0025314243
-
Interrater variability with the expanded disability status scale (EDSS) and functional systems (FS) in a multiple sclerosis clinical trial
-
Noseworthy, J. H., Vandervoort, M. K., Wong, C. J. & Ebers, G. C. Interrater variability with the Expanded Disability Status Scale (EDSS) and Functional Systems (FS) in a multiple sclerosis clinical trial. The Canadian Cooperation MS Study Group. Neurology 40, 971-975 (1990). (Pubitemid 20201827)
-
(1990)
Neurology
, vol.40
, Issue.6
, pp. 971-975
-
-
Noseworthy, J.H.1
Vandervoort, M.K.2
Wong, C.J.3
Ebers, G.C.4
-
49
-
-
0025728367
-
The natural history of multiple sclerosis: A geographically based study. 4. applications to planning and interpretation of clinical therapeutic trials
-
Weinshenker, B. G. et al. The natural history of multiple sclerosis: a geographically based study. 4. Applications to planning and interpretation of clinical therapeutic trials. Brain 114, 1057-1067 (1991).
-
(1991)
Brain
, vol.114
, pp. 1057-1067
-
-
Weinshenker, B.G.1
-
50
-
-
0037056364
-
Benefit of interferon β-1a on msfc progression in secondary progressive ms
-
Cohen, J. A. et al. Benefit of interferon β-1a on MSFC progression in secondary progressive MS. Neurology 59, 679-687 (2002).
-
(2002)
Neurology
, vol.59
, pp. 679-687
-
-
Cohen, J.A.1
-
51
-
-
0032919071
-
Development of a multiple sclerosis functional composite as a clinical trial outcome measure
-
DOI 10.1093/brain/122.5.871
-
Cutter, G. R. et al. Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain 122, 871-882 (1999). (Pubitemid 29219261)
-
(1999)
Brain
, vol.122
, Issue.5
, pp. 871-882
-
-
Cutter, G.R.1
Baier, M.L.2
Rudick, R.A.3
Cookfair, D.L.4
Fischer, J.S.5
Petkau, J.6
Syndulko, K.7
Weinshenker, B.G.8
Antel, J.P.9
Confavreux, C.10
Ellison, G.W.11
Lublin, F.12
Miller, A.E.13
Rao, S.M.14
Reingold, S.15
Thompson, A.16
Willoughby, E.17
-
52
-
-
77953476309
-
Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: A randomised, double-blind, placebo-controlled, parallel-group trial
-
Kapoor, R. et al. Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial. Lancet Neurol. 9, 681-688 (2010).
-
(2010)
Lancet Neurol
, vol.9
, pp. 681-688
-
-
Kapoor, R.1
-
53
-
-
0035836672
-
Comparisons of patient self-report, neurologic examination, and functional impairment in MS
-
Hoogervorst, E. L. et al. Comparisons of patient self-report, neurologic examination, and functional impairment in MS. Neurology 56, 934-937 (2001). (Pubitemid 32290811)
-
(2001)
Neurology
, vol.56
, Issue.7
, pp. 934-937
-
-
Hoogervorst, E.L.J.1
Van Winsen, L.M.L.2
Eikelenboom, M.J.3
Kalkers, N.F.4
Uitdehaag, B.M.J.5
Polman, C.H.6
-
54
-
-
0346707263
-
The patient's perception of a (reliable) change in the Multiple Sclerosis Functional Composite
-
DOI 10.1191/1352458504ms972oa
-
Hoogervorst, E. L., Kalkers, N. F., Cutter, G. R., Uitdehaag, B. M. & Polman, C. H. The patient's perception of a (reliable) change in the Multiple Sclerosis Functional Composite. Mult. Scler. 10, 55-60 (2004). (Pubitemid 38100527)
-
(2004)
Multiple Sclerosis
, vol.10
, Issue.1
, pp. 55-60
-
-
Hoogervorst, E.L.J.1
Kalkers, N.F.2
Cutter, G.R.3
Uitdehaag, B.M.J.4
Polman, C.H.5
-
55
-
-
0033824616
-
Clinical significance of the multiple sclerosis functional composite: Relationship to patient-reported quality of life
-
Miller, D. M., Rudick, R. A., Cutter, G., Baier, M. & Fischer, J. S. Clinical significance of the Multiple Sclerosis Functional Composite: relationship to patient-reported quality of life. Arch. Neurol. 57, 1319-1324 (2000).
-
(2000)
Arch. Neurol
, vol.57
, pp. 1319-1324
-
-
Miller, D.M.1
Rudick, R.A.2
Cutter, G.3
Baier, M.4
Fischer, J.S.5
-
56
-
-
10644294592
-
The multiple sclerosis functional composite: Different practice effects in the three test components
-
DOI 10.1016/j.jns.2004.09.033, PII S0022510X04003570
-
Solari, A., Radice, D., Manneschi, L., Motti, L. & Montanari, E. The Multiple Sclerosis Functional Composite: different practice effects in the three test components. J. Neurol. Sci. 228, 71-74 (2005). (Pubitemid 39656497)
-
(2005)
Journal of the Neurological Sciences
, vol.228
, Issue.1
, pp. 71-74
-
-
Solari, A.1
Radice, D.2
Manneschi, L.3
Motti, L.4
Montanari, E.5
-
57
-
-
0037161254
-
Quantitative functional measures in MS: What is a reliable change?
-
Schwid, S. R., Goodman, A. D., McDermott, M. P., Bever, C. F. & Cook, S. D. Quantitative functional measures in MS: what is a reliable change? Neurology 58, 1294-1296 (2002). (Pubitemid 34411881)
-
(2002)
Neurology
, vol.58
, Issue.8
, pp. 1294-1296
-
-
Schwid, S.R.1
Goodman, A.D.2
McDermott, M.P.3
Bever, C.F.4
Cook, S.D.5
-
58
-
-
77955041173
-
Progression on the multiple sclerosis functional composite in multiple sclerosis: What is the optimal cut-off for the three components?
-
Bosma, L. V. et al. Progression on the Multiple Sclerosis Functional Composite in multiple sclerosis: what is the optimal cut-off for the three components? Mult. Scler. 16, 862-867 (2010).
-
(2010)
Mult. Scler
, vol.16
, pp. 862-867
-
-
Bosma, L.V.1
-
59
-
-
34250660553
-
Clinical impact of 20% worsening on Timed 25-foot Walk and 9-hole Peg Test in multiple sclerosis
-
DOI 10.1177/1352458506070768
-
Kragt, J. J., van der Linden, F. A., Nielsen, J. M., Uitdehaag, B. M. & Polman, C. H. Clinical impact of 20% worsening on Timed 25-foot Walk and 9-hole Peg Test in multiple sclerosis. Mult. Scler. 12, 594-598 (2006). (Pubitemid 46940633)
-
(2006)
Multiple Sclerosis
, vol.12
, Issue.5
, pp. 594-598
-
-
Kragt, J.J.1
Van Der Linden, F.2
Nielsen, J.M.3
Uitdehaag, B.M.J.4
Polman, C.H.5
-
60
-
-
77951677636
-
The multiple sclerosis functional composite: A clinically meaningful measure of disability
-
Polman, C. H. & Rudick, R. A. The multiple sclerosis functional composite: a clinically meaningful measure of disability. Neurology 74 (Suppl. 3), S8-S15 (2010).
-
(2010)
Neurology
, vol.74
, Issue.SUPPL. 3
-
-
Polman, C.H.1
Rudick, R.A.2
-
61
-
-
29144523871
-
A comprehensive review of the Paced Auditory Serial Addition Test (PASAT)
-
DOI 10.1016/j.acn.2005.07.006, PII S0887617705001320
-
Tombaugh, T. N. A comprehensive review of the Paced Auditory Serial Addition Test (PASAT). Arch. Clin. Neuropsychol. 21, 53-76 (2006). (Pubitemid 41802927)
-
(2006)
Archives of Clinical Neuropsychology
, vol.21
, Issue.1
, pp. 53-76
-
-
Tombaugh, T.N.1
-
62
-
-
34248584875
-
Cognitive screening in multiple sclerosis
-
Scherer, P. Cognitive screening in multiple sclerosis. J. Neurol. 254 (Suppl. 2), II26-II29 (2007).
-
(2007)
J. Neurol
, vol.254
, Issue.SUPPL. 2
-
-
Scherer, P.1
-
63
-
-
33846555710
-
Screening for cognitive impairment in multiple sclerosis using the Symbol Digit Modalities Test
-
DOI 10.1177/1352458506070750
-
Parmenter, B. A., Weinstock-Guttman, B., Garg, N., Munschauer, F. & Benedict, R. H. Screening for cognitive impairment in multiple sclerosis using the Symbol Digit Modalities Test. Mult. Scler. 13, 52-57 (2007). (Pubitemid 46152761)
-
(2007)
Multiple Sclerosis
, vol.13
, Issue.1
, pp. 52-57
-
-
Parmenter, B.A.1
Weinstock-Guttman, B.2
Garg, N.3
Munschauer, F.4
Benedict, R.H.B.5
-
64
-
-
77957913088
-
Predicting loss of employment over three years in multiple sclerosis: Clinically meaningful cognitive decline
-
Morrow, S. A. et al. Predicting loss of employment over three years in multiple sclerosis: clinically meaningful cognitive decline. Clin. Neuropsychol. 24, 1131-1145 (2010).
-
(2010)
Clin. Neuropsychol
, vol.24
, pp. 1131-1145
-
-
Morrow, S.A.1
-
65
-
-
77951689597
-
Evaluating loss of visual function in multiple sclerosis as measured by low-contrast letter acuity
-
Balcer, L. J. & Frohman, E. M. Evaluating loss of visual function in multiple sclerosis as measured by low-contrast letter acuity. Neurology 74 (Suppl. 3), S16-S23 (2010).
-
(2010)
Neurology
, vol.74
, Issue.SUPPL. 3
-
-
Balcer, L.J.1
Frohman, E.M.2
-
66
-
-
0034043107
-
New low-contrast vision charts: Reliability and test characteristics in patients with multiple sclerosis
-
Balcer, L. J. et al. New low-contrast vision charts: reliability and test characteristics in patients with multiple sclerosis. Mult. Scler. 6, 163-171 (2000). (Pubitemid 30392113)
-
(2000)
Multiple Sclerosis
, vol.6
, Issue.3
, pp. 163-171
-
-
Balcer, L.J.1
Baier, M.L.2
Pelak, V.S.3
Fox, R.J.4
Shuwairi, S.5
Galetta, S.L.6
Cutter, G.R.7
Maguire, M.G.8
-
67
-
-
67650492773
-
Vision related quality of life in multiple sclerosis: Correlation with new measures of low and high contrast letter acuity
-
Mowry, E. M. et al. Vision related quality of life in multiple sclerosis: correlation with new measures of low and high contrast letter acuity. J. Neurol. Neurosurg. Psychiatry 80, 767-772 (2009).
-
(2009)
J. Neurol. Neurosurg. Psychiatry
, vol.80
, pp. 767-772
-
-
Mowry, E.M.1
-
68
-
-
25144520110
-
Characterizing the mechanisms of progression in multiple sclerosis: Evidence and new hypotheses for future directions
-
DOI 10.1001/archneur.62.9.1345
-
Frohman, E. M. et al. Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions. Arch. Neurol. 62, 1345-1356 (2005). (Pubitemid 41352050)
-
(2005)
Archives of Neurology
, vol.62
, Issue.9
, pp. 1345-1356
-
-
Frohman, E.M.1
Filippi, M.2
Stuve, O.3
Waxman, S.G.4
Corboy, J.5
Phillips, J.T.6
Lucchinetti, C.7
Wilken, J.8
Karandikar, N.9
Hemmer, B.10
Monson, N.11
De Keyser, J.12
Hartung, H.13
Steinman, L.14
Oksenberg, J.R.15
Cree, B.A.C.16
Hauser, S.17
Racke, M.K.18
-
69
-
-
62349108495
-
MRI as an outcome in multiple sclerosis clinical trials
-
Daumer, M., Neuhaus, A., Morrissey, S., Hintzen, R. & Ebers, G. C. MRI as an outcome in multiple sclerosis clinical trials. Neurology 72, 705-711 (2009).
-
(2009)
Neurology
, vol.72
, pp. 705-711
-
-
Daumer, M.1
Neuhaus, A.2
Morrissey, S.3
Hintzen, R.4
Ebers, G.C.5
-
70
-
-
84869098364
-
Measurement and clinical effect of grey matter pathology in multiple sclerosis
-
Geurts, J. J., Calabrese, M., Fisher, E. & Rudick, R. A. Measurement and clinical effect of grey matter pathology in multiple sclerosis. Lancet Neurol. 11, 1082-1092 (2012).
-
(2012)
Lancet Neurol
, vol.11
, pp. 1082-1092
-
-
Geurts, J.J.1
Calabrese, M.2
Fisher, E.3
Rudick, R.A.4
-
71
-
-
61849095259
-
Sample sizes for brain atrophy outcomes in trials for secondary progressive multiple sclerosis
-
Altmann, D. R. et al. Sample sizes for brain atrophy outcomes in trials for secondary progressive multiple sclerosis. Neurology 72, 595-601 (2009).
-
(2009)
Neurology
, vol.72
, pp. 595-601
-
-
Altmann, D.R.1
-
72
-
-
84859813422
-
Disability outcome measures in multiple sclerosis clinical trials: Current status and future prospects
-
Cohen, J. A., Reingold, S. C., Polman, C. H. & Wolinsky, J. S. Disability outcome measures in multiple sclerosis clinical trials: current status and future prospects. Lancet Neurol. 11, 467-476 (2012).
-
(2012)
Lancet Neurol
, vol.11
, pp. 467-476
-
-
Cohen, J.A.1
Reingold, S.C.2
Polman, C.H.3
Wolinsky, J.S.4
-
73
-
-
60049089535
-
Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: A retrospective analysis of the natalizumab safety and efficacy in relapsing-remitting multiple sclerosis (affirm) study
-
Havrdova, E. et al. Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study. Lancet Neurol. 8, 254-260 (2009).
-
(2009)
Lancet Neurol
, vol.8
, pp. 254-260
-
-
Havrdova, E.1
-
74
-
-
79952735730
-
Sustained disease-activity-free status in patients with relapsing-remitting multiple sclerosis treated with cladribine tablets in the clarity study: A post-hoc and subgroup analysis
-
Giovannoni, G. et al. Sustained disease-activity-free status in patients with relapsing-remitting multiple sclerosis treated with cladribine tablets in the CLARITY study: a post-hoc and subgroup analysis. Lancet Neurol. 10, 329-337 (2011).
-
(2011)
Lancet Neurol
, vol.10
, pp. 329-337
-
-
Giovannoni, G.1
-
75
-
-
0032946328
-
The natural history of multiple sclerosis: A geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis
-
DOI 10.1093/brain/122.4.625
-
Cottrell, D. A. et al. The natural history of multiple sclerosis: a geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis. Brain 122, 625-639 (1999). (Pubitemid 29158771)
-
(1999)
Brain
, vol.122
, Issue.4
, pp. 625-639
-
-
Cottrell, D.A.1
Kremenchutzky, M.2
Rice, G.P.A.3
Koopman, W.J.4
Hader, W.5
Baskerville, J.6
Ebers, G.C.7
-
76
-
-
0034676548
-
Relapses and progression of disability in multiple sclerosis
-
Confavreux, C., Vukusic, S., Moreau, T. & Adeleine, P. Relapses and progression of disability in multiple sclerosis. N. Engl. J. Med. 343, 1430-1438 (2000).
-
(2000)
N. Engl. J. Med
, vol.343
, pp. 1430-1438
-
-
Confavreux, C.1
Vukusic, S.2
Moreau, T.3
Adeleine, P.4
-
77
-
-
73349133703
-
The natural history of primary progressive multiple sclerosis
-
Koch, M., Kingwell, E., Rieckmann, P. & Tremlett, H. The natural history of primary progressive multiple sclerosis. Neurology 73, 1996-2002 (2009).
-
(2009)
Neurology
, vol.73
, pp. 1996-2002
-
-
Koch, M.1
Kingwell, E.2
Rieckmann, P.3
Tremlett, H.4
-
78
-
-
33644887189
-
Disability progression in multiple sclerosis is slower than previously reported
-
DOI 10.1212/01.wnl.0000194259.90286.fe, PII 0000611420060124000007
-
Tremlett, H., Paty, D. & Devonshire, V. Disability progression in multiple sclerosis is slower than previously reported. Neurology 66, 172-177 (2006). (Pubitemid 43970148)
-
(2006)
Neurology
, vol.66
, Issue.2
, pp. 172-177
-
-
Tremlett, H.1
Paty, D.2
Devonshire, V.3
-
79
-
-
84883740388
-
FTY720 in patients with primary progressive multiple sclerosis
-
US National Institutes of Health. [online]
-
US National Institutes of Health. FTY720 in patients with primary progressive multiple sclerosis. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT00731692.
-
ClinicalTrials.Gov
-
-
-
80
-
-
44049085489
-
Therapeutic potential of fluoxetine in neurological disorders
-
DOI 10.1111/j.1527-3458.2008.00040.x
-
Mostert, J. P., Koch, M. W., Heerings, M., Heersema, D. J. & De Keyser, J. Therapeutic potential of fluoxetine in neurological disorders. CNS Neurosci. Ther. 14, 153-164 (2008). (Pubitemid 351713316)
-
(2008)
CNS Neuroscience and Therapeutics
, vol.14
, Issue.2
, pp. 153-164
-
-
Mostert, J.P.1
Koch, M.W.2
Heerings, M.3
Heersema, D.J.4
De Keyser, J.5
-
81
-
-
0036791912
-
Treatment of multiple sclerosis with the pregnancy hormone estriol
-
Sicotte, N. L. et al. Treatment of multiple sclerosis with the pregnancy hormone estriol. Ann. Neurol. 52, 421-428 (2002).
-
(2002)
Ann. Neurol
, vol.52
, pp. 421-428
-
-
Sicotte, N.L.1
-
82
-
-
67651114103
-
Protective effects of progesterone administration on axonal pathology in mice with experimental autoimmune encephalomyelitis
-
Garay, L. et al. Protective effects of progesterone administration on axonal pathology in mice with experimental autoimmune encephalomyelitis. Brain Res. 1283, 177-185 (2009).
-
(2009)
Brain Res
, vol.1283
, pp. 177-185
-
-
Garay, L.1
-
83
-
-
0034747862
-
Pirfenidone for chronic progressive multiple sclerosis
-
DOI 10.1191/135245801681138004
-
Walker, J. E. & Margolin, S. B. Pirfenidone for chronic progressive multiple sclerosis. Mult. Scler. 7, 305-312 (2001). (Pubitemid 33028867)
-
(2001)
Multiple Sclerosis
, vol.7
, Issue.5
, pp. 305-312
-
-
Walker, J.E.1
Margolin, S.B.2
-
84
-
-
15544387329
-
A double-blind, randomized, controlled study of oral pirfenidone for treatment of secondary progressive multiple sclerosis
-
DOI 10.1191/1352458505ms1134oa
-
Walker, J. E., Giri, S. N. & Margolin, S. B. A double-blind, randomized, controlled study of oral pirfenidone for treatment of secondary progressive multiple sclerosis. Mult. Scler. 11, 149-158 (2005). (Pubitemid 40403252)
-
(2005)
Multiple Sclerosis
, vol.11
, Issue.2
, pp. 149-158
-
-
Walker, J.E.1
Giri, S.N.2
Margolin, S.B.3
-
85
-
-
78650993786
-
A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis
-
Chataway, J. et al. A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis. Mult. Scler. 17, 81-88 (2011).
-
(2011)
Mult. Scler
, vol.17
, pp. 81-88
-
-
Chataway, J.1
-
86
-
-
79956063286
-
Designing a seamless phase ii/iii clinical trial using early outcomes for treatment selection: An application in multiple sclerosis
-
Friede, T. et al. Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: an application in multiple sclerosis. Stat. Med. 30, 1528-1540 (2011).
-
(2011)
Stat. Med
, vol.30
, pp. 1528-1540
-
-
Friede, T.1
-
87
-
-
0024536437
-
Optimal two-stage designs for phase II clinical trials
-
DOI 10.1016/0197-2456(89)90015-9
-
Simon, R. Optimal two-stage designs for phase II clinical trials. Control. Clin. Trials. 10, 1-10 (1989). (Pubitemid 19099520)
-
(1989)
Controlled Clinical Trials
, vol.10
, Issue.1
, pp. 1-10
-
-
Simon, R.1
|