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Volumn 34, Issue 2, 2013, Pages 181-186

Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis

Author keywords

Axonal damage; Biomarkers; Cerebrospinal fluid; Cytoskeletal proteins; Multiple sclerosis

Indexed keywords

BETA TUBULIN; BETA TUBULIN 2; BETA TUBULIN 3; BIOLOGICAL MARKER; CYTOSKELETON PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; ISOPROTEIN; NEUROFILAMENT LIGHT PROTEIN; UNCLASSIFIED DRUG;

EID: 84876196550     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-012-0974-4     Document Type: Article
Times cited : (40)

References (43)
  • 1
    • 0034727066 scopus 로고    scopus 로고
    • Multiple sclerosis
    • 11006371 10.1056/NEJM200009283431307 1:STN:280:DC%2BD3cvlvF2quw%3D%3D
    • Noseworthy JH, Lucchinetti C, Rodriguez M et al (2000) Multiple sclerosis. N Engl J Med 343:938-952
    • (2000) N Engl J Med , vol.343 , pp. 938-952
    • Noseworthy, J.H.1    Lucchinetti, C.2    Rodriguez, M.3
  • 2
    • 47549090868 scopus 로고    scopus 로고
    • Temporal trends in the incidence of multiple sclerosis: A systematic review
    • 18606967 10.1212/01.wnl.0000316802.35974.34
    • Alonso A, Hernán MA (2008) Temporal trends in the incidence of multiple sclerosis: a systematic review. Neurology 71:129-135
    • (2008) Neurology , vol.71 , pp. 129-135
    • Alonso, A.1    Hernán, M.A.2
  • 3
    • 33846604242 scopus 로고    scopus 로고
    • How common are the "common" neurologic disorders?
    • 17261678 10.1212/01.wnl.0000252807.38124.a3 1:STN:280: DC%2BD2s%2FlslChug%3D%3D
    • Hirtz D, Thurman DJ, Gwinn-Hardy K et al (2007) How common are the "common" neurologic disorders? Neurology 68:326-337
    • (2007) Neurology , vol.68 , pp. 326-337
    • Hirtz, D.1    Thurman, D.J.2    Gwinn-Hardy, K.3
  • 4
    • 33749681309 scopus 로고    scopus 로고
    • Sex ratio of multiple sclerosis in Canada: A longitudinal study
    • 17052660 10.1016/S1474-4422(06)70581-6
    • Orton SM, Herrera BN, Yee IM et al (2006) Sex ratio of multiple sclerosis in Canada: a longitudinal study. Lancet Neurol 5:932-936
    • (2006) Lancet Neurol , vol.5 , pp. 932-936
    • Orton, S.M.1    Herrera, B.N.2    Yee, I.M.3
  • 5
    • 79955665687 scopus 로고    scopus 로고
    • Role of gender in multiple sclerosis: Clinical effects and potential molecular mechanisms
    • 21474189 10.1016/j.jneuroim.2011.03.003 1:CAS:528:DC%2BC3MXmtFCmtbs%3D
    • Greer JM, McCombe PA (2011) Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms. J Neuroimmunol 234:7-18
    • (2011) J Neuroimmunol , vol.234 , pp. 7-18
    • Greer, J.M.1    McCombe, P.A.2
  • 6
    • 1642513783 scopus 로고    scopus 로고
    • Genetics of multiple sclerosis
    • 14747002 10.1016/S1474-4422(03)00663-X 1:CAS:528:DC%2BD2cXitFWju7c%3D
    • Dyment DA, Ebers GC, Sadovnick AD (2004) Genetics of multiple sclerosis. Lancet Neurol 3(2):104-110
    • (2004) Lancet Neurol , vol.3 , Issue.2 , pp. 104-110
    • Dyment, D.A.1    Ebers, G.C.2    Sadovnick, A.D.3
  • 7
    • 38949107656 scopus 로고    scopus 로고
    • Environmental factors and multiple sclerosis
    • 18275928 10.1016/S1474-4422(08)70042-5
    • Ebers GC (2008) Environmental factors and multiple sclerosis. Lancet Neurol 7(3):268-277
    • (2008) Lancet Neurol , vol.7 , Issue.3 , pp. 268-277
    • Ebers, G.C.1
  • 8
    • 0036051404 scopus 로고    scopus 로고
    • Multiple sclerosis complexity in selected populations: The challenge of Sardinia, insular Italy
    • 12099914 10.1046/j.1468-1331.2002.00412.x 1:STN:280: DC%2BD38zls12rsg%3D%3D
    • Sotgiu S, Pugliatti M, Sanna A et al (2002) Multiple sclerosis complexity in selected populations: the challenge of Sardinia, insular Italy. Eur J Neurol 9:329-341
    • (2002) Eur J Neurol , vol.9 , pp. 329-341
    • Sotgiu, S.1    Pugliatti, M.2    Sanna, A.3
  • 9
    • 33746588738 scopus 로고    scopus 로고
    • The epidemiology of multiple sclerosis in Europe
    • 16834700 10.1111/j.1468-1331.2006.01342.x 1:STN:280: DC%2BD28vhsVOguw%3D%3D
    • Pugliatti M, Rosati G, Carton H et al (2006) The epidemiology of multiple sclerosis in Europe. Eur J Neurol 13:700-722
    • (2006) Eur J Neurol , vol.13 , pp. 700-722
    • Pugliatti, M.1    Rosati, G.2    Carton, H.3
  • 10
    • 48349129527 scopus 로고    scopus 로고
    • Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis
    • 18041806 10.1002/nbm.1229
    • Budde MD, Kim JH, Liang HF et al (2008) Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis. NMR Biomed 21:589-597
    • (2008) NMR Biomed , vol.21 , pp. 589-597
    • Budde, M.D.1    Kim, J.H.2    Liang, H.F.3
  • 11
    • 0034026912 scopus 로고    scopus 로고
    • Acute axonal injury in multiple sclerosis: Correlation with demyelination and inflammation
    • 10825356 10.1093/brain/123.6.1174
    • Bitsch A, Schuchardt J, Bunkowski S et al (2000) Acute axonal injury in multiple sclerosis: correlation with demyelination and inflammation. Brain 123:1174-1183
    • (2000) Brain , vol.123 , pp. 1174-1183
    • Bitsch, A.1    Schuchardt, J.2    Bunkowski, S.3
  • 12
    • 0038605526 scopus 로고    scopus 로고
    • Axonal injury in multiple sclerosis
    • 12691628 10.1007/s11910-003-0083-0
    • Rammohan KW (2003) Axonal injury in multiple sclerosis. Curr Neurol Neurosci Rep 3(3):231-237
    • (2003) Curr Neurol Neurosci Rep , vol.3 , Issue.3 , pp. 231-237
    • Rammohan, K.W.1
  • 13
    • 11144297111 scopus 로고    scopus 로고
    • Biological markers in CSF and blood for axonal degeneration in multiple sclerosis
    • 15620855 10.1016/S1474-4422(04)00964-0
    • Teunissen CE, Dijkstra PC, Polman C (2005) Biological markers in CSF and blood for axonal degeneration in multiple sclerosis. Lancet Neurol 4:32-41
    • (2005) Lancet Neurol , vol.4 , pp. 32-41
    • Teunissen, C.E.1    Dijkstra, P.C.2    Polman, C.3
  • 14
    • 0344740564 scopus 로고    scopus 로고
    • Biological indicators of the neurodegenerative phase of multiple sclerosis
    • Zaffaroni M (2003) Biological indicators of the neurodegenerative phase of multiple sclerosis. J Neurol Sci 24(Suppl 5):S279-S282
    • (2003) J Neurol Sci , vol.24 , Issue.SUPPL. 5
    • Zaffaroni, M.1
  • 15
    • 0031922504 scopus 로고    scopus 로고
    • Neurofilament protein in cerebrospinal fluid: A potential marker of activity in multiple sclerosis
    • 9527161 10.1136/jnnp.64.3.402 1:STN:280:DyaK1c7os1eqsw%3D%3D
    • Lycke JN, Karlsson JE, Andersen O, Rosengren LE (1998) Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis. J Neurol Neurosurg Psychiatry 64(3):402-404
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , Issue.3 , pp. 402-404
    • Lycke, J.N.1    Karlsson, J.E.2    Andersen, O.3    Rosengren, L.E.4
  • 16
    • 0842329792 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers in MS patients and their healthy siblings
    • 14705970 10.1034/j.1600-0404.2003.00197.x 1:STN:280: DC%2BD2c%2FgvV2iuw%3D%3D
    • Haghighi S, Andersen O, Odén A, Rosengren L (2004) Cerebrospinal fluid markers in MS patients and their healthy siblings. Acta Neurol Scand 109(2):97-99
    • (2004) Acta Neurol Scand , vol.109 , Issue.2 , pp. 97-99
    • Haghighi, S.1    Andersen, O.2    Odén, A.3    Rosengren, L.4
  • 17
    • 0346103689 scopus 로고    scopus 로고
    • Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS
    • 14694036 10.1212/01.WNL.0000098880.19793.B6
    • Malmeström C, Haghighi S, Rosengren L et al (2003) Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS. Neurology 61(12):1720-1725
    • (2003) Neurology , vol.61 , Issue.12 , pp. 1720-1725
    • Malmeström, C.1    Haghighi, S.2    Rosengren, L.3
  • 18
    • 0142011171 scopus 로고    scopus 로고
    • Elevated neurofilament levels in neurological diseases
    • 14499942 10.1016/S0006-8993(03)03219-0 1:CAS:528:DC%2BD3sXnt1aru7Y%3D
    • Norgren N, Rosengren L, Stigbrand T (2003) Elevated neurofilament levels in neurological diseases. Brain Res 987(1):25-31
    • (2003) Brain Res , vol.987 , Issue.1 , pp. 25-31
    • Norgren, N.1    Rosengren, L.2    Stigbrand, T.3
  • 19
    • 0036145606 scopus 로고    scopus 로고
    • Heightened intrathecal release of axonal cytoskeletal proteins in multiple sclerosis is associated with progressive disease and clinical disability
    • 11777552 10.1016/S0165-5728(01)00455-6 1:CAS:528:DC%2BD38XkvVyj
    • Semra YK, Seidi OA, Sharief MK (2002) Heightened intrathecal release of axonal cytoskeletal proteins in multiple sclerosis is associated with progressive disease and clinical disability. J Neuroimmunol 122(1-2):132-139
    • (2002) J Neuroimmunol , vol.122 , Issue.1-2 , pp. 132-139
    • Semra, Y.K.1    Seidi, O.A.2    Sharief, M.K.3
  • 20
    • 0028879187 scopus 로고
    • Glial fibrillary acidic protein in CSF of multiple sclerosis patients: Relation to neurological deficit
    • 8583233 10.1016/0022-510X(95)00152-R 1:CAS:528:DyaK28XjvF2isg%3D%3D
    • Rosengren LE, Lycke J, Andersen O (1995) Glial fibrillary acidic protein in CSF of multiple sclerosis patients: relation to neurological deficit. J Neurol Sci 133(1-2):61-65
    • (1995) J Neurol Sci , vol.133 , Issue.1-2 , pp. 61-65
    • Rosengren, L.E.1    Lycke, J.2    Andersen, O.3
  • 21
    • 0036314155 scopus 로고    scopus 로고
    • Markers for different glial cell responses in multiple sclerosis: Clinical and pathological correlations
    • 12076997 10.1093/brain/awf165 1:STN:280:DC%2BD38zjtlKktg%3D%3D
    • Petzold A, Eikelenboom MJ, Gveric D et al (2002) Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations. Brain 125(Pt 7):1462-1473
    • (2002) Brain , vol.125 , Issue.PART 7 , pp. 1462-1473
    • Petzold, A.1    Eikelenboom, M.J.2    Gveric, D.3
  • 22
    • 0030709242 scopus 로고    scopus 로고
    • Multiple forms of tubulin: Different gene products and covalent modifications
    • 9348671 10.1016/S0074-7696(08)62138-5 1:CAS:528:DyaK1cXktFOi
    • Luduena RF (1998) Multiple forms of tubulin: different gene products and covalent modifications. Int Rev Cytol 178:207-275
    • (1998) Int Rev Cytol , vol.178 , pp. 207-275
    • Luduena, R.F.1
  • 23
    • 0011202760 scopus 로고
    • Identification of conserved isotype defining variable region sequences for four vertebrate β-tubulin polypeptide classes
    • 3459176 10.1073/pnas.83.12.4327 1:CAS:528:DyaL28XltV2ktro%3D
    • Sullivan KF, Cleveland DW (1986) Identification of conserved isotype defining variable region sequences for four vertebrate β-tubulin polypeptide classes. Proc Natl Acad Sci USA 83:4327-4331
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 4327-4331
    • Sullivan, K.F.1    Cleveland, D.W.2
  • 24
    • 0030627521 scopus 로고    scopus 로고
    • Tubulin synthesis and assembly in differentiating neurons
    • 9250358 10.1139/o97-032
    • Laferrière NB, MacRae TH, Brown DL (1997) Tubulin synthesis and assembly in differentiating neurons. Biochem Cell Biol 75(2):103-117
    • (1997) Biochem Cell Biol , vol.75 , Issue.2 , pp. 103-117
    • Laferrière, N.B.1    Macrae, T.H.2    Brown, D.L.3
  • 25
    • 0001020243 scopus 로고
    • Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: Induction of a specific beta-tubulin isotype
    • 3132717 10.1073/pnas.85.12.4530 1:CAS:528:DyaL1cXkvFSlur4%3D
    • Hoffman PN, Cleveland DW (1988) Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. Proc Natl Acad Sci USA 85(12):4530-4533
    • (1988) Proc Natl Acad Sci USA , vol.85 , Issue.12 , pp. 4530-4533
    • Hoffman, P.N.1    Cleveland, D.W.2
  • 26
    • 0024062564 scopus 로고
    • Differential distribution of beta-tubulin isotypes in cerebellum
    • 2461292 1:CAS:528:DyaL1cXkvFSitbw%3D
    • Burgoyne RD, Cambray-Deakin MA, Lewis SA et al (1988) Differential distribution of beta-tubulin isotypes in cerebellum. EMBO J 7(8):2311-2319
    • (1988) EMBO J , vol.7 , Issue.8 , pp. 2311-2319
    • Burgoyne, R.D.1    Cambray-Deakin, M.A.2    Lewis, S.A.3
  • 27
    • 0024321129 scopus 로고
    • Differential utilization of beta-tubulin isotypes in differentiating neurites
    • 2503525 10.1083/jcb.109.2.663 1:CAS:528:DyaL1MXkvFClsrk%3D
    • Joshi HC, Cleveland DW (1989) Differential utilization of beta-tubulin isotypes in differentiating neurites. J Cell Biol 109(2):663-673
    • (1989) J Cell Biol , vol.109 , Issue.2 , pp. 663-673
    • Joshi, H.C.1    Cleveland, D.W.2
  • 28
    • 0025115745 scopus 로고
    • Post-translational modification of class III beta-tubulin
    • 2402501 10.1073/pnas.87.18.7195 1:CAS:528:DyaK3cXlvVyksLs%3D
    • Lee MK, Rebhun LI, Frankfurter A (1990) Post-translational modification of class III beta-tubulin. Proc Natl Acad Sci USA 87(18):7195-7199
    • (1990) Proc Natl Acad Sci USA , vol.87 , Issue.18 , pp. 7195-7199
    • Lee, M.K.1    Rebhun, L.I.2    Frankfurter, A.3
  • 29
    • 0027396253 scopus 로고
    • Expression of the class III beta-tubulin gene during axonal regeneration of rat dorsal root ganglion neurons
    • 8423633 10.1002/jnr.490340113 1:CAS:528:DyaK3sXlslWhuw%3D%3D
    • Moskowitz PF, Smith R, Pickett J et al (1993) Expression of the class III beta-tubulin gene during axonal regeneration of rat dorsal root ganglion neurons. J Neurosci Res 34(1):129-134
    • (1993) J Neurosci Res , vol.34 , Issue.1 , pp. 129-134
    • Moskowitz, P.F.1    Smith, R.2    Pickett, J.3
  • 30
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis
    • 11456302 10.1002/ana.1032 1:STN:280:DC%2BD38%2FitFOhug%3D%3D
    • McDonald WI, Compston A, Edan G et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 50:121-127
    • (2001) Ann Neurol , vol.50 , pp. 121-127
    • McDonald, W.I.1    Compston, A.2    Edan, G.3
  • 31
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • 6685237 10.1212/WNL.33.11.1444 1:STN:280:DyaL2c%2FktValsQ%3D%3D
    • Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444-1452
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 32
    • 80054699616 scopus 로고    scopus 로고
    • Development of biomarkers for multiple sclerosis as a neurodegenerative disorder
    • doi: 10.1016/j.pneurobio.2011.04.007 (in press)
    • Ziemann U, Wahl M, Hattingen E, Tumani H (2011) Development of biomarkers for multiple sclerosis as a neurodegenerative disorder. Prog Neurobiol. doi: 10.1016/j.pneurobio.2011.04.007 (in press)
    • (2011) Prog Neurobiol.
    • Ziemann, U.1    Wahl, M.2    Hattingen, E.3    Tumani, H.4
  • 33
    • 67649472442 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers in multiple sclerosis
    • 19426803 10.1016/j.nbd.2009.04.010 1:CAS:528:DC%2BD1MXotFCgtr0%3D
    • Tumani H, Hartung HP, Hemmer B et al (2009) Cerebrospinal fluid biomarkers in multiple sclerosis. Neurobiol Dis 35(2):117-127
    • (2009) Neurobiol Dis , vol.35 , Issue.2 , pp. 117-127
    • Tumani, H.1    Hartung, H.P.2    Hemmer, B.3
  • 34
    • 3142556134 scopus 로고    scopus 로고
    • Development of biomarkers in multiple sclerosis
    • 15180926 10.1093/brain/awh176
    • Bielekova B, Martin R (2004) Development of biomarkers in multiple sclerosis. Brain 127:1463-1478
    • (2004) Brain , vol.127 , pp. 1463-1478
    • Bielekova, B.1    Martin, R.2
  • 35
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • 10852536 10.1002/1531-8249(200006)47:6<707: AID-ANA3>3.0.CO;2-Q 1:STN:280:DC%2BD3czgvFektA%3D%3D
    • Lucchinetti C, Brück W, Parisi J et al (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47(6):707-717
    • (2000) Ann Neurol , vol.47 , Issue.6 , pp. 707-717
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3
  • 36
    • 41949128622 scopus 로고    scopus 로고
    • Biological marker for axonal degeneration in CSF and blood of patient with the first event indicative for multiple sclerosis
    • 10.1016/j.neulet.2008.02.064 1:CAS:528:DC%2BD1cXks1art7Y%3D
    • Hein K, Kohler A, Diem R et al (2008) Biological marker for axonal degeneration in CSF and blood of patient with the first event indicative for multiple sclerosis. Neurosci Lett 436:72-76
    • (2008) Neurosci Lett , vol.436 , pp. 72-76
    • Hein, K.1    Kohler, A.2    Diem, R.3
  • 37
    • 71249151075 scopus 로고    scopus 로고
    • Role of the oligodendroglial cytoskeleton in differentiation and myelination
    • 19455583 10.1002/glia.20885
    • Bauer NG, Richter-Landsberg C et al (2009) Role of the oligodendroglial cytoskeleton in differentiation and myelination. Glia 57(16):1691-1705
    • (2009) Glia , vol.57 , Issue.16 , pp. 1691-1705
    • Bauer, N.G.1    Richter-Landsberg, C.2
  • 38
    • 77949904336 scopus 로고    scopus 로고
    • Neurofilament light as a prognostic marker in multiple sclerosis
    • 20086018 10.1177/1352458509359725 1:CAS:528:DC%2BC3cXlt1Oltrc%3D
    • Salzer J, Svenningsson A, Sundstrom P (2010) Neurofilament light as a prognostic marker in multiple sclerosis. Mult Scler 16:287-292
    • (2010) Mult Scler , vol.16 , pp. 287-292
    • Salzer, J.1    Svenningsson, A.2    Sundstrom, P.3
  • 39
    • 8644272511 scopus 로고    scopus 로고
    • Neurofilament and glial fibrillary acidic protein in multiple sclerosis
    • 15534240 10.1212/01.WNL.0000142988.49341.D1 1:CAS:528: DC%2BD2cXoslSlsrs%3D
    • Norgren N, Sundström P, Svenningsson A et al (2004) Neurofilament and glial fibrillary acidic protein in multiple sclerosis. Neurology 63(9):1586-1590
    • (2004) Neurology , vol.63 , Issue.9 , pp. 1586-1590
    • Norgren, N.1    Sundström, P.2    Svenningsson, A.3
  • 40
    • 79959967979 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein: A potential biomarker for progression in multiple sclerosis
    • 10.1007/s00415-010-5863-2
    • Axelsson M, Malmeström C, Nilsson S et al (2010) Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis. J Neurol 258(5):882-888
    • (2010) J Neurol , vol.258 , Issue.5 , pp. 882-888
    • Axelsson, M.1    Malmeström, C.2    Nilsson, S.3
  • 41
    • 0033022516 scopus 로고    scopus 로고
    • Pathogenesis of tissue injury in MS lesions
    • 10426362 10.1016/S0165-5728(99)00081-8 1:CAS:528:DyaK1MXktVGru7c%3D
    • Trapp BD, Bö L, Mörk S, Chang A (1999) Pathogenesis of tissue injury in MS lesions. J Neuroimmunol 98(1):49-56
    • (1999) J Neuroimmunol , vol.98 , Issue.1 , pp. 49-56
    • Trapp, B.D.1    Bö, L.2    Mörk, S.3    Chang, A.4
  • 42
    • 84866735910 scopus 로고    scopus 로고
    • Neurofilament proteins as body fluid biomarkers of neurodegeneration in multiple sclerosis
    • 315406. doi: 10.1155/2011/315406
    • Gresle MM, Butzkueven H, Shaw G (2011) Neurofilament proteins as body fluid biomarkers of neurodegeneration in multiple sclerosis. Mult Scler Int 2011:315406. doi: 10.1155/2011/315406
    • (2011) Mult Scler Int
    • Gresle, M.M.1    Butzkueven, H.2    Shaw, G.3
  • 43
    • 79551478161 scopus 로고    scopus 로고
    • Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab
    • 21280078 10.1002/ana.22247 1:CAS:528:DC%2BC3MXisVCis7Y%3D
    • Gunnarsson M, Malmestrom C, Axelsson M et al (2011) Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab. Ann Neurol 69:83-89
    • (2011) Ann Neurol , vol.69 , pp. 83-89
    • Gunnarsson, M.1    Malmestrom, C.2    Axelsson, M.3


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