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Volumn 5, Issue 4, 2006, Pages 343-354

Secondary progressive multiple sclerosis: Current knowledge and future challenges

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; BETA INTERFERON; BETA1A INTERFERON; CLADRIBINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; IMMUNOGLOBULIN; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; METHOTREXATE; METHYLPREDNISOLONE; MITOXANTRONE; PLACEBO;

EID: 33644974688     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(06)70410-0     Document Type: Review
Times cited : (243)

References (144)
  • 1
    • 76549217481 scopus 로고
    • Problems of experimental trials of therapy in MS: Report by the panel on the evaluation of experimental trials of therapy in MS
    • GA Schumacher, G Beebe, RF Kibler Problems of experimental trials of therapy in MS: report by the panel on the evaluation of experimental trials of therapy in MS Ann N Y Acad Sci 122 1965 552 568
    • (1965) Ann N Y Acad Sci , vol.122 , pp. 552-568
    • Schumacher, G.A.1    Beebe, G.2    Kibler, R.F.3
  • 2
    • 0020686503 scopus 로고
    • New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
    • CM Poser, DW Paty, L Scheinberg New diagnostic criteria for multiple sclerosis: guidelines for research protocols Ann Neurol 13 1983 227 231
    • (1983) Ann Neurol , vol.13 , pp. 227-231
    • Poser, C.M.1    Paty, D.W.2    Scheinberg, L.3
  • 4
    • 0030911461 scopus 로고    scopus 로고
    • Primary progressive multiple sclerosis
    • AJ Thompson, CH Polman, DH Miller Primary progressive multiple sclerosis Brain 120 1997 1085 1096
    • (1997) Brain , vol.120 , pp. 1085-1096
    • Thompson, A.J.1    Polman, C.H.2    Miller, D.H.3
  • 5
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis
    • WI McDonald, A Compston, G Edan Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis Ann Neurol 50 2001 121 127
    • (2001) Ann Neurol , vol.50 , pp. 121-127
    • McDonald, W.I.1    Compston, A.2    Edan, G.3
  • 6
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey
    • for the National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis S.C.
    • FD Lublin, SC Reingold for the National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis Defining the clinical course of multiple sclerosis: results of an international survey Neurology 46 1996 907 911
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold2
  • 7
    • 84892273340 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis
    • D.A.S. Compston 4th edn. Churchill-Livingstone London
    • C Confavreux, DAS Compston The natural history of multiple sclerosis DAS Compston McAlpine's multiple sclerosis 4th edn. 2005 Churchill-Livingstone London
    • (2005) McAlpine's Multiple Sclerosis
    • Confavreux, C.1    Compston, D.A.S.2
  • 8
    • 0001113985 scopus 로고
    • Some aspects of the natural history of disseminated sclerosis: Incidence, course and prognosis, factors affecting onset and course
    • D McAlpine, ND Compston Some aspects of the natural history of disseminated sclerosis: incidence, course and prognosis, factors affecting onset and course Q J Med 21 1952 135 167
    • (1952) Q J Med , vol.21 , pp. 135-167
    • McAlpine, D.1    Compston, N.D.2
  • 10
    • 0018942701 scopus 로고
    • Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients
    • C Confavreux, G Aimard, M Devic Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients Brain 103 1980 281 300
    • (1980) Brain , vol.103 , pp. 281-300
    • Confavreux, C.1    Aimard, G.2    Devic, M.3
  • 11
    • 0037441370 scopus 로고    scopus 로고
    • Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis
    • S Vukusic, C Confavreux Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis J Neurol Sci 206 2003 135 137
    • (2003) J Neurol Sci , vol.206 , pp. 135-137
    • Vukusic, S.1    Confavreux, C.2
  • 12
    • 0019366388 scopus 로고
    • Clinical studies on multiple sclerosis I: Presentation of an incidence material from Gothenburg
    • T Broman, O Andersen, L Bergmann Clinical studies on multiple sclerosis I: presentation of an incidence material from Gothenburg Acta Neurol Scand 63 1981 6 33
    • (1981) Acta Neurol Scand , vol.63 , pp. 6-33
    • Broman, T.1    Andersen, O.2    Bergmann, L.3
  • 13
    • 0037983828 scopus 로고    scopus 로고
    • Long-term tollow-up of patients with clinically isolated syndromes, relapsing-remitting and secondary progressive multiple sclerosis
    • M Eriksson, O Andersen, B Runmarker Long-term tollow-up of patients with clinically isolated syndromes, relapsing-remitting and secondary progressive multiple sclerosis Mult Scler 9 2003 260 274
    • (2003) Mult Scler , vol.9 , pp. 260-274
    • Eriksson, M.1    Andersen, O.2    Runmarker, B.3
  • 14
    • 0024504359 scopus 로고
    • The natural history of multiple sclerosis: A geographically based study I: Clinical course and disability
    • BG Weinshenker, B Bass, GP Rice The natural history of multiple sclerosis: a geographically based study I: clinical course and disability Brain 112 1989 133 146
    • (1989) Brain , vol.112 , pp. 133-146
    • Weinshenker, B.G.1    Bass, B.2    Rice, G.P.3
  • 15
    • 0034565136 scopus 로고    scopus 로고
    • A prospective study on the prognosis of multiple sclerosis
    • MP Amato, G Ponziani A prospective study on the prognosis of multiple sclerosis Neurol Sci 21 suppl 2 2000 831 838
    • (2000) Neurol Sci , vol.21 , Issue.SUPPL. 2 , pp. 831-838
    • Amato, M.P.1    Ponziani, G.2
  • 16
    • 0035033099 scopus 로고    scopus 로고
    • Disability an prognosis in multiple sclerosis: Demographic and clinical variables important for the ability to walk and awarding of disability pension
    • KM Myhr, T Riise, C Vedeler Disability an prognosis in multiple sclerosis: demographic and clinical variables important for the ability to walk and awarding of disability pension Mult Scler 7 2001 59 65
    • (2001) Mult Scler , vol.7 , pp. 59-65
    • Myhr, K.M.1    Riise, T.2    Vedeler, C.3
  • 17
    • 0012527355 scopus 로고
    • Studies on disseminated sclerosis: With special reference to symptomatology, course and prognosis
    • R Müller Studies on disseminated sclerosis: with special reference to symptomatology, course and prognosis Acta Med Scand 133 suppl 222 1949 1 214
    • (1949) Acta Med Scand , vol.133 , Issue.SUPPL. 222 , pp. 1-214
    • Müller, R.1
  • 18
    • 0001467782 scopus 로고
    • Course and prognosis of disseminated sclerosis in relation to age at onset
    • R Müller Course and prognosis of disseminated sclerosis in relation to age at onset Arch Neurol Psychiatry 66 1951 561 570
    • (1951) Arch Neurol Psychiatry , vol.66 , pp. 561-570
    • Müller, R.1
  • 19
    • 0026604711 scopus 로고
    • Early prognostic factors for disability in multiple sclerosis, a European multicenter study
    • T Riise, M Gronning, O Fernandez Early prognostic factors for disability in multiple sclerosis, a European multicenter study Acta Neurol Scand 85 1992 212 218
    • (1992) Acta Neurol Scand , vol.85 , pp. 212-218
    • Riise, T.1    Gronning, M.2    Fernandez, O.3
  • 20
    • 0027537209 scopus 로고
    • Prognostic factors in a multiple sclerosis incidence cohort with twenty five years of follow-up
    • B Runmarker, O Andersen Prognostic factors in a multiple sclerosis incidence cohort with twenty five years of follow-up Brain 116 1993 117 134
    • (1993) Brain , vol.116 , pp. 117-134
    • Runmarker, B.1    Andersen, O.2
  • 21
    • 0028934677 scopus 로고
    • Multivariate analysis of predictive factors of multiple sclerosis with a validated method to assess clinical events
    • M Trojano, C Avolio, C Manzari Multivariate analysis of predictive factors of multiple sclerosis with a validated method to assess clinical events J Neurol Neurosurg Psychiatry 58 1995 300 306
    • (1995) J Neurol Neurosurg Psychiatry , vol.58 , pp. 300-306
    • Trojano, M.1    Avolio, C.2    Manzari, C.3
  • 22
    • 0037379402 scopus 로고    scopus 로고
    • Early clinical predictors and progression of irreversible disability in multiple sclerosis: An amnesic process
    • C Confavreux, S Vukusic, P Adeleine Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process Brain 126 2003 770 782
    • (2003) Brain , vol.126 , pp. 770-782
    • Confavreux, C.1    Vukusic, S.2    Adeleine, P.3
  • 23
    • 0021035886 scopus 로고
    • Rating neurological impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • JF Kurtzke Rating neurological impairment in multiple sclerosis: an expanded disability status scale (EDSS) Neurology 33 1983 1444 1452
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 24
    • 0034676548 scopus 로고    scopus 로고
    • Relapses and progression of disability in multiple sclerosis
    • C Confavreux, S Vukusic, T Moreau, P Adeleine Relapses and progression of disability in multiple sclerosis N Eng J Med 343 2000 1430 1438
    • (2000) N Eng J Med , vol.343 , pp. 1430-1438
    • Confavreux, C.1    Vukusic, S.2    Moreau, T.3    Adeleine, P.4
  • 25
    • 0037441414 scopus 로고    scopus 로고
    • Primary and secondary progressive multiple sclerosis
    • S Vukusic, C Confavreux Primary and secondary progressive multiple sclerosis J Neurol Sci 206 2003 153 155
    • (2003) J Neurol Sci , vol.206 , pp. 153-155
    • Vukusic, S.1    Confavreux, C.2
  • 26
    • 0023770787 scopus 로고
    • Course and prognosis of chronic progressive multiple sclerosis: Results of an epidemiological study
    • JM Minderhoud, JH van der Hoeven, AJA Prange Course and prognosis of chronic progressive multiple sclerosis: results of an epidemiological study Acta Neurol Scand 78 1988 10 15
    • (1988) Acta Neurol Scand , vol.78 , pp. 10-15
    • Minderhoud, J.M.1    Van Der Hoeven, J.H.2    Prange, A.J.A.3
  • 27
    • 0032946328 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis: A geographically based study 5: The clinical features and natural history of primary progressive multiple sclerosis
    • DA Cottrell, M Kremenchutzky, GPA Rice The natural history of multiple sclerosis: a geographically based study 5: the clinical features and natural history of primary progressive multiple sclerosis Brain 122 1999 625 639
    • (1999) Brain , vol.122 , pp. 625-639
    • Cottrell, D.A.1    Kremenchutzky, M.2    Rice, G.P.A.3
  • 28
    • 0032881051 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis - A geographically based study 7: Progressive-relapsing and relapsing-progressive multiple sclerosis, a re-evaluation
    • M Kremenchutzky, D Cottrell, G Rice The natural history of multiple sclerosis - a geographically based study 7: progressive-relapsing and relapsing-progressive multiple sclerosis, a re-evaluation Brain 122 1999 1941 1949
    • (1999) Brain , vol.122 , pp. 1941-1949
    • Kremenchutzky, M.1    Cottrell, D.2    Rice, G.3
  • 29
    • 0028132773 scopus 로고
    • A comparison of the pathology of primary and secondary progressive multiple sclerosis
    • T Revesz, D Kidd, AJ Thompson, RO Barnard, WI McDonald A comparison of the pathology of primary and secondary progressive multiple sclerosis Brain 117 1994 759 765
    • (1994) Brain , vol.117 , pp. 759-765
    • Revesz, T.1    Kidd, D.2    Thompson, A.J.3    Barnard, R.O.4    McDonald, W.I.5
  • 30
    • 0034765063 scopus 로고    scopus 로고
    • Immunopathology of secondary-progressive multiple sclerosis
    • JW Prineas, EE Kwon, ES Cho Immunopathology of secondary-progressive multiple sclerosis Ann Neurol 50 2001 646 657
    • (2001) Ann Neurol , vol.50 , pp. 646-657
    • Prineas, J.W.1    Kwon, E.E.2    Cho, E.S.3
  • 31
    • 27644552194 scopus 로고    scopus 로고
    • Cortical demyelination and diffuse white matter injury in multiple sclerosis
    • A Kutzelnigg, CF Lucchinetti, C Stadelmann Cortical demyelination and diffuse white matter injury in multiple sclerosis Brain 128 2005 2705 2712
    • (2005) Brain , vol.128 , pp. 2705-2712
    • Kutzelnigg, A.1    Lucchinetti, C.F.2    Stadelmann, C.3
  • 32
    • 2442708947 scopus 로고    scopus 로고
    • Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    • B Serafini, B Rosicarelli, R Magliozzi, E Stigliano, F Aloisi Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis Brain Pathol 14 2004 164 174
    • (2004) Brain Pathol , vol.14 , pp. 164-174
    • Serafini, B.1    Rosicarelli, B.2    Magliozzi, R.3    Stigliano, E.4    Aloisi, F.5
  • 34
    • 18544404188 scopus 로고    scopus 로고
    • Distinct chemokine receptor and cytokine expression profile in secondary progressive MS
    • TL Sorensen, F Sellebjerg Distinct chemokine receptor and cytokine expression profile in secondary progressive MS Neurology 57 2001 1371 1376
    • (2001) Neurology , vol.57 , pp. 1371-1376
    • Sorensen, T.L.1    Sellebjerg, F.2
  • 35
    • 0035157253 scopus 로고    scopus 로고
    • CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis
    • C Trebst, TL Sorensen, P Kivisakk CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis Am J Pathol 159 2001 1701 1710
    • (2001) Am J Pathol , vol.159 , pp. 1701-1710
    • Trebst, C.1    Sorensen, T.L.2    Kivisakk, P.3
  • 36
    • 22144434812 scopus 로고    scopus 로고
    • Immunological patterns identifying disease course and disease evolution in multiple sclerosis patients
    • R Furlan, M Rovaris, M Khademi Immunological patterns identifying disease course and disease evolution in multiple sclerosis patients J Neuroimmunol 165 2005 192 200
    • (2005) J Neuroimmunol , vol.165 , pp. 192-200
    • Furlan, R.1    Rovaris, M.2    Khademi, M.3
  • 37
    • 10344247674 scopus 로고    scopus 로고
    • Expression of adhesion molecules on peripheral lymphocytes predicts future lesion development in MS
    • MJ Eikelenboom, J Killestein, T Izeboud Expression of adhesion molecules on peripheral lymphocytes predicts future lesion development in MS J Neuroimmunol 158 2005 222 230
    • (2005) J Neuroimmunol , vol.158 , pp. 222-230
    • Eikelenboom, M.J.1    Killestein, J.2    Izeboud, T.3
  • 38
    • 25844511726 scopus 로고    scopus 로고
    • Sex differences in proinflammatory cytokine profiles of progressive patients in multiple sclerosis
    • MJ Eikelenboom, J Killestein, BM Uitdehaag, CH Polman Sex differences in proinflammatory cytokine profiles of progressive patients in multiple sclerosis Mult Scler 11 2005 520 523
    • (2005) Mult Scler , vol.11 , pp. 520-523
    • Eikelenboom, M.J.1    Killestein, J.2    Uitdehaag, B.M.3    Polman, C.H.4
  • 39
    • 0026100007 scopus 로고
    • Major differences in the dynamics of primary and secondary progressive multiple sclerosis
    • AJ Thompson, AG Kermode, D Wicks Major differences in the dynamics of primary and secondary progressive multiple sclerosis Ann Neurol 29 1991 53 62
    • (1991) Ann Neurol , vol.29 , pp. 53-62
    • Thompson, A.J.1    Kermode, A.G.2    Wicks, D.3
  • 40
    • 0033021883 scopus 로고    scopus 로고
    • Comparison of MS clinical phenotypes using conventional and magnetization transfer MRI
    • M Filippi, G Iannucci, C Tortorella Comparison of MS clinical phenotypes using conventional and magnetization transfer MRI Neurology 52 1999 588 594
    • (1999) Neurology , vol.52 , pp. 588-594
    • Filippi, M.1    Iannucci, G.2    Tortorella, C.3
  • 41
    • 0035208389 scopus 로고    scopus 로고
    • In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis
    • M Rovaris, M Bozzali, G Santuccio In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis Brain 124 2001 2540 2549
    • (2001) Brain , vol.124 , pp. 2540-2549
    • Rovaris, M.1    Bozzali, M.2    Santuccio, G.3
  • 42
    • 0033541029 scopus 로고    scopus 로고
    • Primary and transitional progressive MS: A clinical and MRI cross-sectional study
    • VL Stevenson, DH Miller, M Rovaris Primary and transitional progressive MS: a clinical and MRI cross-sectional study Neurology 52 1999 839 845
    • (1999) Neurology , vol.52 , pp. 839-845
    • Stevenson, V.L.1    Miller, D.H.2    Rovaris, M.3
  • 43
    • 0031966431 scopus 로고    scopus 로고
    • Brain and spinal cord abnormalities in multiple sclerosis: Correlation between MRI parameters, clinical subtypes, and symptoms
    • GJ Lycklama á Nijeholt, MAA van Walderveen, JA Castelijins Brain and spinal cord abnormalities in multiple sclerosis: correlation between MRI parameters, clinical subtypes, and symptoms Brain 121 1998 687 697
    • (1998) Brain , vol.121 , pp. 687-697
    • Lycklama Á Nijeholt, G.J.1    Van Walderveen, M.A.A.2    Castelijins, J.A.3
  • 44
    • 0035956579 scopus 로고    scopus 로고
    • Clinical-MRI correlations in a European trial of interferon beta-1b in secondary progressive MS
    • PD Molyneux, GJ Barker, F Barkhof Clinical-MRI correlations in a European trial of interferon beta-1b in secondary progressive MS Neurology 57 2001 2191 2197
    • (2001) Neurology , vol.57 , pp. 2191-2197
    • Molyneux, P.D.1    Barker, G.J.2    Barkhof, F.3
  • 45
    • 0031546005 scopus 로고    scopus 로고
    • Serial contrast-enhanced MR in patients with multiple sclerosis and varying levels of disability
    • M Filippi, P Rossi, A Campi, B Colombo, C Pereira, G Comi Serial contrast-enhanced MR in patients with multiple sclerosis and varying levels of disability AJNR Am J Neuroradiol 18 1997 1549 1556
    • (1997) AJNR Am J Neuroradiol , vol.18 , pp. 1549-1556
    • Filippi, M.1    Rossi, P.2    Campi, A.3    Colombo, B.4    Pereira, C.5    Comi, G.6
  • 46
    • 0031843531 scopus 로고    scopus 로고
    • Assessing information in T2-weighted MRI scans from secondary progressive MS patients
    • JA Koziol, S Wagner, HP Adams Assessing information in T2-weighted MRI scans from secondary progressive MS patients Neurology 51 1998 228 233
    • (1998) Neurology , vol.51 , pp. 228-233
    • Koziol, J.A.1    Wagner, S.2    Adams, H.P.3
  • 47
    • 0034624943 scopus 로고    scopus 로고
    • Linomide in relapsing and secondary progressive multiple sclerosis: MRI results
    • JS Wolinsky, PA Narayana, JH Noseworthy Linomide in relapsing and secondary progressive multiple sclerosis: MRI results Neurology 54 2000 1734 1741
    • (2000) Neurology , vol.54 , pp. 1734-1741
    • Wolinsky, J.S.1    Narayana, P.A.2    Noseworthy, J.H.3
  • 48
    • 0031932589 scopus 로고    scopus 로고
    • Secondary progressive multiple sclerosis: The relationship between short-term MRI activity and clinical features
    • N Tubridy, AJ Coles, P Molyneux Secondary progressive multiple sclerosis: the relationship between short-term MRI activity and clinical features Brain 121 1998 225 231
    • (1998) Brain , vol.121 , pp. 225-231
    • Tubridy, N.1    Coles, A.J.2    Molyneux, P.3
  • 49
    • 0031891592 scopus 로고    scopus 로고
    • Correlations between monthly enhanced MRI lesion rate and changes in T2 lesion volume in multiple sclerosis
    • PD Molyneux, M Filippi, F Barkhof Correlations between monthly enhanced MRI lesion rate and changes in T2 lesion volume in multiple sclerosis Ann Neurol 43 1998 332 339
    • (1998) Ann Neurol , vol.43 , pp. 332-339
    • Molyneux, P.D.1    Filippi, M.2    Barkhof, F.3
  • 50
    • 0033586376 scopus 로고    scopus 로고
    • Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: A meta-analysis
    • L Kappos, D Moeri, EW Radue Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis Lancet 353 1999 964 969
    • (1999) Lancet , vol.353 , pp. 964-969
    • Kappos, L.1    Moeri, D.2    Radue, E.W.3
  • 51
    • 0027225525 scopus 로고
    • Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions
    • ME Smith, LA Stone, PS Albert Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions Ann Neurol 33 1993 480 489
    • (1993) Ann Neurol , vol.33 , pp. 480-489
    • Smith, M.E.1    Stone, L.A.2    Albert, P.S.3
  • 52
    • 0034743332 scopus 로고    scopus 로고
    • Ring-enhancement in multiple sclerosis: Marker of disease severity
    • K Morgen, NO Jeffries, R Stone Ring-enhancement in multiple sclerosis: marker of disease severity Mult Scler 7 2001 167 171
    • (2001) Mult Scler , vol.7 , pp. 167-171
    • Morgen, K.1    Jeffries, N.O.2    Stone, R.3
  • 53
    • 0029730733 scopus 로고    scopus 로고
    • Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis
    • L Truyen, JHTM van Waesberghe, MAA van Walderveen Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis Neurology 47 1997 1469 1476
    • (1997) Neurology , vol.47 , pp. 1469-1476
    • Truyen, L.1    Waesberghe Jhtm, V.2    Van Walderveen, M.A.A.3
  • 54
    • 0033981062 scopus 로고    scopus 로고
    • A magnetization transfer histogram study of normal appearing brain tissue in multiple sclerosis
    • C Tortorella, B Viti, M Bozzali A magnetization transfer histogram study of normal appearing brain tissue in multiple sclerosis Neurology 54 2000 186 193
    • (2000) Neurology , vol.54 , pp. 186-193
    • Tortorella, C.1    Viti, B.2    Bozzali, M.3
  • 55
    • 0035171038 scopus 로고    scopus 로고
    • Hypointense lesions on T1-weighted spin-echo magnetic resonance imaging: Relation to clinical characteristics in subgroups of patients with multiple sclerosis
    • MAA van Walderveen, GJ Lycklama à Nijeholt, HJ Ader Hypointense lesions on T1-weighted spin-echo magnetic resonance imaging: relation to clinical characteristics in subgroups of patients with multiple sclerosis Arch Neurol 58 2001 76 81
    • (2001) Arch Neurol , vol.58 , pp. 76-81
    • Van Walderveen, M.A.A.1    Lycklama À Nijeholt, G.J.2    Ader, H.J.3
  • 57
    • 0030453516 scopus 로고    scopus 로고
    • Progressive cerebral atrophy in multiple sclerosis: A serial MRI study
    • NA Losseff, L Wang, HM Lai Progressive cerebral atrophy in multiple sclerosis: a serial MRI study Brain 119 1996 2009 2019
    • (1996) Brain , vol.119 , pp. 2009-2019
    • Losseff, N.A.1    Wang, L.2    Lai, H.M.3
  • 58
    • 0034105546 scopus 로고    scopus 로고
    • Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: Longitudinal quantitative analysis
    • Y Ge, RI Grossman, JK Udupa Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: longitudinal quantitative analysis Radiology 214 2000 665 670
    • (2000) Radiology , vol.214 , pp. 665-670
    • Ge, Y.1    Grossman, R.I.2    Udupa, J.K.3
  • 59
    • 0035833970 scopus 로고    scopus 로고
    • Optimizing the association between disability and biological markers in MS
    • NF Kalkers, E Bergers, JA Castelijns Optimizing the association between disability and biological markers in MS Neurology 57 2001 1253 1258
    • (2001) Neurology , vol.57 , pp. 1253-1258
    • Kalkers, N.F.1    Bergers, E.2    Castelijns, J.A.3
  • 60
    • 0035881764 scopus 로고    scopus 로고
    • Inflammation and atrophy in multiple sclerosis: MRI associations with disease course
    • X Lin, LD Blumhardt Inflammation and atrophy in multiple sclerosis: MRI associations with disease course J Neurol Sci 189 2001 99 104
    • (2001) J Neurol Sci , vol.189 , pp. 99-104
    • Lin, X.1    Blumhardt, L.D.2
  • 61
    • 29444434481 scopus 로고    scopus 로고
    • Regional brain atrophy evolves differently in patients with multiple sclerosis according to clinical phenotype
    • E Pagani, MA Rocca, A Gallo Regional brain atrophy evolves differently in patients with multiple sclerosis according to clinical phenotype Am J Neuroradiol 26 2005 341 346
    • (2005) Am J Neuroradiol , vol.26 , pp. 341-346
    • Pagani, E.1    Rocca, M.A.2    Gallo, A.3
  • 62
    • 0029894034 scopus 로고    scopus 로고
    • A spinal cord MRI study of benign and secondary progressive multiple sclerosis
    • M Filippi, A Campi, B Colombo A spinal cord MRI study of benign and secondary progressive multiple sclerosis J Neurol 243 1996 502 505
    • (1996) J Neurol , vol.243 , pp. 502-505
    • Filippi, M.1    Campi, A.2    Colombo, B.3
  • 63
    • 8944248824 scopus 로고    scopus 로고
    • Spinal cord atrophy and disability in multiple sclerosis: A new reproducible and sensitive MRI method with potential to monitor disease progression
    • NA Losseff, SL Webb, JI O'Riordan Spinal cord atrophy and disability in multiple sclerosis: a new reproducible and sensitive MRI method with potential to monitor disease progression Brain 119 1996 701 708
    • (1996) Brain , vol.119 , pp. 701-708
    • Losseff, N.A.1    Webb, S.L.2    O'Riordan, J.I.3
  • 64
    • 0041989798 scopus 로고    scopus 로고
    • Spinal cord atrophy and disability in multiple sclerosis over four years: Application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon β-1a (Rebif) treatment trial
    • X Lin, CR Tench, B Turner, LD Blumhardt, CS Constantinescu Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon β-1a (Rebif) treatment trial J Neurol Neurosurg Psychiatry 74 2003 1090 1094
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 1090-1094
    • Lin, X.1    Tench, C.R.2    Turner, B.3    Blumhardt, L.D.4    Constantinescu, C.S.5
  • 65
    • 0031868819 scopus 로고    scopus 로고
    • Spinal cord atrophy and disability in MS: A longitudinal study
    • VL Stevenson, SM Leary, NA Losseff Spinal cord atrophy and disability in MS: a longitudinal study Neurology 51 1998 234 238
    • (1998) Neurology , vol.51 , pp. 234-238
    • Stevenson, V.L.1    Leary, S.M.2    Losseff, N.A.3
  • 66
    • 20644442872 scopus 로고    scopus 로고
    • Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients
    • P Valsasina, MA Rocca, F Agosta Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients NeuroImage 26 2005 822 828
    • (2005) NeuroImage , vol.26 , pp. 822-828
    • Valsasina, P.1    Rocca, M.A.2    Agosta, F.3
  • 67
    • 0036791829 scopus 로고    scopus 로고
    • Longitudinal brain volume measurement in multiple sclerosis: Rate of brain atrophy is independent of the disease subtype
    • NF Kalkers, N Ameziane, JCJ Boost, A Minneboo, CH Polman, F Barkhof Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype Arch Neurol 59 2002 1572 1576
    • (2002) Arch Neurol , vol.59 , pp. 1572-1576
    • Kalkers, N.F.1    Ameziane, N.2    Boost, J.C.J.3    Minneboo, A.4    Polman, C.H.5    Barkhof, F.6
  • 68
    • 0242367908 scopus 로고    scopus 로고
    • Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: A medium-term follow-up study
    • M Rovaris, F Agosta, MP Sormani Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up study Brain 126 2003 2323 2332
    • (2003) Brain , vol.126 , pp. 2323-2332
    • Rovaris, M.1    Agosta, F.2    Sormani, M.P.3
  • 69
    • 0036717266 scopus 로고    scopus 로고
    • Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis
    • M Rovaris, M Bozzali, G Iannucci Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis Arch Neurol 59 2002 1406 1412
    • (2002) Arch Neurol , vol.59 , pp. 1406-1412
    • Rovaris, M.1    Bozzali, M.2    Iannucci, G.3
  • 70
    • 19944430096 scopus 로고    scopus 로고
    • Short-term accrual of grey matter pathology in patients with progressive multiple sclerosis: An in vivo study using diffusion tensor MRI
    • M Rovaris, A Gallo, P Valsasina Short-term accrual of grey matter pathology in patients with progressive multiple sclerosis: an in vivo study using diffusion tensor MRI NeuroImage 24 2005 1139 1146
    • (2005) NeuroImage , vol.24 , pp. 1139-1146
    • Rovaris, M.1    Gallo, A.2    Valsasina, P.3
  • 71
    • 0037883298 scopus 로고    scopus 로고
    • MRI metrics as surrogate endpoints for EDSS progression in SPMS patients treated with IFN beta-1b
    • MP Sormani, P Bruzzi, K Beckmann MRI metrics as surrogate endpoints for EDSS progression in SPMS patients treated with IFN beta-1b Neurology 60 2003 1462 1466
    • (2003) Neurology , vol.60 , pp. 1462-1466
    • Sormani, M.P.1    Bruzzi, P.2    Beckmann, K.3
  • 72
    • 0033472729 scopus 로고    scopus 로고
    • Effect of interferon-beta1b on magnetic resonance imaging outcomes in secondary progressive multiple sclerosis: Results of a European multicenter, randomized, double-blind, placebo-controlled trial
    • DH Miller, PD Molyneux, GJ Barker Effect of interferon-beta1b on magnetic resonance imaging outcomes in secondary progressive multiple sclerosis: results of a European multicenter, randomized, double-blind, placebo-controlled trial Ann Neurol 46 1999 850 859
    • (1999) Ann Neurol , vol.46 , pp. 850-859
    • Miller, D.H.1    Molyneux, P.D.2    Barker, G.J.3
  • 73
    • 0034646216 scopus 로고    scopus 로고
    • Cladribine and progressive MS: Clinical and MRI outcomes of a multicenter controlled trial
    • GP Rice, M Filippi, G Comi Cladribine and progressive MS: clinical and MRI outcomes of a multicenter controlled trial Neurology 54 2000 1145 1155
    • (2000) Neurology , vol.54 , pp. 1145-1155
    • Rice, G.P.1    Filippi, M.2    Comi, G.3
  • 74
    • 0035849494 scopus 로고    scopus 로고
    • Randomized controlled trial of interferon-beta-1a in secondary progressive MS: MRI results
    • DKB Li, GJ Zhao, DW Paty Randomized controlled trial of interferon-beta-1a in secondary progressive MS: MRI results Neurology 56 2001 1505 1513
    • (2001) Neurology , vol.56 , pp. 1505-1513
    • Li, D.K.B.1    Zhao, G.J.2    Paty, D.W.3
  • 75
    • 0035838312 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI activity in MS
    • GL Mancardi, R Saccardi, M Filippi Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI activity in MS Neurology 57 2001 62 68
    • (2001) Neurology , vol.57 , pp. 62-68
    • Mancardi, G.L.1    Saccardi, R.2    Filippi, M.3
  • 76
    • 0033759398 scopus 로고    scopus 로고
    • The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis
    • PD Molyneux, L Kappos, C Polman The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis Brain 123 2000 2256 2263
    • (2000) Brain , vol.123 , pp. 2256-2263
    • Molyneux, P.D.1    Kappos, L.2    Polman, C.3
  • 77
    • 0034951507 scopus 로고    scopus 로고
    • T1 hypointense lesions in secondary progressive multiple sclerosis: Effect of interferon beta-1b treatment
    • F Barkhof, JH van Waesberghe, M Filippi T1 hypointense lesions in secondary progressive multiple sclerosis: effect of interferon beta-1b treatment Brain 124 2001 1396 1402
    • (2001) Brain , vol.124 , pp. 1396-1402
    • Barkhof, F.1    Van Waesberghe, J.H.2    Filippi, M.3
  • 78
    • 0034642247 scopus 로고    scopus 로고
    • Whole brain volume changes in patients with progressive MS treated with cladribine
    • M Filippi, M Rovaris, G Iannucci, S Mennea, MP Sormani, G Comi Whole brain volume changes in patients with progressive MS treated with cladribine Neurology 55 2000 1714 1718
    • (2000) Neurology , vol.55 , pp. 1714-1718
    • Filippi, M.1    Rovaris, M.2    Iannucci, G.3    Mennea, S.4    Sormani, M.P.5    Comi, G.6
  • 79
    • 0034194016 scopus 로고    scopus 로고
    • The effect of cladribine on T1 'black hole' changes in progressive MS
    • M Filippi, M Rovaris, GPA Rice The effect of cladribine on T1 'black hole' changes in progressive MS J Neurol Sci 176 2000 42 44
    • (2000) J Neurol Sci , vol.176 , pp. 42-44
    • Filippi, M.1    Rovaris, M.2    Rice, G.P.A.3
  • 80
    • 1642482932 scopus 로고    scopus 로고
    • Brain tissue loss occurs after suppression of enhancement in MS patients treated with AHSCT
    • M Inglese, GL Mancardi, E Pagani Brain tissue loss occurs after suppression of enhancement in MS patients treated with AHSCT J Neurol Neurosurg Psychiatry 75 2004 643 644
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 643-644
    • Inglese, M.1    Mancardi, G.L.2    Pagani, E.3
  • 81
    • 0033595570 scopus 로고    scopus 로고
    • Magnetization transfer in multiple sclerosis
    • M Filippi, RI Grossman, G Comi Magnetization transfer in multiple sclerosis Neurology 53 suppl 3 1999 S40 S45
    • (1999) Neurology , vol.53 , Issue.SUPPL. 3
    • Filippi, M.1    Grossman, R.I.2    Comi, G.3
  • 82
    • 28044466886 scopus 로고    scopus 로고
    • Diffusion MRI in multiple sclerosis
    • M Rovaris, A Gass, R Bammer Diffusion MRI in multiple sclerosis Neurology 65 2005 1526 1532
    • (2005) Neurology , vol.65 , pp. 1526-1532
    • Rovaris, M.1    Gass, A.2    Bammer, R.3
  • 83
    • 7044260861 scopus 로고    scopus 로고
    • The spinal cord in multiple sclerosis: Relationship of high spatial-resolution quantitative MR imaging findings to histopathologic results
    • JC Bot, EL Blezer, W Kamphorst The spinal cord in multiple sclerosis: relationship of high spatial-resolution quantitative MR imaging findings to histopathologic results Radiology 233 2004 531 540
    • (2004) Radiology , vol.233 , pp. 531-540
    • Bot, J.C.1    Blezer, E.L.2    Kamphorst, W.3
  • 85
    • 0034633641 scopus 로고    scopus 로고
    • Magnetization transfer imaging to monitor the evolution of MS: A one-year follow up study
    • M Filippi, M Inglese, M Rovaris Magnetization transfer imaging to monitor the evolution of MS: a one-year follow up study Neurology 55 2000 940 946
    • (2000) Neurology , vol.55 , pp. 940-946
    • Filippi, M.1    Inglese, M.2    Rovaris, M.3
  • 86
    • 0035282964 scopus 로고    scopus 로고
    • Magnetization transfer histogram parameters reflect all dimensions of MS pathology, including atrophy
    • NF Kalkers, RQ Hintzen, JH van Waesberghe Magnetization transfer histogram parameters reflect all dimensions of MS pathology, including atrophy J Neurol Sci 184 2001 155 162
    • (2001) J Neurol Sci , vol.184 , pp. 155-162
    • Kalkers, N.F.1    Hintzen, R.Q.2    Van Waesberghe, J.H.3
  • 87
    • 0036145813 scopus 로고    scopus 로고
    • Magnetization transfer ratio histogram analysis of normal-appearing gray matter and normal-appearing white matter in multiple sclerosis
    • Y Ge, RI Grossman, JK Udupa, JS Babb, LJ Mannon, JC McGowan Magnetization transfer ratio histogram analysis of normal-appearing gray matter and normal-appearing white matter in multiple sclerosis J Comput Assist Tomogr 26 2002 62 68
    • (2002) J Comput Assist Tomogr , vol.26 , pp. 62-68
    • Ge, Y.1    Grossman, R.I.2    Udupa, J.K.3    Babb, J.S.4    Mannon, L.J.5    McGowan, J.C.6
  • 88
    • 0032724612 scopus 로고    scopus 로고
    • Axonal loss in multiple sclerosis lesions: Magnetic resonance imaging insights into substrates of disability
    • JH van Waesberghe, W Kamphorst, CJ De Groot Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights into substrates of disability Ann Neurol 46 1999 747 754
    • (1999) Ann Neurol , vol.46 , pp. 747-754
    • Van Waesberghe, J.H.1    Kamphorst, W.2    De Groot, C.J.3
  • 90
    • 0032743218 scopus 로고    scopus 로고
    • Long term changes of MT-derived measures from patients with relapsing-remitting and secondary-progressive multiple sclerosis
    • MA Rocca, G Mastronardo, M Rodegher, G Comi, M Filippi Long term changes of MT-derived measures from patients with relapsing-remitting and secondary-progressive multiple sclerosis Am J Neuroradiol 20 1999 821 827
    • (1999) Am J Neuroradiol , vol.20 , pp. 821-827
    • Rocca, M.A.1    Mastronardo, G.2    Rodegher, M.3    Comi, G.4    Filippi, M.5
  • 91
    • 12244272410 scopus 로고    scopus 로고
    • The effect of interferon beta-1b on quantities derived from MT MRI in secondary progressive MS
    • M Inglese, JHTM van Waesberghe, M Rovaris The effect of interferon beta-1b on quantities derived from MT MRI in secondary progressive MS Neurology 60 2003 853 860
    • (2003) Neurology , vol.60 , pp. 853-860
    • Inglese, M.1    Waesberghe Jhtm, V.2    Rovaris, M.3
  • 92
    • 0033985894 scopus 로고    scopus 로고
    • A conventional and magnetization transfer MRI study of the cervical cord in patients with multiple sclerosis
    • M Filippi, M Bozzali, MA Horsfield A conventional and magnetization transfer MRI study of the cervical cord in patients with multiple sclerosis Neurology 54 2000 207 213
    • (2000) Neurology , vol.54 , pp. 207-213
    • Filippi, M.1    Bozzali, M.2    Horsfield, M.A.3
  • 93
    • 0033645920 scopus 로고    scopus 로고
    • Relative contributions of brain and cervical cord pathology to MS disability: A study with MTR histogram analysis
    • M Rovaris, M Bozzali, G Santuccio Relative contributions of brain and cervical cord pathology to MS disability: a study with MTR histogram analysis J Neurol Neurosurg Psychiatry 69 2000 723 727
    • (2000) J Neurol Neurosurg Psychiatry , vol.69 , pp. 723-727
    • Rovaris, M.1    Bozzali, M.2    Santuccio, G.3
  • 97
    • 0035836716 scopus 로고    scopus 로고
    • Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations
    • O Ciccarelli, DJ Werring, CA Wheeler-Kingshott Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations Neurology 56 2001 926 933
    • (2001) Neurology , vol.56 , pp. 926-933
    • Ciccarelli, O.1    Werring, D.J.2    Wheeler-Kingshott, C.A.3
  • 98
    • 0035041359 scopus 로고    scopus 로고
    • Mean diffusivity and fractional anisotropy histograms in patients with multiple sclerosis
    • M Cercignani, M Inglese, E Pagani, G Comi, M Filippi Mean diffusivity and fractional anisotropy histograms in patients with multiple sclerosis Am J Neuroradiol 22 2001 952 958
    • (2001) Am J Neuroradiol , vol.22 , pp. 952-958
    • Cercignani, M.1    Inglese, M.2    Pagani, E.3    Comi, G.4    Filippi, M.5
  • 99
    • 0036306920 scopus 로고    scopus 로고
    • Intra-voxel and inter-voxel coherence in patients with multiple sclerosis assessed using diffusion tensor MRI
    • M Cercignani, M Bozzali, G Iannucci, G Comi, M Filippi Intra-voxel and inter-voxel coherence in patients with multiple sclerosis assessed using diffusion tensor MRI J Neurol 249 2002 875 883
    • (2002) J Neurol , vol.249 , pp. 875-883
    • Cercignani, M.1    Bozzali, M.2    Iannucci, G.3    Comi, G.4    Filippi, M.5
  • 100
    • 0036086983 scopus 로고    scopus 로고
    • Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging
    • M Bozzali, M Cercignani, MP Sormani, G Comi, M Filippi Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging Am J Neuroradiol 23 2002 985 988
    • (2002) Am J Neuroradiol , vol.23 , pp. 985-988
    • Bozzali, M.1    Cercignani, M.2    Sormani, M.P.3    Comi, G.4    Filippi, M.5
  • 101
    • 33747589457 scopus 로고    scopus 로고
    • Whole-brain T1-mapping in multiple sclerosis: Global changes of normal-appearing grey and white matter
    • (in press).
    • Vrenken H, Geurts JJG, Knol DL, et al. Whole-brain T1-mapping in multiple sclerosis: global changes of normal-appearing grey and white matter. Radiology (in press).
    • Radiology
    • Vrenken, H.1    Geurts, J.J.G.2    Knol, D.L.3
  • 102
    • 0037355862 scopus 로고    scopus 로고
    • Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis: A quantitative T1 relaxation time mapping approach
    • L Vaithianathar, CR Tench, PS Morgan, CS Constantinescu Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis: a quantitative T1 relaxation time mapping approach J Neurol 250 2003 307 315
    • (2003) J Neurol , vol.250 , pp. 307-315
    • Vaithianathar, L.1    Tench, C.R.2    Morgan, P.S.3    Constantinescu, C.S.4
  • 103
    • 0026000851 scopus 로고
    • Immunocytochemical localization of N-acetyl aspartate with monoclonal antibodies
    • MS Simmons, CG Frondosa, JT Coyle Immunocytochemical localization of N-acetyl aspartate with monoclonal antibodies Neuroscience 45 1991 37 45
    • (1991) Neuroscience , vol.45 , pp. 37-45
    • Simmons, M.S.1    Frondosa, C.G.2    Coyle, J.T.3
  • 104
    • 0031962941 scopus 로고    scopus 로고
    • Imaging axonal damage of normal-appearing white matter in multiple sclerosis
    • L Fu, PM Matthews, N De Stefano Imaging axonal damage of normal-appearing white matter in multiple sclerosis Brain 121 1998 59 166
    • (1998) Brain , vol.121 , pp. 59-166
    • Fu, L.1    Matthews, P.M.2    De Stefano, N.3
  • 105
    • 0031852514 scopus 로고    scopus 로고
    • Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis: Results of a longitudinal magnetic resonance spectroscopy study
    • N De Stefano, PM Matthews, LQ Fu Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis: results of a longitudinal magnetic resonance spectroscopy study Brain 121 1998 1469 1477
    • (1998) Brain , vol.121 , pp. 1469-1477
    • De Stefano, N.1    Matthews, P.M.2    Fu, L.Q.3
  • 106
    • 0032470810 scopus 로고    scopus 로고
    • Benign versus secondary progressive multiple sclerosis: The potential role of proton MR spectroscopy in defining the nature of disability
    • A Falini, G Calabrese, M Filippi Benign versus secondary progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability Am J Neuroradiol 19 1998 223 229
    • (1998) Am J Neuroradiol , vol.19 , pp. 223-229
    • Falini, A.1    Calabrese, G.2    Filippi, M.3
  • 107
    • 0033595525 scopus 로고    scopus 로고
    • Localized proton magnetic resonance spectroscopy in relapsing remitting versus secondary progressive multiple sclerosis
    • A Tourbah, JL Stievenart, O Gout Localized proton magnetic resonance spectroscopy in relapsing remitting versus secondary progressive multiple sclerosis Neurology 53 1999 1091 1097
    • (1999) Neurology , vol.53 , pp. 1091-1097
    • Tourbah, A.1    Stievenart, J.L.2    Gout, O.3
  • 108
    • 0032985039 scopus 로고    scopus 로고
    • Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients
    • P Sarchielli, O Presciutti, GP Pelliccioli Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients Brain 122 1999 513 521
    • (1999) Brain , vol.122 , pp. 513-521
    • Sarchielli, P.1    Presciutti, O.2    Pelliccioli, G.P.3
  • 109
    • 0035166271 scopus 로고    scopus 로고
    • Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability
    • N De Stefano, S Narayanan, GS Francis Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability Arch Neurol 58 2001 65 70
    • (2001) Arch Neurol , vol.58 , pp. 65-70
    • De Stefano, N.1    Narayanan, S.2    Francis, G.S.3
  • 110
    • 0344392030 scopus 로고    scopus 로고
    • Gray matter N-acetyl aspartate deficits in secondary progressive but not relapsing-remitting multiple sclerosis
    • E Adalsteinsson, A Langer-Gould, RJ Homer Gray matter N-acetyl aspartate deficits in secondary progressive but not relapsing-remitting multiple sclerosis Am J Neuroradiol 24 2003 1941 1945
    • (2003) Am J Neuroradiol , vol.24 , pp. 1941-1945
    • Adalsteinsson, E.1    Langer-Gould, A.2    Homer, R.J.3
  • 112
    • 0033759074 scopus 로고    scopus 로고
    • Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis
    • H Reddy, S Narayanan, R Arnoutelis Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis Brain 123 2000 2314 2320
    • (2000) Brain , vol.123 , pp. 2314-2320
    • Reddy, H.1    Narayanan, S.2    Arnoutelis, R.3
  • 113
    • 0036317943 scopus 로고    scopus 로고
    • Cortical motor reorganization after a single attack of multiple sclerosis
    • P Pantano, GD Iannetti, F Caramia Cortical motor reorganization after a single attack of multiple sclerosis Brain 125 2002 1607 1615
    • (2002) Brain , vol.125 , pp. 1607-1615
    • Pantano, P.1    Iannetti, G.D.2    Caramia, F.3
  • 114
    • 0037177074 scopus 로고    scopus 로고
    • Evidence for widespread movement-associated functional MRI changes in patients with PPMS
    • MA Rocca, PM Matthews, D Caputo Evidence for widespread movement-associated functional MRI changes in patients with PPMS Neurology 58 2002 866 872
    • (2002) Neurology , vol.58 , pp. 866-872
    • Rocca, M.A.1    Matthews, P.M.2    Caputo, D.3
  • 115
    • 0036331333 scopus 로고    scopus 로고
    • Correlations between structural CNS damage and functional MRI changes in primary progressive MS
    • M Filippi, MA Rocca, A Falini Correlations between structural CNS damage and functional MRI changes in primary progressive MS NeuroImage 15 2002 537 546
    • (2002) NeuroImage , vol.15 , pp. 537-546
    • Filippi, M.1    Rocca, M.A.2    Falini, A.3
  • 116
    • 0042925667 scopus 로고    scopus 로고
    • A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis
    • MA Rocca, C Gavazzi, DM Mezzapesa A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis NeuroImage 19 2003 1770 1777
    • (2003) NeuroImage , vol.19 , pp. 1770-1777
    • Rocca, M.A.1    Gavazzi, C.2    Mezzapesa, D.M.3
  • 117
    • 24944571009 scopus 로고    scopus 로고
    • Cortical adaptation in patients with MS: A cross-sectional functional MRI study of disease phenotypes
    • MA Rocca, B Colombo, A Falini Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes Lancet Neurol 4 2005 618 626
    • (2005) Lancet Neurol , vol.4 , pp. 618-626
    • Rocca, M.A.1    Colombo, B.2    Falini, A.3
  • 118
    • 0032494792 scopus 로고    scopus 로고
    • Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis
    • European Study Group on interferon β-1b in secondary progressive MS
    • European Study Group on interferon β-1b in secondary progressive MS Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis Lancet 352 1998 1491 1497
    • (1998) Lancet , vol.352 , pp. 1491-1497
  • 119
    • 0035846587 scopus 로고    scopus 로고
    • Final analysis of the European multicenter trial on IFNβ-1b in secondary-progressive MS
    • L Kappos, C Polman, C Pozzilli, A Thompson, K Beckmann, F Dahlke Final analysis of the European multicenter trial on IFNβ-1b in secondary-progressive MS Neurology 57 2001 1969 1975
    • (2001) Neurology , vol.57 , pp. 1969-1975
    • Kappos, L.1    Polman, C.2    Pozzilli, C.3    Thompson, A.4    Beckmann, K.5    Dahlke, F.6
  • 120
    • 8844285856 scopus 로고    scopus 로고
    • Interferon beta-1b in secondary progressive MS: A combined analysis of the two trials
    • L Kappos, B Weinshenker, C Pozzilli Interferon beta-1b in secondary progressive MS: a combined analysis of the two trials Neurology 63 2004 1779 1787
    • (2004) Neurology , vol.63 , pp. 1779-1787
    • Kappos, L.1    Weinshenker, B.2    Pozzilli, C.3
  • 121
    • 0035960527 scopus 로고    scopus 로고
    • Interferon-β1b in the treatment of secondary progressive MS: Impact on quality of life
    • JA Freeman, AJ Thompson, R Fitzpatrick Interferon-β1b in the treatment of secondary progressive MS: impact on quality of life Neurology 57 2001 1870 1875
    • (2001) Neurology , vol.57 , pp. 1870-1875
    • Freeman, J.A.1    Thompson, A.J.2    Fitzpatrick, R.3
  • 122
    • 0035849496 scopus 로고    scopus 로고
    • Randomized controlled trial of interferon-beta-1a in secondary progressive MS: Clinical results
    • Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-beta-1a in MS (SPECTRIMS) Study Group
    • Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-beta-1a in MS (SPECTRIMS) Study Group Randomized controlled trial of interferon-beta-1a in secondary progressive MS: clinical results Neurology 56 2001 1496 1504
    • (2001) Neurology , vol.56 , pp. 1496-1504
  • 123
    • 8844222623 scopus 로고    scopus 로고
    • Interferon beta-1b in secondary progressive MS: Results from a 3-year controlled study
    • H Panitch, A Miller, D Paty Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study Neurology 63 2004 1788 1795
    • (2004) Neurology , vol.63 , pp. 1788-1795
    • Panitch, H.1    Miller, A.2    Paty, D.3
  • 124
    • 0037056364 scopus 로고    scopus 로고
    • Benefit of interferon beta-1a on MSFC progression in secondary progressive MS
    • JA Cohen, GR Cutter, JS Fischer Benefit of interferon beta-1a on MSFC progression in secondary progressive MS Neurology 59 2002 679 687
    • (2002) Neurology , vol.59 , pp. 679-687
    • Cohen, J.A.1    Cutter, G.R.2    Fischer, J.S.3
  • 125
    • 25144487669 scopus 로고    scopus 로고
    • Increased disability and MRI lesions after discontinuation of IFN-β-1a in secondary progressive MS
    • X Wu, P Dastidar, H Kuusisto, M Ukkonen, H Huhtala, I Elovaara Increased disability and MRI lesions after discontinuation of IFN-β-1a in secondary progressive MS Acta Neurol Scand 112 2005 242 247
    • (2005) Acta Neurol Scand , vol.112 , pp. 242-247
    • Wu, X.1    Dastidar, P.2    Kuusisto, H.3    Ukkonen, M.4    Huhtala, H.5    Elovaara, I.6
  • 126
    • 0036835646 scopus 로고    scopus 로고
    • Intravenous immunoglobulin G for the treatment of relapsing-remitting multiple sclerosis: A meta-analysis
    • PS Sorensen, F Fazekas, M Lee Intravenous immunoglobulin G for the treatment of relapsing-remitting multiple sclerosis: a meta-analysis Eur J Neurol 9 2002 557 563
    • (2002) Eur J Neurol , vol.9 , pp. 557-563
    • Sorensen, P.S.1    Fazekas, F.2    Lee, M.3
  • 127
    • 4644250609 scopus 로고    scopus 로고
    • Intravenous immunoglobulin in secondary progressive multiple sclerosis: Randomised placebo-controlled trial
    • OR Hommes, PS Sorensen, F Fazekas Intravenous immunoglobulin in secondary progressive multiple sclerosis: randomised placebo-controlled trial Lancet 364 2004 1149 1156
    • (2004) Lancet , vol.364 , pp. 1149-1156
    • Hommes, O.R.1    Sorensen, P.S.2    Fazekas, F.3
  • 128
    • 22144491152 scopus 로고    scopus 로고
    • MRI results from the European study on intravenous immunoglobulin in secondary progressive multiple sclerosis (ESIMS)
    • F Fazekas, PS Sorensen, M Filippi MRI results from the European study on intravenous immunoglobulin in secondary progressive multiple sclerosis (ESIMS) Mult Scler 11 2005 433 440
    • (2005) Mult Scler , vol.11 , pp. 433-440
    • Fazekas, F.1    Sorensen, P.S.2    Filippi, M.3
  • 130
    • 0031817597 scopus 로고    scopus 로고
    • A phase II study of i.v. methylprednisolone in secondary-progressive multiple sclerosis
    • DE Goodkin, RP Kinkel, B Weinstock-Guttman A phase II study of i.v. methylprednisolone in secondary-progressive multiple sclerosis Neurology 51 1998 239 245
    • (1998) Neurology , vol.51 , pp. 239-245
    • Goodkin, D.E.1    Kinkel, R.P.2    Weinstock-Guttman, B.3
  • 131
    • 0034791382 scopus 로고    scopus 로고
    • Low-dose oral methotrexate treatment in chronic progressive multiple sclerosis
    • A Lugaresi, C Caporale, D Farina Low-dose oral methotrexate treatment in chronic progressive multiple sclerosis Neurol Sci 22 2001 209 210
    • (2001) Neurol Sci , vol.22 , pp. 209-210
    • Lugaresi, A.1    Caporale, C.2    Farina, D.3
  • 132
    • 0031797485 scopus 로고    scopus 로고
    • Cyclophosphamide in chronic progressive multiple sclerosis: A comparative study
    • L La Mantia, M Eoli, A Salmaggi, V Torri, C Milanese Cyclophosphamide in chronic progressive multiple sclerosis: a comparative study Ital J Neurol Sci 19 1998 32 36
    • (1998) Ital J Neurol Sci , vol.19 , pp. 32-36
    • La Mantia, L.1    Eoli, M.2    Salmaggi, A.3    Torri, V.4    Milanese, C.5
  • 134
    • 0028906384 scopus 로고
    • Low-dose (7.5 mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis
    • DE Goodkin, RA Rudick, S Vanderburg-Medendorp Low-dose (7.5 mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis Ann Neurol 37 1995 30 40
    • (1995) Ann Neurol , vol.37 , pp. 30-40
    • Goodkin, D.E.1    Rudick, R.A.2    Vanderburg-Medendorp, S.3
  • 135
    • 3042515126 scopus 로고    scopus 로고
    • Cyclophosophamide treatment of multiple sclerosis
    • J.A. Cohen R.A. Rudick 2nd edn. Martin Dunitz London
    • DR Smith, HL Weiner Cyclophosophamide treatment of multiple sclerosis JA Cohen RA Rudick Multiple sclerosis therapeutics 2nd edn. 2003 Martin Dunitz London 483 500
    • (2003) Multiple Sclerosis Therapeutics , pp. 483-500
    • Smith, D.R.1    Weiner, H.L.2
  • 136
    • 0025967752 scopus 로고
    • The Canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis
    • The Canadian Cooperative Multiple Sclerosis Study Group
    • The Canadian Cooperative Multiple Sclerosis Study Group The Canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis Lancet 337 1991 441 446
    • (1991) Lancet , vol.337 , pp. 441-446
  • 137
    • 12844251832 scopus 로고    scopus 로고
    • Stabilization of rapidly worsening multiple sclerosis for 36 months in patients treated with interferon beta plus cyclophosphamide followed by interferon beta
    • T Patti, E Reggio, F Palermo Stabilization of rapidly worsening multiple sclerosis for 36 months in patients treated with interferon beta plus cyclophosphamide followed by interferon beta J Neurol 251 2004 1502 1506
    • (2004) J Neurol , vol.251 , pp. 1502-1506
    • Patti, T.1    Reggio, E.2    Palermo, F.3
  • 138
    • 0041846718 scopus 로고    scopus 로고
    • Cyclophosphamide is effective in stabilizing rapidly deteriorating secondary progressive multiple sclerosis
    • P Perini, P Gallo Cyclophosphamide is effective in stabilizing rapidly deteriorating secondary progressive multiple sclerosis J Neurol 250 2003 834 838
    • (2003) J Neurol , vol.250 , pp. 834-838
    • Perini, P.1    Gallo, P.2
  • 139
    • 0037153729 scopus 로고    scopus 로고
    • Mitoxantrone in progressive multiple sclerosis: A placebo-controlled, double-blind, randomised, multicentre trial
    • HP Hartung, R Gonsette, N Konig Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomised, multicentre trial Lancet 360 2002 2018 2025
    • (2002) Lancet , vol.360 , pp. 2018-2025
    • Hartung, H.P.1    Gonsette, R.2    Konig, N.3
  • 140
    • 24644485224 scopus 로고    scopus 로고
    • Effect of mitoxantrone on MRI in progressive MS: Results of the MIMS trial
    • H Krapf, SP Morrissey, O Zenker Effect of mitoxantrone on MRI in progressive MS: results of the MIMS trial Neurology 65 2005 690 695
    • (2005) Neurology , vol.65 , pp. 690-695
    • Krapf, H.1    Morrissey, S.P.2    Zenker, O.3
  • 141
    • 0032882173 scopus 로고    scopus 로고
    • Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis
    • AJ Coles, MG Wing, P Molyneux Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis Ann Neurol 46 1999 296 304
    • (1999) Ann Neurol , vol.46 , pp. 296-304
    • Coles, A.J.1    Wing, M.G.2    Molyneux, P.3
  • 142
    • 0033546980 scopus 로고    scopus 로고
    • Quantitative MRI in patients with secondary progressive MS treated with monoclonal antibody Campath 1H
    • A Paolillo, AJ Coles, P Molyneux Quantitative MRI in patients with secondary progressive MS treated with monoclonal antibody Campath 1H Neurology 53 1999 751 757
    • (1999) Neurology , vol.53 , pp. 751-757
    • Paolillo, A.1    Coles, A.J.2    Molyneux, P.3
  • 143
    • 31544467633 scopus 로고    scopus 로고
    • The window of therapeutic opportunity in multiple sclerosis: Evidence from monoclonal antibody therapy
    • (in press).
    • Coles AJ, Cox A, Le Page E, et al. The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy. J Neurol (in press).
    • J Neurol
    • Coles, A.J.1    Cox, A.2    Le Page, E.3
  • 144
    • 18544374335 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation for multiple sclerosis: A retrospective multicenter study
    • A Fassas, JR Passweg, A Anagnostopoulos Hematopoietic stem cell transplantation for multiple sclerosis: a retrospective multicenter study J Neurol 249 2002 1088 1097
    • (2002) J Neurol , vol.249 , pp. 1088-1097
    • Fassas, A.1    Passweg, J.R.2    Anagnostopoulos, A.3


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