-
1
-
-
60849139085
-
Metabolic enzymes as oncogenes or tumor suppressors
-
Thompson CB: Metabolic enzymes as oncogenes or tumor suppressors. N Engl J Med 2009, 360:813-815
-
(2009)
N Engl J Med
, vol.360
, pp. 813-815
-
-
Thompson, C.B.1
-
2
-
-
77957192661
-
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: Prevalence and prognostic value
-
Abbas S, Lugthart S, Kavelaars FG, Schelen A, Koenders J, Zeilemaker A, van Putten WJ, Rijneveld A, Lowenberg B, Valk PJ: Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. Blood 2010, 116:2122-2126
-
(2010)
Blood
, vol.116
, pp. 2122-2126
-
-
Abbas, S.1
Lugthart, S.2
Kavelaars, F.G.3
Schelen, A.4
Koenders, J.5
Zeilemaker, A.6
Van Putten, W.J.7
Rijneveld, A.8
Lowenberg, B.9
Valk, P.J.10
-
3
-
-
76549109434
-
Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
-
Abdel-Wahab O, Manshouri T, Patel J, Harris K, Yao J, Hedvat C, Heguy A, Bueso-Ramos C, Kantarjian H, Levine RL, Verstovsek S: Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res 2010, 70:447-452
-
(2010)
Cancer Res
, vol.70
, pp. 447-452
-
-
Abdel-Wahab, O.1
Manshouri, T.2
Patel, J.3
Harris, K.4
Yao, J.5
Hedvat, C.6
Heguy, A.7
Bueso-Ramos, C.8
Kantarjian, H.9
Levine, R.L.10
Verstovsek, S.11
-
4
-
-
77957814608
-
IDH1 R132H mutation is a rare event in myeloproliferative neoplasms as determined by a mutation specific antibody
-
Andrulis M, Capper D, Meyer J, Penzel R, Hartmann C, Zentgraf H, von Deimling A: IDH1 R132H mutation is a rare event in myeloproliferative neoplasms as determined by a mutation specific antibody. Haematologica 2010, 95:1797-1798
-
(2010)
Haematologica
, vol.95
, pp. 1797-1798
-
-
Andrulis, M.1
Capper, D.2
Meyer, J.3
Penzel, R.4
Hartmann, C.5
Zentgraf, H.6
Von Deimling, A.7
-
5
-
-
77950968519
-
Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation
-
Chou WC, Hou HA, Chen CY, Tang JL, Yao M, Tsay W, Ko BS, Wu SJ, Huang SY, Hsu SC, Chen YC, Huang YN, Chang YC, Lee FY, Liu MC, Liu CW, Tseng MH, Huang CF, Tien HF: Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation. Blood 2010, 115:2749-2754
-
(2010)
Blood
, vol.115
, pp. 2749-2754
-
-
Chou, W.C.1
Hou, H.A.2
Chen, C.Y.3
Tang, J.L.4
Yao, M.5
Tsay, W.6
Ko, B.S.7
Wu, S.J.8
Huang, S.Y.9
Hsu, S.C.10
Chen, Y.C.11
Huang, Y.N.12
Chang, Y.C.13
Lee, F.Y.14
Liu, M.C.15
Liu, C.W.16
Tseng, M.H.17
Huang, C.F.18
Tien, H.F.19
-
6
-
-
75449119103
-
Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms
-
Green A, Beer P: Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms. N Engl J Med 2010, 362:369-370
-
(2010)
N Engl J Med
, vol.362
, pp. 369-370
-
-
Green, A.1
Beer, P.2
-
7
-
-
77952424259
-
Molecular alterations of the IDH1 gene in AML: A Children's Oncology Group and Southwest Oncology Group study
-
Ho PA, Alonzo TA, Kopecky KJ, Miller KL, Kuhn J, Zeng R, Gerbing RB, Raimondi SC, Hirsch BA, Oehler V, Hurwitz CA, Franklin JL, Gamis AS, Petersdorf SH, Anderson JE, Reaman GH, Baker LH, Willman CL, Bernstein ID, Radich JP, Appelbaum FR, Stirewalt DL, Meshinchi S: Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study. Leukemia 2010, 24:909-913
-
(2010)
Leukemia
, vol.24
, pp. 909-913
-
-
Ho, P.A.1
Alonzo, T.A.2
Kopecky, K.J.3
Miller, K.L.4
Kuhn, J.5
Zeng, R.6
Gerbing, R.B.7
Raimondi, S.C.8
Hirsch, B.A.9
Oehler, V.10
Hurwitz, C.A.11
Franklin, J.L.12
Gamis, A.S.13
Petersdorf, S.H.14
Anderson, J.E.15
Reaman, G.H.16
Baker, L.H.17
Willman, C.L.18
Bernstein, I.D.19
Radich, J.P.20
Appelbaum, F.R.21
Stirewalt, D.L.22
Meshinchi, S.23
more..
-
8
-
-
77952536841
-
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
-
Marcucci G, Maharry K, Wu YZ, Radmacher MD, Mrozek K, Margeson D, Holland KB, Whitman SP, Becker H, Schwind S, Metzeler KH, Powell BL, Carter TH, Kolitz JE, Wetzler M, Carroll AJ, Baer MR, Caligiuri MA, Larson RA, Bloomfield CD: IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2010, 28:2348-2355
-
(2010)
J Clin Oncol
, vol.28
, pp. 2348-2355
-
-
Marcucci, G.1
Maharry, K.2
Wu, Y.Z.3
Radmacher, M.D.4
Mrozek, K.5
Margeson, D.6
Holland, K.B.7
Whitman, S.P.8
Becker, H.9
Schwind, S.10
Metzeler, K.H.11
Powell, B.L.12
Carter, T.H.13
Kolitz, J.E.14
Wetzler, M.15
Carroll, A.J.16
Baer, M.R.17
Caligiuri, M.A.18
Larson, R.A.19
Bloomfield, C.D.20
more..
-
9
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, et al.: Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009, 361:1058-1066
-
(2009)
N Engl J Med
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
Larson, D.E.4
McLellan, M.D.5
Chen, K.6
-
10
-
-
77954573304
-
IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms
-
Pardanani A, Lasho TL, Finke CM, Mai M, McClure RF, Tefferi A: IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms. Leukemia 2010, 24:1146-1151
-
(2010)
Leukemia
, vol.24
, pp. 1146-1151
-
-
Pardanani, A.1
Lasho, T.L.2
Finke, C.M.3
Mai, M.4
McClure, R.F.5
Tefferi, A.6
-
11
-
-
77955907891
-
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
-
Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Kronke J, Bullinger L, Spath D, Kayser S, Zucknick M, Gotze K, Horst HA, Germing U, Dohner H, Dohner K: IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010, 28: 3636-3643
-
(2010)
J Clin Oncol
, vol.28
, pp. 3636-3643
-
-
Paschka, P.1
Schlenk, R.F.2
Gaidzik, V.I.3
Habdank, M.4
Kronke, J.5
Bullinger, L.6
Spath, D.7
Kayser, S.8
Zucknick, M.9
Gotze, K.10
Horst, H.A.11
Germing, U.12
Dohner, H.13
Dohner, K.14
-
12
-
-
77954658823
-
IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
-
Tefferi A, Lasho TL, Abdel-Wahab O, Guglielmelli P, Patel J, Caramazza D, Pieri L, Finke CM, Kilpivaara O, Wadleigh M, Mai M, McClure RF, Gilliland DG, Levine RL, Pardanani A, Vannucchi AM: IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia 2010, 24:1302-1309
-
(2010)
Leukemia
, vol.24
, pp. 1302-1309
-
-
Tefferi, A.1
Lasho, T.L.2
Abdel-Wahab, O.3
Guglielmelli, P.4
Patel, J.5
Caramazza, D.6
Pieri, L.7
Finke, C.M.8
Kilpivaara, O.9
Wadleigh, M.10
Mai, M.11
McClure, R.F.12
Gilliland, D.G.13
Levine, R.L.14
Pardanani, A.15
Vannucchi, A.M.16
-
13
-
-
77956050251
-
Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia
-
Thol F, Damm F, Wagner K, Gohring G, Schlegelberger B, Hoelzer D, Lubbert M, Heit W, Kanz L, Schlimok G, Raghavachar A, Fiedler W, Kirchner H, Heil G, Heuser M, Krauter J, Ganser A: Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. Blood 2010, 116:614-616
-
(2010)
Blood
, vol.116
, pp. 614-616
-
-
Thol, F.1
Damm, F.2
Wagner, K.3
Gohring, G.4
Schlegelberger, B.5
Hoelzer, D.6
Lubbert, M.7
Heit, W.8
Kanz, L.9
Schlimok, G.10
Raghavachar, A.11
Fiedler, W.12
Kirchner, H.13
Heil, G.14
Heuser, M.15
Krauter, J.16
Ganser, A.17
-
14
-
-
77957806536
-
IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis
-
Thol F, Weissinger EM, Krauter J, Wagner K, Damm F, Wichmann M, Göhring G, Schumann C, Bug G, Ottmann O, Hofmann WK, Schlegelberger B, Ganser A, Heuser M: IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis. Haematologica 2010, 95:1668-1674
-
(2010)
Haematologica
, vol.95
, pp. 1668-1674
-
-
Thol, F.1
Weissinger, E.M.2
Krauter, J.3
Wagner, K.4
Damm, F.5
Wichmann, M.6
Göhring, G.7
Schumann, C.8
Bug, G.9
Ottmann, O.10
Hofmann, W.K.11
Schlegelberger, B.12
Ganser, A.13
Heuser, M.14
-
15
-
-
77952481300
-
Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor
-
Wagner K, Damm F, Gohring G, Gorlich K, Heuser M, Schafer I, Ottmann O, Lubbert M, Heit W, Kanz L, Schlimok G, Raghavachar AA, Fiedler W, Kirchner HH, Brugger W, Zucknick M, Schlegelberger B, Heil G, Ganser A, Krauter J: Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: sNP rs11554137 is an adverse prognostic factor. J Clin Oncol 2010, 28:2356-2364
-
(2010)
J Clin Oncol
, vol.28
, pp. 2356-2364
-
-
Wagner, K.1
Damm, F.2
Gohring, G.3
Gorlich, K.4
Heuser, M.5
Schafer, I.6
Ottmann, O.7
Lubbert, M.8
Heit, W.9
Kanz, L.10
Schlimok, G.11
Raghavachar, A.A.12
Fiedler, W.13
Kirchner, H.H.14
Brugger, W.15
Zucknick, M.16
Schlegelberger, B.17
Heil, G.18
Ganser, A.19
Krauter, J.20
more..
-
16
-
-
77952426827
-
Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms
-
Kosmider O, Gelsi-Boyer V, Slama L, Dreyfus F, Beyne-Rauzy O, Quesnel B, Hunault-Berger M, Slama B, Vey N, Lacombe C, Solary E, Birnbaum D, Bernard OA, Fontenay M: Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms. Leukemia 2010, 24: 1094-1096
-
(2010)
Leukemia
, vol.24
, pp. 1094-1096
-
-
Kosmider, O.1
Gelsi-Boyer, V.2
Slama, L.3
Dreyfus, F.4
Beyne-Rauzy, O.5
Quesnel, B.6
Hunault-Berger, M.7
Slama, B.8
Vey, N.9
Lacombe, C.10
Solary, E.11
Birnbaum, D.12
Bernard, O.A.13
Fontenay, M.14
-
17
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010, 17:225-234
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
Cross, J.R.7
Fantin, V.R.8
Hedvat, C.V.9
Perl, A.E.10
Rabinowitz, J.D.11
Carroll, M.12
Su, S.M.13
Sharp, K.A.14
Levine, R.L.15
Thompson, C.B.16
-
18
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009, 462:739-744
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
Fantin, V.R.7
Jang, H.G.8
Jin, S.9
Keenan, M.C.10
Marks, K.M.11
Prins, R.M.12
Ward, P.S.13
Yen, K.E.14
Liau, L.M.15
Rabinowitz, J.D.16
Cantley, L.C.17
Thompson, C.B.18
Vander Heiden, M.G.19
Su, S.M.20
more..
-
19
-
-
79251510890
-
Acute myeloid leukemia with IDH1 or IDH2 mutations: Frequency and clinicopathologic features
-
Patel KP, Ravandi F, Ma D, Paladugu A, Barkoh BA, Medeiros LJ, Luthra R: Acute myeloid leukemia with IDH1 or IDH2 mutations: frequency and clinicopathologic features. Am J of Clin Path 2011, 135:35-45
-
(2011)
Am J of Clin Path
, vol.135
, pp. 35-45
-
-
Patel, K.P.1
Ravandi, F.2
Ma, D.3
Paladugu, A.4
Barkoh, B.A.5
Medeiros, L.J.6
Luthra, R.7
-
20
-
-
34547567980
-
OligoCalc: An online oligonucleotide properties calculator
-
Kibbe WA: OligoCalc: an online oligonucleotide properties calculator. Nucleic Acids Res 2007, 35:W43-W46
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Kibbe, W.A.1
-
21
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD: IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009, 360:765-773
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
McLendon, R.4
Rasheed, B.A.5
Yuan, W.6
Kos, I.7
Batinic-Haberle, I.8
Jones, S.9
Riggins, G.J.10
Friedman, H.11
Friedman, A.12
Reardon, D.13
Herndon, J.14
Kinzler, K.W.15
Velculescu, V.E.16
Vogelstein, B.17
Bigner, D.D.18
-
22
-
-
77953028158
-
Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing
-
Felsberg J, Wolter M, Seul H, Friedensdorf B, Goppert M, Sabel MC, Reifenberger G: Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing. Acta Neuropathol 2010, 119:501-507
-
(2010)
Acta Neuropathol
, vol.119
, pp. 501-507
-
-
Felsberg, J.1
Wolter, M.2
Seul, H.3
Friedensdorf, B.4
Goppert, M.5
Sabel, M.C.6
Reifenberger, G.7
-
23
-
-
77954357852
-
Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies
-
Horbinski C, Kelly L, Nikiforov YE, Durso MB, Nikiforova MN: Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies. J Mol Diagn 2010, 12:487-492
-
(2010)
J Mol Diagn
, vol.12
, pp. 487-492
-
-
Horbinski, C.1
Kelly, L.2
Nikiforov, Y.E.3
Durso, M.B.4
Nikiforova, M.N.5
-
24
-
-
73349109131
-
Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues
-
Horbinski C, Kofler J, Kelly LM, Murdoch GH, Nikiforova MN: Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues. J Neuropathol Exp Neurol 2009, 68:1319-1325
-
(2009)
J Neuropathol Exp Neurol
, vol.68
, pp. 1319-1325
-
-
Horbinski, C.1
Kofler, J.2
Kelly, L.M.3
Murdoch, G.H.4
Nikiforova, M.N.5
-
25
-
-
75949103649
-
PCR- and restriction endonucleasebased detection of IDH1 mutations
-
Meyer J, Pusch S, Balss J, Capper D, Mueller W, Christians A, Hartmann C, von Deimling A: PCR- and restriction endonucleasebased detection of IDH1 mutations. Brain Pathol 2009, 20:298-300
-
(2009)
Brain Pathol
, vol.20
, pp. 298-300
-
-
Meyer, J.1
Pusch, S.2
Balss, J.3
Capper, D.4
Mueller, W.5
Christians, A.6
Hartmann, C.7
Von Deimling, A.8
-
26
-
-
65349150503
-
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
-
Watanabe T, Nobusawa S, Kleihues P, Ohgaki H: IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol 2009, 174:1149-1153
-
(2009)
Am J Pathol
, vol.174
, pp. 1149-1153
-
-
Watanabe, T.1
Nobusawa, S.2
Kleihues, P.3
Ohgaki, H.4
-
27
-
-
66349095408
-
High-resolution DNA melting analysis: Advancements and limitations
-
Wittwer CT: High-resolution DNA melting analysis: advancements and limitations. Hum Mutat 2009, 30:857-859
-
(2009)
Hum Mutat
, vol.30
, pp. 857-859
-
-
Wittwer, C.T.1
-
28
-
-
77149152775
-
Segregation of non-p.R132H mutations in IDH1 in distinct molecular subtypes of glioma
-
Gravendeel LA, Kloosterhof NK, Bralten LB, van Marion R, Dubbink HJ, Dinjens W, Bleeker FE, Hoogenraad CC, Michiels E, Kros JM, van den Bent M, Smitt PA, French PJ: Segregation of non-p.R132H mutations in IDH1 in distinct molecular subtypes of glioma. Hum Mutat 2010, 31:E1186-E1199
-
(2010)
Hum Mutat
, vol.31
-
-
Gravendeel, L.A.1
Kloosterhof, N.K.2
Bralten, L.B.3
Van Marion, R.4
Dubbink, H.J.5
Dinjens, W.6
Bleeker, F.E.7
Hoogenraad, C.C.8
Michiels, E.9
Kros, J.M.10
Van Den Bent, M.11
Smitt, P.A.12
French, P.J.13
-
29
-
-
66349115872
-
Diagnostic guidelines for high resolution melting curve analysis: An interlaboratory validation of BRCA1 mutation scanning using the 96-well LightScanner
-
van der Stoep N, van Paridon CDM, Janssens T, Krenkova P, Stambergova A, Macek M, Matthijs G, Bakker E: Diagnostic guidelines for high resolution melting curve analysis: an interlaboratory validation of BRCA1 mutation scanning using the 96-well LightScanner. Hum Mutat 2009, 30:899-909
-
(2009)
Hum Mutat
, vol.30
, pp. 899-909
-
-
Van Der Stoep, N.1
Van Paridon, C.D.M.2
Janssens, T.3
Krenkova, P.4
Stambergova, A.5
Macek, M.6
Matthijs, G.7
Bakker, E.8
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