A single-tube, sensitive multiplex method for screening of isocitrate dehydrogenase 1 (IDH1) mutations

Blood

Volumn 116, Issue 3, 2010, Pages 495-496

  Chou, Wen Chien ^a   Huang, Yen Ning ^a   Huang, Chi Fei ^a   Tseng, Mei Hsuan ^a   Tien, Hwei Fang ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 1; UNCLASSIFIED DRUG; DNA; IDH1 PROTEIN, HUMAN; PRIMER DNA;

ACUTE GRANULOCYTIC LEUKEMIA; CHRONIC MYELOMONOCYTIC LEUKEMIA; GENE MUTATION; GENE SEQUENCE; HUMAN; LETTER; MULTIPLEX POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REFRACTORY ANEMIA WITH RINGED SIDEROBLASTS; SENSITIVITY ANALYSIS; ENZYMOLOGY; GENETICS; METHODOLOGY; MYELODYSPLASTIC SYNDROME; NOTE; NUCLEOTIDE SEQUENCE; POINT MUTATION; POLYMERASE CHAIN REACTION; STATISTICS;

BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; DNA, NEOPLASM; HUMANS; ISOCITRATE DEHYDROGENASE; LEUKEMIA, MYELOID, ACUTE; MYELODYSPLASTIC SYNDROMES; POINT MUTATION; POLYMERASE CHAIN REACTION;

EID: 77955885249     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-04-280636     Document Type: Letter

References (9)

1. Chou WC, Hou HA, Chen CY, et al. Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation. Blood. 2010;115(14):2749-2754.
2. Ward PS, Patel J, Wise DR, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010;17(3):225-234.
3. Wagner K, Damm F, Gohring G, et al. Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor. J Clin Oncol. 2010;28(14):2356-2364.
4. Marcucci G, Maharry K, Wu YZ, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2010;28(14):2348-2355.
5. Kosmider O, Gelsi-Boyer V, Slama L, et al. Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms. Leukemia. 2010;24(5):1094-1096.
6. Ho PA, Alonzo TA, Kopecky KJ, et al. Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study. Leukemia. 2010;24(5):903-913.
7. Green A, Beer P. Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms. N Engl J Med. 2010;362(4):369-370.
8. Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360(8):765-773.
9. Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009;361(11):1058- 1066.