Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 11, 2013, Pages 2359-2368

  Befani, Christina ^a   Mylonis, Ilias ^a   Gkotinakou, Ioanna Maria ^a   Georgoulias, Panagiotis ^a   Hu, Cheng Jun ^b   Simos, George ^a   Liakos, Panagiotis ^a  

^a UNIVERSITY OF THESSALY   (Greece)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Cobalt; EPO; HIF 2 ; Hypoxia; SOD2; USF2

Indexed keywords

COBALT; HYPOXIA INDUCIBLE FACTOR 1; 1-PHENYL-2-PALMITOYLAMINO-3-PYRROLIDINO-1-PROPANOL; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; COBALT CHLORIDE; DEFEROXAMINE; DICARBOXYLIC AMINO ACID; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; ERYTHROPOIETIN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; OXALYLGLYCINE; PGK1 PROTEIN, HUMAN; PHOSPHOGLYCERATE KINASE; PROPANOLAMINE DERIVATIVE; PROTEIN BINDING; PYRROLIDINE DERIVATIVE; SUPEROXIDE DISMUTASE; UPSTREAM STIMULATORY FACTOR; USF2 PROTEIN, HUMAN;

ARTICLE; CANCER CELL; CELL HYPOXIA; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; LIVER CANCER; PROMOTER REGION; ANTAGONISTS AND INHIBITORS; CELL NUCLEUS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIVER TUMOR; METABOLISM; PATHOLOGY; SECRETION (PROCESS); TUMOR CELL LINE;

AMINO ACIDS, DICARBOXYLIC; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CELL LINE, TUMOR; CELL NUCLEUS; COBALT; DEFEROXAMINE; ERYTHROPOIETIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; PHOSPHOGLYCERATE KINASE; PROMOTER REGIONS, GENETIC; PROPANOLAMINES; PROTEIN BINDING; PYRROLIDINES; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TRANSCRIPTION, GENETIC; UPSTREAM STIMULATORY FACTORS;

EID: 84883506031     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.07.025     Document Type: Article

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