Novel small-molecule inhibitors of Bcl-XL to treat lung cancer

Cancer Research

Volumn 73, Issue 17, 2013, Pages 5485-5496

  Park, Dongkyoo ^a   Magis, Andrew T ^b   Li, Rui ^a   Owonikoko, Taofeek K ^a   Sica, Gabriel L ^a   Sun, Shi Yong ^a   Ramalingam, Suresh S ^a   Khuri, Fadlo R ^a   Curran, Walter J ^a   Deng, Xingming ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BCL2 RELATED PROTEIN A1; BXI 61; BXI 72; CYTOCHROME C; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL; PROTEIN INHIBITOR; PROTEIN MCL 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BRONCHUS MUCOSA; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME RELEASE; EPITHELIUM CELL; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOPENIA; LUNG CANCER; MITOCHONDRION; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; RADIOSENSITIVITY; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTOPENIA; WEIGHT REDUCTION;

ACRIDINES; AMINOPYRIDINES; ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; BENZIMIDAZOLES; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CELL PROLIFERATION; CYTOCHROMES C; FEMALE; HUMANS; LUNG; LUNG NEOPLASMS; MICE; MICE, NUDE; NITROPHENOLS; PIPERAZINES; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION TOLERANCE; RADIATION, IONIZING; SMALL MOLECULE LIBRARIES; SULFONAMIDES; SURVIVAL RATE;

EID: 84883472162     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-2272     Document Type: Article

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