-
1
-
-
79953709986
-
Targeting the mTOR kinase domain: The second generation of mTOR inhibitors
-
Zhang YJ, Duan Y, Zheng XF. Targeting the mTOR kinase domain: the second generation of mTOR inhibitors. Drug Discov Today 2011;16:325-31.
-
(2011)
Drug Discov Today
, vol.16
, pp. 325-331
-
-
Zhang, Y.J.1
Duan, Y.2
Zheng, X.F.3
-
2
-
-
78650647490
-
A comprehensive map of the mTOR signaling network
-
Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage D, Therrien M, Lemieux S, et al. A comprehensive map of the mTOR signaling network. Mol Syst Biol 2010;6:453.
-
(2010)
Mol Syst Biol
, vol.6
, pp. 453
-
-
Caron, E.1
Ghosh, S.2
Matsuoka, Y.3
Ashton-Beaucage, D.4
Therrien, M.5
Lemieux, S.6
-
3
-
-
2942724235
-
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 2004;10:594-601.
-
(2004)
Nat Med
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
Berger, R.4
Xue, Q.5
McMahon, L.M.6
-
4
-
-
37049010979
-
Targeting protein translation in human non-small cell lung cancer via combined MEK and mammalian target of rapamycin suppression
-
DOI 10.1158/0008-5472.CAN-07-0702
-
Legrier ME, Yang CP, Yan HG, Lopez-Barcons L, Keller SM, Perez-Soler R, et al. Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression. Cancer Res 2007;67:11300-8. (Pubitemid 350248556)
-
(2007)
Cancer Research
, vol.67
, Issue.23
, pp. 11300-11308
-
-
Legrier, M.-E.1
Yang, C.-P.H.2
Yan, H.-G.3
Lopez-Barcons, L.4
Keller, S.M.5
Perez-Soler, R.6
Horwitz, S.B.7
McDaid, H.M.8
-
5
-
-
34547683568
-
Rationale for a phase I trial of erlotinib and the mammalian target of rapamycin inhibitor everolimus (RAD001) for patients with relapsed non small cell lung cancer
-
Johnson BE, Jackman D, Janne PA. Rationale for a phase I trial of erlotinib and the mammalian target of rapamycin inhibitor everolimus (RAD001) for patients with relapsed non small cell lung cancer. Clin Cancer Res 2007;13:s4628-31.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Johnson, B.E.1
Jackman, D.2
Janne, P.A.3
-
6
-
-
54749095517
-
Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation
-
Wang X, Yue P, Kim YA, Fu H, Khuri FR, Sun SY. Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation. Cancer Res 2008;68:7409-18.
-
(2008)
Cancer Res
, vol.68
, pp. 7409-7418
-
-
Wang, X.1
Yue, P.2
Kim, Y.A.3
Fu, H.4
Khuri, F.R.5
Sun, S.Y.6
-
7
-
-
48749099976
-
Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins
-
Wangpaichitr M, Wu C, You M, Kuo MT, Feun L, Lampidis T, et al. Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins. Eur J Pharmacol 2008;591:124-7.
-
(2008)
Eur J Pharmacol
, vol.591
, pp. 124-127
-
-
Wangpaichitr, M.1
Wu, C.2
You, M.3
Kuo, M.T.4
Feun, L.5
Lampidis, T.6
-
8
-
-
74849131091
-
Targeting mTOR globally in cancer: Thinking beyond rapamycin
-
Shor B, Gibbons JJ, Abraham RT, Yu K. Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle 2009;8:3831-7.
-
(2009)
Cell Cycle
, vol.8
, pp. 3831-3837
-
-
Shor, B.1
Gibbons, J.J.2
Abraham, R.T.3
Yu, K.4
-
9
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
DOI 10.1158/0008-5472.CAN-05-0917
-
Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, et al. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 2005;65:7052-8. (Pubitemid 41161231)
-
(2005)
Cancer Research
, vol.65
, Issue.16
, pp. 7052-7058
-
-
Sun, S.-Y.1
Rosenberg, L.M.2
Wang, X.3
Zhou, Z.4
Yue, P.5
Fu, H.6
Khuri, F.R.7
-
10
-
-
58149136153
-
Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy
-
Wang X, Hawk N, Yue P, Kauh J, Ramalingam SS, Fu H, et al. Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy. Cancer Biol Ther 2008;7:1952-8.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1952-1958
-
-
Wang, X.1
Hawk, N.2
Yue, P.3
Kauh, J.4
Ramalingam, S.S.5
Fu, H.6
-
11
-
-
32944457518
-
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
DOI 10.1158/0008-5472.CAN-05-2925
-
O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66:1500-8. (Pubitemid 43259931)
-
(2006)
Cancer Research
, vol.66
, Issue.3
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.-B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hofmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
Baselga, J.11
Rosen, N.12
-
12
-
-
0032146987
-
Bcl-2-family proteins: The role of the BH3 domain in apoptosis
-
DOI 10.1016/S0962-8924(98)01321-X
-
Kelekar A, Thompson CB. Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol 1998;8:324-30. (Pubitemid 28362590)
-
(1998)
Trends in Cell Biology
, vol.8
, Issue.8
, pp. 324-330
-
-
Kelekar, A.1
Thompson, C.B.2
-
13
-
-
13944277343
-
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
-
DOI 10.1016/j.molcel.2005.02.003
-
Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, et al. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 2005;17:525-35. (Pubitemid 40269117)
-
(2005)
Molecular Cell
, vol.17
, Issue.4
, pp. 525-535
-
-
Kuwana, T.1
Bouchier-Hayes, L.2
Chipuk, J.E.3
Bonzon, C.4
Sullivan, B.A.5
Green, D.R.6
Newmeyer, D.D.7
-
14
-
-
29144463145
-
The multidomain proapoptotic molecules Bax and Bak are directly activated by heat
-
DOI 10.1073/pnas.0506712102
-
Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM, et al. The multidomain proapoptotic molecules Bax and Bak are directly activated by heat. Proc Natl Acad Sci U S A 2005;102:17975-80. (Pubitemid 41798487)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.50
, pp. 17975-17980
-
-
Pagliari, L.J.1
Kuwana, T.2
Bonzon, C.3
Newmeyer, D.D.4
Tu, S.5
Beere, H.M.6
Green, D.R.7
-
15
-
-
68149107692
-
BAD: Undertaker by night, candyman by day
-
Danial NN. BAD: undertaker by night, candyman by day. Oncogene 2008;27 (Suppl 1):S53-70.
-
(2008)
Oncogene
, vol.27
, Issue.SUPPL. 1
-
-
Danial, N.N.1
-
16
-
-
74049125266
-
BH3-only proteins: The death-puppeteer's wires
-
Ghiotto F, Fais F, Bruno S. BH3-only proteins: the death-puppeteer's wires. Cytometry A 2010;77:11-21.
-
(2010)
Cytometry A
, vol.77
, pp. 11-21
-
-
Ghiotto, F.1
Fais, F.2
Bruno, S.3
-
17
-
-
0033635733
-
BH3-Only proteins-essential initiators of apoptotic cell death
-
Huang DC, Strasser A. BH3-Only proteins-essential initiators of apoptotic cell death. Cell 2000;103:839-42.
-
(2000)
Cell
, vol.103
, pp. 839-842
-
-
Huang, D.C.1
Strasser, A.2
-
18
-
-
0035886878
-
L but not Bcl-2
-
DOI 10.1042/0264-6021:3590345
-
Hirai I, Wang HG. Survival-factor-induced phosphorylation of Bad results in its dissociation from Bcl-x(L) but not Bcl-2. Biochem J 2001;359:345-52. (Pubitemid 32999778)
-
(2001)
Biochemical Journal
, vol.359
, Issue.2
, pp. 345-352
-
-
Hirai, I.1
Wang, H.-G.2
-
19
-
-
0034682812
-
BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival
-
Tan Y, Demeter MR, Ruan H, Comb MJ. BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival. J Biol Chem 2000;275:25865-9.
-
(2000)
J Biol Chem
, vol.275
, pp. 25865-25869
-
-
Tan, Y.1
Demeter, M.R.2
Ruan, H.3
Comb, M.J.4
-
20
-
-
0036849099
-
Survival signaling goes BAD
-
DOI 10.1016/S1534-5807(02)00328-3
-
Bergmann A. Survival signaling goes BAD. Dev Cell 2002;3:607-8. (Pubitemid 35339476)
-
(2002)
Developmental Cell
, vol.3
, Issue.5
, pp. 607-608
-
-
Bergmann, A.1
-
21
-
-
0033635235
-
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
-
Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, et al. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 2000;6:41-51.
-
(2000)
Mol Cell
, vol.6
, pp. 41-51
-
-
Datta, S.R.1
Katsov, A.2
Hu, L.3
Petros, A.4
Fesik, S.W.5
Yaffe, M.B.6
-
22
-
-
0030584088
-
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
-
DOI 10.1016/S0092-8674(00)81382-3
-
Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 1996;87:619-28. (Pubitemid 26386936)
-
(1996)
Cell
, vol.87
, Issue.4
, pp. 619-628
-
-
Zha, J.1
Harada, H.2
Yang, E.3
Jockel, J.4
Korsmeyer, S.J.5
-
23
-
-
0032747134
-
Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase
-
Scheid MP, Schubert KM, Duronio V. Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase. J Biol Chem 1999;274:31108-13.
-
(1999)
J Biol Chem
, vol.274
, pp. 31108-31113
-
-
Scheid, M.P.1
Schubert, K.M.2
Duronio, V.3
-
24
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
DOI 10.1126/science.275.5300.661
-
Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997;275:661-5. (Pubitemid 27061332)
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
25
-
-
0034326803
-
Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin
-
Hayakawa J, Ohmichi M, Kurachi H, Kanda Y, Hisamoto K, Nishio Y, et al. Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin. Cancer Res 2000;60:5988-94.
-
(2000)
Cancer Res
, vol.60
, pp. 5988-5994
-
-
Hayakawa, J.1
Ohmichi, M.2
Kurachi, H.3
Kanda, Y.4
Hisamoto, K.5
Nishio, Y.6
-
26
-
-
0030959304
-
Bcl-2 phosphorylation required for anti-apoptosis function
-
DOI 10.1074/jbc.272.18.11671
-
Ito T, Deng X, Carr B, May WS. Bcl-2 phosphorylation required for antiapoptosis function. J Biol Chem 1997;272:11671-3. (Pubitemid 27202724)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.18
, pp. 11671-11673
-
-
Ito, T.1
Deng, X.2
Carr, B.3
May, W.S.4
-
27
-
-
56249149266
-
Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells
-
Lin Y, Liu X, Yue P, Benbrook DM, Berlin KD, Khuri FR, et al. Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells. Mol Cancer Ther 2008;7:3556-65.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3556-3565
-
-
Lin, Y.1
Liu, X.2
Yue, P.3
Benbrook, D.M.4
Berlin, K.D.5
Khuri, F.R.6
-
28
-
-
33845738765
-
Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells
-
DOI 10.1158/0008-5472.CAN-06-2471
-
Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res 2006;66:11115-9. (Pubitemid 46009936)
-
(2006)
Cancer Research
, vol.66
, Issue.23
, pp. 11115-11119
-
-
Liu, X.1
Yue, P.2
Schonthal, A.H.3
Khuri, F.R.4
Sun, S.-Y.5
-
29
-
-
4544305469
-
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation
-
DOI 10.1074/jbc.M404056200
-
Jin Z, Gao F, Flagg T, Deng X. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. J Biol Chem 2004;279:40209-19. (Pubitemid 39258297)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.38
, pp. 40209-40219
-
-
Jin, Z.1
Gao, F.2
Flagg, T.3
Deng, X.4
-
30
-
-
0035853811
-
Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells
-
Antonsson B, Montessuit S, Sanchez B, Martinou JC. Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J Biol Chem 2001;276:11615-23.
-
(2001)
J Biol Chem
, vol.276
, pp. 11615-11623
-
-
Antonsson, B.1
Montessuit, S.2
Sanchez, B.3
Martinou, J.C.4
-
31
-
-
0035736487
-
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
-
DOI 10.1038/ncb1101-973
-
Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol 2001;3:973-82. (Pubitemid 34428742)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.11
, pp. 973-982
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Zou, Y.4
Spohn, B.5
Hung, M.-C.6
-
32
-
-
0030731915
-
Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells
-
Sun SY, Yue P, Dawson MI, Shroot B, Michel S, Lamph WW, et al. Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res 1997;57:4931-9. (Pubitemid 27469005)
-
(1997)
Cancer Research
, vol.57
, Issue.21
, pp. 4931-4939
-
-
Sun, S.-Y.1
Yue, P.2
Dawson, M.I.3
Shroot, B.4
Michel, S.5
Lamph, W.W.6
Heyman, R.A.7
Teng, M.8
Chandraratna, R.A.S.9
Shudo, K.10
Hong, W.K.11
Lotan, R.12
-
33
-
-
34347230544
-
Sulforhodamine B colorimetric assay for cytotoxicity screening
-
Vichai V, Kirtikara K. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc 2006;1:1112-6.
-
(2006)
Nat Protoc
, vol.1
, pp. 1112-1116
-
-
Vichai, V.1
Kirtikara, K.2
-
34
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
DOI 10.1038/nature03579
-
Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005;435:677-81. (Pubitemid 40825512)
-
(2005)
Nature
, vol.435
, Issue.7042
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
Joseph, M.K.11
Kitada, S.12
Korsmeyer, S.J.13
Kunzer, A.R.14
Letai, A.15
Li, C.16
Mitten, M.J.17
Nettesheim, D.G.18
Ng, S.19
Nimmer, P.M.20
O'Connor, J.M.21
Oleksijew, A.22
Petros, A.M.23
Reed, J.C.24
Shen, W.25
Tahir, S.K.26
Thompson, C.B.27
Tomaselli, K.J.28
Wang, B.29
Wendt, M.D.30
Zhang, H.31
Fesik, S.W.32
Rosenberg, S.H.33
more..
-
35
-
-
79951819984
-
ShRNA-targeted MAP4K4 inhibits hepatocellular carcinoma growth
-
Liu AW, Cai J, Zhao XL, Jiang TH, He TF, Fu HQ, et al. ShRNA-targeted MAP4K4 inhibits hepatocellular carcinoma growth. Clin Cancer Res 2011;17:710-20.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 710-720
-
-
Liu, A.W.1
Cai, J.2
Zhao, X.L.3
Jiang, T.H.4
He, T.F.5
Fu, H.Q.6
-
36
-
-
0022448025
-
Immunohistochemical measurement of estrogen receptors in breast cancer tissue samples
-
Jonat W, Maass H, Stegner HE. Immunohistochemical measurement of estrogen receptors in breast cancer tissue samples. Cancer Res 1986;46:4296-8s.
-
(1986)
Cancer Res
, vol.46
-
-
Jonat, W.1
Maass, H.2
Stegner, H.E.3
-
37
-
-
52049125046
-
PTOV1 expression predicts prostate cancer in men with isolated highgrade prostatic intraepithelial neoplasia in needle biopsy
-
Morote J, Fernandez S, Alana L, Iglesias C, Planas J, Reventos J, et al. PTOV1 expression predicts prostate cancer in men with isolated highgrade prostatic intraepithelial neoplasia in needle biopsy. Clin Cancer Res 2008;14:2617-22.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2617-2622
-
-
Morote, J.1
Fernandez, S.2
Alana, L.3
Iglesias, C.4
Planas, J.5
Reventos, J.6
-
38
-
-
2542428498
-
Nicotine induces multi-site phosphorylation of Bad in association with suppression of apoptosis
-
DOI 10.1074/jbc.M402566200
-
Jin Z, Gao F, Flagg T, Deng X. Nicotine induces multi-site phosphorylation of Bad in association with suppression of apoptosis. J Biol Chem 2004;279:23837-44. (Pubitemid 38685702)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.22
, pp. 23837-23844
-
-
Jin, Z.1
Gao, F.2
Flagg, T.3
Deng, X.4
-
39
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery
-
DOI 10.1016/S0092-8674(00)80405-5
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-41. (Pubitemid 27456390)
-
(1997)
Cell
, vol.91
, Issue.2
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Xu, T.3
Masters, S.4
Haian, F.5
Gotoh, Y.6
Greenberg, M.E.7
-
40
-
-
0346995278
-
Mitogen-Activated Protein Kinase Pathway-Dependent Tumor-Specific Survival Signaling in Melanoma Cells through Inactivation of the Proapoptotic Protein Bad
-
Eisenmann KM, VanBrocklin MW, Staffend NA, Kitchen SM, Koo HM. Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein bad. Cancer Res 2003;63:8330-7. (Pubitemid 37549486)
-
(2003)
Cancer Research
, vol.63
, Issue.23
, pp. 8330-8337
-
-
Eisenmann, K.M.1
VanBrocklin, M.W.2
Staffend, N.A.3
Kitchen, S.M.4
Koo, H.-M.5
-
41
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004;4:335-48. (Pubitemid 38579480)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.5
, pp. 335-348
-
-
Bjornsti, M.-A.1
Houghton, P.J.2
-
42
-
-
2942625430
-
L sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers
-
DOI 10.1038/sj.emboj.7600225
-
Jeong SY, Gaume B, Lee YJ, Hsu YT, Ryu SW, Yoon SH, et al. Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers. EMBO J 2004;23:2146-55. (Pubitemid 38737741)
-
(2004)
EMBO Journal
, vol.23
, Issue.10
, pp. 2146-2155
-
-
Jeong, S.-Y.1
Gaume, B.2
Lee, Y.-J.3
Hsu, Y.-T.4
Ryu, S.-W.5
Yoon, S.-H.6
Youle, R.J.7
-
43
-
-
0038732434
-
Overexpression of BAD potentiates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand treatment in the prostatic carcinoma cell line LNCaP
-
Taghiyev AF, Guseva NV, Harada H, Knudson CM, Rokhlin OW, Cohen MB. Overexpression of BAD potentiates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand treatment in the prostatic carcinoma cell line LNCaP. Mol Cancer Res 2003;1:500-7. (Pubitemid 36581862)
-
(2003)
Molecular Cancer Research
, vol.1
, Issue.7
, pp. 500-507
-
-
Taghiyev, A.F.1
Guseva, N.V.2
Harada, H.3
Knudson, C.M.4
Rokhlin, O.W.5
Cohen, M.B.6
-
44
-
-
0030707613
-
Dimerization properties of human BAD: Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-X(L) proteins
-
DOI 10.1074/jbc.272.49.30866
-
Ottilie S, Diaz JL, Horne W, Chang J, Wang Y, Wilson G, et al. Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. J Biol Chem 1997;272:30866-72. (Pubitemid 27527529)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.49
, pp. 30866-30872
-
-
Ottilie, S.1
Diaz, J.-L.2
Horne, W.3
Chang, J.4
Wang, Y.5
Wilson, G.6
Chang, S.7
Weeks, S.8
Fritz, L.C.9
Oltersdorf, T.10
-
45
-
-
0034652115
-
Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases
-
DOI 10.1073/pnas.97.4.1578
-
Deng X, Ruvolo P, Carr B, May WS Jr. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proc Natl Acad Sci U S A 2000;97:1578-83. (Pubitemid 30118484)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.4
, pp. 1578-1583
-
-
Deng, X.1
Ruvolo, P.2
Carr, B.3
May Jr., W.S.4
-
46
-
-
0028928968
-
Prohibitin, an antiproliferative protein, is localized to mitochondria
-
Ikonen E, Fiedler K, Parton RG, Simons K. Prohibitin, an antiproliferative protein, is localized to mitochondria. FEBS Lett 1995;358:273-7.
-
(1995)
FEBS Lett
, vol.358
, pp. 273-277
-
-
Ikonen, E.1
Fiedler, K.2
Parton, R.G.3
Simons, K.4
-
47
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
DOI 10.1016/S1097-2765(03)00050-9
-
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003;11:577-90. (Pubitemid 36385115)
-
(2003)
Molecular Cell
, vol.11
, Issue.3
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
Petrenko, O.4
Chittenden, T.5
Pancoska, P.6
Moll, U.M.7
-
48
-
-
70349696241
-
Calcium/calmodulin-dependent protein kinase II linksERstress withFas andmitochondrialapoptosispathways
-
Timmins JM, Ozcan L, Seimon TA, Li G, Malagelada C, Backs J, et al. Calcium/calmodulin-dependent protein kinase II linksERstress withFas andmitochondrialapoptosispathways. J Clin Invest2009;119:2925-41.
-
(2009)
J Clin Invest
, vol.119
, pp. 2925-2941
-
-
Timmins, J.M.1
Ozcan, L.2
Seimon, T.A.3
Li, G.4
Malagelada, C.5
Backs, J.6
-
49
-
-
0038482050
-
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
-
DOI 10.1074/jbc.M301010200
-
Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem 2003;278:18811-6. (Pubitemid 36799262)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.21
, pp. 18811-18816
-
-
Ley, R.1
Balmanno, K.2
Hadfield, K.3
Weston, C.4
Cook, S.J.5
-
51
-
-
33644855216
-
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
-
DOI 10.1016/j.molcel.2006.02.009, PII S1097276506001110
-
Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membranepermeabilization and apoptosis by destabilization of MCL-1. Mol Cell 2006;21:749-60. (Pubitemid 43376126)
-
(2006)
Molecular Cell
, vol.21
, Issue.6
, pp. 749-760
-
-
Maurer, U.1
Charvet, C.2
Wagman, A.S.3
Dejardin, E.4
Green, D.R.5
-
52
-
-
33645232372
-
Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation
-
Arnold HK, Sears RC. Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation. Mol Cell Biol 2006;26:2832-44.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2832-2844
-
-
Arnold, H.K.1
Sears, R.C.2
-
53
-
-
80052448870
-
Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT
-
Svejda B, Kidd M, Kazberouk A, Lawrence B, Pfragner R, Modlin IM. Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT. Cancer 2011;117:4141-54.
-
(2011)
Cancer
, vol.117
, pp. 4141-4154
-
-
Svejda, B.1
Kidd, M.2
Kazberouk, A.3
Lawrence, B.4
Pfragner, R.5
Modlin, I.M.6
-
54
-
-
33645526144
-
Cancer statistics, 2006
-
Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. Cancer statistics, 2006. CA Cancer J Clin 2006;56:106-30.
-
(2006)
CA Cancer J Clin
, vol.56
, pp. 106-130
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Murray, T.4
Xu, J.5
Smigal, C.6
-
55
-
-
0034637606
-
155
-
DOI 10.1074/jbc.M002526200
-
Zhou XM, Liu Y, Payne G, Lutz RJ, Chittenden T. Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155. J Biol Chem 2000;275:25046-51. (Pubitemid 30626615)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.32
, pp. 25046-25051
-
-
Zhou, X.-M.1
Liu, Y.2
Payne, G.3
Lutz, R.J.4
Chittenden, T.5
-
56
-
-
0027983480
-
Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression
-
DOI 10.1016/0092-8674(94)90402-2
-
de Groot RP, Ballou LM, Sassone-Corsi P. Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression. Cell 1994;79:81-91. (Pubitemid 24309515)
-
(1994)
Cell
, vol.79
, Issue.1
, pp. 81-91
-
-
De Groot, R.P.1
Ballou, L.M.2
Sassone-Corsi, P.3
|