Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening

Journal of Medicinal Chemistry

Volumn 52, Issue 16, 2009, Pages 5144-5151

  Ostrov, David A ^a   Magis, Andrew T ^a   Wronski, Thomas J ^b   Chan, Edward K L ^c   Toro, Edgardo J ^c   Donatelli, Richard E ^c   Sajek, Kristen ^c   Haroun, Ireni N ^c   Nagib, Michael I ^c   Piedrahita, Ana ^c   Harris, Ashley ^c   Holliday, L Shannon ^a,c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CALCITRIOL; ENOXACIN; LEVOFLOXACIN; NORFLOXACIN; PEFLOXACIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BONE MARROW CULTURE; CELL COUNT; CELL DIFFERENTIATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME SUBUNIT; IN VITRO STUDY; MICROFILAMENT; MOLECULAR INTERACTION; MOLECULAR SIZE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; SEQUENCE HOMOLOGY; TISSUE SLICE;

ACTINS; ANIMALS; BINDING SITES; BONE MARROW CELLS; BONE RESORPTION; CELL DIFFERENTIATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENOXACIN; MICE; MICROFILAMENTS; MODELS, MOLECULAR; OSTEOCLASTS; PROTEIN BINDING; PROTEIN SUBUNITS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 69049093857     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900277z     Document Type: Article

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