Treatment of the elderly when cure is the goal: The influence of age on treatment selection and efficacy for stage III non-small cell lung cancer

Journal of Thoracic Oncology

Volumn 6, Issue 3, 2011, Pages 537-544

  Coate, Linda E ^a   Massey, Christine ^a   Hope, Andrew ^b   Sacher, Adrian ^a   Barrett, Katherine ^b   Pierre, Andrew ^c   Leighl, Natasha ^a   Brade, Anthony ^c   De Perrot, Marc ^b   Waddell, Tom ^b   Liu, Geoffrey ^a   Feld, Ronald ^a   Burkes, Ronald ^a   Cho, B C John ^c   Darling, Gail ^b   Sun, Alexander ^c   Keshavjee, Shaf ^b   Bezjak, Andrea ^c   Shepherd, Frances A ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Combined modality treatment; Elderly; Locally advanced; Non small cell lung cancer; Stage III NSCLC; Trimodality

Indexed keywords

ANTINEOPLASTIC AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CHILD; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HUMAN; INFANT; LOG RANK TEST; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MULTIMODALITY CANCER THERAPY; MULTIVARIATE ANALYSIS; PALLIATIVE THERAPY; PERFORMANCE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TOXICITY; TREATMENT PLANNING; UNIVARIATE ANALYSIS;

EID: 79951773013     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e31820b8b9b     Document Type: Article

References (34)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-249.
2. Havlik RJ, Yancik R, Long S, et al. The National Institute on Aging and the National Cancer Institute SEER collaborative study on comorbidity and early diagnosis of cancer in the elderly. Cancer 1994;74:2101-2106. (Pubitemid 24304381)
3. Hayat MJ, Howlader N, Reichman ME, et al. Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. Oncologist 2007;12:20-37. (Pubitemid 46143500)
4. Hutchins LF, Unger JM, Crowley JJ, et al. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 1999;341:2061-2067. (Pubitemid 30035956)
5. Fruh M, Rolland E, Pignon JP, et al. Pooled analysis of the effect of age on adjuvant cisplatin-based chemotherapy for completely resected nonsmall- cell lung cancer. J Clin Oncol 2008;26:3573-3581.
6. Wheatley-Price P, Ding K, Seymour L, et al. Erlotinib for advanced non-small-cell lung cancer in the elderly: an analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR. 21. J Clin Oncol 2008;26:2350-2357.
7. Stinchcombe TE, Fried D, Morris DE, et al. Combined modality therapy for stage III non-small cell lung cancer. Oncologist 2006;11:809-823. (Pubitemid 44157569)
8. Furuse K, Fukuoka M, Kawahara M, et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer. J Clin Oncol 1999;17:2692-2699. (Pubitemid 29415225)
9. Movsas B, Scott C, Sause W, et al. The benefit of treatment intensification is age and histology-dependent in patients with locally advanced non-small cell lung cancer (NSCLC): a quality-adjusted survival analysis of radiation therapy oncology group (RTOG) chemoradiation studies. Int J Radiat Oncol Biol Phys 1999;45:1143-1149.
10. Werner-Wasik M, Scott C, Cox JD, et al. Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): identification of five groups with different survival. Int J Radiat Oncol Biol Phys 2000;48:1475-1482.
11. Schild SE, Stella PJ, Geyer SM, et al. The outcome of combinedmodality therapy for stage III non-small-cell lung cancer in the elderly. J Clin Oncol 2003;21:3201-3206. (Pubitemid 46606250)
12. van Meerbeeck JP, Kramer GW, Van Schil PE, et al. Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer. J Natl Cancer Inst 2007;99:442-450. (Pubitemid 47073567)
13. Albain KS, Swann RS, Rusch VW, et al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial. Lancet 2009;374:379-386.
14. Hotta K, Ueoka H, Kiura K, et al. An overview of 48 elderly-specific clinical trials of systemic chemotherapy for advanced non-small cell lung cancer. Lung Cancer 2004;46:61-76. (Pubitemid 39201385)
15. Gridelli C, Langer C, Maione P, et al. Lung cancer in the elderly. J Clin Oncol 2007;25:1898-1907. (Pubitemid 46854424)
16. Asmis TR, Ding K, Seymour L, et al. Age and comorbidity as independent prognostic factors in the treatment of non small-cell lung cancer: a review of National Cancer Institute of Canada Clinical Trials Group trials. J Clin Oncol 2008;26:54-59.
17. Stanley KE. Prognostic factors for survival in patients with inoperable lung cancer. J Natl Cancer Inst 1980;65:25-32. (Pubitemid 10071592)
18. Azzoli CG, Baker S Jr, Temin S, et al. American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol 2009;27:6251-6266.
19. Chrischilles EA, Pendergast JF, Kahn KL, et al. Adverse events among the elderly receiving chemotherapy for advanced non-small-cell lung cancer. J Clin Oncol 2010;28:620-627.
20. de Rijke JM, Schouten LJ, ten Velde GP, et al. Influence of age, comorbidity and performance status on the choice of treatment for patients with non-small cell lung cancer; results of a population-based study. Lung Cancer 2004;46:233-245. (Pubitemid 39334825)
21. Owonikoko TK, Ragin CC, Belani CP, et al. Lung cancer in elderly patients: an analysis of the surveillance, epidemiology, and end results database. J Clin Oncol 2007;25:5570-5577.
22. Mohile SG, Xian Y, Dale W, et al. Association of a cancer diagnosis with vulnerability and frailty in older Medicare beneficiaries. J Natl Cancer Inst 2009;101:1206-1215.
23. Langer CJ Hsu C, Curran WJ, et al. Elderly patients (pts) with locally advanced non-small cell lung cancer (LA-NSCLC) benefit from combined modality therapy: Secondary analysis of Radiation Therapy Oncology Group (RTOG) 94-10. Presented at the Annual Meeting of the American Society of Clinical Oncology, Orlando, FL, May 18-21, 2002.
24. Rocha Lima CM, Herndon JE II, Kosty M, et al. Therapy choices among older patients with lung carcinoma: an evaluation of two trials of the Cancer and Leukemia Group B. Cancer 2002;94:181-187. (Pubitemid 34049057)
25. Pepe C, Hasan B, Winton TL, et al. Adjuvant vinorelbine and cisplatin in elderly patients: National Cancer Institute of Canada and Intergroup Study JBR. 10. J Clin Oncol 2007;25:1553-1561. (Pubitemid 46733082)
26. Siu LL, Shepherd FA, Murray N, et al. Influence of age on the treatment of limited-stage small-cell lung cancer. J Clin Oncol 1996;14:821-828. (Pubitemid 26085527)
27. Marley SB, Lewis JL, Davidson RJ, et al. Evidence for a continuous decline in haemopoietic cell function from birth: application to evaluating bone marrow failure in children. Br J Haematol 1999;106:162-166. (Pubitemid 29343544)
28. Wasil T, Lichtman SM. Clinical pharmacology issues relevant to the dosing and toxicity of chemotherapy drugs in the elderly. Oncologist 2005;10:602-612. (Pubitemid 41429123)
29. Seidenfeld J, Horstmann E, Emanuel EJ, et al. Participants in phase 1 oncology research trials: are they vulnerable? Arch Intern Med 2008; 168:16-20.
30. Hollings DD, Higgins RS, Faber LP, et al. Age is a strong risk factor for atrial fibrillation after pulmonary lobectomy. Am J Surg 199;558-561.
31. Chambers A, Routledge T, Pilling J, et al. In elderly patients with lung cancer is resection justified in terms of morbidity, mortality and residual quality of life? Interact Cardiovasc Thorac Surg 2010;10:1015-1021.
32. Sundaresan S, Langer B, Oliver T, et al. Standards for thoracic surgical oncology in a single-payer healthcare system. Ann Thorac Surg 2007; 84:693-701. (Pubitemid 47069189)
33. Rodin MB, Mohile SG. A practical approach to geriatric assessment in oncology. J Clin Oncol 2007;25:1936-1944. (Pubitemid 46854429)
34. Jatoi A, Hillman S, Stella P, et al. Should elderly non-small-cell lung cancer patients be offered elderly-specific trials? Results of a pooled analysis from the North Central Cancer Treatment Group. J Clin Oncol 2005;23:9113-9119.