Nicotine enhances the antiapoptotic function of mcl-1 through phosphorylation

Molecular Cancer Research

Volumn 7, Issue 12, 2009, Pages 1954-1961

  Zhao, Jinfeng ^b,c   Xin, Meiguo ^c   Wang, Ton ^c   Zhang, Yangde ^b   Deng, Xingming ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINE; PROTEIN BCL 2; PROTEIN MCL 1; TOBACCO SMOKE;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CIGARETTE SMOKING; CONTROLLED STUDY; HALF LIFE TIME; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE;

APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FLAVONOIDS; HALF-LIFE; HUMANS; LUNG NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NICOTINE; PHOSPHORYLATION; PHOSPHOTHREONINE; PROPRANOLOL; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ADRENERGIC, BETA;

NICOTIANA TABACUM;

EID: 73849102975     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-09-0304     Document Type: Article

References (37)

1. Heusch WL, Maneckjee R. Signaling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis 1998;19:551-6.
2. Dresler CM. Is it more important to quit smoking than which chemotherapy is used? Lung Cancer 2003;39:119-24.
3. Hecht SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 1991;91:1194-210.
4. Benowitz N. Drug therapy: pharmacologic aspects of cigarette smoking and nicotine addiction. N Engl J Med 1988;319:1318-30.
5. Wright SC, Zhong J, Zheng H, Larrick JW. Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB J 1993;7:1045-51.
6. Linette GP, Grusby MJ, Hedrick SM, Hansen TH, Glimcher LH, Korsmeyer SJ. Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1994;1: 197-205.
7. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
8. Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002;2:647-56.
9. Brambilla E, Negoescu A, Gazzeri S, et al. Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors. Am J Pathol 1996;149:1941-52.
10. Ferron PE, Bagni I, Guidoboni M, Beccati MD, Nenci I. Combined and sequential expression of p53, Rb, Ras and Bcl-2 in bronchial preneoplastic lesions. Tumori 1997;83:587-93.
11. Sartorius UA, Krammer PH. Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines. Int J Cancer 2002;97:584-92.
12. Mai H, May WS, Gao F, Jin Z, Deng X. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. J Biol Chem 2003;278:1886-91.
13. Jin Z, Gao F, FlaggT, Deng X. Nicotine inducesmultisite phosphorylation of Bad in association with suppression of apoptosis. J Biol Chem 2004;279:23837-44.
14. Xin M, Deng X. Nicotine inactivation of Bax's proapoptotic function through phosphorylation. J Biol Chem 2005;280:10781-9.
15. Song L, Coppola D, Livingston S, Cress D, Haura E. Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells. Cancer Biol Ther 2005;4:267-76.
16. Kobayashi S, Lee S, Meng X, et al. Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1. J Biol Chem 2007;282:18407-17.
17. Chao J, Li J, Huang H, et al. Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol Cell Biol 1998;18:4883-98.
18. Nijhawan D, Fang M, Traer E, et al. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 2003;17: 1475-86.
19. Liu H, Peng H, Cheng Y, Yuan H, Yang Y. Stabilization and enhancement of the antiapoptotic activity of Mcl-1 by TCTP. Mol Cell Biol 2005;25:3117-26.
20. Domina A, Vrana J, Gregory M, Hann S, Craig R. Mcl-1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. Oncogene 2004;23: 5301-15.
21. Domina A, Smith J, Craig R. Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition. J Biol Chem 2000;275:21688-94.
22. Maurer U, Charvet C, Wagman A, Dejardin E, Green D. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of Mcl-1. Mol Cell 2006;21:749-60.
23. Niell HB. Extensive stage small cell lung cancer. Curr Treat Options Oncol 2001;2:71-6.
24. Couturier S, Bertrand D, Matter JM, et al. A neuronal nicotinic acetylcholine receptor subunit (α 7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX. Neuron 1990;5:847-56.
25. Perissin L, Rapozzi V, Zorzet S, Giraldi T. Blockers of adrenergic neurons and receptors, tumor progression and effects of rotational stress in mice. Anti-cancer Res 1996;16:3409-13.
26. Deng X, Gao F, Flagg T, May WS. Mono- and multi-site phosphorylation enhances Bcl2's anti-apoptotic function and inhibition of cell cycle entry functions. Proc Natl Acad Sci U S A 2004;101:153-8.
27. Zhong Q, Gao W, Du F, Wang X. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 2005;121:1085-95.
28. Semizarov D, Frost L, Sarthy A, Kroeger P, Halbert D, Fesik S. Specificity of short interfering RNA determined through gene expression signatures. Proc Natl Acad Sci U S A 2003;100:6347-52.
29. Kozopas K, Yang T, Buchan H, Zhou P, Craig R. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci U S A 1993;90:3516-20.
30. Fang H, Yen Y. Mcl-1, a highly regulated cell death and survival controller. J Biomed Sci 2006;13:201-4.
31. Biasio AD, Vrana JA, Zhou P, et al. W N-terminal truncation of anti-apoptotic MCL1, but not G2/M-induced phosphorylation, is associated with stabilization and abundant expression in tumor cells. J Biol Chem 2007;282: 23919-36.
32. Arnold H, Sears R. Protein phosphatase 2A regulatory subunit B56α associates with c-Myc and negatively regulates c-Myc accumulation. Mol Cell Biol 2008;26:2832-44.
33. Park PG, Merryman J, Orloff M, Schuller HM. β-Adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung disease. Cancer Res 1995;55:3504-8.
34. Shin V, Wu W, Chu K, et al. Functional role of β-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. Toxicol Sci 2007;96:21-9.
35. Wong H,Yu L,LamE,TaiE,WuW, ChoC.Nicotine promotes colon tumor growth and angiohenesis through â-adrenergic activation. Toxicol Sci 2007;97:279-87.
36. Shin V, Jin H, Ng E, et al. Nicotine and 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and β-adrenergic receptor signaling pathways. Toxicol Appl Pharmacol 2008;233:254-61.
37. Deng X, Ruvolo P, Carr BK, May WS. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proc Natl Acad Sci U S A 2000;97:1578-183.