메뉴 건너뛰기




Volumn 29, Issue 5, 2013, Pages 537-543

Deciphering the role of stroma in pancreatic cancer

Author keywords

cancer associated fibroblasts; pancreatic cancer; stellate cells; stroma; tumor microenvironment

Indexed keywords

ANTINEOPLASTIC AGENT; GEMCITABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; K RAS PROTEIN; PACLITAXEL; PIRFENIDONE; PROTEIN PATCHED 1; PROTEIN PATCHED 2; STAT3 PROTEIN;

EID: 84883456329     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0b013e328363affe     Document Type: Review
Times cited : (114)

References (59)
  • 2
    • 84883445034 scopus 로고    scopus 로고
    • Drug combo effective against pancreatic cancer
    • Drug combo effective against pancreatic cancer. Cancer Discov. 2013; 3:OF8.
    • (2013) Cancer Discov. , vol.3
  • 3
    • 84871492380 scopus 로고    scopus 로고
    • FOLFIRINOX for locally advanced and metastatic pancreatic cancer: Single institution retrospective review of efficacy and toxicity
    • Gunturu KS, Yao X, Cong X, et al. FOLFIRINOX for locally advanced and metastatic pancreatic cancer: single institution retrospective review of efficacy and toxicity. Med Oncol 2013; 30:361.
    • (2013) Med Oncol , vol.30 , pp. 361
    • Gunturu, K.S.1    Yao, X.2    Cong, X.3
  • 4
    • 83355169753 scopus 로고    scopus 로고
    • Gemcitabine plus nabpaclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial
    • Von Hoff DD, Ramanathan RK, Borad MJ, et al. Gemcitabine plus nabpaclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol 2011; 29:4548-4554.
    • (2011) J Clin Oncol , vol.29 , pp. 4548-4554
    • Von Hoff, D.D.1    Ramanathan, R.K.2    Borad, M.J.3
  • 5
    • 84876159000 scopus 로고    scopus 로고
    • A phase II trial of nab- Paclitaxel as second-line therapy in patients with advanced pancreatic cancer
    • Hosein PJ, de Lima Lopes G Jr, Pastorini VH, et al. A phase II trial of nab- Paclitaxel as second-line therapy in patients with advanced pancreatic cancer. Am J Clin Oncol 2013; 36:151-156.
    • (2013) Am J Clin Oncol , vol.36 , pp. 151-156
    • Hosein, P.J.1    De Lima Lopes, Jr.G.2    Pastorini, V.H.3
  • 6
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321:1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 7
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • Biankin AV, Waddell N, Kassahn KS, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012; 491: 399-405.
    • (2012) Nature , vol.491 , pp. 399-405
    • Biankin, A.V.1    Waddell, N.2    Kassahn, K.S.3
  • 9
    • 42049097658 scopus 로고    scopus 로고
    • Pancreatic stellate cells: Partners in crime with pancreatic cancer cells
    • Vonlaufen A, Joshi S, Qu C, et al. Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res 2008; 68:2085-2093.
    • (2008) Cancer Res , vol.68 , pp. 2085-2093
    • Vonlaufen, A.1    Joshi, S.2    Qu, C.3
  • 10
    • 38849141696 scopus 로고    scopus 로고
    • Cancer-associated stromal fibroblasts promote pancreatic tumor progression
    • Hwang RF, Moore T, Arumugam T, et al. Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res 2008; 68:918-926.
    • (2008) Cancer Res , vol.68 , pp. 918-926
    • Hwang, R.F.1    Moore, T.2    Arumugam, T.3
  • 11
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009; 324:1457-1461.
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 12
    • 4744346521 scopus 로고    scopus 로고
    • Desmoplastic reaction influences pancreatic cancer growth behavior
    • Hartel M, Di Mola FF, Gardini A, et al. Desmoplastic reaction influences pancreatic cancer growth behavior. World J Surg 2004; 28:818-825.
    • (2004) World J Surg , vol.28 , pp. 818-825
    • Hartel, M.1    Di Mola, F.F.2    Gardini, A.3
  • 13
    • 77956133518 scopus 로고    scopus 로고
    • CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer
    • Ikenaga N, Ohuchida K, Mizumoto K, et al. CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer. Gastroenterology 2010; 139:1041-1051.
    • (2010) Gastroenterology , vol.139 , pp. 1041-1051
    • Ikenaga, N.1    Ohuchida, K.2    Mizumoto, K.3
  • 14
    • 84855201311 scopus 로고    scopus 로고
    • StellaTUM: Current consensus and discussion on pancreatic stellate cell research
    • Erkan M, Adler G, Apte MV, et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut 2012; 61:172-178.
    • (2012) Gut , vol.61 , pp. 172-178
    • Erkan, M.1    Adler, G.2    Apte, M.V.3
  • 15
    • 78149315330 scopus 로고    scopus 로고
    • Role of pancreatic stellate cells in pancreatic cancer metastasis
    • Xu Z, Vonlaufen A, Phillips PA, et al. Role of pancreatic stellate cells in pancreatic cancer metastasis. Am J Pathol 2010; 177:2585-2596.
    • (2010) Am J Pathol , vol.177 , pp. 2585-2596
    • Xu, Z.1    Vonlaufen, A.2    Phillips, P.A.3
  • 16
    • 78650175637 scopus 로고    scopus 로고
    • Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells
    • Kikuta K, Masamune A, Watanabe T, et al. Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Biochem Biophys Res Commun 2010; 403:380-384.
    • (2010) Biochem Biophys Res Commun , vol.403 , pp. 380-384
    • Kikuta, K.1    Masamune, A.2    Watanabe, T.3
  • 17
    • 84860431671 scopus 로고    scopus 로고
    • Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells
    • Hamada S, Masamune A, Takikawa T, et al. Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells. Biochem Biophys Res Commun 2012; 421:349-354.
    • (2012) Biochem Biophys Res Commun , vol.421 , pp. 349-354
    • Hamada, S.1    Masamune, A.2    Takikawa, T.3
  • 18
    • 27744493024 scopus 로고    scopus 로고
    • Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging
    • Hung SC, Deng WP, Yang WK, et al. Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging. Clin Cancer Res 2005; 11:7749-7756.
    • (2005) Clin Cancer Res , vol.11 , pp. 7749-7756
    • Hung, S.C.1    Deng, W.P.2    Yang, W.K.3
  • 19
    • 49349100584 scopus 로고    scopus 로고
    • Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling
    • Qiao L, Xu ZL, Zhao TJ, et al. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Lett 2008; 269:67-77.
    • (2008) Cancer Lett , vol.269 , pp. 67-77
    • Qiao, L.1    Xu, Z.L.2    Zhao, T.J.3
  • 20
    • 42549148535 scopus 로고    scopus 로고
    • The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo
    • Lu YR, Yuan Y, Wang XJ, et al. The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo. Cancer Biol Ther 2008; 7:245-251.
    • (2008) Cancer Biol Ther , vol.7 , pp. 245-251
    • Lu, Y.R.1    Yuan, Y.2    Wang, X.J.3
  • 21
    • 33846483151 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: Impact on in vivo tumor growth
    • Ramasamy R, Lam EW, Soeiro I, et al. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia 2007; 21:304-310.
    • (2007) Leukemia , vol.21 , pp. 304-310
    • Ramasamy, R.1    Lam, E.W.2    Soeiro, I.3
  • 22
    • 64349103828 scopus 로고    scopus 로고
    • Tissue-resident stem cells promote breast cancer growth and metastasis
    • Muehlberg FL, Song YH, Krohn A, et al. Tissue-resident stem cells promote breast cancer growth and metastasis. Carcinogenesis 2009; 30:589-597.
    • (2009) Carcinogenesis , vol.30 , pp. 589-597
    • Muehlberg, F.L.1    Song, Y.H.2    Krohn, A.3
  • 23
    • 34948896045 scopus 로고    scopus 로고
    • Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    • Karnoub AE, Dash AB, Vo AP, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007; 449:557-563.
    • (2007) Nature , vol.449 , pp. 557-563
    • Karnoub, A.E.1    Dash, A.B.2    Vo, A.P.3
  • 24
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res 2007; 67:1030-1037.
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 25
    • 84873702799 scopus 로고    scopus 로고
    • Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells
    • Kabashima-Niibe A, Higuchi H, Takaishi H, et al. Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells. Cancer Sci 2013; 104:157-164.
    • (2013) Cancer Sci , vol.104 , pp. 157-164
    • Kabashima-Niibe, A.1    Higuchi, H.2    Takaishi, H.3
  • 26
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003; 425:851-856.
    • (2003) Nature , vol.425 , pp. 851-856
    • Thayer, S.P.1    Di Magliano, M.P.2    Heiser, P.W.3
  • 27
  • 28
    • 0030601955 scopus 로고    scopus 로고
    • Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development
    • Marigo V, Johnson RL, Vortkamp A, Tabin CJ. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol 1996; 180:273-283.
    • (1996) Dev Biol , vol.180 , pp. 273-283
    • Marigo, V.1    Johnson, R.L.2    Vortkamp, A.3    Tabin, C.J.4
  • 29
    • 0030805592 scopus 로고    scopus 로고
    • Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    • Lee J, Platt KA, Censullo P, Ruiz i Altaba A. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 1997; 124: 2537-2552.
    • (1997) Development , vol.124 , pp. 2537-2552
    • Lee, J.1    Platt, K.A.2    Censullo, P.3    Ruiz Altaba, I.A.4
  • 30
    • 0030913610 scopus 로고    scopus 로고
    • Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice
    • Platt KA, Michaud J, Joyner AL. Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech Dev 1997; 62:121-135.
    • (1997) Mech Dev , vol.62 , pp. 121-135
    • Platt, K.A.1    Michaud, J.2    Joyner, A.L.3
  • 31
    • 0036801765 scopus 로고    scopus 로고
    • Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
    • Bai CB, Auerbach W, Lee JS, et al. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 2002; 129:4753-4761.
    • (2002) Development , vol.129 , pp. 4753-4761
    • Bai, C.B.1    Auerbach, W.2    Lee, J.S.3
  • 32
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • Sasaki H, Nishizaki Y, Hui C, et al. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 1999; 126:3915-3924.
    • (1999) Development , vol.126 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.3
  • 33
    • 0033194243 scopus 로고    scopus 로고
    • Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1
    • Kogerman P, Grimm T, Kogerman L, et al. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol 1999; 1:312-319.
    • (1999) Nat Cell Biol , vol.1 , pp. 312-319
    • Kogerman, P.1    Grimm, T.2    Kogerman, L.3
  • 34
    • 0032808138 scopus 로고    scopus 로고
    • Gli proteins encode context-dependent positive and negative functions: Implications for development and disease
    • Ruiz i Altaba A. Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 1999; 126:3205-3216.
    • (1999) Development , vol.126 , pp. 3205-3216
    • Ruiz, I.1    Altaba, A.2
  • 35
    • 0033583035 scopus 로고    scopus 로고
    • Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
    • Dai P, Akimaru H, Tanaka Y, et al. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J Biol Chem 1999; 274:8143-8152.
    • (1999) J Biol Chem , vol.274 , pp. 8143-8152
    • Dai, P.1    Akimaru, H.2    Tanaka, Y.3
  • 36
    • 63149124772 scopus 로고    scopus 로고
    • Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
    • Tian H, Callahan CA, DuPree KJ, et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A 2009; 106:4254-4259.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4254-4259
    • Tian, H.1    Callahan, C.A.2    Dupree, K.J.3
  • 37
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • Yauch RL, Gould SE, Scales SJ, et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008; 455:406-410.
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3
  • 38
    • 58149143021 scopus 로고    scopus 로고
    • Sonic hedgehog promotes desmoplasia in pancreatic cancer
    • Bailey JM, Swanson BJ, Hamada T, et al. Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer Res 2008; 14:5995-6004.
    • (2008) Clin Cancer Res , vol.14 , pp. 5995-6004
    • Bailey, J.M.1    Swanson, B.J.2    Hamada, T.3
  • 39
    • 84876664218 scopus 로고    scopus 로고
    • Tumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition
    • Chang Q, FoltzWD, Chaudary N, et al. Tumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition. Int J Cancer 2013; 133:225-234.
    • (2013) Int J Cancer , vol.133 , pp. 225-234
    • Chang, Q.1    Foltzwd Chaudary, N.2
  • 40
    • 84876890682 scopus 로고    scopus 로고
    • Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRASinduced transformation
    • Mills LD, Zhang Y, Marler RJ, et al. Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRASinduced transformation. J Biol Chem 2013.
    • (2013) J Biol Chem
    • Mills, L.D.1    Zhang, Y.2    Marler, R.J.3
  • 41
    • 84866537713 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth
    • Porembka MR, Mitchem JB, Belt BA, et al. Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth. Cancer Immunol Immunother 2012; 61: 1373-1385.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1373-1385
    • Porembka, M.R.1    Mitchem, J.B.2    Belt, B.A.3
  • 42
    • 84862147254 scopus 로고    scopus 로고
    • Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
    • Pylayeva-Gupta Y, Lee KE, Hajdu CH, et al. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 2012; 21:836-847.
    • (2012) Cancer Cell , vol.21 , pp. 836-847
    • Pylayeva-Gupta, Y.1    Lee, K.E.2    Hajdu, C.H.3
  • 43
    • 84862150896 scopus 로고    scopus 로고
    • Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
    • Bayne LJ, Beatty GL, Jhala N, et al. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell 2012; 21:822-835.
    • (2012) Cancer Cell , vol.21 , pp. 822-835
    • Bayne, L.J.1    Beatty, G.L.2    Jhala, N.3
  • 44
    • 84877848590 scopus 로고    scopus 로고
    • Pancreatic cancer associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3- dependent manner
    • Mace TA, Ameen Z, Collins A, et al. Pancreatic cancer associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3- dependent manner. Cancer Res 2013.
    • (2013) Cancer Res
    • Mace, T.A.1    Ameen, Z.2    Collins, A.3
  • 45
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005; 7:469-483.
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3
  • 46
    • 35148814410 scopus 로고    scopus 로고
    • Dynamics of the immune reaction to pancreatic cancer from inception to invasion
    • Clark CE, Hingorani SR, Mick R, et al. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res 2007; 67:9518-9527.
    • (2007) Cancer Res , vol.67 , pp. 9518-9527
    • Clark, C.E.1    Hingorani, S.R.2    Mick, R.3
  • 47
    • 84863012865 scopus 로고    scopus 로고
    • Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
    • Collins MA, Bednar F, Zhang Y, et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest 2012; 122:639-653.
    • (2012) J Clin Invest , vol.122 , pp. 639-653
    • Collins, M.A.1    Bednar, F.2    Zhang, Y.3
  • 48
    • 52149094275 scopus 로고    scopus 로고
    • The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
    • Erkan M, Michalski CW, Rieder S, et al. The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol 2008; 6:1155-1161.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1155-1161
    • Erkan, M.1    Michalski, C.W.2    Rieder, S.3
  • 49
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420:860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 50
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004; 4:71-78.
    • (2004) Nat Rev Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 51
    • 84860522009 scopus 로고    scopus 로고
    • Activation state of stromal inflammatory cells in murine metastatic pancreatic adenocarcinoma
    • Benson DD, Meng X, Fullerton DA, et al. Activation state of stromal inflammatory cells in murine metastatic pancreatic adenocarcinoma. Am J Physiol Regul Integr Comp Physiol 2012; 302:R1067-R1075.
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.302
    • Benson, D.D.1    Meng, X.2    Fullerton, D.A.3
  • 52
    • 55949135598 scopus 로고    scopus 로고
    • Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma
    • Cohen SJ, Alpaugh RK, Palazzo I, et al. Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma. Pancreas 2008; 37:154-158.
    • (2008) Pancreas , vol.37 , pp. 154-158
    • Cohen, S.J.1    Alpaugh, R.K.2    Palazzo, I.3
  • 53
    • 84876852414 scopus 로고    scopus 로고
    • Kindlin-2 expression in peritumoral stroma is associated with poor prognosis in pancreatic ductal adenocarcinoma
    • Mahawithitwong P, Ohuchida K, Ikenaga N, et al. Kindlin-2 expression in peritumoral stroma is associated with poor prognosis in pancreatic ductal adenocarcinoma. Pancreas 2013; 42:663-669.
    • (2013) Pancreas , vol.42 , pp. 663-669
    • Mahawithitwong, P.1    Ohuchida, K.2    Ikenaga, N.3
  • 54
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • Provenzano PP, Cuevas C, Chang AE, et al. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012; 21:418-429.
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3
  • 55
    • 84871157346 scopus 로고    scopus 로고
    • Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
    • Jacobetz MA, Chan DS, Neesse A, et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 2013; 62:112-120.
    • (2013) Gut , vol.62 , pp. 112-120
    • Jacobetz, M.A.1    Chan, D.S.2    Neesse, A.3
  • 56
    • 84875992738 scopus 로고    scopus 로고
    • Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells
    • Kozono S, Ohuchida K, Eguchi D, et al. Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells. Cancer Res 2013; 73:2345-2356.
    • (2013) Cancer Res , vol.73 , pp. 2345-2356
    • Kozono, S.1    Ohuchida, K.2    Eguchi, D.3
  • 57
    • 40549096726 scopus 로고    scopus 로고
    • Improved lentiviral transduction of human mesenchymal stem cells for therapeutic intervention in pancreatic cancer
    • Kallifatidis G, Beckermann BM, Groth A, et al. Improved lentiviral transduction of human mesenchymal stem cells for therapeutic intervention in pancreatic cancer. Cancer Gene Ther 2008; 15:231-240.
    • (2008) Cancer Gene Ther , vol.15 , pp. 231-240
    • Kallifatidis, G.1    Beckermann, B.M.2    Groth, A.3
  • 58
    • 80155213401 scopus 로고    scopus 로고
    • Selective targeting of genetically engineered mesenchymal stem cells to tumor stroma microenvironments using tissuespecific suicide gene expression suppresses growth of hepatocellular carcinoma
    • Niess H, Bao Q, Conrad C, et al. Selective targeting of genetically engineered mesenchymal stem cells to tumor stroma microenvironments using tissuespecific suicide gene expression suppresses growth of hepatocellular carcinoma. Ann Surg 2011; 254:767-774.
    • (2011) Ann Surg , vol.254 , pp. 767-774
    • Niess, H.1    Bao, Q.2    Conrad, C.3
  • 59
    • 84865271049 scopus 로고    scopus 로고
    • TRAIL-engineered pancreas-derived mesenchymal stem cells: Characterization and cytotoxic effects on pancreatic cancer cells
    • Moniri MR, Sun XY, Rayat J, et al. TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells. Cancer Gene Ther 2012; 19:652-658.
    • (2012) Cancer Gene Ther , vol.19 , pp. 652-658
    • Moniri, M.R.1    Sun, X.Y.2    Rayat, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.