Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging

Clinical Cancer Research

Volumn 11, Issue 21, 2005, Pages 7749-7756

  Hung, Shih Chieh ^a,c,d,e   Deng, Win Ping ^b   Yang, Wen K ^a,e   Liu, Ren Shyan ^c,d   Lee, Chien Chih ^b   Su, Tzu Chi ^a,e   Lin, Rue Jen ^a,e   Yang, Den Mei ^a,e   Chang, Chi Wei ^c   Chen, Wei Hong ^b   Wei, Hon Jian ^b   Gelovani, Juri G ^f  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 (4 FLUORO 3 HYDROXYMETHYLBUTYL)GUANINE; ENHANCED GREEN FLUORESCENT PROTEIN; FLUORINE 18; GUANINE DERIVATIVE; HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CAPILLARY ENDOTHELIUM; CELL PROLIFERATION; CELL STRAIN HT29; CONTROLLED STUDY; CYTOMETRY; DERMIS; ENDOTHELIUM CELL; HAIR FOLLICLE; HISTOCHEMISTRY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOFLUORESCENCE; LIFESPAN; MESENCHYME CELL; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REPORTER GENE; STEM CELL; STEM CELL GENE THERAPY; STROMA; SUICIDE GENE; TUMOR; TUMOR GROWTH; VALIDATION PROCESS;

ANIMALS; ANTIGENS, CD31; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CYTOKINES; FLOW CYTOMETRY; GENE THERAPY; GENES, REPORTER; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LENTIVIRUS; MESODERM; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS; POLYMERASE CHAIN REACTION; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BIOSYNTHESIS; STEM CELLS; TIME FACTORS;

EID: 27744493024     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-05-0876     Document Type: Article

References (44)

1. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6.
2. Holash J, Maisonpierre PC, Compton D, et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999;284:1994-8.
3. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000;407:249-57.
4. De Palma M, Venneri MA, Roca C, Naldini L. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat Med 2003;9:789-95.
5. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-4.
6. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7.
7. Bruder SP, Fink DJ, Caplan AI. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 1994;56:283-94.
8. Jin HK, Carter JE, Huntley GW, Schuchman EH. Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase-deficient mice delays the onset of neurological abnormalities and extends their life span. J Clin Invest 2002;109:1183-91.
9. Spees JL, Olson SD, Ylostalo J, et al. Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc Natl Acad Sci U S A 2003;100:2397-402.
10. Reyes M, Dudek A, Jahagirdar B, et al. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest 2002;109:337-46.
11. Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-5.
12. Studeny M, Marini FC, Champlin RE, et al. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-β delivery into tumors. Cancer Res 2002;62:3603-8.
13. Nakamura K, Ito Y, Kawano Y, et al. Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther 2004;11:1155-64.
14. Doubrovin M, Ponomarev V, Beresten T, et al. Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo. Proc Natl Acad Sci U S A 2001;98:9300-5.
15. Jacobs A, Dubrovin M, Hewett J, et al. Functional coexpression of HSV-1 thymidine kinase and green fluorescent protein: implications for noninvasive imaging of transgene expression. Neoplasia 1999;1:154-61.
16. Ray P, Wu AM, Gambhir SS. Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice. Cancer Res 2003;63:1160-5.
17. Ray P, De A, Min JJ, et al. Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res 2004;64:1323-30.
18. Chen WS, Wei SJ, Liu JM, et al. Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, Etodolac. Int J Cancer 2001;91:894-9.
19. Hung SC, Yang DM, Chang CF, et al. Immortalization without neoplastic transformation of human mesenchymal stem cells by transduction with HPV16 E6E7 genes. Int J Cancer 2004;110:313-9.
20. Chang LJ, Zaiss AK. Lentiviral vectors. Preparation and use. Methods Mol Med 2002;69:303-18.
21. Zaiss AK, Son S, Chang LJ. RNA 3′ readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy. J Virol 2002;76:7209-19.
22. Tjuvajev JG, Doubrovin M, Akhurst T, et al. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J Nucl Med 2002;43:1072-83.
23. Deng WP, Yang WK, Lai WF, et al. Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir. Eur J Nucl Med Mol Imaging 2004;31:99-109.
24. Fareed MU, Moolten FL. Suicide gene transduction sensitizes murine embryonic and human mesenchymal stem cells to ablation on demand: a fail-safe protection against cellular misbehavior. Gene Ther 2002;9:955-62.
25. 18F]FHBG) for gene therapy. Nucl Med Biol 2002;28:875-83.
26. Lee K, Kinahan PE, Fessler JA, et al. Pragmatic fully 3D image reconstruction for the MiCES mouse imaging PET scanner. Phys Med Biol 2004;49:4563-78.
27. Jockusch H, Voigt S, Eberhard D. Localization of GFP in frozen sections from unfixed mouse tissues: immobilization of a highly soluble marker protein by formaldehyde vapor. J Histochem Cytochem 2003;51:401-4.
28. St Croix B, Rago C, Velculescu V, et al. Genes expressed in human tumor endothelium. Science 2000;289:1197-202.
29. Hung SC, Chen NJ, Hsieh SL, et al. Isolation and characterization of size-sieved stem cells from human bone marrow. Stem Cells 2002;20:249-58.
30. Miyagawa M, Anton M, Haubner R, et al. PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene. J Nucl Med 2004;45:1917-23.
31. Wu JC, Chen IY, Sundaresan G, et al. Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography. Circulation 2003;108:1302-5.
32. Dubey P, Su H, Adonai N, et al. Quantitative imaging of the T cell antitumor response by positron-emission tomography. Proc Natl Acad Sci U S A 2003;100:1232-7.
33. Koehne G, Doubrovin M, Doubrovina E, et al. Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes. Nat Biotechnol 2003;21:405-13.
34. Su H, Forbes A, Gambhir SS, Braun J. Quantitation of cell number by a positron emission tomography reporter gene strategy. Mol Imaging Biol 2004;6:139-48.
35. Aboody KS, Brown A, Rainov NG, et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci U S A 2000;97:12846-51.
36. Relf M, LeJeune S, Scott PA, et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor β-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 1997;57:963-9.
37. Serganova I, Doubrovin M, Vider J, et al. Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice. Cancer Res 2004;64:6101-8.
38. Gambhir SS, Bauer E, Black ME, et al. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc Natl Acad Sci U S A 2000;97:2785-90.
39. Cottler-Fox MH, Lapidot T, Petit I, et al. Stem Cell Mobilization. Hematology (Am Soc Hematol Educ Program) 2003:419-37.
40. Hung SC, Cheng H, Pan CY, et al. In vitro differentiation of size-sieved stem cells into electrically active neural cells. Stem Cells 2002;20:522-9.
41. Duda DG, Fukumura D, Munn LL, et al. Differential transplantability of tumor-associated stromal cells. Cancer Res 2004;64:5920-4.
42. 18F-fluoro-5-fluoro-1-β-D- arabinofuranosyluracil as a potential PET imaging agent for suicide gene expression. J Nucl Med 2004;45:2063-9.
43. Tjuvajev JG, Avril N, Oku T, et al. Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res 1998;58:4333-41.
44. Wen B, Burgman P, Zanzonico P, et al. A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxia. Eur J Nucl Med Mol Imaging 2004;31:1530-8.