메뉴 건너뛰기




Volumn 19, Issue 9, 2012, Pages 652-658

TRAIL-engineered pancreas-derived mesenchymal stem cells: Characterization and cytotoxic effects on pancreatic cancer cells

Author keywords

cytotherapy; gene therapy; mesenchymal stem cells; pancreatic cancer

Indexed keywords

5' NUCLEOTIDASE; CD34 ANTIGEN; CELL SURFACE RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; ENDOGLIN; FAS ANTIGEN; HERMES ANTIGEN; PROTEIN DCR1; PROTEIN DCR2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; UNCLASSIFIED DRUG;

EID: 84865271049     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2012.46     Document Type: Article
Times cited : (64)

References (42)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61: 212-236.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 4
    • 0025186688 scopus 로고
    • Preoperative staging and assessment of resectability of pancreatic cancer
    • Warshaw AL, Gu ZY, Wittenberg J, Waltman AC. Preoperative staging and assessment of resectability of pancreatic cancer. Arch Surg 1990; 125: 230-233.
    • (1990) Arch Surg , vol.125 , pp. 230-233
    • Warshaw, A.L.1    Gu, Z.Y.2    Wittenberg, J.3    Waltman, A.C.4
  • 5
    • 0029991497 scopus 로고    scopus 로고
    • Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors
    • Conlon KC, Klimstra DS, Brennan MF. Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors. Ann Surg 1996; 223: 273-279.
    • (1996) Ann Surg , vol.223 , pp. 273-279
    • Conlon, K.C.1    Klimstra, D.S.2    Brennan, M.F.3
  • 6
    • 18544365651 scopus 로고    scopus 로고
    • Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: Randomized controlled trial evaluating survival, morbidity, and mortality
    • discussion 366-368
    • Yeo CJ, Cameron JL, Lillemoe KD, Sohn TA, Campbell KA, Sauter PK et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg 2002; 236: 355-366 discussion 366-368.
    • (2002) Ann Surg , vol.236 , pp. 355-366
    • Yeo, C.J.1    Cameron, J.L.2    Lillemoe, K.D.3    Sohn, T.A.4    Campbell, K.A.5    Sauter, P.K.6
  • 8
    • 71549114206 scopus 로고    scopus 로고
    • Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles
    • Loebinger MR, Kyrtatos PG, Turmaine M, Price AN, Pankhurst Q, Lythgoe MF et al. Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles. Cancer Res 2009; 69: 8862-8867.
    • (2009) Cancer Res , vol.69 , pp. 8862-8867
    • Loebinger, M.R.1    Kyrtatos, P.G.2    Turmaine, M.3    Price, A.N.4    Pankhurst, Q.5    Lythgoe, M.F.6
  • 11
    • 69549113506 scopus 로고    scopus 로고
    • Dual-targeted antitumor effects against brainstem glioma by intravenous delivery of tumor necrosis factor-related, apoptosis-inducing, ligand-engineered human mesenchymal stem cells
    • discussion 624
    • Yang B, Wu X, Mao Y, Bao W, Gao L, Zhou P et al. Dual-targeted antitumor effects against brainstem glioma by intravenous delivery of tumor necrosis factor-related, apoptosis-inducing, ligand-engineered human mesenchymal stem cells. Neurosurgery 2009; 65: 610-624 discussion 624.
    • (2009) Neurosurgery , vol.65 , pp. 610-624
    • Yang, B.1    Wu, X.2    Mao, Y.3    Bao, W.4    Gao, L.5    Zhou, P.6
  • 13
    • 70350243071 scopus 로고    scopus 로고
    • Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging
    • Kidd S, Spaeth E, Dembinski JL, Dietrich M, Watson K, Klopp A et al. Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging. Stem Cells 2009; 27: 2614-2623.
    • (2009) Stem Cells , vol.27 , pp. 2614-2623
    • Kidd, S.1    Spaeth, E.2    Dembinski, J.L.3    Dietrich, M.4    Watson, K.5    Klopp, A.6
  • 14
    • 77954728855 scopus 로고    scopus 로고
    • Mesenchymal stem cells protect breast cancer cells through regulatory T cells: Role of mesenchymal stem cell-derived TGF-beta
    • Patel SA, Meyer JR, Greco SJ, Corcoran KE, Bryan M, Rameshwar P. Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta. J Immunol 2010; 184: 5885-5894.
    • (2010) J Immunol , vol.184 , pp. 5885-5894
    • Patel, S.A.1    Meyer, J.R.2    Greco, S.J.3    Corcoran, K.E.4    Bryan, M.5    Rameshwar, P.6
  • 15
    • 33846908513 scopus 로고    scopus 로고
    • Differential gene expression associated with migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells
    • Menon LG, Picinich S, Koneru R, Gao H, Lin SY, Koneru M et al. Differential gene expression associated with migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells. Stem Cells 2007; 25: 520-528.
    • (2007) Stem Cells , vol.25 , pp. 520-528
    • Menon, L.G.1    Picinich, S.2    Koneru, R.3    Gao, H.4    Lin, S.Y.5    Koneru, M.6
  • 16
    • 77954084666 scopus 로고    scopus 로고
    • Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment
    • Kidd S, Caldwell L, Dietrich M, Samudio I, Spaeth EL, Watson K et al. Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment. Cytotherapy 2010; 12: 615-625.
    • (2010) Cytotherapy , vol.12 , pp. 615-625
    • Kidd, S.1    Caldwell, L.2    Dietrich, M.3    Samudio, I.4    Spaeth, E.L.5    Watson, K.6
  • 17
    • 70449429426 scopus 로고    scopus 로고
    • Targeting tumor stroma using engineered mesenchymal stem cells reduces the growth of pancreatic carcinoma
    • Zischek C, Niess H, Ischenko I, Conrad C, Huss R, Jauch KW et al. Targeting tumor stroma using engineered mesenchymal stem cells reduces the growth of pancreatic carcinoma. Ann Surg 2009; 250: 747-753.
    • (2009) Ann Surg , vol.250 , pp. 747-753
    • Zischek, C.1    Niess, H.2    Ischenko, I.3    Conrad, C.4    Huss, R.5    Jauch, K.W.6
  • 18
    • 0036644833 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors
    • Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, Andreeff M. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 2002; 62: 3603-3608.
    • (2002) Cancer Res , vol.62 , pp. 3603-3608
    • Studeny, M.1    Marini, F.C.2    Champlin, R.E.3    Zompetta, C.4    Fidler, I.J.5    Andreeff, M.6
  • 19
    • 17544367410 scopus 로고    scopus 로고
    • Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
    • Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 1996; 271: 12687-12690.
    • (1996) J Biol Chem , vol.271 , pp. 12687-12690
    • Pitti, R.M.1    Marsters, S.A.2    Ruppert, S.3    Donahue, C.J.4    Moore, A.5    Ashkenazi, A.6
  • 20
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995; 3: 673-682.
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1    Schooley, K.2    Smolak, P.J.3    Din, W.S.4    Huang, C.P.5    Nicholl, J.K.6
  • 21
    • 70149122276 scopus 로고    scopus 로고
    • TRAIL as a target in anti-cancer therapy
    • Wu GS. TRAIL as a target in anti-cancer therapy. Cancer Lett 2009; 285: 1-5.
    • (2009) Cancer Lett , vol.285 , pp. 1-5
    • Wu, G.S.1
  • 22
    • 79953725744 scopus 로고    scopus 로고
    • HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species
    • Zhu DM, Shi J, Liu S, Liu Y, Zheng D. HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species. PloS One 2011; 6: e18291.
    • (2011) PloS One , vol.6
    • Zhu, D.M.1    Shi, J.2    Liu, S.3    Liu, Y.4    Zheng, D.5
  • 23
    • 43549106847 scopus 로고    scopus 로고
    • A combined procedure to deliver autologous mesenchymal stromal cells to patients with traumatic brain injury
    • Zhang ZX, Guan LX, Zhang K, Zhang Q, Dai LJ. A combined procedure to deliver autologous mesenchymal stromal cells to patients with traumatic brain injury. Cytotherapy 2008; 10: 134-139.
    • (2008) Cytotherapy , vol.10 , pp. 134-139
    • Zhang, Z.X.1    Guan, L.X.2    Zhang, K.3    Zhang, Q.4    Dai, L.J.5
  • 24
    • 83055191358 scopus 로고    scopus 로고
    • MSCTRAIL-mediated HepG2 cell death in direct and indirect co-cultures
    • Sun XY, Nong J, Qin K, Lu H, Moniri MR, Dai LJ et al. MSCTRAIL-mediated HepG2 cell death in direct and indirect co-cultures. Anticancer Res 2011; 31: 3705-3712.
    • (2011) Anticancer Res , vol.31 , pp. 3705-3712
    • Sun, X.Y.1    Nong, J.2    Qin, K.3    Lu, H.4    Moniri, M.R.5    Dai, L.J.6
  • 25
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315-317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5    Krause, D.6
  • 27
    • 79960133978 scopus 로고    scopus 로고
    • The xCELLigence system for real-time and label-free monitoring of cell viability
    • Ke N, Wang X, Xu X, Abassi YA. The xCELLigence system for real-time and label-free monitoring of cell viability. Methods Mol Biol 2011; 740: 33-43.
    • (2011) Methods Mol Biol , vol.740 , pp. 33-43
    • Ke, N.1    Wang, X.2    Xu, X.3    Abassi, Y.A.4
  • 28
    • 84856450676 scopus 로고    scopus 로고
    • In vitro effects of an in silico-modelled 17beta-estradiol derivative in combination with dichloroacetic acid on MCF-7 and MCF-12A cells
    • Stander XX, Stander BA, Joubert AM. In vitro effects of an in silico-modelled 17beta-estradiol derivative in combination with dichloroacetic acid on MCF-7 and MCF-12A cells. Cell Prolif 2011; 44: 567-581.
    • (2011) Cell Prolif , vol.44 , pp. 567-581
    • Stander, X.X.1    Stander, B.A.2    Joubert, A.M.3
  • 31
    • 78650385933 scopus 로고    scopus 로고
    • TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors
    • Stadel D, Mohr A, Ref C, MacFarlane M, Zhou S, Humphreys R et al. TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors. Clin Cancer Res 2010; 16: 5734-5749.
    • (2010) Clin Cancer Res , vol.16 , pp. 5734-5749
    • Stadel, D.1    Mohr, A.2    Ref, C.3    MacFarlane, M.4    Zhou, S.5    Humphreys, R.6
  • 32
    • 13444291202 scopus 로고    scopus 로고
    • Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter
    • Jacob D, Davis JJ, Zhang L, Zhu H, Teraishi F, Fang B. Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter. Cancer Gene Ther 2005; 12: 109-115.
    • (2005) Cancer Gene Ther , vol.12 , pp. 109-115
    • Jacob, D.1    Davis, J.J.2    Zhang, L.3    Zhu, H.4    Teraishi, F.5    Fang, B.6
  • 33
    • 77954541163 scopus 로고    scopus 로고
    • TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5
    • Lemke J, Noack A, Adam D, Tchikov V, Bertsch U, Roder C et al. TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5. J Mol Med 2010; 88: 729-740.
    • (2010) J Mol Med , vol.88 , pp. 729-740
    • Lemke, J.1    Noack, A.2    Adam, D.3    Tchikov, V.4    Bertsch, U.5    Roder, C.6
  • 34
    • 78649822978 scopus 로고    scopus 로고
    • Targeting of XIAP combined with systemic mesenchymal stem cell-mediated delivery of sTRAIL ligand inhibits metastatic growth of pancreatic carcinoma cells
    • Mohr A, Albarenque SM, Deedigan L, Yu R, Reidy M, Fulda S et al. Targeting of XIAP combined with systemic mesenchymal stem cell-mediated delivery of sTRAIL ligand inhibits metastatic growth of pancreatic carcinoma cells. Stem Cells 2010; 28: 2109-2120.
    • (2010) Stem Cells , vol.28 , pp. 2109-2120
    • Mohr, A.1    Albarenque, S.M.2    Deedigan, L.3    Yu, R.4    Reidy, M.5    Fulda, S.6
  • 35
    • 52649109068 scopus 로고    scopus 로고
    • The TRAIL apoptotic pathway in cancer onset, progression and therapy
    • Johnstone RW, Frew AJ, Smyth MJ. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer 2008; 8: 782-798.
    • (2008) Nat Rev Cancer , vol.8 , pp. 782-798
    • Johnstone, R.W.1    Frew, A.J.2    Smyth, M.J.3
  • 36
    • 41849115243 scopus 로고    scopus 로고
    • Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model
    • Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao RC et al. Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Res 2008; 18: 500-507.
    • (2008) Cell Res , vol.18 , pp. 500-507
    • Qiao, L.1    Xu, Z.2    Zhao, T.3    Zhao, Z.4    Shi, M.5    Zhao, R.C.6
  • 37
    • 78649392268 scopus 로고    scopus 로고
    • Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesench-ymal stem cells requires their substantial intratumoral presence
    • Luetzkendorf J, Mueller LP, Mueller T, Caysa H, Nerger K, Schmoll HJ. Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesench-ymal stem cells requires their substantial intratumoral presence. J Cell Mol Med 2010; 14: 2292-2304.
    • (2010) J Cell Mol Med , vol.14 , pp. 2292-2304
    • Luetzkendorf, J.1    Mueller, L.P.2    Mueller, T.3    Caysa, H.4    Nerger, K.5    Schmoll, H.J.6
  • 38
    • 14644437742 scopus 로고    scopus 로고
    • Mechanisms of resistance to TRAIL-induced apoptosis in cancer
    • Zhang L, Fang B. Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther 2005; 12: 228-237.
    • (2005) Cancer Gene Ther , vol.12 , pp. 228-237
    • Zhang, L.1    Fang, B.2
  • 39
    • 0034956807 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death
    • Ibrahim SM, Ringel J, Schmidt C, Ringel B, Muller P, Koczan D et al. Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death. Pancreas 2001; 23: 72-79.
    • (2001) Pancreas , vol.23 , pp. 72-79
    • Ibrahim, S.M.1    Ringel, J.2    Schmidt, C.3    Ringel, B.4    Muller, P.5    Koczan, D.6
  • 40
    • 65349134138 scopus 로고    scopus 로고
    • High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients
    • Sanlioglu AD, Dirice E, Elpek O, Korcum AF, Ozdogan M, Suleymanlar I et al. High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients. Pancreas 2009; 38: 154-160.
    • (2009) Pancreas , vol.38 , pp. 154-160
    • Sanlioglu, A.D.1    Dirice, E.2    Elpek, O.3    Korcum, A.F.4    Ozdogan, M.5    Suleymanlar, I.6
  • 41
    • 79952899402 scopus 로고    scopus 로고
    • TRAIL-transduced multipotent mesenchymal stromal cells (TRAIL-MSC) overcome TRAIL resistance in selected CRC cell lines in vitro and in vivo
    • Mueller LP, Luetzkendorf J, Widder M, Nerger K, Caysa H, Mueller T. TRAIL-transduced multipotent mesenchymal stromal cells (TRAIL-MSC) overcome TRAIL resistance in selected CRC cell lines in vitro and in vivo. Cancer Gene Ther 2011; 18: 229-239.
    • (2011) Cancer Gene Ther , vol.18 , pp. 229-239
    • Mueller, L.P.1    Luetzkendorf, J.2    Widder, M.3    Nerger, K.4    Caysa, H.5    Mueller, T.6
  • 42
    • 84864838071 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated cancer therapy: A dual-targeted strategy of personalized medicine
    • Sun XY, Nong J, Qin K, Warnock GL, Dai LJ. Mesenchymal stem cell-mediated cancer therapy: a dual-targeted strategy of personalized medicine. World J Stem Cells 2011; 3: 96-103.
    • (2011) World J Stem Cells , vol.3 , pp. 96-103
    • Sun, X.Y.1    Nong, J.2    Qin, K.3    Warnock, G.L.4    Dai, L.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.